VC 2.00I 15-JUL-2003 02-AUG-2003 08:00:09 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: u:\usr\bin\vc.exe u:\archive\hx142\lpl\hx142.inp FNI: U:\archive\hx142\lpl\hx142.inp FNO: U:\archive\hx142\lpl\hx142.out RADX: U:\archive\hx142\lpl\hx142.radx (132 exposures) -------------------------------------------------------------------------------- QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- LPLM TABLE: Summary of LPL parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) DSB = 0.00000E+00 0.00000E+00 0.00000E+00 RADIATION DAMAGE: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) DSB = 7.17785E-12 4.41151E-03 25.000000 FL = 1.54119E-13 9.47213E-05 0.536785 DAMAGE REPAIR/MISREPAIR: A0= 9.500000E-01 (=95.000%) (1-A0)= 5.000000E-02 (=5.000%) RHT= 1.948729 h (=116.92 minute) LAM= 3.5569186E-01 (1/h) BMR= 8.0953477E-04 (1/h) LAM/BMR= 4.3937811E+02 GAM= 0.250 ***** EQUIVALENT LQ MODEL PARAMETERS ***** alpha = 0.536785 (1/Gy) beta = 0.177808 (1/Gy^2) alpha/beta = 3.018903 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg DFAR TABLE: Cell survival as a function of dose and dose rate (FRDL=100.0%). ====================================================================================================== --- Duration (h) --- Dose Dose Rate ---- LETHAL DAMAGE PER CELL ---- SIM ID Exposure Sim (Gy) (Gy/h) Mutations Residual Total SF(dose) ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 2 6.667E-01 7.267E+01 1.000E-01 1.500E-01 1.640E-03 5.368E-02 5.5318E-02 9.461842E-01 3 1.667E+00 7.367E+01 2.500E-01 1.500E-01 9.129E-03 1.342E-01 1.4333E-01 8.664720E-01 4 3.333E+00 7.533E+01 5.000E-01 1.500E-01 3.059E-02 2.684E-01 2.9898E-01 7.415719E-01 5 6.667E+00 7.867E+01 1.000E+00 1.500E-01 9.033E-02 5.368E-01 6.2712E-01 5.341294E-01 6 1.000E+01 7.000E+01 1.500E+00 1.500E-01 1.585E-01 8.052E-01 9.6367E-01 3.814887E-01 7 1.333E+01 7.333E+01 2.000E+00 1.500E-01 2.291E-01 1.074E+00 1.3027E+00 2.718064E-01 8 2.000E+01 8.000E+01 3.000E+00 1.500E-01 3.719E-01 1.610E+00 1.9823E+00 1.377578E-01 9 2.667E+01 8.667E+01 4.000E+00 1.500E-01 5.150E-01 2.147E+00 2.6622E+00 6.979532E-02 10 3.333E+01 9.333E+01 5.000E+00 1.500E-01 6.582E-01 2.684E+00 3.3421E+00 3.536095E-02 11 4.000E+01 1.000E+02 6.000E+00 1.500E-01 8.014E-01 3.221E+00 4.0221E+00 1.791516E-02 12 4.667E+01 1.067E+02 7.000E+00 1.500E-01 9.446E-01 3.757E+00 4.7021E+00 9.076474E-03 13 5.333E+01 1.133E+02 8.000E+00 1.500E-01 1.088E+00 4.294E+00 5.3820E+00 4.598474E-03 14 6.000E+01 1.200E+02 9.000E+00 1.500E-01 1.231E+00 4.831E+00 6.0620E+00 2.329755E-03 15 6.667E+01 1.267E+02 1.000E+01 1.500E-01 1.374E+00 5.368E+00 6.7420E+00 1.180339E-03 16 8.333E+01 1.433E+02 1.250E+01 1.500E-01 1.732E+00 6.710E+00 8.4419E+00 2.156494E-04 17 1.000E+02 1.600E+02 1.500E+01 1.500E-01 2.090E+00 8.052E+00 1.0142E+01 3.939940E-05 18 1.167E+02 1.767E+02 1.750E+01 1.500E-01 2.448E+00 9.394E+00 1.1842E+01 7.198318E-06 19 1.333E+02 1.933E+02 2.000E+01 1.500E-01 2.806E+00 1.074E+01 1.3542E+01 1.315141E-06 20 1.667E+02 2.267E+02 2.500E+01 1.500E-01 3.522E+00 1.342E+01 1.6941E+01 4.389906E-08 21 2.000E+02 2.600E+02 3.000E+01 1.500E-01 4.238E+00 1.610E+01 2.0341E+01 1.465339E-09 22 2.333E+02 2.933E+02 3.500E+01 1.500E-01 4.953E+00 1.879E+01 2.3741E+01 4.891261E-11 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 24 3.333E-01 7.233E+01 1.000E-01 3.000E-01 1.704E-03 5.368E-02 5.5382E-02 9.461236E-01 25 8.333E-01 7.283E+01 2.500E-01 3.000E-01 1.000E-02 1.342E-01 1.4420E-01 8.657163E-01 26 1.667E+00 7.367E+01 5.000E-01 3.000E-01 3.621E-02 2.684E-01 3.0460E-01 7.374169E-01 27 3.333E+00 7.533E+01 1.000E+00 3.000E-01 1.205E-01 5.368E-01 6.5731E-01 5.182412E-01 28 5.000E+00 7.700E+01 1.500E+00 3.000E-01 2.300E-01 8.052E-01 1.0352E+00 3.551602E-01 29 6.667E+00 7.867E+01 2.000E+00 3.000E-01 3.527E-01 1.074E+00 1.4262E+00 2.402149E-01 30 1.000E+01 7.000E+01 3.000E+00 3.000E-01 6.153E-01 1.610E+00 2.2257E+00 1.079945E-01 31 1.333E+01 7.333E+01 4.000E+00 3.000E-01 8.864E-01 2.147E+00 3.0335E+00 4.814693E-02 32 1.667E+01 7.667E+01 5.000E+00 3.000E-01 1.160E+00 2.684E+00 3.8436E+00 2.141606E-02 33 2.000E+01 8.000E+01 6.000E+00 3.000E-01 1.434E+00 3.221E+00 4.6544E+00 9.520018E-03 34 2.333E+01 8.333E+01 7.000E+00 3.000E-01 1.708E+00 3.757E+00 5.4653E+00 4.231176E-03 35 2.667E+01 8.667E+01 8.000E+00 3.000E-01 1.982E+00 4.294E+00 6.2762E+00 1.880459E-03 36 3.000E+01 9.000E+01 9.000E+00 3.000E-01 2.256E+00 4.831E+00 7.0872E+00 8.357208E-04 37 3.333E+01 9.333E+01 1.000E+01 3.000E-01 2.530E+00 5.368E+00 7.8982E+00 3.714128E-04 38 4.167E+01 1.017E+02 1.250E+01 3.000E-01 3.216E+00 6.710E+00 9.9257E+00 4.890406E-05 39 5.000E+01 1.100E+02 1.500E+01 3.000E-01 3.901E+00 8.052E+00 1.1953E+01 6.439211E-06 40 5.833E+01 1.183E+02 1.750E+01 3.000E-01 4.587E+00 9.394E+00 1.3981E+01 8.478527E-07 41 6.667E+01 1.267E+02 2.000E+01 3.000E-01 5.272E+00 1.074E+01 1.6008E+01 1.116370E-07 42 8.333E+01 1.433E+02 2.500E+01 3.000E-01 6.643E+00 1.342E+01 2.0063E+01 1.935458E-09 43 1.000E+02 1.600E+02 3.000E+01 3.000E-01 8.014E+00 1.610E+01 2.4118E+01 3.355515E-11 44 1.167E+02 1.767E+02 3.500E+01 3.000E-01 9.385E+00 1.879E+01 2.8173E+01 5.817478E-13 45 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 46 1.667E-01 7.217E+01 1.000E-01 6.000E-01 1.737E-03 5.368E-02 5.5415E-02 9.460920E-01 47 4.167E-01 7.242E+01 2.500E-01 6.000E-01 1.049E-02 1.342E-01 1.4468E-01 8.652964E-01 48 8.333E-01 7.283E+01 5.000E-01 6.000E-01 3.965E-02 2.684E-01 3.0805E-01 7.348817E-01 49 1.667E+00 7.367E+01 1.000E+00 6.000E-01 1.424E-01 5.368E-01 6.7923E-01 5.070056E-01 50 2.500E+00 7.450E+01 1.500E+00 6.000E-01 2.897E-01 8.052E-01 1.0948E+00 3.345904E-01 51 3.333E+00 7.533E+01 2.000E+00 6.000E-01 4.682E-01 1.074E+00 1.5417E+00 2.140064E-01 52 5.000E+00 7.700E+01 3.000E+00 6.000E-01 8.848E-01 1.610E+00 2.4952E+00 8.248161E-02 53 6.667E+00 7.867E+01 4.000E+00 6.000E-01 1.347E+00 2.147E+00 3.4938E+00 3.038543E-02 54 8.333E+00 6.833E+01 5.000E+00 6.000E-01 1.831E+00 2.684E+00 4.5149E+00 1.094494E-02 55 1.000E+01 7.000E+01 6.000E+00 6.000E-01 2.326E+00 3.221E+00 5.5471E+00 3.898555E-03 56 1.167E+01 7.167E+01 7.000E+00 6.000E-01 2.827E+00 3.757E+00 6.5850E+00 1.380945E-03 57 1.333E+01 7.333E+01 8.000E+00 6.000E-01 3.331E+00 4.294E+00 7.6256E+00 4.878039E-04 58 1.500E+01 7.500E+01 9.000E+00 6.000E-01 3.837E+00 4.831E+00 8.6676E+00 1.720739E-04 59 1.667E+01 7.667E+01 1.000E+01 6.000E-01 4.342E+00 5.368E+00 9.7103E+00 6.065777E-05 60 2.083E+01 8.083E+01 1.250E+01 6.000E-01 5.608E+00 6.710E+00 1.2318E+01 4.470101E-06 61 2.500E+01 8.500E+01 1.500E+01 6.000E-01 6.875E+00 8.052E+00 1.4926E+01 3.292673E-07 62 2.917E+01 8.917E+01 1.750E+01 6.000E-01 8.141E+00 9.394E+00 1.7535E+01 2.425186E-08 63 3.333E+01 9.333E+01 2.000E+01 6.000E-01 9.407E+00 1.074E+01 2.0143E+01 1.786221E-09 64 4.167E+01 1.017E+02 2.500E+01 6.000E-01 1.194E+01 1.342E+01 2.5360E+01 9.689768E-12 65 5.000E+01 1.100E+02 3.000E+01 6.000E-01 1.447E+01 1.610E+01 3.0577E+01 5.256435E-14 66 5.833E+01 1.183E+02 3.500E+01 6.000E-01 1.701E+01 1.879E+01 3.5794E+01 2.851472E-16 67 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 68 8.333E-02 7.208E+01 1.000E-01 1.200E+00 1.754E-03 5.368E-02 5.5433E-02 9.460758E-01 69 2.083E-01 7.221E+01 2.500E-01 1.200E+00 1.074E-02 1.342E-01 1.4494E-01 8.650747E-01 70 4.167E-01 7.242E+01 5.000E-01 1.200E+00 4.157E-02 2.684E-01 3.0996E-01 7.334760E-01 71 8.333E-01 7.283E+01 1.000E+00 1.200E+00 1.559E-01 5.368E-01 6.9265E-01 5.002474E-01 72 1.250E+00 7.325E+01 1.500E+00 1.200E+00 3.295E-01 8.052E-01 1.1347E+00 3.215157E-01 73 1.667E+00 7.367E+01 2.000E+00 1.200E+00 5.517E-01 1.074E+00 1.6253E+00 1.968581E-01 74 2.500E+00 7.450E+01 3.000E+00 1.200E+00 1.108E+00 1.610E+00 2.7182E+00 6.599300E-02 75 3.333E+00 7.533E+01 4.000E+00 1.200E+00 1.771E+00 2.147E+00 3.9186E+00 1.986951E-02 76 4.167E+00 7.617E+01 5.000E+00 1.200E+00 2.507E+00 2.684E+00 5.1911E+00 5.566075E-03 77 5.000E+00 7.700E+01 6.000E+00 1.200E+00 3.291E+00 3.221E+00 6.5121E+00 1.485410E-03 78 5.833E+00 7.783E+01 7.000E+00 1.200E+00 4.108E+00 3.757E+00 7.8657E+00 3.836785E-04 79 6.667E+00 6.667E+01 8.000E+00 1.200E+00 4.947E+00 4.294E+00 9.2413E+00 9.694865E-05 80 7.500E+00 6.750E+01 9.000E+00 1.200E+00 5.801E+00 4.831E+00 1.0632E+01 2.413706E-05 81 8.333E+00 6.833E+01 1.000E+01 1.200E+00 6.664E+00 5.368E+00 1.2032E+01 5.949669E-06 82 1.042E+01 7.042E+01 1.250E+01 1.200E+00 8.848E+00 6.710E+00 1.5558E+01 1.750764E-07 83 1.250E+01 7.250E+01 1.500E+01 1.200E+00 1.105E+01 8.052E+00 1.9101E+01 5.066108E-09 84 1.458E+01 7.458E+01 1.750E+01 1.200E+00 1.326E+01 9.394E+00 2.2650E+01 1.456803E-10 85 1.667E+01 7.667E+01 2.000E+01 1.200E+00 1.547E+01 1.074E+01 2.6201E+01 4.179379E-12 86 2.083E+01 8.083E+01 2.500E+01 1.200E+00 1.989E+01 1.342E+01 3.3305E+01 3.432683E-15 87 2.500E+01 8.500E+01 3.000E+01 1.200E+00 2.431E+01 1.610E+01 4.0411E+01 2.817661E-18 88 2.917E+01 8.917E+01 3.500E+01 1.200E+00 2.873E+01 1.879E+01 4.7516E+01 2.312633E-21 89 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 90 8.333E-03 7.201E+01 1.000E-01 1.200E+01 1.770E-03 5.368E-02 5.5448E-02 9.460611E-01 91 2.083E-02 7.202E+01 2.500E-01 1.200E+01 1.098E-02 1.342E-01 1.4518E-01 8.648683E-01 92 4.167E-02 7.204E+01 5.000E-01 1.200E+01 4.341E-02 2.684E-01 3.1181E-01 7.321232E-01 93 8.333E-02 7.208E+01 1.000E+00 1.200E+01 1.697E-01 5.368E-01 7.0647E-01 4.933807E-01 94 1.250E-01 7.212E+01 1.500E+00 1.200E+01 3.733E-01 8.052E-01 1.1784E+00 3.077573E-01 95 1.667E-01 7.217E+01 2.000E+00 1.200E+01 6.491E-01 1.074E+00 1.7226E+00 1.785957E-01 96 2.500E-01 7.225E+01 3.000E+00 1.200E+01 1.399E+00 1.610E+00 3.0094E+00 4.932162E-02 97 3.333E-01 7.233E+01 4.000E+00 1.200E+01 2.387E+00 2.147E+00 4.5338E+00 1.073992E-02 98 4.167E-01 7.242E+01 5.000E+00 1.200E+01 3.584E+00 2.684E+00 6.2678E+00 1.896452E-03 99 5.000E-01 7.250E+01 6.000E+00 1.200E+01 4.967E+00 3.221E+00 8.1873E+00 2.781593E-04 100 5.833E-01 7.258E+01 7.000E+00 1.200E+01 6.514E+00 3.757E+00 1.0272E+01 3.459807E-05 101 6.667E-01 7.267E+01 8.000E+00 1.200E+01 8.209E+00 4.294E+00 1.2503E+01 3.715487E-06 102 7.500E-01 7.275E+01 9.000E+00 1.200E+01 1.003E+01 4.831E+00 1.4866E+01 3.499308E-07 103 8.333E-01 7.283E+01 1.000E+01 1.200E+01 1.198E+01 5.368E+00 1.7346E+01 2.930228E-08 104 1.042E+00 7.304E+01 1.250E+01 1.200E+01 1.727E+01 6.710E+00 2.3984E+01 3.834450E-11 105 1.250E+00 7.325E+01 1.500E+01 1.200E+01 2.308E+01 8.052E+00 3.1133E+01 3.013317E-14 106 1.458E+00 7.346E+01 1.750E+01 1.200E+01 2.928E+01 9.394E+00 3.8678E+01 1.594031E-17 107 1.667E+00 7.367E+01 2.000E+01 1.200E+01 3.580E+01 1.074E+01 4.6532E+01 6.188016E-21 108 2.083E+00 7.408E+01 2.500E+01 1.200E+01 4.950E+01 1.342E+01 6.2919E+01 4.729400E-28 109 2.500E+00 6.250E+01 3.000E+01 1.200E+01 6.382E+01 1.610E+01 7.9924E+01 1.948093E-35 110 2.917E+00 6.292E+01 3.500E+01 1.200E+01 7.853E+01 1.879E+01 9.7320E+01 5.426450E-43 111 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 112 1.852E-03 7.200E+01 1.000E-01 5.400E+01 1.771E-03 5.368E-02 5.5450E-02 9.460598E-01 113 4.630E-03 7.200E+01 2.500E-01 5.400E+01 1.100E-02 1.342E-01 1.4520E-01 8.648501E-01 114 9.259E-03 7.201E+01 5.000E-01 5.400E+01 4.358E-02 2.684E-01 3.1197E-01 7.320021E-01 115 1.852E-02 7.202E+01 1.000E+00 5.400E+01 1.710E-01 5.368E-01 7.0776E-01 4.927490E-01 116 2.778E-02 7.203E+01 1.500E+00 5.400E+01 3.775E-01 8.052E-01 1.1826E+00 3.064697E-01 117 3.704E-02 7.204E+01 2.000E+00 5.400E+01 6.587E-01 1.074E+00 1.7323E+00 1.768819E-01 118 5.556E-02 7.206E+01 3.000E+00 5.400E+01 1.430E+00 1.610E+00 3.0401E+00 4.783071E-02 119 7.407E-02 7.207E+01 4.000E+00 5.400E+01 2.455E+00 2.147E+00 4.6026E+00 1.002589E-02 120 9.259E-02 7.209E+01 5.000E+00 5.400E+01 3.711E+00 2.684E+00 6.3951E+00 1.669703E-03 121 1.111E-01 7.211E+01 6.000E+00 5.400E+01 5.176E+00 3.221E+00 8.3963E+00 2.257080E-04 122 1.296E-01 7.213E+01 7.000E+00 5.400E+01 6.830E+00 3.757E+00 1.0587E+01 2.523245E-05 123 1.481E-01 7.215E+01 8.000E+00 5.400E+01 8.658E+00 4.294E+00 1.2952E+01 2.371385E-06 124 1.667E-01 7.217E+01 9.000E+00 5.400E+01 1.064E+01 4.831E+00 1.5476E+01 1.900933E-07 125 1.852E-01 7.219E+01 1.000E+01 5.400E+01 1.278E+01 5.368E+00 1.8146E+01 1.316546E-08 126 2.315E-01 7.223E+01 1.250E+01 5.400E+01 1.868E+01 6.710E+00 2.5388E+01 9.423178E-12 127 2.778E-01 7.228E+01 1.500E+01 5.400E+01 2.527E+01 8.052E+00 3.3326E+01 3.361929E-15 128 3.241E-01 7.232E+01 1.750E+01 5.400E+01 3.245E+01 9.394E+00 4.1845E+01 6.710692E-19 129 3.704E-01 7.237E+01 2.000E+01 5.400E+01 4.012E+01 1.074E+01 5.0854E+01 8.209395E-23 130 4.630E-01 7.246E+01 2.500E+01 5.400E+01 5.664E+01 1.342E+01 7.0062E+01 3.737330E-31 131 5.556E-01 7.256E+01 3.000E+01 5.400E+01 7.441E+01 1.610E+01 9.0510E+01 4.921030E-40 132 6.481E-01 6.065E+01 3.500E+01 5.400E+01 9.311E+01 1.879E+01 1.1190E+02 2.536930E-49 ------------------------------------------------------------------------------------------------------ NOTE: SF=EXP{-(lethal residual damage + lethal mutations)}. QECK TABLE: Cell survival, corrected for repopulation effects, as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. ===================================================================================================================== TSIM DOSE DOSE RATE - SURVIVING FRACTION - --------- EXPECTED NUMBER OF CELLS ----------- SIM ID (day) (Gy) (Gy/h) no repop repop N(t)/N(0) N(0)*S(D) N(t)*S(D) NSC(t) --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 2 3.028E+00 1.000E-01 1.500E-01 9.4618E-01 9.4618E-01 1.0000E+00 9.4618E-01 9.4618E-01 9.4618E-01 3 3.069E+00 2.500E-01 1.500E-01 8.6647E-01 8.6647E-01 1.0000E+00 8.6647E-01 8.6647E-01 8.6647E-01 4 3.139E+00 5.000E-01 1.500E-01 7.4157E-01 7.4157E-01 1.0000E+00 7.4157E-01 7.4157E-01 7.4157E-01 5 3.278E+00 1.000E+00 1.500E-01 5.3413E-01 5.3413E-01 1.0000E+00 5.3413E-01 5.3413E-01 5.3413E-01 6 2.917E+00 1.500E+00 1.500E-01 3.8149E-01 3.8149E-01 1.0000E+00 3.8149E-01 3.8149E-01 3.8149E-01 7 3.056E+00 2.000E+00 1.500E-01 2.7181E-01 2.7181E-01 1.0000E+00 2.7181E-01 2.7181E-01 2.7181E-01 8 3.333E+00 3.000E+00 1.500E-01 1.3776E-01 1.3776E-01 1.0000E+00 1.3776E-01 1.3776E-01 1.3776E-01 9 3.611E+00 4.000E+00 1.500E-01 6.9795E-02 6.9795E-02 1.0000E+00 6.9795E-02 6.9795E-02 6.9795E-02 10 3.889E+00 5.000E+00 1.500E-01 3.5361E-02 3.5361E-02 1.0000E+00 3.5361E-02 3.5361E-02 3.5361E-02 11 4.167E+00 6.000E+00 1.500E-01 1.7915E-02 1.7915E-02 1.0000E+00 1.7915E-02 1.7915E-02 1.7915E-02 12 4.444E+00 7.000E+00 1.500E-01 9.0765E-03 9.0765E-03 1.0000E+00 9.0765E-03 9.0765E-03 9.0765E-03 13 4.722E+00 8.000E+00 1.500E-01 4.5985E-03 4.5985E-03 1.0000E+00 4.5985E-03 4.5985E-03 4.5985E-03 14 5.000E+00 9.000E+00 1.500E-01 2.3298E-03 2.3298E-03 1.0000E+00 2.3298E-03 2.3298E-03 2.3298E-03 15 5.278E+00 1.000E+01 1.500E-01 1.1803E-03 1.1803E-03 1.0000E+00 1.1803E-03 1.1803E-03 1.1803E-03 16 5.972E+00 1.250E+01 1.500E-01 2.1565E-04 2.1565E-04 1.0000E+00 2.1565E-04 2.1565E-04 2.1565E-04 17 6.667E+00 1.500E+01 1.500E-01 3.9399E-05 3.9399E-05 1.0000E+00 3.9399E-05 3.9399E-05 3.9399E-05 18 7.361E+00 1.750E+01 1.500E-01 7.1983E-06 7.1983E-06 1.0000E+00 7.1983E-06 7.1983E-06 7.1983E-06 19 8.056E+00 2.000E+01 1.500E-01 1.3151E-06 1.3151E-06 1.0000E+00 1.3151E-06 1.3151E-06 1.3151E-06 20 9.444E+00 2.500E+01 1.500E-01 4.3899E-08 4.3899E-08 1.0000E+00 4.3899E-08 4.3899E-08 4.3899E-08 21 1.083E+01 3.000E+01 1.500E-01 1.4653E-09 1.4653E-09 1.0000E+00 1.4653E-09 1.4653E-09 1.4653E-09 22 1.222E+01 3.500E+01 1.500E-01 4.8913E-11 4.8913E-11 1.0000E+00 4.8913E-11 4.8913E-11 4.8913E-11 23 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 24 3.014E+00 1.000E-01 3.000E-01 9.4612E-01 9.4612E-01 1.0000E+00 9.4612E-01 9.4612E-01 9.4612E-01 25 3.035E+00 2.500E-01 3.000E-01 8.6572E-01 8.6572E-01 1.0000E+00 8.6572E-01 8.6572E-01 8.6572E-01 26 3.069E+00 5.000E-01 3.000E-01 7.3742E-01 7.3742E-01 1.0000E+00 7.3742E-01 7.3742E-01 7.3742E-01 27 3.139E+00 1.000E+00 3.000E-01 5.1824E-01 5.1824E-01 1.0000E+00 5.1824E-01 5.1824E-01 5.1824E-01 28 3.208E+00 1.500E+00 3.000E-01 3.5516E-01 3.5516E-01 1.0000E+00 3.5516E-01 3.5516E-01 3.5516E-01 29 3.278E+00 2.000E+00 3.000E-01 2.4021E-01 2.4021E-01 1.0000E+00 2.4021E-01 2.4021E-01 2.4021E-01 30 2.917E+00 3.000E+00 3.000E-01 1.0799E-01 1.0799E-01 1.0000E+00 1.0799E-01 1.0799E-01 1.0799E-01 31 3.056E+00 4.000E+00 3.000E-01 4.8147E-02 4.8147E-02 1.0000E+00 4.8147E-02 4.8147E-02 4.8147E-02 32 3.194E+00 5.000E+00 3.000E-01 2.1416E-02 2.1416E-02 1.0000E+00 2.1416E-02 2.1416E-02 2.1416E-02 33 3.333E+00 6.000E+00 3.000E-01 9.5200E-03 9.5200E-03 1.0000E+00 9.5200E-03 9.5200E-03 9.5200E-03 34 3.472E+00 7.000E+00 3.000E-01 4.2312E-03 4.2312E-03 1.0000E+00 4.2312E-03 4.2312E-03 4.2312E-03 35 3.611E+00 8.000E+00 3.000E-01 1.8805E-03 1.8805E-03 1.0000E+00 1.8805E-03 1.8805E-03 1.8805E-03 36 3.750E+00 9.000E+00 3.000E-01 8.3572E-04 8.3572E-04 1.0000E+00 8.3572E-04 8.3572E-04 8.3572E-04 37 3.889E+00 1.000E+01 3.000E-01 3.7141E-04 3.7141E-04 1.0000E+00 3.7141E-04 3.7141E-04 3.7141E-04 38 4.236E+00 1.250E+01 3.000E-01 4.8904E-05 4.8904E-05 1.0000E+00 4.8904E-05 4.8904E-05 4.8904E-05 39 4.583E+00 1.500E+01 3.000E-01 6.4392E-06 6.4392E-06 1.0000E+00 6.4392E-06 6.4392E-06 6.4392E-06 40 4.931E+00 1.750E+01 3.000E-01 8.4785E-07 8.4785E-07 1.0000E+00 8.4785E-07 8.4785E-07 8.4785E-07 41 5.278E+00 2.000E+01 3.000E-01 1.1164E-07 1.1164E-07 1.0000E+00 1.1164E-07 1.1164E-07 1.1164E-07 42 5.972E+00 2.500E+01 3.000E-01 1.9355E-09 1.9355E-09 1.0000E+00 1.9355E-09 1.9355E-09 1.9355E-09 43 6.667E+00 3.000E+01 3.000E-01 3.3555E-11 3.3555E-11 1.0000E+00 3.3555E-11 3.3555E-11 3.3555E-11 44 7.361E+00 3.500E+01 3.000E-01 5.8175E-13 5.8175E-13 1.0000E+00 5.8175E-13 5.8175E-13 5.8175E-13 45 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 46 3.007E+00 1.000E-01 6.000E-01 9.4609E-01 9.4609E-01 1.0000E+00 9.4609E-01 9.4609E-01 9.4609E-01 47 3.017E+00 2.500E-01 6.000E-01 8.6530E-01 8.6530E-01 1.0000E+00 8.6530E-01 8.6530E-01 8.6530E-01 48 3.035E+00 5.000E-01 6.000E-01 7.3488E-01 7.3488E-01 1.0000E+00 7.3488E-01 7.3488E-01 7.3488E-01 49 3.069E+00 1.000E+00 6.000E-01 5.0701E-01 5.0701E-01 1.0000E+00 5.0701E-01 5.0701E-01 5.0701E-01 50 3.104E+00 1.500E+00 6.000E-01 3.3459E-01 3.3459E-01 1.0000E+00 3.3459E-01 3.3459E-01 3.3459E-01 51 3.139E+00 2.000E+00 6.000E-01 2.1401E-01 2.1401E-01 1.0000E+00 2.1401E-01 2.1401E-01 2.1401E-01 52 3.208E+00 3.000E+00 6.000E-01 8.2482E-02 8.2482E-02 1.0000E+00 8.2482E-02 8.2482E-02 8.2482E-02 53 3.278E+00 4.000E+00 6.000E-01 3.0385E-02 3.0385E-02 1.0000E+00 3.0385E-02 3.0385E-02 3.0385E-02 54 2.847E+00 5.000E+00 6.000E-01 1.0945E-02 1.0945E-02 1.0000E+00 1.0945E-02 1.0945E-02 1.0945E-02 55 2.917E+00 6.000E+00 6.000E-01 3.8986E-03 3.8986E-03 1.0000E+00 3.8986E-03 3.8986E-03 3.8986E-03 56 2.986E+00 7.000E+00 6.000E-01 1.3809E-03 1.3809E-03 1.0000E+00 1.3809E-03 1.3809E-03 1.3809E-03 57 3.056E+00 8.000E+00 6.000E-01 4.8780E-04 4.8780E-04 1.0000E+00 4.8780E-04 4.8780E-04 4.8780E-04 58 3.125E+00 9.000E+00 6.000E-01 1.7207E-04 1.7207E-04 1.0000E+00 1.7207E-04 1.7207E-04 1.7207E-04 59 3.194E+00 1.000E+01 6.000E-01 6.0658E-05 6.0658E-05 1.0000E+00 6.0658E-05 6.0658E-05 6.0658E-05 60 3.368E+00 1.250E+01 6.000E-01 4.4701E-06 4.4701E-06 1.0000E+00 4.4701E-06 4.4701E-06 4.4701E-06 61 3.542E+00 1.500E+01 6.000E-01 3.2927E-07 3.2927E-07 1.0000E+00 3.2927E-07 3.2927E-07 3.2927E-07 62 3.715E+00 1.750E+01 6.000E-01 2.4252E-08 2.4252E-08 1.0000E+00 2.4252E-08 2.4252E-08 2.4252E-08 63 3.889E+00 2.000E+01 6.000E-01 1.7862E-09 1.7862E-09 1.0000E+00 1.7862E-09 1.7862E-09 1.7862E-09 64 4.236E+00 2.500E+01 6.000E-01 9.6898E-12 9.6898E-12 1.0000E+00 9.6898E-12 9.6898E-12 9.6898E-12 65 4.583E+00 3.000E+01 6.000E-01 5.2564E-14 5.2564E-14 1.0000E+00 5.2564E-14 5.2564E-14 5.2564E-14 66 4.931E+00 3.500E+01 6.000E-01 2.8515E-16 2.8515E-16 1.0000E+00 2.8515E-16 2.8515E-16 2.8515E-16 67 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 68 3.003E+00 1.000E-01 1.200E+00 9.4608E-01 9.4608E-01 1.0000E+00 9.4608E-01 9.4608E-01 9.4608E-01 69 3.009E+00 2.500E-01 1.200E+00 8.6507E-01 8.6507E-01 1.0000E+00 8.6507E-01 8.6507E-01 8.6507E-01 70 3.017E+00 5.000E-01 1.200E+00 7.3348E-01 7.3348E-01 1.0000E+00 7.3348E-01 7.3348E-01 7.3348E-01 71 3.035E+00 1.000E+00 1.200E+00 5.0025E-01 5.0025E-01 1.0000E+00 5.0025E-01 5.0025E-01 5.0025E-01 72 3.052E+00 1.500E+00 1.200E+00 3.2152E-01 3.2152E-01 1.0000E+00 3.2152E-01 3.2152E-01 3.2152E-01 73 3.069E+00 2.000E+00 1.200E+00 1.9686E-01 1.9686E-01 1.0000E+00 1.9686E-01 1.9686E-01 1.9686E-01 74 3.104E+00 3.000E+00 1.200E+00 6.5993E-02 6.5993E-02 1.0000E+00 6.5993E-02 6.5993E-02 6.5993E-02 75 3.139E+00 4.000E+00 1.200E+00 1.9870E-02 1.9870E-02 1.0000E+00 1.9870E-02 1.9870E-02 1.9870E-02 76 3.174E+00 5.000E+00 1.200E+00 5.5661E-03 5.5661E-03 1.0000E+00 5.5661E-03 5.5661E-03 5.5661E-03 77 3.208E+00 6.000E+00 1.200E+00 1.4854E-03 1.4854E-03 1.0000E+00 1.4854E-03 1.4854E-03 1.4854E-03 78 3.243E+00 7.000E+00 1.200E+00 3.8368E-04 3.8368E-04 1.0000E+00 3.8368E-04 3.8368E-04 3.8368E-04 79 2.778E+00 8.000E+00 1.200E+00 9.6949E-05 9.6949E-05 1.0000E+00 9.6949E-05 9.6949E-05 9.6949E-05 80 2.812E+00 9.000E+00 1.200E+00 2.4137E-05 2.4137E-05 1.0000E+00 2.4137E-05 2.4137E-05 2.4137E-05 81 2.847E+00 1.000E+01 1.200E+00 5.9497E-06 5.9497E-06 1.0000E+00 5.9497E-06 5.9497E-06 5.9497E-06 82 2.934E+00 1.250E+01 1.200E+00 1.7508E-07 1.7508E-07 1.0000E+00 1.7508E-07 1.7508E-07 1.7508E-07 83 3.021E+00 1.500E+01 1.200E+00 5.0661E-09 5.0661E-09 1.0000E+00 5.0661E-09 5.0661E-09 5.0661E-09 84 3.108E+00 1.750E+01 1.200E+00 1.4568E-10 1.4568E-10 1.0000E+00 1.4568E-10 1.4568E-10 1.4568E-10 85 3.194E+00 2.000E+01 1.200E+00 4.1794E-12 4.1794E-12 1.0000E+00 4.1794E-12 4.1794E-12 4.1794E-12 86 3.368E+00 2.500E+01 1.200E+00 3.4327E-15 3.4327E-15 1.0000E+00 3.4327E-15 3.4327E-15 3.4327E-15 87 3.542E+00 3.000E+01 1.200E+00 2.8177E-18 2.8177E-18 1.0000E+00 2.8177E-18 2.8177E-18 2.8177E-18 88 3.715E+00 3.500E+01 1.200E+00 2.3126E-21 2.3126E-21 1.0000E+00 2.3126E-21 2.3126E-21 2.3126E-21 89 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 90 3.000E+00 1.000E-01 1.200E+01 9.4606E-01 9.4606E-01 1.0000E+00 9.4606E-01 9.4606E-01 9.4606E-01 91 3.001E+00 2.500E-01 1.200E+01 8.6487E-01 8.6487E-01 1.0000E+00 8.6487E-01 8.6487E-01 8.6487E-01 92 3.002E+00 5.000E-01 1.200E+01 7.3212E-01 7.3212E-01 1.0000E+00 7.3212E-01 7.3212E-01 7.3212E-01 93 3.003E+00 1.000E+00 1.200E+01 4.9338E-01 4.9338E-01 1.0000E+00 4.9338E-01 4.9338E-01 4.9338E-01 94 3.005E+00 1.500E+00 1.200E+01 3.0776E-01 3.0776E-01 1.0000E+00 3.0776E-01 3.0776E-01 3.0776E-01 95 3.007E+00 2.000E+00 1.200E+01 1.7860E-01 1.7860E-01 1.0000E+00 1.7860E-01 1.7860E-01 1.7860E-01 96 3.010E+00 3.000E+00 1.200E+01 4.9322E-02 4.9322E-02 1.0000E+00 4.9322E-02 4.9322E-02 4.9322E-02 97 3.014E+00 4.000E+00 1.200E+01 1.0740E-02 1.0740E-02 1.0000E+00 1.0740E-02 1.0740E-02 1.0740E-02 98 3.017E+00 5.000E+00 1.200E+01 1.8965E-03 1.8965E-03 1.0000E+00 1.8965E-03 1.8965E-03 1.8965E-03 99 3.021E+00 6.000E+00 1.200E+01 2.7816E-04 2.7816E-04 1.0000E+00 2.7816E-04 2.7816E-04 2.7816E-04 100 3.024E+00 7.000E+00 1.200E+01 3.4598E-05 3.4598E-05 1.0000E+00 3.4598E-05 3.4598E-05 3.4598E-05 101 3.028E+00 8.000E+00 1.200E+01 3.7155E-06 3.7155E-06 1.0000E+00 3.7155E-06 3.7155E-06 3.7155E-06 102 3.031E+00 9.000E+00 1.200E+01 3.4993E-07 3.4993E-07 1.0000E+00 3.4993E-07 3.4993E-07 3.4993E-07 103 3.035E+00 1.000E+01 1.200E+01 2.9302E-08 2.9302E-08 1.0000E+00 2.9302E-08 2.9302E-08 2.9302E-08 104 3.043E+00 1.250E+01 1.200E+01 3.8345E-11 3.8345E-11 1.0000E+00 3.8345E-11 3.8345E-11 3.8345E-11 105 3.052E+00 1.500E+01 1.200E+01 3.0133E-14 3.0133E-14 1.0000E+00 3.0133E-14 3.0133E-14 3.0133E-14 106 3.061E+00 1.750E+01 1.200E+01 1.5940E-17 1.5940E-17 1.0000E+00 1.5940E-17 1.5940E-17 1.5940E-17 107 3.069E+00 2.000E+01 1.200E+01 6.1880E-21 6.1880E-21 1.0000E+00 6.1880E-21 6.1880E-21 6.1880E-21 108 3.087E+00 2.500E+01 1.200E+01 4.7294E-28 4.7294E-28 1.0000E+00 4.7294E-28 4.7294E-28 4.7294E-28 109 2.604E+00 3.000E+01 1.200E+01 1.9481E-35 1.9481E-35 1.0000E+00 1.9481E-35 1.9481E-35 1.9481E-35 110 2.622E+00 3.500E+01 1.200E+01 5.4265E-43 5.4265E-43 1.0000E+00 5.4265E-43 5.4265E-43 5.4265E-43 111 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 112 3.000E+00 1.000E-01 5.400E+01 9.4606E-01 9.4606E-01 1.0000E+00 9.4606E-01 9.4606E-01 9.4606E-01 113 3.000E+00 2.500E-01 5.400E+01 8.6485E-01 8.6485E-01 1.0000E+00 8.6485E-01 8.6485E-01 8.6485E-01 114 3.000E+00 5.000E-01 5.400E+01 7.3200E-01 7.3200E-01 1.0000E+00 7.3200E-01 7.3200E-01 7.3200E-01 115 3.001E+00 1.000E+00 5.400E+01 4.9275E-01 4.9275E-01 1.0000E+00 4.9275E-01 4.9275E-01 4.9275E-01 116 3.001E+00 1.500E+00 5.400E+01 3.0647E-01 3.0647E-01 1.0000E+00 3.0647E-01 3.0647E-01 3.0647E-01 117 3.002E+00 2.000E+00 5.400E+01 1.7688E-01 1.7688E-01 1.0000E+00 1.7688E-01 1.7688E-01 1.7688E-01 118 3.002E+00 3.000E+00 5.400E+01 4.7831E-02 4.7831E-02 1.0000E+00 4.7831E-02 4.7831E-02 4.7831E-02 119 3.003E+00 4.000E+00 5.400E+01 1.0026E-02 1.0026E-02 1.0000E+00 1.0026E-02 1.0026E-02 1.0026E-02 120 3.004E+00 5.000E+00 5.400E+01 1.6697E-03 1.6697E-03 1.0000E+00 1.6697E-03 1.6697E-03 1.6697E-03 121 3.005E+00 6.000E+00 5.400E+01 2.2571E-04 2.2571E-04 1.0000E+00 2.2571E-04 2.2571E-04 2.2571E-04 122 3.005E+00 7.000E+00 5.400E+01 2.5232E-05 2.5232E-05 1.0000E+00 2.5232E-05 2.5232E-05 2.5232E-05 123 3.006E+00 8.000E+00 5.400E+01 2.3714E-06 2.3714E-06 1.0000E+00 2.3714E-06 2.3714E-06 2.3714E-06 124 3.007E+00 9.000E+00 5.400E+01 1.9009E-07 1.9009E-07 1.0000E+00 1.9009E-07 1.9009E-07 1.9009E-07 125 3.008E+00 1.000E+01 5.400E+01 1.3165E-08 1.3165E-08 1.0000E+00 1.3165E-08 1.3165E-08 1.3165E-08 126 3.010E+00 1.250E+01 5.400E+01 9.4232E-12 9.4232E-12 1.0000E+00 9.4232E-12 9.4232E-12 9.4232E-12 127 3.012E+00 1.500E+01 5.400E+01 3.3619E-15 3.3619E-15 1.0000E+00 3.3619E-15 3.3619E-15 3.3619E-15 128 3.014E+00 1.750E+01 5.400E+01 6.7107E-19 6.7107E-19 1.0000E+00 6.7107E-19 6.7107E-19 6.7107E-19 129 3.015E+00 2.000E+01 5.400E+01 8.2094E-23 8.2094E-23 1.0000E+00 8.2094E-23 8.2094E-23 8.2094E-23 130 3.019E+00 2.500E+01 5.400E+01 3.7373E-31 3.7373E-31 1.0000E+00 3.7373E-31 3.7373E-31 3.7373E-31 131 3.023E+00 3.000E+01 5.400E+01 4.9210E-40 4.9210E-40 1.0000E+00 4.9210E-40 4.9210E-40 4.9210E-40 132 2.527E+00 3.500E+01 5.400E+01 2.5369E-49 2.5369E-49 1.0000E+00 2.5369E-49 2.5369E-49 2.5369E-49 --------------------------------------------------------------------------------------------------------------------- NOTE: N(0) is the initial number of cells (time=0 day), N(t) is the expected number of unirradiated (control) cells at TSIM, i.e., N(t)=N(0)*EXP[LN(2)*TSIM/TPOT]. The surviving fraction S(D) is the expected number of cells, per irradiated cell, that has not sustained lethal DNA damage (no corrections for repopulation effects). NSC(t) is the expected number of cells that survive irradiation, including repopulation effects (recommended method). The product N(t)*S(D) is an alternate method of estimating the surviving fraction with repopulation effects. DFAR TABLE: Mutagenesis and the induction of enhanced genetic instability (GI). Key GI model parameters are: (1-FRDL)=0.0%, NCM=1, NCG=1, and NCG*PGH*PGA=4.250E-06. ====================================================================================================== Dose Dose Rate -- NON-LETHAL MUTATIONS PER CELL -- **** PROBABILITY PER CELL **** SIM ID (Gy) (Gy/h) Mutations Residual Total AGF EGI EGI/SF ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 2 1.000E-01 1.500E-01 1.296E-01 0.00E+00 1.29591E-01 5.211E-07 5.211E-07 5.508E-07 3 2.500E-01 1.500E-01 3.381E-01 0.00E+00 3.38061E-01 1.245E-06 1.245E-06 1.437E-06 4 5.000E-01 1.500E-01 7.107E-01 0.00E+00 7.10653E-01 2.240E-06 2.240E-06 3.020E-06 5 1.000E+00 1.500E-01 1.503E+00 0.00E+00 1.50293E+00 3.412E-06 3.412E-06 6.387E-06 6 1.500E+00 1.500E-01 2.319E+00 0.00E+00 2.31879E+00 3.759E-06 3.759E-06 9.855E-06 7 2.000E+00 1.500E-01 3.141E+00 0.00E+00 3.14146E+00 3.629E-06 3.629E-06 1.335E-05 8 3.000E+00 1.500E-01 4.791E+00 0.00E+00 4.79132E+00 2.805E-06 2.805E-06 2.036E-05 9 4.000E+00 1.500E-01 6.442E+00 0.00E+00 6.44213E+00 1.911E-06 1.911E-06 2.738E-05 10 5.000E+00 1.500E-01 8.093E+00 0.00E+00 8.09302E+00 1.216E-06 1.216E-06 3.439E-05 11 6.000E+00 1.500E-01 9.744E+00 0.00E+00 9.74391E+00 7.419E-07 7.419E-07 4.141E-05 12 7.000E+00 1.500E-01 1.139E+01 0.00E+00 1.13948E+01 4.395E-07 4.395E-07 4.843E-05 13 8.000E+00 1.500E-01 1.305E+01 0.00E+00 1.30457E+01 2.550E-07 2.550E-07 5.544E-05 14 9.000E+00 1.500E-01 1.470E+01 0.00E+00 1.46966E+01 1.455E-07 1.455E-07 6.246E-05 15 1.000E+01 1.500E-01 1.635E+01 0.00E+00 1.63475E+01 8.200E-08 8.200E-08 6.947E-05 16 1.250E+01 1.500E-01 2.047E+01 0.00E+00 2.04747E+01 1.876E-08 1.876E-08 8.701E-05 17 1.500E+01 1.500E-01 2.460E+01 0.00E+00 2.46019E+01 4.119E-09 4.119E-09 1.046E-04 18 1.750E+01 1.500E-01 2.873E+01 0.00E+00 2.87292E+01 8.789E-10 8.789E-10 1.221E-04 19 2.000E+01 1.500E-01 3.286E+01 0.00E+00 3.28564E+01 1.836E-10 1.836E-10 1.396E-04 20 2.500E+01 1.500E-01 4.111E+01 0.00E+00 4.11109E+01 7.669E-12 7.669E-12 1.747E-04 21 3.000E+01 1.500E-01 4.937E+01 0.00E+00 4.93653E+01 3.074E-13 3.074E-13 2.098E-04 22 3.500E+01 1.500E-01 5.762E+01 0.00E+00 5.76198E+01 1.198E-14 1.198E-14 2.449E-04 23 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 24 1.000E-01 3.000E-01 1.298E-01 0.00E+00 1.29770E-01 5.218E-07 5.218E-07 5.515E-07 25 2.500E-01 3.000E-01 3.405E-01 0.00E+00 3.40505E-01 1.253E-06 1.253E-06 1.447E-06 26 5.000E-01 3.000E-01 7.264E-01 0.00E+00 7.26386E-01 2.277E-06 2.277E-06 3.087E-06 27 1.000E+00 3.000E-01 1.587E+00 0.00E+00 1.58748E+00 3.496E-06 3.496E-06 6.747E-06 28 1.500E+00 3.000E-01 2.519E+00 0.00E+00 2.51902E+00 3.802E-06 3.802E-06 1.071E-05 29 2.000E+00 3.000E-01 3.487E+00 0.00E+00 3.48742E+00 3.560E-06 3.560E-06 1.482E-05 30 3.000E+00 3.000E-01 5.473E+00 0.00E+00 5.47289E+00 2.512E-06 2.512E-06 2.326E-05 31 4.000E+00 3.000E-01 7.482E+00 0.00E+00 7.48180E+00 1.531E-06 1.531E-06 3.180E-05 32 5.000E+00 3.000E-01 9.497E+00 0.00E+00 9.49712E+00 8.644E-07 8.644E-07 4.036E-05 33 6.000E+00 3.000E-01 1.151E+01 0.00E+00 1.15142E+01 4.659E-07 4.659E-07 4.893E-05 34 7.000E+00 3.000E-01 1.353E+01 0.00E+00 1.35318E+01 2.433E-07 2.433E-07 5.751E-05 35 8.000E+00 3.000E-01 1.555E+01 0.00E+00 1.55495E+01 1.243E-07 1.243E-07 6.608E-05 36 9.000E+00 3.000E-01 1.757E+01 0.00E+00 1.75672E+01 6.239E-08 6.239E-08 7.466E-05 37 1.000E+01 3.000E-01 1.958E+01 0.00E+00 1.95850E+01 3.091E-08 3.091E-08 8.323E-05 38 1.250E+01 3.000E-01 2.463E+01 0.00E+00 2.46293E+01 5.119E-09 5.119E-09 1.047E-04 39 1.500E+01 3.000E-01 2.967E+01 0.00E+00 2.96737E+01 8.120E-10 8.120E-10 1.261E-04 40 1.750E+01 3.000E-01 3.472E+01 0.00E+00 3.47181E+01 1.251E-10 1.251E-10 1.475E-04 41 2.000E+01 3.000E-01 3.976E+01 0.00E+00 3.97625E+01 1.886E-11 1.886E-11 1.690E-04 42 2.500E+01 3.000E-01 4.985E+01 0.00E+00 4.98512E+01 4.100E-13 4.100E-13 2.118E-04 43 3.000E+01 3.000E-01 5.994E+01 0.00E+00 5.99399E+01 8.547E-15 8.547E-15 2.547E-04 44 3.500E+01 3.000E-01 7.003E+01 0.00E+00 7.00287E+01 1.731E-16 1.731E-16 2.976E-04 45 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 46 1.000E-01 6.000E-01 1.299E-01 0.00E+00 1.29863E-01 5.222E-07 5.222E-07 5.519E-07 47 2.500E-01 6.000E-01 3.419E-01 0.00E+00 3.41863E-01 1.257E-06 1.257E-06 1.453E-06 48 5.000E-01 6.000E-01 7.360E-01 0.00E+00 7.36029E-01 2.299E-06 2.299E-06 3.128E-06 49 1.000E+00 6.000E-01 1.649E+00 0.00E+00 1.64885E+00 3.553E-06 3.553E-06 7.008E-06 50 1.500E+00 6.000E-01 2.686E+00 0.00E+00 2.68608E+00 3.820E-06 3.820E-06 1.142E-05 51 2.000E+00 6.000E-01 3.811E+00 0.00E+00 3.81090E+00 3.466E-06 3.466E-06 1.620E-05 52 3.000E+00 6.000E-01 6.228E+00 0.00E+00 6.22751E+00 2.183E-06 2.183E-06 2.647E-05 53 4.000E+00 6.000E-01 8.771E+00 0.00E+00 8.77062E+00 1.133E-06 1.133E-06 3.727E-05 54 5.000E+00 6.000E-01 1.138E+01 0.00E+00 1.13767E+01 5.292E-07 5.292E-07 4.835E-05 55 6.000E+00 6.000E-01 1.401E+01 0.00E+00 1.40140E+01 2.322E-07 2.322E-07 5.956E-05 56 7.000E+00 6.000E-01 1.667E+01 0.00E+00 1.66670E+01 9.782E-08 9.782E-08 7.083E-05 57 8.000E+00 6.000E-01 1.933E+01 0.00E+00 1.93277E+01 4.007E-08 4.007E-08 8.214E-05 58 9.000E+00 6.000E-01 2.199E+01 0.00E+00 2.19922E+01 1.608E-08 1.608E-08 9.346E-05 59 1.000E+01 6.000E-01 2.466E+01 0.00E+00 2.46587E+01 6.357E-09 6.357E-09 1.048E-04 60 1.250E+01 6.000E-01 3.133E+01 0.00E+00 3.13282E+01 5.951E-10 5.951E-10 1.331E-04 61 1.500E+01 6.000E-01 3.800E+01 0.00E+00 3.79989E+01 5.317E-11 5.317E-11 1.615E-04 62 1.750E+01 6.000E-01 4.467E+01 0.00E+00 4.46699E+01 4.604E-12 4.604E-12 1.898E-04 63 2.000E+01 6.000E-01 5.134E+01 0.00E+00 5.13409E+01 3.897E-13 3.897E-13 2.182E-04 64 2.500E+01 6.000E-01 6.468E+01 0.00E+00 6.46829E+01 2.663E-15 2.663E-15 2.749E-04 65 3.000E+01 6.000E-01 7.802E+01 0.00E+00 7.80249E+01 1.743E-17 1.743E-17 3.316E-04 66 3.500E+01 6.000E-01 9.137E+01 0.00E+00 9.13669E+01 1.107E-19 1.107E-19 3.882E-04 67 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 68 1.000E-01 1.200E+00 1.299E-01 0.00E+00 1.29911E-01 5.223E-07 5.223E-07 5.521E-07 69 2.500E-01 1.200E+00 3.426E-01 0.00E+00 3.42580E-01 1.260E-06 1.260E-06 1.456E-06 70 5.000E-01 1.200E+00 7.414E-01 0.00E+00 7.41390E-01 2.311E-06 2.311E-06 3.151E-06 71 1.000E+00 1.200E+00 1.686E+00 0.00E+00 1.68643E+00 3.585E-06 3.585E-06 7.167E-06 72 1.500E+00 1.200E+00 2.798E+00 0.00E+00 2.79769E+00 3.823E-06 3.823E-06 1.189E-05 73 2.000E+00 1.200E+00 4.045E+00 0.00E+00 4.04476E+00 3.384E-06 3.384E-06 1.719E-05 74 3.000E+00 1.200E+00 6.852E+00 0.00E+00 6.85198E+00 1.922E-06 1.922E-06 2.912E-05 75 4.000E+00 1.200E+00 9.960E+00 0.00E+00 9.96000E+00 8.411E-07 8.411E-07 4.233E-05 76 5.000E+00 1.200E+00 1.327E+01 0.00E+00 1.32700E+01 3.139E-07 3.139E-07 5.640E-05 77 6.000E+00 1.200E+00 1.672E+01 0.00E+00 1.67158E+01 1.055E-07 1.055E-07 7.104E-05 78 7.000E+00 1.200E+00 2.025E+01 0.00E+00 2.02530E+01 3.302E-08 3.302E-08 8.607E-05 79 8.000E+00 1.200E+00 2.385E+01 0.00E+00 2.38517E+01 9.827E-09 9.827E-09 1.014E-04 80 9.000E+00 1.200E+00 2.749E+01 0.00E+00 2.74919E+01 2.820E-09 2.820E-09 1.168E-04 81 1.000E+01 1.200E+00 3.116E+01 0.00E+00 3.11601E+01 7.879E-10 7.879E-10 1.324E-04 82 1.250E+01 1.200E+00 4.040E+01 0.00E+00 4.04000E+01 3.006E-11 3.006E-11 1.717E-04 83 1.500E+01 1.200E+00 4.969E+01 0.00E+00 4.96870E+01 1.070E-12 1.070E-12 2.111E-04 84 1.750E+01 1.200E+00 5.899E+01 0.00E+00 5.89914E+01 3.652E-14 3.652E-14 2.507E-04 85 2.000E+01 1.200E+00 6.830E+01 0.00E+00 6.83024E+01 1.213E-15 1.213E-15 2.902E-04 86 2.500E+01 1.200E+00 8.693E+01 0.00E+00 8.69302E+01 1.268E-18 1.268E-18 3.694E-04 87 3.000E+01 1.200E+00 1.056E+02 0.00E+00 1.05560E+02 1.264E-21 1.264E-21 4.485E-04 88 3.500E+01 1.200E+00 1.242E+02 0.00E+00 1.24190E+02 1.220E-24 1.220E-24 5.277E-04 89 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 90 1.000E-01 1.200E+01 1.300E-01 0.00E+00 1.29955E-01 5.225E-07 5.225E-07 5.523E-07 91 2.500E-01 1.200E+01 3.432E-01 0.00E+00 3.43249E-01 1.262E-06 1.262E-06 1.459E-06 92 5.000E-01 1.200E+01 7.466E-01 0.00E+00 7.46559E-01 2.323E-06 2.323E-06 3.173E-06 93 1.000E+00 1.200E+01 1.725E+00 0.00E+00 1.72513E+00 3.617E-06 3.617E-06 7.332E-06 94 1.500E+00 1.200E+01 2.920E+00 0.00E+00 2.92014E+00 3.819E-06 3.819E-06 1.241E-05 95 2.000E+00 1.200E+01 4.317E+00 0.00E+00 4.31737E+00 3.277E-06 3.277E-06 1.835E-05 96 3.000E+00 1.200E+01 7.667E+00 0.00E+00 7.66730E+00 1.607E-06 1.607E-06 3.259E-05 97 4.000E+00 1.200E+01 1.168E+01 0.00E+00 1.16826E+01 5.332E-07 5.332E-07 4.965E-05 98 5.000E+00 1.200E+01 1.628E+01 0.00E+00 1.62848E+01 1.312E-07 1.312E-07 6.921E-05 99 6.000E+00 1.200E+01 2.141E+01 0.00E+00 2.14065E+01 2.531E-08 2.531E-08 9.097E-05 100 7.000E+00 1.200E+01 2.699E+01 0.00E+00 2.69898E+01 3.968E-09 3.968E-09 1.147E-04 101 8.000E+00 1.200E+01 3.298E+01 0.00E+00 3.29844E+01 5.208E-10 5.208E-10 1.402E-04 102 9.000E+00 1.200E+01 3.935E+01 0.00E+00 3.93465E+01 5.851E-11 5.851E-11 1.672E-04 103 1.000E+01 1.200E+01 4.604E+01 0.00E+00 4.60377E+01 5.733E-12 5.733E-12 1.956E-04 104 1.250E+01 1.200E+01 6.399E+01 0.00E+00 6.39939E+01 1.043E-14 1.043E-14 2.719E-04 105 1.500E+01 1.200E+01 8.338E+01 0.00E+00 8.33778E+01 1.068E-17 1.068E-17 3.543E-04 106 1.750E+01 1.200E+01 1.039E+02 0.00E+00 1.03870E+02 7.035E-21 7.035E-21 4.414E-04 107 2.000E+01 1.200E+01 1.252E+02 0.00E+00 1.25229E+02 3.293E-24 3.293E-24 5.321E-04 108 2.500E+01 1.200E+01 1.698E+02 0.00E+00 1.69847E+02 3.413E-31 3.413E-31 7.216E-04 109 3.000E+01 1.200E+01 2.162E+02 0.00E+00 2.16196E+02 1.789E-38 1.789E-38 9.184E-04 110 3.500E+01 1.200E+01 2.636E+02 0.00E+00 2.63641E+02 6.077E-46 6.077E-46 1.120E-03 111 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 112 1.000E-01 5.400E+01 1.300E-01 0.00E+00 1.29959E-01 5.225E-07 5.225E-07 5.523E-07 113 2.500E-01 5.400E+01 3.433E-01 0.00E+00 3.43308E-01 1.262E-06 1.262E-06 1.459E-06 114 5.000E-01 5.400E+01 7.470E-01 0.00E+00 7.47022E-01 2.324E-06 2.324E-06 3.175E-06 115 1.000E+00 5.400E+01 1.729E+00 0.00E+00 1.72872E+00 3.620E-06 3.620E-06 7.347E-06 116 1.500E+00 5.400E+01 2.932E+00 0.00E+00 2.93188E+00 3.819E-06 3.819E-06 1.246E-05 117 2.000E+00 5.400E+01 4.344E+00 0.00E+00 4.34437E+00 3.266E-06 3.266E-06 1.846E-05 118 3.000E+00 5.400E+01 7.753E+00 0.00E+00 7.75325E+00 1.576E-06 1.576E-06 3.295E-05 119 4.000E+00 5.400E+01 1.188E+01 0.00E+00 1.18752E+01 5.060E-07 5.060E-07 5.047E-05 120 5.000E+00 5.400E+01 1.664E+01 0.00E+00 1.66413E+01 1.181E-07 1.181E-07 7.072E-05 121 6.000E+00 5.400E+01 2.199E+01 0.00E+00 2.19916E+01 2.109E-08 2.109E-08 9.346E-05 122 7.000E+00 5.400E+01 2.787E+01 0.00E+00 2.78737E+01 2.989E-09 2.989E-09 1.185E-04 123 8.000E+00 5.400E+01 3.424E+01 0.00E+00 3.42417E+01 3.451E-10 3.451E-10 1.455E-04 124 9.000E+00 5.400E+01 4.106E+01 0.00E+00 4.10551E+01 3.317E-11 3.317E-11 1.745E-04 125 1.000E+01 5.400E+01 4.828E+01 0.00E+00 4.82779E+01 2.701E-12 2.701E-12 2.052E-04 126 1.250E+01 5.400E+01 6.792E+01 0.00E+00 6.79235E+01 2.720E-15 2.720E-15 2.886E-04 127 1.500E+01 5.400E+01 8.952E+01 0.00E+00 8.95185E+01 1.279E-18 1.279E-18 3.804E-04 128 1.750E+01 5.400E+01 1.127E+02 0.00E+00 1.12740E+02 3.215E-22 3.215E-22 4.790E-04 129 2.000E+01 5.400E+01 1.373E+02 0.00E+00 1.37332E+02 4.790E-26 4.790E-26 5.835E-04 130 2.500E+01 5.400E+01 1.898E+02 0.00E+00 1.89848E+02 3.014E-34 3.014E-34 8.065E-04 131 3.000E+01 5.400E+01 2.458E+02 0.00E+00 2.45838E+02 5.139E-43 5.139E-43 1.044E-03 132 3.500E+01 5.400E+01 3.045E+02 0.00E+00 3.04453E+02 3.280E-52 3.280E-52 1.293E-03 ------------------------------------------------------------------------------------------------------ AGF: function or expression of at least 1 of the 1 critical gene targets is altered. EGI: altered gene function or expression causes enhanced genetic instability. NEOM TABLE: Neoplastic transformation as a function of dose and dose rate at t=42.000 days. Parameters: TFS=1.1500E-05 (1/wk), TFU=2.0000E-03 (1/wk), NCM=1, NCG=1, and NCG*PGH*PGA=4.3E-06. ====================================================================================================== Dose Dose Rate Non-Lethal Genetic Instability *** TRANSFORMATION FREQUENCY *** SIM ID (Gy) (Gy/h) Mutations EGI EGI/SF BKG TPS TPI ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 2 1.000E-01 1.500E-01 1.296E-01 5.211E-07 5.508E-07 6.8995E-05 6.9002E-05 6.5288E-05 3 2.500E-01 1.500E-01 3.381E-01 1.245E-06 1.437E-06 6.8995E-05 6.9012E-05 5.9797E-05 4 5.000E-01 1.500E-01 7.107E-01 2.240E-06 3.020E-06 6.8995E-05 6.9031E-05 5.1191E-05 5 1.000E+00 1.500E-01 1.503E+00 3.412E-06 6.387E-06 6.8995E-05 6.9071E-05 3.6893E-05 6 1.500E+00 1.500E-01 2.319E+00 3.759E-06 9.855E-06 6.8995E-05 6.9112E-05 2.6365E-05 7 2.000E+00 1.500E-01 3.141E+00 3.629E-06 1.335E-05 6.8994E-05 6.9154E-05 1.8796E-05 8 3.000E+00 1.500E-01 4.791E+00 2.805E-06 2.036E-05 6.8994E-05 6.9237E-05 9.5379E-06 9 4.000E+00 1.500E-01 6.442E+00 1.911E-06 2.738E-05 6.8993E-05 6.9320E-05 4.8382E-06 10 5.000E+00 1.500E-01 8.093E+00 1.216E-06 3.439E-05 6.8993E-05 6.9403E-05 2.4542E-06 11 6.000E+00 1.500E-01 9.744E+00 7.419E-07 4.141E-05 6.8992E-05 6.9486E-05 1.2449E-06 12 7.000E+00 1.500E-01 1.139E+01 4.395E-07 4.843E-05 6.8992E-05 6.9570E-05 6.3145E-07 13 8.000E+00 1.500E-01 1.305E+01 2.550E-07 5.544E-05 6.8991E-05 6.9653E-05 3.2030E-07 14 9.000E+00 1.500E-01 1.470E+01 1.455E-07 6.246E-05 6.8991E-05 6.9736E-05 1.6247E-07 15 1.000E+01 1.500E-01 1.635E+01 8.200E-08 6.947E-05 6.8990E-05 6.9819E-05 8.2410E-08 16 1.250E+01 1.500E-01 2.047E+01 1.876E-08 8.701E-05 6.8989E-05 7.0027E-05 1.5101E-08 17 1.500E+01 1.500E-01 2.460E+01 4.119E-09 1.046E-04 6.8988E-05 7.0235E-05 2.7672E-09 18 1.750E+01 1.500E-01 2.873E+01 8.789E-10 1.221E-04 6.8987E-05 7.0443E-05 5.0707E-10 19 2.000E+01 1.500E-01 3.286E+01 1.836E-10 1.396E-04 6.8986E-05 7.0651E-05 9.2916E-11 20 2.500E+01 1.500E-01 4.111E+01 7.669E-12 1.747E-04 6.8983E-05 7.1067E-05 3.1198E-12 21 3.000E+01 1.500E-01 4.937E+01 3.074E-13 2.098E-04 6.8981E-05 7.1483E-05 1.0475E-13 22 3.500E+01 1.500E-01 5.762E+01 1.198E-14 2.449E-04 6.8978E-05 7.1899E-05 3.5168E-15 23 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 24 1.000E-01 3.000E-01 1.298E-01 5.218E-07 5.515E-07 6.8995E-05 6.9002E-05 6.5284E-05 25 2.500E-01 3.000E-01 3.405E-01 1.253E-06 1.447E-06 6.8995E-05 6.9012E-05 5.9745E-05 26 5.000E-01 3.000E-01 7.264E-01 2.277E-06 3.087E-06 6.8995E-05 6.9032E-05 5.0905E-05 27 1.000E+00 3.000E-01 1.587E+00 3.496E-06 6.747E-06 6.8995E-05 6.9075E-05 3.5798E-05 28 1.500E+00 3.000E-01 2.519E+00 3.802E-06 1.071E-05 6.8994E-05 6.9122E-05 2.4549E-05 29 2.000E+00 3.000E-01 3.487E+00 3.560E-06 1.482E-05 6.8994E-05 6.9171E-05 1.6616E-05 30 3.000E+00 3.000E-01 5.473E+00 2.512E-06 2.326E-05 6.8994E-05 6.9271E-05 7.4809E-06 31 4.000E+00 3.000E-01 7.482E+00 1.531E-06 3.180E-05 6.8993E-05 6.9372E-05 3.3401E-06 32 5.000E+00 3.000E-01 9.497E+00 8.644E-07 4.036E-05 6.8992E-05 6.9474E-05 1.4879E-06 33 6.000E+00 3.000E-01 1.151E+01 4.659E-07 4.893E-05 6.8992E-05 6.9576E-05 6.6236E-07 34 7.000E+00 3.000E-01 1.353E+01 2.433E-07 5.751E-05 6.8991E-05 6.9677E-05 2.9482E-07 35 8.000E+00 3.000E-01 1.555E+01 1.243E-07 6.608E-05 6.8991E-05 6.9779E-05 1.3122E-07 36 9.000E+00 3.000E-01 1.757E+01 6.239E-08 7.466E-05 6.8990E-05 6.9881E-05 5.8401E-08 37 1.000E+01 3.000E-01 1.958E+01 3.091E-08 8.323E-05 6.8989E-05 6.9982E-05 2.5992E-08 38 1.250E+01 3.000E-01 2.463E+01 5.119E-09 1.047E-04 6.8988E-05 7.0237E-05 3.4349E-09 39 1.500E+01 3.000E-01 2.967E+01 8.120E-10 1.261E-04 6.8987E-05 7.0491E-05 4.5390E-10 40 1.750E+01 3.000E-01 3.472E+01 1.251E-10 1.475E-04 6.8985E-05 7.0745E-05 5.9981E-11 41 2.000E+01 3.000E-01 3.976E+01 1.886E-11 1.690E-04 6.8984E-05 7.0999E-05 7.9261E-12 42 2.500E+01 3.000E-01 4.985E+01 4.100E-13 2.118E-04 6.8981E-05 7.1508E-05 1.3840E-13 43 3.000E+01 3.000E-01 5.994E+01 8.547E-15 2.547E-04 6.8978E-05 7.2016E-05 2.4165E-15 44 3.500E+01 3.000E-01 7.003E+01 1.731E-16 2.976E-04 6.8975E-05 7.2524E-05 4.2191E-17 45 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 46 1.000E-01 6.000E-01 1.299E-01 5.222E-07 5.519E-07 6.8995E-05 6.9002E-05 6.5282E-05 47 2.500E-01 6.000E-01 3.419E-01 1.257E-06 1.453E-06 6.8995E-05 6.9012E-05 5.9716E-05 48 5.000E-01 6.000E-01 7.360E-01 2.299E-06 3.128E-06 6.8995E-05 6.9032E-05 5.0731E-05 49 1.000E+00 6.000E-01 1.649E+00 3.553E-06 7.008E-06 6.8995E-05 6.9078E-05 3.5023E-05 50 1.500E+00 6.000E-01 2.686E+00 3.820E-06 1.142E-05 6.8994E-05 6.9131E-05 2.3130E-05 51 2.000E+00 6.000E-01 3.811E+00 3.466E-06 1.620E-05 6.8994E-05 6.9187E-05 1.4807E-05 52 3.000E+00 6.000E-01 6.228E+00 2.183E-06 2.647E-05 6.8993E-05 6.9309E-05 5.7167E-06 53 4.000E+00 6.000E-01 8.771E+00 1.133E-06 3.727E-05 6.8993E-05 6.9437E-05 2.1099E-06 54 5.000E+00 6.000E-01 1.138E+01 5.292E-07 4.835E-05 6.8992E-05 6.9569E-05 7.6142E-07 55 6.000E+00 6.000E-01 1.401E+01 2.322E-07 5.956E-05 6.8991E-05 6.9702E-05 2.7174E-07 56 7.000E+00 6.000E-01 1.667E+01 9.782E-08 7.083E-05 6.8990E-05 6.9835E-05 9.6439E-08 57 8.000E+00 6.000E-01 1.933E+01 4.007E-08 8.214E-05 6.8990E-05 6.9969E-05 3.4131E-08 58 9.000E+00 6.000E-01 2.199E+01 1.608E-08 9.346E-05 6.8989E-05 7.0104E-05 1.2063E-08 59 1.000E+01 6.000E-01 2.466E+01 6.357E-09 1.048E-04 6.8988E-05 7.0238E-05 4.2605E-09 60 1.250E+01 6.000E-01 3.133E+01 5.951E-10 1.331E-04 6.8986E-05 7.0574E-05 3.1547E-10 61 1.500E+01 6.000E-01 3.800E+01 5.317E-11 1.615E-04 6.8984E-05 7.0910E-05 2.3348E-11 62 1.750E+01 6.000E-01 4.467E+01 4.604E-12 1.898E-04 6.8982E-05 7.1246E-05 1.7279E-12 63 2.000E+01 6.000E-01 5.134E+01 3.897E-13 2.182E-04 6.8980E-05 7.1583E-05 1.2786E-13 64 2.500E+01 6.000E-01 6.468E+01 2.663E-15 2.749E-04 6.8976E-05 7.2255E-05 7.0013E-16 65 3.000E+01 6.000E-01 7.802E+01 1.743E-17 3.316E-04 6.8972E-05 7.2927E-05 3.8334E-18 66 3.500E+01 6.000E-01 9.137E+01 1.107E-19 3.882E-04 6.8968E-05 7.3599E-05 2.0987E-20 67 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 68 1.000E-01 1.200E+00 1.299E-01 5.223E-07 5.521E-07 6.8995E-05 6.9002E-05 6.5281E-05 69 2.500E-01 1.200E+00 3.426E-01 1.260E-06 1.456E-06 6.8995E-05 6.9012E-05 5.9701E-05 70 5.000E-01 1.200E+00 7.414E-01 2.311E-06 3.151E-06 6.8995E-05 6.9033E-05 5.0634E-05 71 1.000E+00 1.200E+00 1.686E+00 3.585E-06 7.167E-06 6.8995E-05 6.9080E-05 3.4557E-05 72 1.500E+00 1.200E+00 2.798E+00 3.823E-06 1.189E-05 6.8994E-05 6.9136E-05 2.2228E-05 73 2.000E+00 1.200E+00 4.045E+00 3.384E-06 1.719E-05 6.8994E-05 6.9199E-05 1.3622E-05 74 3.000E+00 1.200E+00 6.852E+00 1.922E-06 2.912E-05 6.8993E-05 6.9341E-05 4.5760E-06 75 4.000E+00 1.200E+00 9.960E+00 8.411E-07 4.233E-05 6.8992E-05 6.9497E-05 1.3809E-06 76 5.000E+00 1.200E+00 1.327E+01 3.139E-07 5.640E-05 6.8991E-05 6.9664E-05 3.8776E-07 77 6.000E+00 1.200E+00 1.672E+01 1.055E-07 7.104E-05 6.8990E-05 6.9838E-05 1.0374E-07 78 7.000E+00 1.200E+00 2.025E+01 3.302E-08 8.607E-05 6.8989E-05 7.0016E-05 2.6864E-08 79 8.000E+00 1.200E+00 2.385E+01 9.827E-09 1.014E-04 6.8988E-05 7.0197E-05 6.8055E-09 80 9.000E+00 1.200E+00 2.749E+01 2.820E-09 1.168E-04 6.8987E-05 7.0381E-05 1.6988E-09 81 1.000E+01 1.200E+00 3.116E+01 7.879E-10 1.324E-04 6.8986E-05 7.0566E-05 4.1984E-10 82 1.250E+01 1.200E+00 4.040E+01 3.006E-11 1.717E-04 6.8983E-05 7.1031E-05 1.2436E-11 83 1.500E+01 1.200E+00 4.969E+01 1.070E-12 2.111E-04 6.8981E-05 7.1499E-05 3.6222E-13 84 1.750E+01 1.200E+00 5.899E+01 3.652E-14 2.507E-04 6.8978E-05 7.1968E-05 1.0484E-14 85 2.000E+01 1.200E+00 6.830E+01 1.213E-15 2.902E-04 6.8975E-05 7.2437E-05 3.0274E-16 86 2.500E+01 1.200E+00 8.693E+01 1.268E-18 3.694E-04 6.8970E-05 7.3376E-05 2.5188E-19 87 3.000E+01 1.200E+00 1.056E+02 1.264E-21 4.485E-04 6.8964E-05 7.4314E-05 2.0939E-22 88 3.500E+01 1.200E+00 1.242E+02 1.220E-24 5.277E-04 6.8959E-05 7.5253E-05 1.7403E-25 89 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 90 1.000E-01 1.200E+01 1.300E-01 5.225E-07 5.523E-07 6.8995E-05 6.9002E-05 6.5280E-05 91 2.500E-01 1.200E+01 3.432E-01 1.262E-06 1.459E-06 6.8995E-05 6.9013E-05 5.9687E-05 92 5.000E-01 1.200E+01 7.466E-01 2.323E-06 3.173E-06 6.8995E-05 6.9033E-05 5.0541E-05 93 1.000E+00 1.200E+01 1.725E+00 3.617E-06 7.332E-06 6.8995E-05 6.9082E-05 3.4084E-05 94 1.500E+00 1.200E+01 2.920E+00 3.819E-06 1.241E-05 6.8994E-05 6.9142E-05 2.1279E-05 95 2.000E+00 1.200E+01 4.317E+00 3.277E-06 1.835E-05 6.8994E-05 6.9213E-05 1.2361E-05 96 3.000E+00 1.200E+01 7.667E+00 1.607E-06 3.259E-05 6.8993E-05 6.9382E-05 3.4220E-06 97 4.000E+00 1.200E+01 1.168E+01 5.332E-07 4.965E-05 6.8992E-05 6.9584E-05 7.4733E-07 98 5.000E+00 1.200E+01 1.628E+01 1.312E-07 6.921E-05 6.8990E-05 6.9816E-05 1.3240E-07 99 6.000E+00 1.200E+01 2.141E+01 2.531E-08 9.097E-05 6.8989E-05 7.0074E-05 1.9492E-08 100 7.000E+00 1.200E+01 2.699E+01 3.968E-09 1.147E-04 6.8987E-05 7.0355E-05 2.4342E-09 101 8.000E+00 1.200E+01 3.298E+01 5.208E-10 1.402E-04 6.8986E-05 7.0658E-05 2.6253E-10 102 9.000E+00 1.200E+01 3.935E+01 5.851E-11 1.672E-04 6.8984E-05 7.0978E-05 2.4837E-11 103 1.000E+01 1.200E+01 4.604E+01 5.733E-12 1.956E-04 6.8982E-05 7.1315E-05 2.0897E-12 104 1.250E+01 1.200E+01 6.399E+01 1.043E-14 2.719E-04 6.8976E-05 7.2220E-05 2.7692E-15 105 1.500E+01 1.200E+01 8.338E+01 1.068E-17 3.543E-04 6.8971E-05 7.3197E-05 2.2057E-18 106 1.750E+01 1.200E+01 1.039E+02 7.035E-21 4.414E-04 6.8965E-05 7.4229E-05 1.1832E-21 107 2.000E+01 1.200E+01 1.252E+02 3.293E-24 5.321E-04 6.8959E-05 7.5305E-05 4.6599E-25 108 2.500E+01 1.200E+01 1.698E+02 3.413E-31 7.216E-04 6.8945E-05 7.7553E-05 3.6678E-32 109 3.000E+01 1.200E+01 2.162E+02 1.789E-38 9.184E-04 6.8932E-05 7.9887E-05 1.5563E-39 110 3.500E+01 1.200E+01 2.636E+02 6.077E-46 1.120E-03 6.8918E-05 8.2276E-05 4.4647E-47 111 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 112 1.000E-01 5.400E+01 1.300E-01 5.225E-07 5.523E-07 6.8995E-05 6.9002E-05 6.5280E-05 113 2.500E-01 5.400E+01 3.433E-01 1.262E-06 1.459E-06 6.8995E-05 6.9013E-05 5.9685E-05 114 5.000E-01 5.400E+01 7.470E-01 2.324E-06 3.175E-06 6.8995E-05 6.9033E-05 5.0532E-05 115 1.000E+00 5.400E+01 1.729E+00 3.620E-06 7.347E-06 6.8995E-05 6.9082E-05 3.4040E-05 116 1.500E+00 5.400E+01 2.932E+00 3.819E-06 1.246E-05 6.8994E-05 6.9143E-05 2.1190E-05 117 2.000E+00 5.400E+01 4.344E+00 3.266E-06 1.846E-05 6.8994E-05 6.9214E-05 1.2243E-05 118 3.000E+00 5.400E+01 7.753E+00 1.576E-06 3.295E-05 6.8993E-05 6.9386E-05 3.3188E-06 119 4.000E+00 5.400E+01 1.188E+01 5.060E-07 5.047E-05 6.8992E-05 6.9594E-05 6.9774E-07 120 5.000E+00 5.400E+01 1.664E+01 1.181E-07 7.072E-05 6.8990E-05 6.9834E-05 1.1660E-07 121 6.000E+00 5.400E+01 2.199E+01 2.109E-08 9.346E-05 6.8989E-05 7.0104E-05 1.5823E-08 122 7.000E+00 5.400E+01 2.787E+01 2.989E-09 1.185E-04 6.8987E-05 7.0400E-05 1.7764E-09 123 8.000E+00 5.400E+01 3.424E+01 3.451E-10 1.455E-04 6.8985E-05 7.0721E-05 1.6771E-10 124 9.000E+00 5.400E+01 4.106E+01 3.317E-11 1.745E-04 6.8983E-05 7.1064E-05 1.3509E-11 125 1.000E+01 5.400E+01 4.828E+01 2.701E-12 2.052E-04 6.8981E-05 7.1428E-05 9.4039E-13 126 1.250E+01 5.400E+01 6.792E+01 2.720E-15 2.886E-04 6.8975E-05 7.2418E-05 6.8241E-16 127 1.500E+01 5.400E+01 8.952E+01 1.279E-18 3.804E-04 6.8969E-05 7.3506E-05 2.4712E-19 128 1.750E+01 5.400E+01 1.127E+02 3.215E-22 4.790E-04 6.8962E-05 7.4676E-05 5.0113E-23 129 2.000E+01 5.400E+01 1.373E+02 4.790E-26 5.835E-04 6.8955E-05 7.5915E-05 6.2322E-27 130 2.500E+01 5.400E+01 1.898E+02 3.014E-34 8.065E-04 6.8940E-05 7.8560E-05 2.9360E-35 131 3.000E+01 5.400E+01 2.458E+02 5.139E-43 1.044E-03 6.8923E-05 8.1379E-05 4.0047E-44 132 3.500E+01 5.400E+01 3.045E+02 3.280E-52 1.293E-03 6.8906E-05 8.4330E-05 2.1394E-53 ------------------------------------------------------------------------------------------------------ TPS: Transformation frequency per survivor, TPI: Transformation frequency per irradiated cell EGI: Probabilty random mutational events caused enhanced genetic instability (EGI). BKG: Background (spontaneous) cell transformation frequency LPLM TABLE: LQ model dose protraction factor(s) and cell survival estimates (FRDL=100.0%). LQ model parameters are: alpha = 0.537 (1/Gy), alpha/beta = 3.019 (Gy), lamda = 3.557E-01 (1/h). ====================================================================================================== --- Duration (h) --- Dose Dose Rate* ***** G FACTOR ***** ******* SF(dose) ******* SIM ID Exposure Sim (Gy) (Gy/h) GL GEFF SF1 SF2 ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 2 6.667E-01 7.267E+01 1.000E-01 1.500E-01 9.254E-01 9.221E-01 9.4618E-01 9.461842E-01 3 1.667E+00 7.367E+01 2.500E-01 1.500E-01 8.285E-01 8.215E-01 8.6640E-01 8.664720E-01 4 3.333E+00 7.533E+01 5.000E-01 1.500E-01 6.988E-01 6.882E-01 7.4122E-01 7.415719E-01 5 6.667E+00 7.867E+01 1.000E+00 1.500E-01 5.209E-01 5.080E-01 5.3290E-01 5.341294E-01 6 1.000E+01 7.000E+01 1.500E+00 1.500E-01 4.087E-01 3.962E-01 3.7958E-01 3.814887E-01 7 1.333E+01 7.333E+01 2.000E+00 1.500E-01 3.336E-01 3.221E-01 2.6960E-01 2.718064E-01 8 2.000E+01 8.000E+01 3.000E+00 1.500E-01 2.417E-01 2.324E-01 1.3573E-01 1.377578E-01 9 2.667E+01 8.667E+01 4.000E+00 1.500E-01 1.886E-01 1.810E-01 6.8305E-02 6.979532E-02 10 3.333E+01 9.333E+01 5.000E+00 1.500E-01 1.545E-01 1.481E-01 3.4372E-02 3.536095E-02 11 4.000E+01 1.000E+02 6.000E+00 1.500E-01 1.307E-01 1.252E-01 1.7296E-02 1.791516E-02 12 4.667E+01 1.067E+02 7.000E+00 1.500E-01 1.132E-01 1.084E-01 8.7035E-03 9.076474E-03 13 5.333E+01 1.133E+02 8.000E+00 1.500E-01 9.987E-02 9.559E-02 4.3797E-03 4.598474E-03 14 6.000E+01 1.200E+02 9.000E+00 1.500E-01 8.932E-02 8.547E-02 2.2039E-03 2.329755E-03 15 6.667E+01 1.267E+02 1.000E+01 1.500E-01 8.079E-02 7.728E-02 1.1090E-03 1.180339E-03 16 8.333E+01 1.433E+02 1.250E+01 1.500E-01 6.520E-02 6.234E-02 1.9920E-04 2.156494E-04 17 1.000E+02 1.600E+02 1.500E+01 1.500E-01 5.465E-02 5.224E-02 3.5782E-05 3.939940E-05 18 1.167E+02 1.767E+02 1.750E+01 1.500E-01 4.703E-02 4.495E-02 6.4274E-06 7.198318E-06 19 1.333E+02 1.933E+02 2.000E+01 1.500E-01 4.128E-02 3.945E-02 1.1545E-06 1.315141E-06 20 1.667E+02 2.267E+02 2.500E+01 1.500E-01 3.317E-02 3.169E-02 3.7251E-08 4.389906E-08 21 2.000E+02 2.600E+02 3.000E+01 1.500E-01 2.772E-02 2.648E-02 1.2019E-09 1.465339E-09 22 2.333E+02 2.933E+02 3.500E+01 1.500E-01 2.381E-02 2.274E-02 3.8779E-11 4.891261E-11 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 24 3.333E-01 7.233E+01 1.000E-01 3.000E-01 9.616E-01 9.581E-01 9.4612E-01 9.461236E-01 25 8.333E-01 7.283E+01 2.500E-01 3.000E-01 9.081E-01 9.000E-01 8.6564E-01 8.657163E-01 26 1.667E+00 7.367E+01 5.000E-01 3.000E-01 8.285E-01 8.146E-01 7.3696E-01 7.374169E-01 27 3.333E+00 7.533E+01 1.000E+00 3.000E-01 6.988E-01 6.779E-01 5.1631E-01 5.182412E-01 28 5.000E+00 7.700E+01 1.500E+00 3.000E-01 5.990E-01 5.749E-01 3.5175E-01 3.551602E-01 29 6.667E+00 7.867E+01 2.000E+00 3.000E-01 5.209E-01 4.958E-01 2.3596E-01 2.402149E-01 30 1.000E+01 7.000E+01 3.000E+00 3.000E-01 4.087E-01 3.845E-01 1.0389E-01 1.079945E-01 31 1.333E+01 7.333E+01 4.000E+00 3.000E-01 3.336E-01 3.116E-01 4.5224E-02 4.814693E-02 32 1.667E+01 7.667E+01 5.000E+00 3.000E-01 2.806E-01 2.609E-01 1.9618E-02 2.141606E-02 33 2.000E+01 8.000E+01 6.000E+00 3.000E-01 2.417E-01 2.240E-01 8.5011E-03 9.520018E-03 34 2.333E+01 8.333E+01 7.000E+00 3.000E-01 2.120E-01 1.960E-01 3.6826E-03 4.231176E-03 35 2.667E+01 8.667E+01 8.000E+00 3.000E-01 1.886E-01 1.742E-01 1.5951E-03 1.880459E-03 36 3.000E+01 9.000E+01 9.000E+00 3.000E-01 1.699E-01 1.567E-01 6.9089E-04 8.357208E-04 37 3.333E+01 9.333E+01 1.000E+01 3.000E-01 1.545E-01 1.423E-01 2.9925E-04 3.714128E-04 38 4.167E+01 1.017E+02 1.250E+01 3.000E-01 1.258E-01 1.158E-01 3.6946E-05 4.890406E-05 39 5.000E+01 1.100E+02 1.500E+01 3.000E-01 1.061E-01 9.752E-02 4.5615E-06 6.439211E-06 40 5.833E+01 1.183E+02 1.750E+01 3.000E-01 9.175E-02 8.423E-02 5.6319E-07 8.478527E-07 41 6.667E+01 1.267E+02 2.000E+01 3.000E-01 8.079E-02 7.413E-02 6.9533E-08 1.116370E-07 42 8.333E+01 1.433E+02 2.500E+01 3.000E-01 6.520E-02 5.978E-02 1.0599E-09 1.935458E-09 43 1.000E+02 1.600E+02 3.000E+01 3.000E-01 5.465E-02 5.008E-02 1.6157E-11 3.355515E-11 44 1.167E+02 1.767E+02 3.500E+01 3.000E-01 4.703E-02 4.309E-02 2.4629E-13 5.817478E-13 45 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 46 1.667E-01 7.217E+01 1.000E-01 6.000E-01 9.805E-01 9.769E-01 9.4609E-01 9.460920E-01 47 4.167E-01 7.242E+01 2.500E-01 6.000E-01 9.524E-01 9.437E-01 8.6521E-01 8.652964E-01 48 8.333E-01 7.283E+01 5.000E-01 6.000E-01 9.081E-01 8.920E-01 7.3436E-01 7.348817E-01 49 1.667E+00 7.367E+01 1.000E+00 6.000E-01 8.285E-01 8.011E-01 5.0454E-01 5.070056E-01 50 2.500E+00 7.450E+01 1.500E+00 6.000E-01 7.593E-01 7.241E-01 3.2990E-01 3.345904E-01 51 3.333E+00 7.533E+01 2.000E+00 6.000E-01 6.988E-01 6.583E-01 2.0792E-01 2.140064E-01 52 5.000E+00 7.700E+01 3.000E+00 6.000E-01 5.990E-01 5.529E-01 7.6613E-02 8.248161E-02 53 6.667E+00 7.867E+01 4.000E+00 6.000E-01 5.209E-01 4.734E-01 2.6537E-02 3.038543E-02 54 8.333E+00 6.833E+01 5.000E+00 6.000E-01 4.589E-01 4.119E-01 8.8830E-03 1.094494E-02 55 1.000E+01 7.000E+01 6.000E+00 6.000E-01 4.087E-01 3.634E-01 2.9178E-03 3.898555E-03 56 1.167E+01 7.167E+01 7.000E+00 6.000E-01 3.676E-01 3.245E-01 9.4847E-04 1.380945E-03 57 1.333E+01 7.333E+01 8.000E+00 6.000E-01 3.336E-01 2.927E-01 3.0653E-04 4.878039E-04 58 1.500E+01 7.500E+01 9.000E+00 6.000E-01 3.049E-01 2.664E-01 9.8752E-05 1.720739E-04 59 1.667E+01 7.667E+01 1.000E+01 6.000E-01 2.806E-01 2.442E-01 3.1758E-05 6.065777E-05 60 2.083E+01 8.083E+01 1.250E+01 6.000E-01 2.335E-01 2.019E-01 1.8563E-06 4.470101E-06 61 2.500E+01 8.500E+01 1.500E+01 6.000E-01 1.996E-01 1.718E-01 1.0833E-07 3.292673E-07 62 2.917E+01 8.917E+01 1.750E+01 6.000E-01 1.742E-01 1.495E-01 6.3194E-09 2.425186E-08 63 3.333E+01 9.333E+01 2.000E+01 6.000E-01 1.545E-01 1.323E-01 3.6861E-10 1.786221E-09 64 4.167E+01 1.017E+02 2.500E+01 6.000E-01 1.258E-01 1.074E-01 1.2542E-12 9.689768E-12 65 5.000E+01 1.100E+02 3.000E+01 6.000E-01 1.061E-01 9.044E-02 4.2671E-15 5.256435E-14 66 5.833E+01 1.183E+02 3.500E+01 6.000E-01 9.175E-02 7.808E-02 1.4518E-17 2.851472E-16 67 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 68 8.333E-02 7.208E+01 1.000E-01 1.200E+00 9.902E-01 9.865E-01 9.4607E-01 9.460758E-01 69 2.083E-01 7.221E+01 2.500E-01 1.200E+00 9.758E-01 9.667E-01 8.6499E-01 8.650747E-01 70 4.167E-01 7.242E+01 5.000E-01 1.200E+00 9.524E-01 9.351E-01 7.3291E-01 7.334760E-01 71 8.333E-01 7.283E+01 1.000E+00 1.200E+00 9.081E-01 8.766E-01 4.9745E-01 5.002474E-01 72 1.250E+00 7.325E+01 1.500E+00 1.200E+00 8.669E-01 8.237E-01 3.1600E-01 3.215157E-01 73 1.667E+00 7.367E+01 2.000E+00 1.200E+00 8.285E-01 7.757E-01 1.8960E-01 1.968581E-01 74 2.500E+00 7.450E+01 3.000E+00 1.200E+00 7.593E-01 6.923E-01 5.9282E-02 6.599300E-02 75 3.333E+00 7.533E+01 4.000E+00 1.200E+00 6.988E-01 6.227E-01 1.5998E-02 1.986951E-02 76 4.167E+00 7.617E+01 5.000E+00 1.200E+00 6.458E-01 5.640E-01 3.8698E-03 5.566075E-03 77 5.000E+00 7.700E+01 6.000E+00 1.200E+00 5.990E-01 5.142E-01 8.6289E-04 1.485410E-03 78 5.833E+00 7.783E+01 7.000E+00 1.200E+00 5.577E-01 4.715E-01 1.8111E-04 3.836785E-04 79 6.667E+00 6.667E+01 8.000E+00 1.200E+00 5.209E-01 4.347E-01 3.6342E-05 9.694865E-05 80 7.500E+00 6.750E+01 9.000E+00 1.200E+00 4.882E-01 4.028E-01 7.0524E-06 2.413706E-05 81 8.333E+00 6.833E+01 1.000E+01 1.200E+00 4.589E-01 3.748E-01 1.3350E-06 5.949669E-06 82 1.042E+01 7.042E+01 1.250E+01 1.200E+00 3.977E-01 3.185E-01 1.9388E-08 1.750764E-07 83 1.250E+01 7.250E+01 1.500E+01 1.200E+00 3.498E-01 2.762E-01 2.6592E-10 5.066108E-09 84 1.458E+01 7.458E+01 1.750E+01 1.200E+00 3.117E-01 2.434E-01 3.5492E-12 1.456803E-10 85 1.667E+01 7.667E+01 2.000E+01 1.200E+00 2.806E-01 2.174E-01 4.6758E-14 4.179379E-12 86 2.083E+01 8.083E+01 2.500E+01 1.200E+00 2.335E-01 1.789E-01 7.9918E-18 3.432683E-15 87 2.500E+01 8.500E+01 3.000E+01 1.200E+00 1.996E-01 1.519E-01 1.3572E-21 2.817661E-18 88 2.917E+01 8.917E+01 3.500E+01 1.200E+00 1.742E-01 1.319E-01 2.3014E-25 2.312633E-21 89 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 90 8.333E-03 7.201E+01 1.000E-01 1.200E+01 9.990E-01 9.952E-01 9.4605E-01 9.460611E-01 91 2.083E-02 7.202E+01 2.500E-01 1.200E+01 9.975E-01 9.882E-01 8.6478E-01 8.648683E-01 92 4.167E-02 7.204E+01 5.000E-01 1.200E+01 9.951E-01 9.766E-01 7.3152E-01 7.321232E-01 93 8.333E-02 7.208E+01 1.000E+00 1.200E+01 9.902E-01 9.543E-01 4.9025E-01 4.933807E-01 94 1.250E-01 7.212E+01 1.500E+00 1.200E+01 9.853E-01 9.330E-01 3.0138E-01 3.077573E-01 95 1.667E-01 7.217E+01 2.000E+00 1.200E+01 9.805E-01 9.126E-01 1.7017E-01 1.785957E-01 96 2.500E-01 7.225E+01 3.000E+00 1.200E+01 9.710E-01 8.742E-01 4.2247E-02 4.932162E-02 97 3.333E-01 7.233E+01 4.000E+00 1.200E+01 9.616E-01 8.389E-01 7.5751E-03 1.073992E-02 98 4.167E-01 7.242E+01 5.000E+00 1.200E+01 9.524E-01 8.062E-01 9.9037E-04 1.896452E-03 99 5.000E-01 7.250E+01 6.000E+00 1.200E+01 9.433E-01 7.759E-01 9.5286E-05 2.781593E-04 100 5.833E-01 7.258E+01 7.000E+00 1.200E+01 9.343E-01 7.477E-01 6.8073E-06 3.459807E-05 101 6.667E-01 7.267E+01 8.000E+00 1.200E+01 9.254E-01 7.213E-01 3.6425E-07 3.715487E-06 102 7.500E-01 7.275E+01 9.000E+00 1.200E+01 9.167E-01 6.967E-01 1.4723E-08 3.499308E-07 103 8.333E-01 7.283E+01 1.000E+01 1.200E+01 9.081E-01 6.736E-01 4.5320E-10 2.930228E-08 104 1.042E+00 7.304E+01 1.250E+01 1.200E+01 8.871E-01 6.218E-01 2.4096E-14 3.834450E-11 105 1.250E+00 7.325E+01 1.500E+01 1.200E+01 8.669E-01 5.769E-01 2.7599E-19 3.013317E-14 106 1.458E+00 7.346E+01 1.750E+01 1.200E+01 8.474E-01 5.378E-01 7.5989E-25 1.594031E-17 107 1.667E+00 7.367E+01 2.000E+01 1.200E+01 8.285E-01 5.033E-01 5.5686E-31 6.188016E-21 108 2.083E+00 7.408E+01 2.500E+01 1.200E+01 7.927E-01 4.454E-01 8.1740E-45 4.729400E-28 109 2.500E+00 6.250E+01 3.000E+01 1.200E+01 7.593E-01 3.988E-01 1.7198E-60 1.948093E-35 110 2.917E+00 6.292E+01 3.500E+01 1.200E+01 7.281E-01 3.605E-01 9.3073E-78 5.426450E-43 111 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 112 1.852E-03 7.200E+01 1.000E-01 5.400E+01 9.998E-01 9.960E-01 9.4605E-01 9.460598E-01 113 4.630E-03 7.200E+01 2.500E-01 5.400E+01 9.995E-01 9.901E-01 8.6476E-01 8.648501E-01 114 9.259E-03 7.201E+01 5.000E-01 5.400E+01 9.989E-01 9.804E-01 7.3140E-01 7.320021E-01 115 1.852E-02 7.202E+01 1.000E+00 5.400E+01 9.978E-01 9.615E-01 4.8958E-01 4.927490E-01 116 2.778E-02 7.203E+01 1.500E+00 5.400E+01 9.967E-01 9.435E-01 3.0001E-01 3.064697E-01 117 3.704E-02 7.204E+01 2.000E+00 5.400E+01 9.956E-01 9.261E-01 1.6835E-01 1.768819E-01 118 5.556E-02 7.206E+01 3.000E+00 5.400E+01 9.934E-01 8.934E-01 4.0756E-02 4.783071E-02 119 7.407E-02 7.207E+01 4.000E+00 5.400E+01 9.913E-01 8.631E-01 6.9623E-03 1.002589E-02 120 9.259E-02 7.209E+01 5.000E+00 5.400E+01 9.891E-01 8.349E-01 8.4116E-04 1.669703E-03 121 1.111E-01 7.211E+01 6.000E+00 5.400E+01 9.870E-01 8.085E-01 7.2039E-05 2.257080E-04 122 1.296E-01 7.213E+01 7.000E+00 5.400E+01 9.848E-01 7.839E-01 4.3833E-06 2.523245E-05 123 1.481E-01 7.215E+01 8.000E+00 5.400E+01 9.827E-01 7.608E-01 1.8991E-07 2.371385E-06 124 1.667E-01 7.217E+01 9.000E+00 5.400E+01 9.805E-01 7.391E-01 5.8719E-09 1.900933E-07 125 1.852E-01 7.219E+01 1.000E+01 5.400E+01 9.784E-01 7.186E-01 1.2985E-10 1.316546E-08 126 2.315E-01 7.223E+01 1.250E+01 5.400E+01 9.731E-01 6.723E-01 2.2111E-15 9.423178E-12 127 2.778E-01 7.228E+01 1.500E+01 5.400E+01 9.679E-01 6.318E-01 4.8616E-21 3.361929E-15 128 3.241E-01 7.232E+01 1.750E+01 5.400E+01 9.627E-01 5.959E-01 1.4272E-27 6.710692E-19 129 3.704E-01 7.237E+01 2.000E+01 5.400E+01 9.575E-01 5.641E-01 5.7806E-35 8.209395E-23 130 4.630E-01 7.246E+01 2.500E+01 5.400E+01 9.473E-01 5.097E-01 2.8339E-52 3.737330E-31 131 5.556E-01 7.256E+01 3.000E+01 5.400E+01 9.373E-01 4.650E-01 7.3731E-73 4.921030E-40 132 6.481E-01 6.065E+01 3.500E+01 5.400E+01 9.274E-01 4.275E-01 1.2999E-96 2.536930E-49 ------------------------------------------------------------------------------------------------------ GL=[2*[x+exp(-x)-1]/(x*x), where x = {lamda}*{irradiation time} and GEFF=-(alpha+LOG(SF)/D)/(beta*D). In the formula for GEFF, SF is surviving fraction as computed using the LPL model. The effects of lethal residual damage are included in the GEFF dose protraction factor but not GL. The SF estimates are: SF1=EXP{-dose*[alpha+gl*beta*dose]} and SF2=EXP{-dose*(alpha+geff*beta*dose)}. QECK TABLE: Tumor control probability (TCP) estimates as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. The *MAX* estimate is recommended (the other TCP estimates are mainly included in the table for diagnostic purposes). ===================================================================================================================== TSIM DOSE ---- EXPECTED NUMBER OF CELLS ---- ------ TUMOR CONTROL PROBABILITY (TCP) ------- SIM ID (day) (Gy) N(0)*S(D) N(t)*S(D) NSC(t) N(0)*S(D) N(t)*S(D) NSC(t) *MAX* --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 2 3.028E+00 1.000E-01 9.4618E-01 9.4618E-01 9.4618E-01 3.8822E-01 3.8822E-01 3.8822E-01 3.8822E-01 3 3.069E+00 2.500E-01 8.6647E-01 8.6647E-01 8.6647E-01 4.2043E-01 4.2043E-01 4.2043E-01 4.2043E-01 4 3.139E+00 5.000E-01 7.4157E-01 7.4157E-01 7.4157E-01 4.7636E-01 4.7636E-01 4.7636E-01 4.7636E-01 5 3.278E+00 1.000E+00 5.3413E-01 5.3413E-01 5.3413E-01 5.8618E-01 5.8618E-01 5.8618E-01 5.8618E-01 6 2.917E+00 1.500E+00 3.8149E-01 3.8149E-01 3.8149E-01 6.8284E-01 6.8284E-01 6.8284E-01 6.8284E-01 7 3.056E+00 2.000E+00 2.7181E-01 2.7181E-01 2.7181E-01 7.6200E-01 7.6200E-01 7.6200E-01 7.6200E-01 8 3.333E+00 3.000E+00 1.3776E-01 1.3776E-01 1.3776E-01 8.7131E-01 8.7131E-01 8.7131E-01 8.7131E-01 9 3.611E+00 4.000E+00 6.9795E-02 6.9795E-02 6.9795E-02 9.3258E-01 9.3258E-01 9.3258E-01 9.3258E-01 10 3.889E+00 5.000E+00 3.5361E-02 3.5361E-02 3.5361E-02 9.6526E-01 9.6526E-01 9.6526E-01 9.6526E-01 11 4.167E+00 6.000E+00 1.7915E-02 1.7915E-02 1.7915E-02 9.8224E-01 9.8224E-01 9.8224E-01 9.8224E-01 12 4.444E+00 7.000E+00 9.0765E-03 9.0765E-03 9.0765E-03 9.9096E-01 9.9096E-01 9.9096E-01 9.9096E-01 13 4.722E+00 8.000E+00 4.5985E-03 4.5985E-03 4.5985E-03 9.9541E-01 9.9541E-01 9.9541E-01 9.9541E-01 14 5.000E+00 9.000E+00 2.3298E-03 2.3298E-03 2.3298E-03 9.9767E-01 9.9767E-01 9.9767E-01 9.9767E-01 15 5.278E+00 1.000E+01 1.1803E-03 1.1803E-03 1.1803E-03 9.9882E-01 9.9882E-01 9.9882E-01 9.9882E-01 16 5.972E+00 1.250E+01 2.1565E-04 2.1565E-04 2.1565E-04 9.9978E-01 9.9978E-01 9.9978E-01 9.9978E-01 17 6.667E+00 1.500E+01 3.9399E-05 3.9399E-05 3.9399E-05 9.9996E-01 9.9996E-01 9.9996E-01 9.9996E-01 18 7.361E+00 1.750E+01 7.1983E-06 7.1983E-06 7.1983E-06 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 19 8.056E+00 2.000E+01 1.3151E-06 1.3151E-06 1.3151E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 20 9.444E+00 2.500E+01 4.3899E-08 4.3899E-08 4.3899E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 21 1.083E+01 3.000E+01 1.4653E-09 1.4653E-09 1.4653E-09 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 22 1.222E+01 3.500E+01 4.8913E-11 4.8913E-11 4.8913E-11 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 23 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 24 3.014E+00 1.000E-01 9.4612E-01 9.4612E-01 9.4612E-01 3.8824E-01 3.8824E-01 3.8824E-01 3.8824E-01 25 3.035E+00 2.500E-01 8.6572E-01 8.6572E-01 8.6572E-01 4.2075E-01 4.2075E-01 4.2075E-01 4.2075E-01 26 3.069E+00 5.000E-01 7.3742E-01 7.3742E-01 7.3742E-01 4.7835E-01 4.7835E-01 4.7835E-01 4.7835E-01 27 3.139E+00 1.000E+00 5.1824E-01 5.1824E-01 5.1824E-01 5.9557E-01 5.9557E-01 5.9557E-01 5.9557E-01 28 3.208E+00 1.500E+00 3.5516E-01 3.5516E-01 3.5516E-01 7.0106E-01 7.0106E-01 7.0106E-01 7.0106E-01 29 3.278E+00 2.000E+00 2.4021E-01 2.4021E-01 2.4021E-01 7.8646E-01 7.8646E-01 7.8646E-01 7.8646E-01 30 2.917E+00 3.000E+00 1.0799E-01 1.0799E-01 1.0799E-01 8.9763E-01 8.9763E-01 8.9763E-01 8.9763E-01 31 3.056E+00 4.000E+00 4.8147E-02 4.8147E-02 4.8147E-02 9.5299E-01 9.5299E-01 9.5299E-01 9.5299E-01 32 3.194E+00 5.000E+00 2.1416E-02 2.1416E-02 2.1416E-02 9.7881E-01 9.7881E-01 9.7881E-01 9.7881E-01 33 3.333E+00 6.000E+00 9.5200E-03 9.5200E-03 9.5200E-03 9.9053E-01 9.9053E-01 9.9053E-01 9.9053E-01 34 3.472E+00 7.000E+00 4.2312E-03 4.2312E-03 4.2312E-03 9.9578E-01 9.9578E-01 9.9578E-01 9.9578E-01 35 3.611E+00 8.000E+00 1.8805E-03 1.8805E-03 1.8805E-03 9.9812E-01 9.9812E-01 9.9812E-01 9.9812E-01 36 3.750E+00 9.000E+00 8.3572E-04 8.3572E-04 8.3572E-04 9.9916E-01 9.9916E-01 9.9916E-01 9.9916E-01 37 3.889E+00 1.000E+01 3.7141E-04 3.7141E-04 3.7141E-04 9.9963E-01 9.9963E-01 9.9963E-01 9.9963E-01 38 4.236E+00 1.250E+01 4.8904E-05 4.8904E-05 4.8904E-05 9.9995E-01 9.9995E-01 9.9995E-01 9.9995E-01 39 4.583E+00 1.500E+01 6.4392E-06 6.4392E-06 6.4392E-06 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 40 4.931E+00 1.750E+01 8.4785E-07 8.4785E-07 8.4785E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 41 5.278E+00 2.000E+01 1.1164E-07 1.1164E-07 1.1164E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 42 5.972E+00 2.500E+01 1.9355E-09 1.9355E-09 1.9355E-09 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 43 6.667E+00 3.000E+01 3.3555E-11 3.3555E-11 3.3555E-11 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 44 7.361E+00 3.500E+01 5.8175E-13 5.8175E-13 5.8175E-13 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 45 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 46 3.007E+00 1.000E-01 9.4609E-01 9.4609E-01 9.4609E-01 3.8826E-01 3.8826E-01 3.8826E-01 3.8826E-01 47 3.017E+00 2.500E-01 8.6530E-01 8.6530E-01 8.6530E-01 4.2093E-01 4.2093E-01 4.2093E-01 4.2093E-01 48 3.035E+00 5.000E-01 7.3488E-01 7.3488E-01 7.3488E-01 4.7956E-01 4.7956E-01 4.7956E-01 4.7956E-01 49 3.069E+00 1.000E+00 5.0701E-01 5.0701E-01 5.0701E-01 6.0230E-01 6.0230E-01 6.0230E-01 6.0230E-01 50 3.104E+00 1.500E+00 3.3459E-01 3.3459E-01 3.3459E-01 7.1563E-01 7.1563E-01 7.1563E-01 7.1563E-01 51 3.139E+00 2.000E+00 2.1401E-01 2.1401E-01 2.1401E-01 8.0734E-01 8.0734E-01 8.0734E-01 8.0734E-01 52 3.208E+00 3.000E+00 8.2482E-02 8.2482E-02 8.2482E-02 9.2083E-01 9.2083E-01 9.2083E-01 9.2083E-01 53 3.278E+00 4.000E+00 3.0385E-02 3.0385E-02 3.0385E-02 9.7007E-01 9.7007E-01 9.7007E-01 9.7007E-01 54 2.847E+00 5.000E+00 1.0945E-02 1.0945E-02 1.0945E-02 9.8911E-01 9.8911E-01 9.8911E-01 9.8911E-01 55 2.917E+00 6.000E+00 3.8986E-03 3.8986E-03 3.8986E-03 9.9611E-01 9.9611E-01 9.9611E-01 9.9611E-01 56 2.986E+00 7.000E+00 1.3809E-03 1.3809E-03 1.3809E-03 9.9862E-01 9.9862E-01 9.9862E-01 9.9862E-01 57 3.056E+00 8.000E+00 4.8780E-04 4.8780E-04 4.8780E-04 9.9951E-01 9.9951E-01 9.9951E-01 9.9951E-01 58 3.125E+00 9.000E+00 1.7207E-04 1.7207E-04 1.7207E-04 9.9983E-01 9.9983E-01 9.9983E-01 9.9983E-01 59 3.194E+00 1.000E+01 6.0658E-05 6.0658E-05 6.0658E-05 9.9994E-01 9.9994E-01 9.9994E-01 9.9994E-01 60 3.368E+00 1.250E+01 4.4701E-06 4.4701E-06 4.4701E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 61 3.542E+00 1.500E+01 3.2927E-07 3.2927E-07 3.2927E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 62 3.715E+00 1.750E+01 2.4252E-08 2.4252E-08 2.4252E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 63 3.889E+00 2.000E+01 1.7862E-09 1.7862E-09 1.7862E-09 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 64 4.236E+00 2.500E+01 9.6898E-12 9.6898E-12 9.6898E-12 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 65 4.583E+00 3.000E+01 5.2564E-14 5.2564E-14 5.2564E-14 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 66 4.931E+00 3.500E+01 2.8515E-16 2.8515E-16 2.8515E-16 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 67 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 68 3.003E+00 1.000E-01 9.4608E-01 9.4608E-01 9.4608E-01 3.8826E-01 3.8826E-01 3.8826E-01 3.8826E-01 69 3.009E+00 2.500E-01 8.6507E-01 8.6507E-01 8.6507E-01 4.2102E-01 4.2102E-01 4.2102E-01 4.2102E-01 70 3.017E+00 5.000E-01 7.3348E-01 7.3348E-01 7.3348E-01 4.8024E-01 4.8024E-01 4.8024E-01 4.8024E-01 71 3.035E+00 1.000E+00 5.0025E-01 5.0025E-01 5.0025E-01 6.0638E-01 6.0638E-01 6.0638E-01 6.0638E-01 72 3.052E+00 1.500E+00 3.2152E-01 3.2152E-01 3.2152E-01 7.2505E-01 7.2505E-01 7.2505E-01 7.2505E-01 73 3.069E+00 2.000E+00 1.9686E-01 1.9686E-01 1.9686E-01 8.2131E-01 8.2131E-01 8.2131E-01 8.2131E-01 74 3.104E+00 3.000E+00 6.5993E-02 6.5993E-02 6.5993E-02 9.3614E-01 9.3614E-01 9.3614E-01 9.3614E-01 75 3.139E+00 4.000E+00 1.9870E-02 1.9870E-02 1.9870E-02 9.8033E-01 9.8033E-01 9.8033E-01 9.8033E-01 76 3.174E+00 5.000E+00 5.5661E-03 5.5661E-03 5.5661E-03 9.9445E-01 9.9445E-01 9.9445E-01 9.9445E-01 77 3.208E+00 6.000E+00 1.4854E-03 1.4854E-03 1.4854E-03 9.9852E-01 9.9852E-01 9.9852E-01 9.9852E-01 78 3.243E+00 7.000E+00 3.8368E-04 3.8368E-04 3.8368E-04 9.9962E-01 9.9962E-01 9.9962E-01 9.9962E-01 79 2.778E+00 8.000E+00 9.6949E-05 9.6949E-05 9.6949E-05 9.9990E-01 9.9990E-01 9.9990E-01 9.9990E-01 80 2.812E+00 9.000E+00 2.4137E-05 2.4137E-05 2.4137E-05 9.9998E-01 9.9998E-01 9.9998E-01 9.9998E-01 81 2.847E+00 1.000E+01 5.9497E-06 5.9497E-06 5.9497E-06 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 82 2.934E+00 1.250E+01 1.7508E-07 1.7508E-07 1.7508E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 83 3.021E+00 1.500E+01 5.0661E-09 5.0661E-09 5.0661E-09 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 84 3.108E+00 1.750E+01 1.4568E-10 1.4568E-10 1.4568E-10 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 85 3.194E+00 2.000E+01 4.1794E-12 4.1794E-12 4.1794E-12 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 86 3.368E+00 2.500E+01 3.4327E-15 3.4327E-15 3.4327E-15 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 87 3.542E+00 3.000E+01 2.8177E-18 2.8177E-18 2.8177E-18 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 88 3.715E+00 3.500E+01 2.3126E-21 2.3126E-21 2.3126E-21 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 89 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 90 3.000E+00 1.000E-01 9.4606E-01 9.4606E-01 9.4606E-01 3.8827E-01 3.8827E-01 3.8827E-01 3.8827E-01 91 3.001E+00 2.500E-01 8.6487E-01 8.6487E-01 8.6487E-01 4.2111E-01 4.2111E-01 4.2111E-01 4.2111E-01 92 3.002E+00 5.000E-01 7.3212E-01 7.3212E-01 7.3212E-01 4.8089E-01 4.8089E-01 4.8089E-01 4.8089E-01 93 3.003E+00 1.000E+00 4.9338E-01 4.9338E-01 4.9338E-01 6.1056E-01 6.1056E-01 6.1056E-01 6.1056E-01 94 3.005E+00 1.500E+00 3.0776E-01 3.0776E-01 3.0776E-01 7.3509E-01 7.3509E-01 7.3509E-01 7.3509E-01 95 3.007E+00 2.000E+00 1.7860E-01 1.7860E-01 1.7860E-01 8.3644E-01 8.3644E-01 8.3644E-01 8.3644E-01 96 3.010E+00 3.000E+00 4.9322E-02 4.9322E-02 4.9322E-02 9.5187E-01 9.5187E-01 9.5187E-01 9.5187E-01 97 3.014E+00 4.000E+00 1.0740E-02 1.0740E-02 1.0740E-02 9.8932E-01 9.8932E-01 9.8932E-01 9.8932E-01 98 3.017E+00 5.000E+00 1.8965E-03 1.8965E-03 1.8965E-03 9.9811E-01 9.9811E-01 9.9811E-01 9.9811E-01 99 3.021E+00 6.000E+00 2.7816E-04 2.7816E-04 2.7816E-04 9.9972E-01 9.9972E-01 9.9972E-01 9.9972E-01 100 3.024E+00 7.000E+00 3.4598E-05 3.4598E-05 3.4598E-05 9.9997E-01 9.9997E-01 9.9997E-01 9.9997E-01 101 3.028E+00 8.000E+00 3.7155E-06 3.7155E-06 3.7155E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 102 3.031E+00 9.000E+00 3.4993E-07 3.4993E-07 3.4993E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 103 3.035E+00 1.000E+01 2.9302E-08 2.9302E-08 2.9302E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 104 3.043E+00 1.250E+01 3.8345E-11 3.8345E-11 3.8345E-11 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 105 3.052E+00 1.500E+01 3.0133E-14 3.0133E-14 3.0133E-14 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 106 3.061E+00 1.750E+01 1.5940E-17 1.5940E-17 1.5940E-17 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 107 3.069E+00 2.000E+01 6.1880E-21 6.1880E-21 6.1880E-21 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 108 3.087E+00 2.500E+01 4.7294E-28 4.7294E-28 4.7294E-28 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 109 2.604E+00 3.000E+01 1.9481E-35 1.9481E-35 1.9481E-35 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 110 2.622E+00 3.500E+01 5.4265E-43 5.4265E-43 5.4265E-43 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 111 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 112 3.000E+00 1.000E-01 9.4606E-01 9.4606E-01 9.4606E-01 3.8827E-01 3.8827E-01 3.8827E-01 3.8827E-01 113 3.000E+00 2.500E-01 8.6485E-01 8.6485E-01 8.6485E-01 4.2111E-01 4.2111E-01 4.2111E-01 4.2111E-01 114 3.000E+00 5.000E-01 7.3200E-01 7.3200E-01 7.3200E-01 4.8095E-01 4.8095E-01 4.8095E-01 4.8095E-01 115 3.001E+00 1.000E+00 4.9275E-01 4.9275E-01 4.9275E-01 6.1094E-01 6.1094E-01 6.1094E-01 6.1094E-01 116 3.001E+00 1.500E+00 3.0647E-01 3.0647E-01 3.0647E-01 7.3604E-01 7.3604E-01 7.3604E-01 7.3604E-01 117 3.002E+00 2.000E+00 1.7688E-01 1.7688E-01 1.7688E-01 8.3788E-01 8.3788E-01 8.3788E-01 8.3788E-01 118 3.002E+00 3.000E+00 4.7831E-02 4.7831E-02 4.7831E-02 9.5330E-01 9.5330E-01 9.5330E-01 9.5330E-01 119 3.003E+00 4.000E+00 1.0026E-02 1.0026E-02 1.0026E-02 9.9002E-01 9.9002E-01 9.9002E-01 9.9002E-01 120 3.004E+00 5.000E+00 1.6697E-03 1.6697E-03 1.6697E-03 9.9833E-01 9.9833E-01 9.9833E-01 9.9833E-01 121 3.005E+00 6.000E+00 2.2571E-04 2.2571E-04 2.2571E-04 9.9977E-01 9.9977E-01 9.9977E-01 9.9977E-01 122 3.005E+00 7.000E+00 2.5232E-05 2.5232E-05 2.5232E-05 9.9997E-01 9.9997E-01 9.9997E-01 9.9997E-01 123 3.006E+00 8.000E+00 2.3714E-06 2.3714E-06 2.3714E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 124 3.007E+00 9.000E+00 1.9009E-07 1.9009E-07 1.9009E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 125 3.008E+00 1.000E+01 1.3165E-08 1.3165E-08 1.3165E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 126 3.010E+00 1.250E+01 9.4232E-12 9.4232E-12 9.4232E-12 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 127 3.012E+00 1.500E+01 3.3619E-15 3.3619E-15 3.3619E-15 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 128 3.014E+00 1.750E+01 6.7107E-19 6.7107E-19 6.7107E-19 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 129 3.015E+00 2.000E+01 8.2094E-23 8.2094E-23 8.2094E-23 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 130 3.019E+00 2.500E+01 3.7373E-31 3.7373E-31 3.7373E-31 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 131 3.023E+00 3.000E+01 4.9210E-40 4.9210E-40 4.9210E-40 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 132 2.527E+00 3.500E+01 2.5369E-49 2.5369E-49 2.5369E-49 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 --------------------------------------------------------------------------------------------------------------------- NOTE: TCP={probability no cells survive}=EXP{-(expected number of surviving cells)}. TCP estimates are based on the expected number of surviving cells with and without corrections for repopulation effects. The *MAX* TCP is the peak (all time points after irradiation) estimate derived from NSC(t). RADX EXPOSURE SUMMARY ============================================================================== SCENARIO ----- DURATION ----- ------ DOSE (Gy) ----- -- DOSE RATE (Gy/h) -- NUMBER hours days Background Total Background Total* ------------------------------------------------------------------------------ 1 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 2 6.667E-01 2.778E-02 0.0000E+00 1.0000E-01 0.0000E+00 1.5000E-01 3 1.667E+00 6.944E-02 0.0000E+00 2.5000E-01 0.0000E+00 1.5000E-01 4 3.333E+00 1.389E-01 0.0000E+00 5.0000E-01 0.0000E+00 1.5000E-01 5 6.667E+00 2.778E-01 0.0000E+00 1.0000E+00 0.0000E+00 1.5000E-01 6 1.000E+01 4.167E-01 0.0000E+00 1.5000E+00 0.0000E+00 1.5000E-01 7 1.333E+01 5.556E-01 0.0000E+00 2.0000E+00 0.0000E+00 1.5000E-01 8 2.000E+01 8.333E-01 0.0000E+00 3.0000E+00 0.0000E+00 1.5000E-01 9 2.667E+01 1.111E+00 0.0000E+00 4.0000E+00 0.0000E+00 1.5000E-01 10 3.333E+01 1.389E+00 0.0000E+00 5.0000E+00 0.0000E+00 1.5000E-01 11 4.000E+01 1.667E+00 0.0000E+00 6.0000E+00 0.0000E+00 1.5000E-01 12 4.667E+01 1.944E+00 0.0000E+00 7.0000E+00 0.0000E+00 1.5000E-01 13 5.333E+01 2.222E+00 0.0000E+00 8.0000E+00 0.0000E+00 1.5000E-01 14 6.000E+01 2.500E+00 0.0000E+00 9.0000E+00 0.0000E+00 1.5000E-01 15 6.667E+01 2.778E+00 0.0000E+00 1.0000E+01 0.0000E+00 1.5000E-01 16 8.333E+01 3.472E+00 0.0000E+00 1.2500E+01 0.0000E+00 1.5000E-01 17 1.000E+02 4.167E+00 0.0000E+00 1.5000E+01 0.0000E+00 1.5000E-01 18 1.167E+02 4.861E+00 0.0000E+00 1.7500E+01 0.0000E+00 1.5000E-01 19 1.333E+02 5.556E+00 0.0000E+00 2.0000E+01 0.0000E+00 1.5000E-01 20 1.667E+02 6.944E+00 0.0000E+00 2.5000E+01 0.0000E+00 1.5000E-01 21 2.000E+02 8.333E+00 0.0000E+00 3.0000E+01 0.0000E+00 1.5000E-01 22 2.333E+02 9.722E+00 0.0000E+00 3.5000E+01 0.0000E+00 1.5000E-01 23 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 24 3.333E-01 1.389E-02 0.0000E+00 1.0000E-01 0.0000E+00 3.0000E-01 25 8.333E-01 3.472E-02 0.0000E+00 2.5000E-01 0.0000E+00 3.0000E-01 26 1.667E+00 6.944E-02 0.0000E+00 5.0000E-01 0.0000E+00 3.0000E-01 27 3.333E+00 1.389E-01 0.0000E+00 1.0000E+00 0.0000E+00 3.0000E-01 28 5.000E+00 2.083E-01 0.0000E+00 1.5000E+00 0.0000E+00 3.0000E-01 29 6.667E+00 2.778E-01 0.0000E+00 2.0000E+00 0.0000E+00 3.0000E-01 30 1.000E+01 4.167E-01 0.0000E+00 3.0000E+00 0.0000E+00 3.0000E-01 31 1.333E+01 5.556E-01 0.0000E+00 4.0000E+00 0.0000E+00 3.0000E-01 32 1.667E+01 6.944E-01 0.0000E+00 5.0000E+00 0.0000E+00 3.0000E-01 33 2.000E+01 8.333E-01 0.0000E+00 6.0000E+00 0.0000E+00 3.0000E-01 34 2.333E+01 9.722E-01 0.0000E+00 7.0000E+00 0.0000E+00 3.0000E-01 35 2.667E+01 1.111E+00 0.0000E+00 8.0000E+00 0.0000E+00 3.0000E-01 36 3.000E+01 1.250E+00 0.0000E+00 9.0000E+00 0.0000E+00 3.0000E-01 37 3.333E+01 1.389E+00 0.0000E+00 1.0000E+01 0.0000E+00 3.0000E-01 38 4.167E+01 1.736E+00 0.0000E+00 1.2500E+01 0.0000E+00 3.0000E-01 39 5.000E+01 2.083E+00 0.0000E+00 1.5000E+01 0.0000E+00 3.0000E-01 40 5.833E+01 2.431E+00 0.0000E+00 1.7500E+01 0.0000E+00 3.0000E-01 41 6.667E+01 2.778E+00 0.0000E+00 2.0000E+01 0.0000E+00 3.0000E-01 42 8.333E+01 3.472E+00 0.0000E+00 2.5000E+01 0.0000E+00 3.0000E-01 43 1.000E+02 4.167E+00 0.0000E+00 3.0000E+01 0.0000E+00 3.0000E-01 44 1.167E+02 4.861E+00 0.0000E+00 3.5000E+01 0.0000E+00 3.0000E-01 45 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 46 1.667E-01 6.944E-03 0.0000E+00 1.0000E-01 0.0000E+00 6.0000E-01 47 4.167E-01 1.736E-02 0.0000E+00 2.5000E-01 0.0000E+00 6.0000E-01 48 8.333E-01 3.472E-02 0.0000E+00 5.0000E-01 0.0000E+00 6.0000E-01 49 1.667E+00 6.944E-02 0.0000E+00 1.0000E+00 0.0000E+00 6.0000E-01 50 2.500E+00 1.042E-01 0.0000E+00 1.5000E+00 0.0000E+00 6.0000E-01 51 3.333E+00 1.389E-01 0.0000E+00 2.0000E+00 0.0000E+00 6.0000E-01 52 5.000E+00 2.083E-01 0.0000E+00 3.0000E+00 0.0000E+00 6.0000E-01 53 6.667E+00 2.778E-01 0.0000E+00 4.0000E+00 0.0000E+00 6.0000E-01 54 8.333E+00 3.472E-01 0.0000E+00 5.0000E+00 0.0000E+00 6.0000E-01 55 1.000E+01 4.167E-01 0.0000E+00 6.0000E+00 0.0000E+00 6.0000E-01 56 1.167E+01 4.861E-01 0.0000E+00 7.0000E+00 0.0000E+00 6.0000E-01 57 1.333E+01 5.556E-01 0.0000E+00 8.0000E+00 0.0000E+00 6.0000E-01 58 1.500E+01 6.250E-01 0.0000E+00 9.0000E+00 0.0000E+00 6.0000E-01 59 1.667E+01 6.944E-01 0.0000E+00 1.0000E+01 0.0000E+00 6.0000E-01 60 2.083E+01 8.681E-01 0.0000E+00 1.2500E+01 0.0000E+00 6.0000E-01 61 2.500E+01 1.042E+00 0.0000E+00 1.5000E+01 0.0000E+00 6.0000E-01 62 2.917E+01 1.215E+00 0.0000E+00 1.7500E+01 0.0000E+00 6.0000E-01 63 3.333E+01 1.389E+00 0.0000E+00 2.0000E+01 0.0000E+00 6.0000E-01 64 4.167E+01 1.736E+00 0.0000E+00 2.5000E+01 0.0000E+00 6.0000E-01 65 5.000E+01 2.083E+00 0.0000E+00 3.0000E+01 0.0000E+00 6.0000E-01 66 5.833E+01 2.431E+00 0.0000E+00 3.5000E+01 0.0000E+00 6.0000E-01 67 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 68 8.333E-02 3.472E-03 0.0000E+00 1.0000E-01 0.0000E+00 1.2000E+00 69 2.083E-01 8.681E-03 0.0000E+00 2.5000E-01 0.0000E+00 1.2000E+00 70 4.167E-01 1.736E-02 0.0000E+00 5.0000E-01 0.0000E+00 1.2000E+00 71 8.333E-01 3.472E-02 0.0000E+00 1.0000E+00 0.0000E+00 1.2000E+00 72 1.250E+00 5.208E-02 0.0000E+00 1.5000E+00 0.0000E+00 1.2000E+00 73 1.667E+00 6.944E-02 0.0000E+00 2.0000E+00 0.0000E+00 1.2000E+00 74 2.500E+00 1.042E-01 0.0000E+00 3.0000E+00 0.0000E+00 1.2000E+00 75 3.333E+00 1.389E-01 0.0000E+00 4.0000E+00 0.0000E+00 1.2000E+00 76 4.167E+00 1.736E-01 0.0000E+00 5.0000E+00 0.0000E+00 1.2000E+00 77 5.000E+00 2.083E-01 0.0000E+00 6.0000E+00 0.0000E+00 1.2000E+00 78 5.833E+00 2.431E-01 0.0000E+00 7.0000E+00 0.0000E+00 1.2000E+00 79 6.667E+00 2.778E-01 0.0000E+00 8.0000E+00 0.0000E+00 1.2000E+00 80 7.500E+00 3.125E-01 0.0000E+00 9.0000E+00 0.0000E+00 1.2000E+00 81 8.333E+00 3.472E-01 0.0000E+00 1.0000E+01 0.0000E+00 1.2000E+00 82 1.042E+01 4.340E-01 0.0000E+00 1.2500E+01 0.0000E+00 1.2000E+00 83 1.250E+01 5.208E-01 0.0000E+00 1.5000E+01 0.0000E+00 1.2000E+00 84 1.458E+01 6.076E-01 0.0000E+00 1.7500E+01 0.0000E+00 1.2000E+00 85 1.667E+01 6.944E-01 0.0000E+00 2.0000E+01 0.0000E+00 1.2000E+00 86 2.083E+01 8.681E-01 0.0000E+00 2.5000E+01 0.0000E+00 1.2000E+00 87 2.500E+01 1.042E+00 0.0000E+00 3.0000E+01 0.0000E+00 1.2000E+00 88 2.917E+01 1.215E+00 0.0000E+00 3.5000E+01 0.0000E+00 1.2000E+00 89 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 90 8.333E-03 3.472E-04 0.0000E+00 1.0000E-01 0.0000E+00 1.2000E+01 91 2.083E-02 8.681E-04 0.0000E+00 2.5000E-01 0.0000E+00 1.2000E+01 92 4.167E-02 1.736E-03 0.0000E+00 5.0000E-01 0.0000E+00 1.2000E+01 93 8.333E-02 3.472E-03 0.0000E+00 1.0000E+00 0.0000E+00 1.2000E+01 94 1.250E-01 5.208E-03 0.0000E+00 1.5000E+00 0.0000E+00 1.2000E+01 95 1.667E-01 6.944E-03 0.0000E+00 2.0000E+00 0.0000E+00 1.2000E+01 96 2.500E-01 1.042E-02 0.0000E+00 3.0000E+00 0.0000E+00 1.2000E+01 97 3.333E-01 1.389E-02 0.0000E+00 4.0000E+00 0.0000E+00 1.2000E+01 98 4.167E-01 1.736E-02 0.0000E+00 5.0000E+00 0.0000E+00 1.2000E+01 99 5.000E-01 2.083E-02 0.0000E+00 6.0000E+00 0.0000E+00 1.2000E+01 100 5.833E-01 2.431E-02 0.0000E+00 7.0000E+00 0.0000E+00 1.2000E+01 101 6.667E-01 2.778E-02 0.0000E+00 8.0000E+00 0.0000E+00 1.2000E+01 102 7.500E-01 3.125E-02 0.0000E+00 9.0000E+00 0.0000E+00 1.2000E+01 103 8.333E-01 3.472E-02 0.0000E+00 1.0000E+01 0.0000E+00 1.2000E+01 104 1.042E+00 4.340E-02 0.0000E+00 1.2500E+01 0.0000E+00 1.2000E+01 105 1.250E+00 5.208E-02 0.0000E+00 1.5000E+01 0.0000E+00 1.2000E+01 106 1.458E+00 6.076E-02 0.0000E+00 1.7500E+01 0.0000E+00 1.2000E+01 107 1.667E+00 6.944E-02 0.0000E+00 2.0000E+01 0.0000E+00 1.2000E+01 108 2.083E+00 8.681E-02 0.0000E+00 2.5000E+01 0.0000E+00 1.2000E+01 109 2.500E+00 1.042E-01 0.0000E+00 3.0000E+01 0.0000E+00 1.2000E+01 110 2.917E+00 1.215E-01 0.0000E+00 3.5000E+01 0.0000E+00 1.2000E+01 111 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 112 1.852E-03 7.716E-05 0.0000E+00 1.0000E-01 0.0000E+00 5.4000E+01 113 4.630E-03 1.929E-04 0.0000E+00 2.5000E-01 0.0000E+00 5.4000E+01 114 9.259E-03 3.858E-04 0.0000E+00 5.0000E-01 0.0000E+00 5.4000E+01 115 1.852E-02 7.716E-04 0.0000E+00 1.0000E+00 0.0000E+00 5.4000E+01 116 2.778E-02 1.157E-03 0.0000E+00 1.5000E+00 0.0000E+00 5.4000E+01 117 3.704E-02 1.543E-03 0.0000E+00 2.0000E+00 0.0000E+00 5.4000E+01 118 5.556E-02 2.315E-03 0.0000E+00 3.0000E+00 0.0000E+00 5.4000E+01 119 7.407E-02 3.086E-03 0.0000E+00 4.0000E+00 0.0000E+00 5.4000E+01 120 9.259E-02 3.858E-03 0.0000E+00 5.0000E+00 0.0000E+00 5.4000E+01 121 1.111E-01 4.630E-03 0.0000E+00 6.0000E+00 0.0000E+00 5.4000E+01 122 1.296E-01 5.401E-03 0.0000E+00 7.0000E+00 0.0000E+00 5.4000E+01 123 1.481E-01 6.173E-03 0.0000E+00 8.0000E+00 0.0000E+00 5.4000E+01 124 1.667E-01 6.944E-03 0.0000E+00 9.0000E+00 0.0000E+00 5.4000E+01 125 1.852E-01 7.716E-03 0.0000E+00 1.0000E+01 0.0000E+00 5.4000E+01 126 2.315E-01 9.645E-03 0.0000E+00 1.2500E+01 0.0000E+00 5.4000E+01 127 2.778E-01 1.157E-02 0.0000E+00 1.5000E+01 0.0000E+00 5.4000E+01 128 3.241E-01 1.350E-02 0.0000E+00 1.7500E+01 0.0000E+00 5.4000E+01 129 3.704E-01 1.543E-02 0.0000E+00 2.0000E+01 0.0000E+00 5.4000E+01 130 4.630E-01 1.929E-02 0.0000E+00 2.5000E+01 0.0000E+00 5.4000E+01 131 5.556E-01 2.315E-02 0.0000E+00 3.0000E+01 0.0000E+00 5.4000E+01 132 6.481E-01 2.701E-02 0.0000E+00 3.5000E+01 0.0000E+00 5.4000E+01 ------------------------------------------------------------------------------ * Dose rate is the delivered dose divided by the duration of the exposure scenario. Total VC execution time (min): 9.88333E-03 VC 2.00I 15-JUL-2003 02-AUG-2003 08:00:09 PM