VC 2.00I 15-JUL-2003 02-AUG-2003 09:27:50 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: u:\usr\bin\vc.exe u:\archive\ncih460\tlk\ncih460.inp FNI: U:\archive\ncih460\tlk\ncih460.inp FNO: U:\archive\ncih460\tlk\ncih460.out RADX: U:\archive\ncih460\tlk\ncih460.radx (44 exposures) -------------------------------------------------------------------------------- QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 8.61342E-12 5.29381E-03 30.000000 Complex DSB = 2.87114E-12 1.76460E-03 10.000000 Total DSB = 1.14846E-11 7.05841E-03 40.000000 DAMAGE REPAIR/MISREPAIR: A1= 7.500000E-01 (=75.000%) A2= 2.500000E-01 (=25.000%) PHI1= 5.000000E-03 (=0.500%) PHI2= 5.000000E-03 (=0.500%) (1-A1)*PHI1= 1.250000E-03 (=0.125%) (1-A2)*PHI2= 3.750000E-03 (=0.375%) (1-A1)*(1-PHI1)= 2.487500E-01 (=24.875%) (1-A2)*(1-PHI2)= 7.462500E-01 (=74.625%) RHT1= 0.221846 h (=13.31 minute) RHT2= 1.866774 h (=112.01 minute) LAM1= 3.1244461E+00 (1/h) LAM2= 3.7130758E-01 (1/h) BMR= 1.1967940E-03 (1/h) LAM1/BMR= 2.6106799E+03 LAM2/BMR= 3.1025187E+02 (LAM1+LAM2)/BMR= 2.9209318E+03 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 3.7500E-02 + 3.7500E-02 = 7.5000000E-02 (1/Gy) beta: 6.8297E-02 + 6.5105E-02 = 1.3340220E-01 (1/Gy^2) alpha/beta: 0.5622096 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg DFAR TABLE: Cell survival as a function of dose and dose rate (FRDL=100.0%). ====================================================================================================== --- Duration (h) --- Dose Dose Rate ---- LETHAL DAMAGE PER CELL ---- SIM ID Exposure Sim (Gy) (Gy/h) Mutations Residual Total SF(dose) ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 2 1.667E-01 7.217E+01 1.000E-01 6.000E-01 8.714E-03 0.000E+00 8.7136E-03 9.913243E-01 3 4.167E-01 7.242E+01 2.500E-01 6.000E-01 2.547E-02 9.246E-11 2.5473E-02 9.748491E-01 4 8.333E-01 7.283E+01 5.000E-01 6.000E-01 6.044E-02 1.143E-10 6.0439E-02 9.413509E-01 5 1.667E+00 7.367E+01 1.000E+00 6.000E-01 1.483E-01 1.325E-10 1.4835E-01 8.621305E-01 6 2.500E+00 7.450E+01 1.500E+00 6.000E-01 2.530E-01 1.396E-10 2.5300E-01 7.764643E-01 7 3.333E+00 7.533E+01 2.000E+00 6.000E-01 3.693E-01 1.595E-10 3.6933E-01 6.911951E-01 8 5.000E+00 7.700E+01 3.000E+00 6.000E-01 6.244E-01 2.501E-10 6.2435E-01 5.356076E-01 9 6.667E+00 7.867E+01 4.000E+00 6.000E-01 8.964E-01 2.683E-10 8.9644E-01 4.080188E-01 10 8.333E+00 8.033E+01 5.000E+00 6.000E-01 1.177E+00 2.762E-10 1.1771E+00 3.081736E-01 11 1.000E+01 8.200E+01 6.000E+00 6.000E-01 1.462E+00 2.799E-10 1.4620E+00 2.317643E-01 12 1.167E+01 8.367E+01 7.000E+00 6.000E-01 1.749E+00 2.818E-10 1.7491E+00 1.739253E-01 13 1.333E+01 8.533E+01 8.000E+00 6.000E-01 2.037E+00 2.827E-10 2.0373E+00 1.303798E-01 14 1.500E+01 8.700E+01 9.000E+00 6.000E-01 2.326E+00 2.833E-10 2.3260E+00 9.768393E-02 15 1.667E+01 8.867E+01 1.000E+01 6.000E-01 2.615E+00 2.836E-10 2.6150E+00 7.316748E-02 16 2.083E+01 9.283E+01 1.250E+01 6.000E-01 3.338E+00 2.838E-10 3.3379E+00 3.551055E-02 17 2.500E+01 9.700E+01 1.500E+01 6.000E-01 4.061E+00 2.838E-10 4.0610E+00 1.723123E-02 18 2.917E+01 1.012E+02 1.750E+01 6.000E-01 4.784E+00 2.839E-10 4.7842E+00 8.361052E-03 19 3.333E+01 1.053E+02 2.000E+01 6.000E-01 5.507E+00 2.839E-10 5.5073E+00 4.056981E-03 20 4.167E+01 1.137E+02 2.500E+01 6.000E-01 6.954E+00 2.839E-10 6.9536E+00 9.551820E-04 21 5.000E+01 1.220E+02 3.000E+01 6.000E-01 8.400E+00 2.839E-10 8.3999E+00 2.248895E-04 22 5.833E+01 1.303E+02 3.500E+01 6.000E-01 9.846E+00 2.839E-10 9.8462E+00 5.294832E-05 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 24 8.333E-04 7.200E+01 1.000E-01 1.200E+02 8.830E-03 0.000E+00 8.8304E-03 9.912084E-01 25 2.083E-03 7.200E+01 2.500E-01 1.200E+02 2.703E-02 9.502E-11 2.7032E-02 9.733303E-01 26 4.167E-03 7.200E+01 5.000E-01 1.200E+02 7.041E-02 1.209E-10 7.0407E-02 9.320143E-01 27 8.333E-03 7.201E+01 1.000E+00 1.200E+02 2.049E-01 1.432E-10 2.0490E-01 8.147253E-01 28 1.250E-02 7.201E+01 1.500E+00 1.200E+02 4.010E-01 2.778E-10 4.0101E-01 6.696418E-01 29 1.667E-02 7.202E+01 2.000E+00 1.200E+02 6.564E-01 3.471E-10 6.5639E-01 5.187226E-01 30 2.500E-02 7.203E+01 3.000E+00 1.200E+02 1.336E+00 3.789E-10 1.3362E+00 2.628528E-01 31 3.333E-02 7.203E+01 4.000E+00 1.200E+02 2.228E+00 2.135E-11 2.2278E+00 1.077659E-01 32 4.167E-02 7.204E+01 5.000E+00 1.200E+02 3.316E+00 6.394E-11 3.3165E+00 3.628137E-02 33 5.000E-02 7.205E+01 6.000E+00 1.200E+02 4.589E+00 1.031E-10 4.5887E+00 1.016618E-02 34 5.833E-02 8.406E+01 7.000E+00 1.200E+02 6.032E+00 2.577E-11 6.0323E+00 2.400002E-03 35 6.667E-02 8.407E+01 8.000E+00 1.200E+02 7.636E+00 3.221E-11 7.6361E+00 4.827108E-04 36 7.500E-02 8.408E+01 9.000E+00 1.200E+02 9.390E+00 3.737E-11 9.3899E+00 8.356292E-05 37 8.333E-02 8.408E+01 1.000E+01 1.200E+02 1.128E+01 4.129E-11 1.1284E+01 1.256766E-05 38 1.042E-01 8.410E+01 1.250E+01 1.200E+02 1.658E+01 0.000E+00 1.6581E+01 6.293814E-08 39 1.250E-01 8.412E+01 1.500E+01 1.200E+02 2.259E+01 0.000E+00 2.2588E+01 1.549886E-10 40 1.458E-01 8.415E+01 1.750E+01 1.200E+02 2.921E+01 0.000E+00 2.9207E+01 2.067594E-13 41 1.667E-01 8.417E+01 2.000E+01 1.200E+02 3.636E+01 0.000E+00 3.6359E+01 1.619880E-16 42 2.083E-01 8.421E+01 2.500E+01 1.200E+02 5.200E+01 0.000E+00 5.1998E+01 2.616024E-23 43 2.500E-01 8.425E+01 3.000E+01 1.200E+02 6.907E+01 0.000E+00 6.9073E+01 1.004121E-30 44 2.917E-01 8.429E+01 3.500E+01 1.200E+02 8.727E+01 0.000E+00 8.7269E+01 1.257290E-38 ------------------------------------------------------------------------------------------------------ NOTE: SF=EXP{-(lethal residual damage + lethal mutations)}. QECK TABLE: Cell survival, corrected for repopulation effects, as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. ===================================================================================================================== TSIM DOSE DOSE RATE - SURVIVING FRACTION - --------- EXPECTED NUMBER OF CELLS ----------- SIM ID (day) (Gy) (Gy/h) no repop repop N(t)/N(0) N(0)*S(D) N(t)*S(D) NSC(t) --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 2 3.007E+00 1.000E-01 6.000E-01 9.9132E-01 9.9132E-01 1.0000E+00 9.9132E-01 9.9132E-01 9.9132E-01 3 3.017E+00 2.500E-01 6.000E-01 9.7485E-01 9.7485E-01 1.0000E+00 9.7485E-01 9.7485E-01 9.7485E-01 4 3.035E+00 5.000E-01 6.000E-01 9.4135E-01 9.4135E-01 1.0000E+00 9.4135E-01 9.4135E-01 9.4135E-01 5 3.069E+00 1.000E+00 6.000E-01 8.6213E-01 8.6213E-01 1.0000E+00 8.6213E-01 8.6213E-01 8.6213E-01 6 3.104E+00 1.500E+00 6.000E-01 7.7646E-01 7.7646E-01 1.0000E+00 7.7646E-01 7.7646E-01 7.7646E-01 7 3.139E+00 2.000E+00 6.000E-01 6.9120E-01 6.9120E-01 1.0000E+00 6.9120E-01 6.9120E-01 6.9120E-01 8 3.208E+00 3.000E+00 6.000E-01 5.3561E-01 5.3561E-01 1.0000E+00 5.3561E-01 5.3561E-01 5.3561E-01 9 3.278E+00 4.000E+00 6.000E-01 4.0802E-01 4.0802E-01 1.0000E+00 4.0802E-01 4.0802E-01 4.0802E-01 10 3.347E+00 5.000E+00 6.000E-01 3.0817E-01 3.0817E-01 1.0000E+00 3.0817E-01 3.0817E-01 3.0817E-01 11 3.417E+00 6.000E+00 6.000E-01 2.3176E-01 2.3176E-01 1.0000E+00 2.3176E-01 2.3176E-01 2.3176E-01 12 3.486E+00 7.000E+00 6.000E-01 1.7393E-01 1.7393E-01 1.0000E+00 1.7393E-01 1.7393E-01 1.7393E-01 13 3.556E+00 8.000E+00 6.000E-01 1.3038E-01 1.3038E-01 1.0000E+00 1.3038E-01 1.3038E-01 1.3038E-01 14 3.625E+00 9.000E+00 6.000E-01 9.7684E-02 9.7684E-02 1.0000E+00 9.7684E-02 9.7684E-02 9.7684E-02 15 3.694E+00 1.000E+01 6.000E-01 7.3167E-02 7.3167E-02 1.0000E+00 7.3167E-02 7.3167E-02 7.3167E-02 16 3.868E+00 1.250E+01 6.000E-01 3.5511E-02 3.5511E-02 1.0000E+00 3.5511E-02 3.5511E-02 3.5511E-02 17 4.042E+00 1.500E+01 6.000E-01 1.7231E-02 1.7231E-02 1.0000E+00 1.7231E-02 1.7231E-02 1.7231E-02 18 4.215E+00 1.750E+01 6.000E-01 8.3611E-03 8.3611E-03 1.0000E+00 8.3611E-03 8.3611E-03 8.3611E-03 19 4.389E+00 2.000E+01 6.000E-01 4.0570E-03 4.0570E-03 1.0000E+00 4.0570E-03 4.0570E-03 4.0570E-03 20 4.736E+00 2.500E+01 6.000E-01 9.5518E-04 9.5518E-04 1.0000E+00 9.5518E-04 9.5518E-04 9.5518E-04 21 5.083E+00 3.000E+01 6.000E-01 2.2489E-04 2.2489E-04 1.0000E+00 2.2489E-04 2.2489E-04 2.2489E-04 22 5.431E+00 3.500E+01 6.000E-01 5.2948E-05 5.2948E-05 1.0000E+00 5.2948E-05 5.2948E-05 5.2948E-05 23 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 24 3.000E+00 1.000E-01 1.200E+02 9.9121E-01 9.9121E-01 1.0000E+00 9.9121E-01 9.9121E-01 9.9121E-01 25 3.000E+00 2.500E-01 1.200E+02 9.7333E-01 9.7333E-01 1.0000E+00 9.7333E-01 9.7333E-01 9.7333E-01 26 3.000E+00 5.000E-01 1.200E+02 9.3201E-01 9.3201E-01 1.0000E+00 9.3201E-01 9.3201E-01 9.3201E-01 27 3.000E+00 1.000E+00 1.200E+02 8.1473E-01 8.1473E-01 1.0000E+00 8.1473E-01 8.1473E-01 8.1473E-01 28 3.001E+00 1.500E+00 1.200E+02 6.6964E-01 6.6964E-01 1.0000E+00 6.6964E-01 6.6964E-01 6.6964E-01 29 3.001E+00 2.000E+00 1.200E+02 5.1872E-01 5.1872E-01 1.0000E+00 5.1872E-01 5.1872E-01 5.1872E-01 30 3.001E+00 3.000E+00 1.200E+02 2.6285E-01 2.6285E-01 1.0000E+00 2.6285E-01 2.6285E-01 2.6285E-01 31 3.001E+00 4.000E+00 1.200E+02 1.0777E-01 1.0777E-01 1.0000E+00 1.0777E-01 1.0777E-01 1.0777E-01 32 3.002E+00 5.000E+00 1.200E+02 3.6281E-02 3.6281E-02 1.0000E+00 3.6281E-02 3.6281E-02 3.6281E-02 33 3.002E+00 6.000E+00 1.200E+02 1.0166E-02 1.0166E-02 1.0000E+00 1.0166E-02 1.0166E-02 1.0166E-02 34 3.502E+00 7.000E+00 1.200E+02 2.4000E-03 2.4000E-03 1.0000E+00 2.4000E-03 2.4000E-03 2.4000E-03 35 3.503E+00 8.000E+00 1.200E+02 4.8271E-04 4.8271E-04 1.0000E+00 4.8271E-04 4.8271E-04 4.8271E-04 36 3.503E+00 9.000E+00 1.200E+02 8.3563E-05 8.3563E-05 1.0000E+00 8.3563E-05 8.3563E-05 8.3563E-05 37 3.503E+00 1.000E+01 1.200E+02 1.2568E-05 1.2568E-05 1.0000E+00 1.2568E-05 1.2568E-05 1.2568E-05 38 3.504E+00 1.250E+01 1.200E+02 6.2938E-08 6.2938E-08 1.0000E+00 6.2938E-08 6.2938E-08 6.2938E-08 39 3.505E+00 1.500E+01 1.200E+02 1.5499E-10 1.5499E-10 1.0000E+00 1.5499E-10 1.5499E-10 1.5499E-10 40 3.506E+00 1.750E+01 1.200E+02 2.0676E-13 2.0676E-13 1.0000E+00 2.0676E-13 2.0676E-13 2.0676E-13 41 3.507E+00 2.000E+01 1.200E+02 1.6199E-16 1.6199E-16 1.0000E+00 1.6199E-16 1.6199E-16 1.6199E-16 42 3.509E+00 2.500E+01 1.200E+02 2.6160E-23 2.6160E-23 1.0000E+00 2.6160E-23 2.6160E-23 2.6160E-23 43 3.510E+00 3.000E+01 1.200E+02 1.0041E-30 1.0041E-30 1.0000E+00 1.0041E-30 1.0041E-30 1.0041E-30 44 3.512E+00 3.500E+01 1.200E+02 1.2573E-38 1.2573E-38 1.0000E+00 1.2573E-38 1.2573E-38 1.2573E-38 --------------------------------------------------------------------------------------------------------------------- NOTE: N(0) is the initial number of cells (time=0 day), N(t) is the expected number of unirradiated (control) cells at TSIM, i.e., N(t)=N(0)*EXP[LN(2)*TSIM/TPOT]. The surviving fraction S(D) is the expected number of cells, per irradiated cell, that has not sustained lethal DNA damage (no corrections for repopulation effects). NSC(t) is the expected number of cells that survive irradiation, including repopulation effects (recommended method). The product N(t)*S(D) is an alternate method of estimating the surviving fraction with repopulation effects. DFAR TABLE: Mutagenesis and the induction of enhanced genetic instability (GI). Key GI model parameters are: (1-FRDL)=0.0%, NCM=1, NCG=1, and NCG*PGH*PGA=4.250E-06. ====================================================================================================== Dose Dose Rate -- NON-LETHAL MUTATIONS PER CELL -- **** PROBABILITY PER CELL **** SIM ID (Gy) (Gy/h) Mutations Residual Total AGF EGI EGI/SF ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 2 1.000E-01 6.000E-01 1.494E+00 0.00E+00 1.49371E+00 6.293E-06 6.293E-06 6.348E-06 3 2.500E-01 6.000E-01 3.738E+00 0.00E+00 3.73756E+00 1.549E-05 1.549E-05 1.588E-05 4 5.000E-01 6.000E-01 7.482E+00 0.00E+00 7.48229E+00 2.993E-05 2.993E-05 3.180E-05 5 1.000E+00 6.000E-01 1.498E+01 0.00E+00 1.49812E+01 5.489E-05 5.489E-05 6.367E-05 6 1.500E+00 6.000E-01 2.249E+01 0.00E+00 2.24874E+01 7.420E-05 7.420E-05 9.557E-05 7 2.000E+00 6.000E-01 3.000E+01 0.00E+00 2.99986E+01 8.812E-05 8.812E-05 1.275E-04 8 3.000E+00 6.000E-01 4.503E+01 0.00E+00 4.50305E+01 1.025E-04 1.025E-04 1.914E-04 9 4.000E+00 6.000E-01 6.007E+01 0.00E+00 6.00697E+01 1.042E-04 1.042E-04 2.553E-04 10 5.000E+00 6.000E-01 7.511E+01 0.00E+00 7.51125E+01 9.836E-05 9.836E-05 3.192E-04 11 6.000E+00 6.000E-01 9.016E+01 0.00E+00 9.01572E+01 8.879E-05 8.879E-05 3.831E-04 12 7.000E+00 6.000E-01 1.052E+02 0.00E+00 1.05203E+02 7.775E-05 7.775E-05 4.470E-04 13 8.000E+00 6.000E-01 1.202E+02 0.00E+00 1.20249E+02 6.661E-05 6.661E-05 5.109E-04 14 9.000E+00 6.000E-01 1.353E+02 0.00E+00 1.35295E+02 5.615E-05 5.615E-05 5.748E-04 15 1.000E+01 6.000E-01 1.503E+02 0.00E+00 1.50342E+02 4.674E-05 4.674E-05 6.387E-04 16 1.250E+01 6.000E-01 1.880E+02 0.00E+00 1.87958E+02 2.836E-05 2.836E-05 7.985E-04 17 1.500E+01 6.000E-01 2.256E+02 0.00E+00 2.25574E+02 1.651E-05 1.651E-05 9.582E-04 18 1.750E+01 6.000E-01 2.632E+02 0.00E+00 2.63191E+02 9.347E-06 9.347E-06 1.118E-03 19 2.000E+01 6.000E-01 3.008E+02 0.00E+00 3.00807E+02 5.183E-06 5.183E-06 1.278E-03 20 2.500E+01 6.000E-01 3.760E+02 0.00E+00 3.76040E+02 1.525E-06 1.525E-06 1.597E-03 21 3.000E+01 6.000E-01 4.513E+02 0.00E+00 4.51272E+02 4.309E-07 4.309E-07 1.916E-03 22 3.500E+01 6.000E-01 5.265E+02 0.00E+00 5.26505E+02 1.183E-07 1.183E-07 2.235E-03 23 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 24 1.000E-01 1.200E+02 1.494E+00 0.00E+00 1.49389E+00 6.293E-06 6.293E-06 6.349E-06 25 2.500E-01 1.200E+02 3.740E+00 0.00E+00 3.73988E+00 1.547E-05 1.547E-05 1.589E-05 26 5.000E-01 1.200E+02 7.497E+00 0.00E+00 7.49686E+00 2.970E-05 2.970E-05 3.186E-05 27 1.000E+00 1.200E+02 1.506E+01 0.00E+00 1.50610E+01 5.215E-05 5.215E-05 6.401E-05 28 1.500E+00 1.200E+02 2.269E+01 0.00E+00 2.26905E+01 6.457E-05 6.457E-05 9.643E-05 29 2.000E+00 1.200E+02 3.038E+01 0.00E+00 3.03833E+01 6.698E-05 6.698E-05 1.291E-04 30 3.000E+00 1.200E+02 4.595E+01 0.00E+00 4.59512E+01 5.133E-05 5.133E-05 1.953E-04 31 4.000E+00 1.200E+02 6.175E+01 0.00E+00 6.17505E+01 2.828E-05 2.828E-05 2.624E-04 32 5.000E+00 1.200E+02 7.777E+01 0.00E+00 7.77679E+01 1.199E-05 1.199E-05 3.305E-04 33 6.000E+00 1.200E+02 9.399E+01 0.00E+00 9.39908E+01 4.060E-06 4.060E-06 3.994E-04 34 7.000E+00 1.200E+02 1.104E+02 0.00E+00 1.10408E+02 1.126E-06 1.126E-06 4.691E-04 35 8.000E+00 1.200E+02 1.270E+02 0.00E+00 1.27008E+02 2.605E-07 2.605E-07 5.396E-04 36 9.000E+00 1.200E+02 1.438E+02 0.00E+00 1.43781E+02 5.105E-08 5.105E-08 6.109E-04 37 1.000E+01 1.200E+02 1.607E+02 0.00E+00 1.60718E+02 8.581E-09 8.581E-09 6.828E-04 38 1.250E+01 1.200E+02 2.037E+02 0.00E+00 2.03718E+02 5.447E-11 5.447E-11 8.654E-04 39 1.500E+01 1.200E+02 2.476E+02 0.00E+00 2.47562E+02 1.630E-13 1.630E-13 1.052E-03 40 1.750E+01 1.200E+02 2.921E+02 0.00E+00 2.92144E+02 2.566E-16 2.566E-16 1.241E-03 41 2.000E+01 1.200E+02 3.374E+02 0.00E+00 3.37372E+02 2.321E-19 2.321E-19 1.433E-03 42 2.500E+01 1.200E+02 4.295E+02 0.00E+00 4.29459E+02 4.770E-26 4.770E-26 1.824E-03 43 3.000E+01 1.200E+02 5.233E+02 0.00E+00 5.23310E+02 2.231E-33 2.231E-33 2.222E-03 44 3.500E+01 1.200E+02 6.185E+02 0.00E+00 6.18533E+02 3.301E-41 3.301E-41 2.625E-03 ------------------------------------------------------------------------------------------------------ AGF: function or expression of at least 1 of the 1 critical gene targets is altered. EGI: altered gene function or expression causes enhanced genetic instability. NEOM TABLE: Neoplastic transformation as a function of dose and dose rate at t=42.000 days. Parameters: TFS=1.1500E-05 (1/wk), TFU=2.0000E-03 (1/wk), NCM=1, NCG=1, and NCG*PGH*PGA=4.3E-06. ====================================================================================================== Dose Dose Rate Non-Lethal Genetic Instability *** TRANSFORMATION FREQUENCY *** SIM ID (Gy) (Gy/h) Mutations EGI EGI/SF BKG TPS TPI ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 2 1.000E-01 6.000E-01 1.494E+00 6.293E-06 6.348E-06 6.8995E-05 6.9071E-05 6.8471E-05 3 2.500E-01 6.000E-01 3.738E+00 1.549E-05 1.588E-05 6.8994E-05 6.9184E-05 6.7444E-05 4 5.000E-01 6.000E-01 7.482E+00 2.993E-05 3.180E-05 6.8993E-05 6.9372E-05 6.5304E-05 5 1.000E+00 6.000E-01 1.498E+01 5.489E-05 6.367E-05 6.8991E-05 6.9750E-05 6.0134E-05 6 1.500E+00 6.000E-01 2.249E+01 7.420E-05 9.557E-05 6.8989E-05 7.0129E-05 5.4452E-05 7 2.000E+00 6.000E-01 3.000E+01 8.812E-05 1.275E-04 6.8986E-05 7.0507E-05 4.8734E-05 8 3.000E+00 6.000E-01 4.503E+01 1.025E-04 1.914E-04 6.8982E-05 7.1265E-05 3.8170E-05 9 4.000E+00 6.000E-01 6.007E+01 1.042E-04 2.553E-04 6.8978E-05 7.2022E-05 2.9387E-05 10 5.000E+00 6.000E-01 7.511E+01 9.836E-05 3.192E-04 6.8973E-05 7.2780E-05 2.2429E-05 11 6.000E+00 6.000E-01 9.016E+01 8.879E-05 3.831E-04 6.8969E-05 7.3538E-05 1.7044E-05 12 7.000E+00 6.000E-01 1.052E+02 7.775E-05 4.470E-04 6.8964E-05 7.4296E-05 1.2922E-05 13 8.000E+00 6.000E-01 1.202E+02 6.661E-05 5.109E-04 6.8960E-05 7.5054E-05 9.7856E-06 14 9.000E+00 6.000E-01 1.353E+02 5.615E-05 5.748E-04 6.8956E-05 7.5812E-05 7.4057E-06 15 1.000E+01 6.000E-01 1.503E+02 4.674E-05 6.387E-04 6.8951E-05 7.6570E-05 5.6025E-06 16 1.250E+01 6.000E-01 1.880E+02 2.836E-05 7.985E-04 6.8940E-05 7.8465E-05 2.7863E-06 17 1.500E+01 6.000E-01 2.256E+02 1.651E-05 9.582E-04 6.8929E-05 8.0359E-05 1.3847E-06 18 1.750E+01 6.000E-01 2.632E+02 9.347E-06 1.118E-03 6.8918E-05 8.2253E-05 6.8772E-07 19 2.000E+01 6.000E-01 3.008E+02 5.183E-06 1.278E-03 6.8907E-05 8.4147E-05 3.4138E-07 20 2.500E+01 6.000E-01 3.760E+02 1.525E-06 1.597E-03 6.8885E-05 8.7933E-05 8.3992E-08 21 3.000E+01 6.000E-01 4.513E+02 4.309E-07 1.916E-03 6.8863E-05 9.1718E-05 2.0627E-08 22 3.500E+01 6.000E-01 5.265E+02 1.183E-07 2.235E-03 6.8841E-05 9.5502E-05 5.0567E-09 23 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 24 1.000E-01 1.200E+02 1.494E+00 6.293E-06 6.349E-06 6.8995E-05 6.9071E-05 6.8463E-05 25 2.500E-01 1.200E+02 3.740E+00 1.547E-05 1.589E-05 6.8994E-05 6.9184E-05 6.7339E-05 26 5.000E-01 1.200E+02 7.497E+00 2.970E-05 3.186E-05 6.8993E-05 6.9373E-05 6.4657E-05 27 1.000E+00 1.200E+02 1.506E+01 5.215E-05 6.401E-05 6.8991E-05 6.9754E-05 5.6831E-05 28 1.500E+00 1.200E+02 2.269E+01 6.457E-05 9.643E-05 6.8989E-05 7.0139E-05 4.6968E-05 29 2.000E+00 1.200E+02 3.038E+01 6.698E-05 1.291E-04 6.8986E-05 7.0526E-05 3.6584E-05 30 3.000E+00 1.200E+02 4.595E+01 5.133E-05 1.953E-04 6.8982E-05 7.1311E-05 1.8744E-05 31 4.000E+00 1.200E+02 6.175E+01 2.828E-05 2.624E-04 6.8977E-05 7.2107E-05 7.7707E-06 32 5.000E+00 1.200E+02 7.777E+01 1.199E-05 3.305E-04 6.8972E-05 7.2914E-05 2.6454E-06 33 6.000E+00 1.200E+02 9.399E+01 4.060E-06 3.994E-04 6.8968E-05 7.3732E-05 7.4957E-07 34 7.000E+00 1.200E+02 1.104E+02 1.126E-06 4.691E-04 6.8963E-05 7.4559E-05 1.7894E-07 35 8.000E+00 1.200E+02 1.270E+02 2.605E-07 5.396E-04 6.8958E-05 7.5395E-05 3.6394E-08 36 9.000E+00 1.200E+02 1.438E+02 5.105E-08 6.109E-04 6.8953E-05 7.6240E-05 6.3708E-09 37 1.000E+01 1.200E+02 1.607E+02 8.581E-09 6.828E-04 6.8948E-05 7.7093E-05 9.6888E-10 38 1.250E+01 1.200E+02 2.037E+02 5.447E-11 8.654E-04 6.8936E-05 7.9259E-05 4.9884E-12 39 1.500E+01 1.200E+02 2.476E+02 1.630E-13 1.052E-03 6.8923E-05 8.1466E-05 1.2626E-14 40 1.750E+01 1.200E+02 2.921E+02 2.566E-16 1.241E-03 6.8910E-05 8.3711E-05 1.7308E-17 41 2.000E+01 1.200E+02 3.374E+02 2.321E-19 1.433E-03 6.8896E-05 8.5987E-05 1.3929E-20 42 2.500E+01 1.200E+02 4.295E+02 4.770E-26 1.824E-03 6.8869E-05 9.0621E-05 2.3707E-27 43 3.000E+01 1.200E+02 5.233E+02 2.231E-33 2.222E-03 6.8842E-05 9.5342E-05 9.5735E-35 44 3.500E+01 1.200E+02 6.185E+02 3.301E-41 2.625E-03 6.8814E-05 1.0013E-04 1.2589E-42 ------------------------------------------------------------------------------------------------------ TPS: Transformation frequency per survivor, TPI: Transformation frequency per irradiated cell EGI: Probabilty random mutational events caused enhanced genetic instability (EGI). BKG: Background (spontaneous) cell transformation frequency TLKM TABLE: LQ model dose protraction factor(s) and cell survival estimates (FRDL=100.0%). LQ model parameters are: alpha = 0.0750 (1/Gy), alpha/beta = 0.5622 (Gy), lamda1 = 3.124E+00 (1/h), lamda2 = 3.713E-01 (1/h). ================================================================================================================= --- Duration (h) --- Dose Dose Rate* *********** G FACTOR *********** ******* SF(dose) ******* SIM ID Exposure Sim (Gy) (Gy/h) GL1 GL2 GEFF SF1 SF2 ----------------------------------------------------------------------------------------------------------------- 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 2 1.667E-01 7.217E+01 1.000E-01 6.000E-01 8.469E-01 9.797E-01 9.097E-01 9.9132E-01 9.913243E-01 3 4.167E-01 7.242E+01 2.500E-01 6.000E-01 6.772E-01 9.504E-01 8.063E-01 9.7481E-01 9.748491E-01 4 8.333E-01 7.283E+01 5.000E-01 6.000E-01 4.950E-01 9.044E-01 6.878E-01 9.4113E-01 9.413509E-01 5 1.667E+00 7.367E+01 1.000E+00 6.000E-01 3.107E-01 8.221E-01 5.498E-01 8.6093E-01 8.621305E-01 6 2.500E+00 7.450E+01 1.500E+00 6.000E-01 2.233E-01 7.509E-01 4.681E-01 7.7352E-01 7.764643E-01 7 3.333E+00 7.533E+01 2.000E+00 6.000E-01 1.736E-01 6.890E-01 4.110E-01 6.8601E-01 6.911951E-01 8 5.000E+00 7.700E+01 3.000E+00 6.000E-01 1.198E-01 5.877E-01 3.326E-01 5.2572E-01 5.356076E-01 9 6.667E+00 7.867E+01 4.000E+00 6.000E-01 9.141E-02 5.090E-01 2.794E-01 3.9450E-01 4.080188E-01 10 8.333E+00 8.033E+01 5.000E+00 6.000E-01 7.386E-02 4.469E-01 2.405E-01 2.9271E-01 3.081736E-01 11 1.000E+01 8.200E+01 6.000E+00 6.000E-01 6.196E-02 3.971E-01 2.107E-01 2.1587E-01 2.317643E-01 12 1.167E+01 8.367E+01 7.000E+00 6.000E-01 5.336E-02 3.565E-01 1.873E-01 1.5867E-01 1.739253E-01 13 1.333E+01 8.533E+01 8.000E+00 6.000E-01 4.686E-02 3.230E-01 1.683E-01 1.1643E-01 1.303798E-01 14 1.500E+01 8.700E+01 9.000E+00 6.000E-01 4.176E-02 2.949E-01 1.528E-01 8.5348E-02 9.768393E-02 15 1.667E+01 8.867E+01 1.000E+01 6.000E-01 3.767E-02 2.711E-01 1.398E-01 6.2533E-02 7.316748E-02 16 2.083E+01 9.283E+01 1.250E+01 6.000E-01 3.025E-02 2.251E-01 1.152E-01 2.8707E-02 3.551055E-02 17 2.500E+01 9.700E+01 1.500E+01 6.000E-01 2.528E-02 1.922E-01 9.782E-02 1.3173E-02 1.723123E-02 18 2.917E+01 1.012E+02 1.750E+01 6.000E-01 2.171E-02 1.676E-01 8.498E-02 6.0441E-03 8.361052E-03 19 3.333E+01 1.053E+02 2.000E+01 6.000E-01 1.902E-02 1.485E-01 7.510E-02 2.7732E-03 4.056981E-03 20 4.167E+01 1.137E+02 2.500E+01 6.000E-01 1.524E-02 1.209E-01 6.091E-02 5.8380E-04 9.551820E-04 21 5.000E+01 1.220E+02 3.000E+01 6.000E-01 1.272E-02 1.019E-01 5.122E-02 1.2290E-04 2.248895E-04 22 5.833E+01 1.303E+02 3.500E+01 6.000E-01 1.091E-02 8.807E-02 4.419E-02 2.5872E-05 5.294832E-05 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 24 8.333E-04 7.200E+01 1.000E-01 1.200E+02 9.991E-01 9.999E-01 9.973E-01 9.9121E-01 9.912084E-01 25 2.083E-03 7.200E+01 2.500E-01 1.200E+02 9.978E-01 9.997E-01 9.933E-01 9.7329E-01 9.733303E-01 26 4.167E-03 7.200E+01 5.000E-01 1.200E+02 9.957E-01 9.995E-01 9.867E-01 9.3168E-01 9.320143E-01 27 8.333E-03 7.201E+01 1.000E+00 1.200E+02 9.914E-01 9.990E-01 9.738E-01 8.1241E-01 8.147253E-01 28 1.250E-02 7.201E+01 1.500E+00 1.200E+02 9.871E-01 9.985E-01 9.612E-01 6.6335E-01 6.696418E-01 29 1.667E-02 7.202E+01 2.000E+00 1.200E+02 9.829E-01 9.979E-01 9.490E-01 5.0743E-01 5.187226E-01 30 2.500E-02 7.203E+01 3.000E+00 1.200E+02 9.745E-01 9.969E-01 9.255E-01 2.4460E-01 2.628528E-01 31 3.333E-02 7.203E+01 4.000E+00 1.200E+02 9.662E-01 9.959E-01 9.032E-01 9.1339E-02 1.077659E-01 32 4.167E-02 7.204E+01 5.000E+00 1.200E+02 9.580E-01 9.949E-01 8.820E-01 2.6518E-02 3.628137E-02 33 5.000E-02 7.205E+01 6.000E+00 1.200E+02 9.499E-01 9.938E-01 8.618E-01 6.0068E-03 1.016618E-02 34 5.833E-02 8.406E+01 7.000E+00 1.200E+02 9.419E-01 9.928E-01 8.425E-01 1.0654E-03 2.400002E-03 35 6.667E-02 8.407E+01 8.000E+00 1.200E+02 9.340E-01 9.918E-01 8.241E-01 1.4845E-04 4.827108E-04 36 7.500E-02 8.408E+01 9.000E+00 1.200E+02 9.263E-01 9.908E-01 8.065E-01 1.6305E-05 8.356292E-05 37 8.333E-02 8.408E+01 1.000E+01 1.200E+02 9.186E-01 9.898E-01 7.897E-01 1.4163E-06 1.256766E-05 38 1.042E-01 8.410E+01 1.250E+01 1.200E+02 8.998E-01 9.872E-01 7.505E-01 1.1513E-09 6.293814E-08 39 1.250E-01 8.412E+01 1.500E+01 1.200E+02 8.816E-01 9.847E-01 7.151E-01 2.3086E-13 1.549886E-10 40 1.458E-01 8.415E+01 1.750E+01 1.200E+02 8.640E-01 9.822E-01 6.828E-01 1.1944E-17 2.067594E-13 41 1.667E-01 8.417E+01 2.000E+01 1.200E+02 8.469E-01 9.797E-01 6.533E-01 1.6632E-22 1.619880E-16 42 2.083E-01 8.421E+01 2.500E+01 1.200E+02 8.142E-01 9.747E-01 6.012E-01 7.3672E-34 2.616024E-23 43 2.500E-01 8.425E+01 3.000E+01 1.200E+02 7.835E-01 9.698E-01 5.566E-01 2.6949E-47 1.004121E-30 44 2.917E-01 8.429E+01 3.500E+01 1.200E+02 7.545E-01 9.649E-01 5.180E-01 1.0599E-62 1.257290E-38 ----------------------------------------------------------------------------------------------------------------- GL=[2*[x+exp(-x)-1]/(x*x), where x = {lamda}*{irradiation time} and GEFF=-(alpha+LOG(SF)/dose)/(beta*dose). In the formula for GEFF, SF is surviving fraction as computed using the TLK model. The effects of lethal residual damage are included in the GEFF dose protraction factor but not GL1 or GL2. The estimates of the surviving fraction are SF1 = EXP{-dose*[alpha+(gl1*beta1+gl2*beta2)*dose]} and SF2 = EXP{-dose*(alpha+geff*beta*dose)}. QECK TABLE: Tumor control probability (TCP) estimates as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. The *MAX* estimate is recommended (the other TCP estimates are mainly included in the table for diagnostic purposes). ===================================================================================================================== TSIM DOSE ---- EXPECTED NUMBER OF CELLS ---- ------ TUMOR CONTROL PROBABILITY (TCP) ------- SIM ID (day) (Gy) N(0)*S(D) N(t)*S(D) NSC(t) N(0)*S(D) N(t)*S(D) NSC(t) *MAX* --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 2 3.007E+00 1.000E-01 9.9132E-01 9.9132E-01 9.9132E-01 3.7108E-01 3.7108E-01 3.7108E-01 3.7108E-01 3 3.017E+00 2.500E-01 9.7485E-01 9.7485E-01 9.7485E-01 3.7725E-01 3.7725E-01 3.7725E-01 3.7725E-01 4 3.035E+00 5.000E-01 9.4135E-01 9.4135E-01 9.4135E-01 3.9010E-01 3.9010E-01 3.9010E-01 3.9010E-01 5 3.069E+00 1.000E+00 8.6213E-01 8.6213E-01 8.6213E-01 4.2226E-01 4.2226E-01 4.2226E-01 4.2226E-01 6 3.104E+00 1.500E+00 7.7646E-01 7.7646E-01 7.7646E-01 4.6003E-01 4.6003E-01 4.6003E-01 4.6003E-01 7 3.139E+00 2.000E+00 6.9120E-01 6.9120E-01 6.9120E-01 5.0098E-01 5.0098E-01 5.0098E-01 5.0098E-01 8 3.208E+00 3.000E+00 5.3561E-01 5.3561E-01 5.3561E-01 5.8531E-01 5.8531E-01 5.8531E-01 5.8531E-01 9 3.278E+00 4.000E+00 4.0802E-01 4.0802E-01 4.0802E-01 6.6497E-01 6.6497E-01 6.6497E-01 6.6497E-01 10 3.347E+00 5.000E+00 3.0817E-01 3.0817E-01 3.0817E-01 7.3479E-01 7.3479E-01 7.3479E-01 7.3479E-01 11 3.417E+00 6.000E+00 2.3176E-01 2.3176E-01 2.3176E-01 7.9313E-01 7.9313E-01 7.9313E-01 7.9313E-01 12 3.486E+00 7.000E+00 1.7393E-01 1.7393E-01 1.7393E-01 8.4036E-01 8.4036E-01 8.4036E-01 8.4036E-01 13 3.556E+00 8.000E+00 1.3038E-01 1.3038E-01 1.3038E-01 8.7776E-01 8.7776E-01 8.7776E-01 8.7776E-01 14 3.625E+00 9.000E+00 9.7684E-02 9.7684E-02 9.7684E-02 9.0694E-01 9.0694E-01 9.0694E-01 9.0694E-01 15 3.694E+00 1.000E+01 7.3167E-02 7.3167E-02 7.3167E-02 9.2945E-01 9.2945E-01 9.2945E-01 9.2945E-01 16 3.868E+00 1.250E+01 3.5511E-02 3.5511E-02 3.5511E-02 9.6511E-01 9.6511E-01 9.6511E-01 9.6511E-01 17 4.042E+00 1.500E+01 1.7231E-02 1.7231E-02 1.7231E-02 9.8292E-01 9.8292E-01 9.8292E-01 9.8292E-01 18 4.215E+00 1.750E+01 8.3611E-03 8.3611E-03 8.3611E-03 9.9167E-01 9.9167E-01 9.9167E-01 9.9167E-01 19 4.389E+00 2.000E+01 4.0570E-03 4.0570E-03 4.0570E-03 9.9595E-01 9.9595E-01 9.9595E-01 9.9595E-01 20 4.736E+00 2.500E+01 9.5518E-04 9.5518E-04 9.5518E-04 9.9905E-01 9.9905E-01 9.9905E-01 9.9905E-01 21 5.083E+00 3.000E+01 2.2489E-04 2.2489E-04 2.2489E-04 9.9978E-01 9.9978E-01 9.9978E-01 9.9978E-01 22 5.431E+00 3.500E+01 5.2948E-05 5.2948E-05 5.2948E-05 9.9995E-01 9.9995E-01 9.9995E-01 9.9995E-01 23 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 24 3.000E+00 1.000E-01 9.9121E-01 9.9121E-01 9.9121E-01 3.7113E-01 3.7113E-01 3.7113E-01 3.7113E-01 25 3.000E+00 2.500E-01 9.7333E-01 9.7333E-01 9.7333E-01 3.7782E-01 3.7782E-01 3.7782E-01 3.7782E-01 26 3.000E+00 5.000E-01 9.3201E-01 9.3201E-01 9.3201E-01 3.9376E-01 3.9376E-01 3.9376E-01 3.9376E-01 27 3.000E+00 1.000E+00 8.1473E-01 8.1473E-01 8.1473E-01 4.4276E-01 4.4276E-01 4.4276E-01 4.4276E-01 28 3.001E+00 1.500E+00 6.6964E-01 6.6964E-01 6.6964E-01 5.1189E-01 5.1189E-01 5.1189E-01 5.1189E-01 29 3.001E+00 2.000E+00 5.1872E-01 5.1872E-01 5.1872E-01 5.9528E-01 5.9528E-01 5.9528E-01 5.9528E-01 30 3.001E+00 3.000E+00 2.6285E-01 2.6285E-01 2.6285E-01 7.6886E-01 7.6886E-01 7.6886E-01 7.6886E-01 31 3.001E+00 4.000E+00 1.0777E-01 1.0777E-01 1.0777E-01 8.9784E-01 8.9784E-01 8.9784E-01 8.9784E-01 32 3.002E+00 5.000E+00 3.6281E-02 3.6281E-02 3.6281E-02 9.6437E-01 9.6437E-01 9.6437E-01 9.6437E-01 33 3.002E+00 6.000E+00 1.0166E-02 1.0166E-02 1.0166E-02 9.8989E-01 9.8989E-01 9.8989E-01 9.8989E-01 34 3.502E+00 7.000E+00 2.4000E-03 2.4000E-03 2.4000E-03 9.9760E-01 9.9760E-01 9.9760E-01 9.9760E-01 35 3.503E+00 8.000E+00 4.8271E-04 4.8271E-04 4.8271E-04 9.9952E-01 9.9952E-01 9.9952E-01 9.9952E-01 36 3.503E+00 9.000E+00 8.3563E-05 8.3563E-05 8.3563E-05 9.9992E-01 9.9992E-01 9.9992E-01 9.9992E-01 37 3.503E+00 1.000E+01 1.2568E-05 1.2568E-05 1.2568E-05 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 38 3.504E+00 1.250E+01 6.2938E-08 6.2938E-08 6.2938E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 39 3.505E+00 1.500E+01 1.5499E-10 1.5499E-10 1.5499E-10 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 40 3.506E+00 1.750E+01 2.0676E-13 2.0676E-13 2.0676E-13 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 41 3.507E+00 2.000E+01 1.6199E-16 1.6199E-16 1.6199E-16 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 42 3.509E+00 2.500E+01 2.6160E-23 2.6160E-23 2.6160E-23 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 43 3.510E+00 3.000E+01 1.0041E-30 1.0041E-30 1.0041E-30 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 44 3.512E+00 3.500E+01 1.2573E-38 1.2573E-38 1.2573E-38 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 --------------------------------------------------------------------------------------------------------------------- NOTE: TCP={probability no cells survive}=EXP{-(expected number of surviving cells)}. TCP estimates are based on the expected number of surviving cells with and without corrections for repopulation effects. The *MAX* TCP is the peak (all time points after irradiation) estimate derived from NSC(t). RADX EXPOSURE SUMMARY ============================================================================== SCENARIO ----- DURATION ----- ------ DOSE (Gy) ----- -- DOSE RATE (Gy/h) -- NUMBER hours days Background Total Background Total* ------------------------------------------------------------------------------ 1 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 2 1.667E-01 6.944E-03 0.0000E+00 1.0000E-01 0.0000E+00 6.0000E-01 3 4.167E-01 1.736E-02 0.0000E+00 2.5000E-01 0.0000E+00 6.0000E-01 4 8.333E-01 3.472E-02 0.0000E+00 5.0000E-01 0.0000E+00 6.0000E-01 5 1.667E+00 6.944E-02 0.0000E+00 1.0000E+00 0.0000E+00 6.0000E-01 6 2.500E+00 1.042E-01 0.0000E+00 1.5000E+00 0.0000E+00 6.0000E-01 7 3.333E+00 1.389E-01 0.0000E+00 2.0000E+00 0.0000E+00 6.0000E-01 8 5.000E+00 2.083E-01 0.0000E+00 3.0000E+00 0.0000E+00 6.0000E-01 9 6.667E+00 2.778E-01 0.0000E+00 4.0000E+00 0.0000E+00 6.0000E-01 10 8.333E+00 3.472E-01 0.0000E+00 5.0000E+00 0.0000E+00 6.0000E-01 11 1.000E+01 4.167E-01 0.0000E+00 6.0000E+00 0.0000E+00 6.0000E-01 12 1.167E+01 4.861E-01 0.0000E+00 7.0000E+00 0.0000E+00 6.0000E-01 13 1.333E+01 5.556E-01 0.0000E+00 8.0000E+00 0.0000E+00 6.0000E-01 14 1.500E+01 6.250E-01 0.0000E+00 9.0000E+00 0.0000E+00 6.0000E-01 15 1.667E+01 6.944E-01 0.0000E+00 1.0000E+01 0.0000E+00 6.0000E-01 16 2.083E+01 8.681E-01 0.0000E+00 1.2500E+01 0.0000E+00 6.0000E-01 17 2.500E+01 1.042E+00 0.0000E+00 1.5000E+01 0.0000E+00 6.0000E-01 18 2.917E+01 1.215E+00 0.0000E+00 1.7500E+01 0.0000E+00 6.0000E-01 19 3.333E+01 1.389E+00 0.0000E+00 2.0000E+01 0.0000E+00 6.0000E-01 20 4.167E+01 1.736E+00 0.0000E+00 2.5000E+01 0.0000E+00 6.0000E-01 21 5.000E+01 2.083E+00 0.0000E+00 3.0000E+01 0.0000E+00 6.0000E-01 22 5.833E+01 2.431E+00 0.0000E+00 3.5000E+01 0.0000E+00 6.0000E-01 23 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 24 8.333E-04 3.472E-05 0.0000E+00 1.0000E-01 0.0000E+00 1.2000E+02 25 2.083E-03 8.681E-05 0.0000E+00 2.5000E-01 0.0000E+00 1.2000E+02 26 4.167E-03 1.736E-04 0.0000E+00 5.0000E-01 0.0000E+00 1.2000E+02 27 8.333E-03 3.472E-04 0.0000E+00 1.0000E+00 0.0000E+00 1.2000E+02 28 1.250E-02 5.208E-04 0.0000E+00 1.5000E+00 0.0000E+00 1.2000E+02 29 1.667E-02 6.944E-04 0.0000E+00 2.0000E+00 0.0000E+00 1.2000E+02 30 2.500E-02 1.042E-03 0.0000E+00 3.0000E+00 0.0000E+00 1.2000E+02 31 3.333E-02 1.389E-03 0.0000E+00 4.0000E+00 0.0000E+00 1.2000E+02 32 4.167E-02 1.736E-03 0.0000E+00 5.0000E+00 0.0000E+00 1.2000E+02 33 5.000E-02 2.083E-03 0.0000E+00 6.0000E+00 0.0000E+00 1.2000E+02 34 5.833E-02 2.431E-03 0.0000E+00 7.0000E+00 0.0000E+00 1.2000E+02 35 6.667E-02 2.778E-03 0.0000E+00 8.0000E+00 0.0000E+00 1.2000E+02 36 7.500E-02 3.125E-03 0.0000E+00 9.0000E+00 0.0000E+00 1.2000E+02 37 8.333E-02 3.472E-03 0.0000E+00 1.0000E+01 0.0000E+00 1.2000E+02 38 1.042E-01 4.340E-03 0.0000E+00 1.2500E+01 0.0000E+00 1.2000E+02 39 1.250E-01 5.208E-03 0.0000E+00 1.5000E+01 0.0000E+00 1.2000E+02 40 1.458E-01 6.076E-03 0.0000E+00 1.7500E+01 0.0000E+00 1.2000E+02 41 1.667E-01 6.944E-03 0.0000E+00 2.0000E+01 0.0000E+00 1.2000E+02 42 2.083E-01 8.681E-03 0.0000E+00 2.5000E+01 0.0000E+00 1.2000E+02 43 2.500E-01 1.042E-02 0.0000E+00 3.0000E+01 0.0000E+00 1.2000E+02 44 2.917E-01 1.215E-02 0.0000E+00 3.5000E+01 0.0000E+00 1.2000E+02 ------------------------------------------------------------------------------ * Dose rate is the delivered dose divided by the duration of the exposure scenario. Total VC execution time (min): 7.81667E-03 VC 2.00I 15-JUL-2003 02-AUG-2003 09:27:50 PM