VC 2.00I 15-JUL-2003 02-AUG-2003 09:24:49 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: vc tlk.inp ..\xdat\ncih460.xdat -c FNI: tlk.inp FNO: tlk.out RADX: ..\xdat\ncih460.radx (9 exposures) XDAT: ..\xdat\ncih460.xdat (9 experiments) -------------------------------------------------------------------------------- MCAT SUMMARY: BEST-FIT MODEL PARAMETERS (method = BCONF): ========================================================================================== --- PARAMETER --- ----- CONSTRAINTS ----- INITIAL OPTIMAL PID CID NAM Minimum Maximum GUESS VALUE 2001 CLRP BMR 0.00000E+00 1.00000E+00 2.00000E-04 1.1967940E-03 2201 CLRP RHT 1.00000E-02 2.40000E+01 1.50000E-01 2.2184642E-01 2202 CLRP RHT 1.00000E-02 2.40000E+01 2.00000E+00 1.8667736E+00 ------------------------------------------------------------------------------------------ FIGURE OF MERIT (FOM): 3.98004E-02 (nfom=656, nsim=5904, nmx=9, nox=9, ndf=5, nap=3) COMBINED UNWEIGHTED RESIDUAL: Stats: min=-6.868E-01 max=6.462E-01, mean=4.8367E-02, stdev=3.7645E-01, var=1.4172E-01 Student's T test (mean=0, NDF=5): Pr>ABS(0.38544)= 7.1576E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.95454)=7.335E-01 (passed normality test) COMBINED WEIGHTED RESIDUAL: Stats: min=-2.289E-01 max=2.154E-01, mean=1.6122E-02, stdev=1.2548E-01, var=1.5746E-02 Student's T test (mean=0, NDF=5): Pr>ABS(0.38544)= 7.1576E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.95454)=7.335E-01 (passed normality test) QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 8.61342E-12 5.29381E-03 30.000000 Complex DSB = 2.87114E-12 1.76460E-03 10.000000 Total DSB = 1.14846E-11 7.05841E-03 40.000000 DAMAGE REPAIR/MISREPAIR: A1= 7.500000E-01 (=75.000%) A2= 2.500000E-01 (=25.000%) PHI1= 5.000000E-03 (=0.500%) PHI2= 5.000000E-03 (=0.500%) (1-A1)*PHI1= 1.250000E-03 (=0.125%) (1-A2)*PHI2= 3.750000E-03 (=0.375%) (1-A1)*(1-PHI1)= 2.487500E-01 (=24.875%) (1-A2)*(1-PHI2)= 7.462500E-01 (=74.625%) RHT1= 0.221846 h (=13.31 minute) RHT2= 1.866774 h (=112.01 minute) LAM1= 3.1244461E+00 (1/h) LAM2= 3.7130758E-01 (1/h) BMR= 1.1967940E-03 (1/h) LAM1/BMR= 2.6106798E+03 LAM2/BMR= 3.1025186E+02 (LAM1+LAM2)/BMR= 2.9209317E+03 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 3.7500E-02 + 3.7500E-02 = 7.5000000E-02 (1/Gy) beta: 6.8297E-02 + 6.5105E-02 = 1.3340220E-01 (1/Gy^2) alpha/beta: 0.5622096 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg MCAT FIT: CELL SURVIVAL AS A FUNCTION OF DOSE AND DOSE RATE (NCIH 460 cells). ===================================================================================================== -------- EXPOSURE SUMMARY -------- Duration Dose Dose Rate ---------------- SURVIVING FRACTION -------------- EXPERIMENT (h) (Gy) (Gy/h)* Measured Norm. Wt Predicted Residual ----------------------------------------------------------------------------------------------------- 1 3.9000E+00 2.3400E+00 6.0000E-01 6.15168E-01 1.11E-01 6.35517E-01 3.2020E-02 2 1.2385E+01 7.4310E+00 6.0000E-01 2.59138E-01 1.11E-01 1.53625E-01 -6.8682E-01 3 2.0292E+01 1.2175E+01 6.0000E-01 1.38010E-02 1.11E-01 3.90103E-02 6.4622E-01 4 2.8142E+01 1.6885E+01 6.0000E-01 5.88200E-03 1.11E-01 9.98893E-03 4.1115E-01 5 1.2667E-02 1.5200E+00 1.2000E+02 7.43642E-01 1.11E-01 6.63581E-01 -1.2065E-01 6 2.5667E-02 3.0800E+00 1.2000E+02 2.74294E-01 1.11E-01 2.46621E-01 -1.1221E-01 7 3.8417E-02 4.6100E+00 1.2000E+02 4.40320E-02 1.11E-01 5.67372E-02 2.2393E-01 8 5.2250E-02 6.2700E+00 1.2000E+02 6.20300E-03 1.11E-01 6.99852E-03 1.1367E-01 9 6.5000E-02 7.8000E+00 1.2000E+02 7.22000E-04 1.11E-01 6.73504E-04 -7.2006E-02 ----------------------------------------------------------------------------------------------------- RESIDUAL: Stats: min=-6.868E-01 max=6.462E-01, mean=4.8367E-02, stdev=3.7645E-01, var=1.4172E-01 Student's T test (mean=0, NDF=5): Pr>ABS(0.38544)= 7.1576E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.95454)=7.335E-01 (passed normality test) WEIGHTED RESIDUAL: Stats: min=-2.289E-01 max=2.154E-01, mean=1.6122E-02, stdev=1.2548E-01, var=1.5746E-02 Student's T test (mean=0, NDF=5): Pr>ABS(0.38544)= 7.1576E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.95454)=7.335E-01 (passed normality test) NOX=9, NPAR=3 CFE.SF: Cell survival data for NCIH 460 cells. ========================================================================================= -------- EXPOSURE SUMMARY -------- ------------ ENDPOINT ------------- DATASET ID Duration Dose Dose Rate Fraction Fraction Standard CFE RADX (h) (Gy) (Gy/h) Killed Viable Error (%) ----------------------------------------------------------------------------------------- 1 1 3.9000E+00 2.3400E+00 6.0000E-01 3.84832E-01 6.15168E-01 1.00E+01 2 2 1.2385E+01 7.4310E+00 6.0000E-01 7.40862E-01 2.59138E-01 1.00E+01 3 3 2.0292E+01 1.2175E+01 6.0000E-01 9.86199E-01 1.38010E-02 1.00E+01 4 4 2.8142E+01 1.6885E+01 6.0000E-01 9.94118E-01 5.88200E-03 1.00E+01 5 5 1.2667E-02 1.5200E+00 1.2000E+02 2.56358E-01 7.43642E-01 1.00E+01 6 6 2.5667E-02 3.0800E+00 1.2000E+02 7.25706E-01 2.74294E-01 1.00E+01 7 7 3.8417E-02 4.6100E+00 1.2000E+02 9.55968E-01 4.40320E-02 1.00E+01 8 8 5.2250E-02 6.2700E+00 1.2000E+02 9.93797E-01 6.20300E-03 1.00E+01 9 9 6.5000E-02 7.8000E+00 1.2000E+02 9.99278E-01 7.22000E-04 1.00E+01 ----------------------------------------------------------------------------------------- CFE.DXA: Additional details from the cell survival assay (NCIH 460). ===================================================================================== DATASET ID ---------- TIME (h) ----------- DOSE ---- LETHAL DAMAGE --- CFE RADX RADX TTP ETSI (Gy) #/(cell Gy) #/(cell) ------------------------------------------------------------------------------------- 1 1 3.900E+00 1.200E+01 4.000E+02 2.3400E+00 2.0763E-01 4.8586E-01 2 2 1.238E+01 1.200E+01 4.000E+02 7.4310E+00 1.8172E-01 1.3504E+00 3 3 2.029E+01 1.200E+01 4.000E+02 1.2175E+01 3.5179E-01 4.2830E+00 4 4 2.814E+01 1.200E+01 4.000E+02 1.6885E+01 3.0417E-01 5.1359E+00 5 5 1.267E-02 1.200E+01 4.000E+02 1.5200E+00 1.9487E-01 2.9620E-01 6 6 2.567E-02 1.200E+01 4.000E+02 3.0800E+00 4.1999E-01 1.2936E+00 7 7 3.842E-02 1.200E+01 4.000E+02 4.6100E+00 6.7741E-01 3.1228E+00 8 8 5.225E-02 1.200E+01 4.000E+02 6.2700E+00 8.1064E-01 5.0827E+00 9 9 6.500E-02 1.200E+01 4.000E+02 7.8000E+00 9.2737E-01 7.2335E+00 ------------------------------------------------------------------------------------- ETSI: Total elapsed time (after irradiation) before colonies are counted. TTP: Time available for repair before cells are plated. Total VC execution time (min): 0.62657 VC 2.00I 15-JUL-2003 02-AUG-2003 09:25:27 PM