VC 2.00I 15-JUL-2003 02-AUG-2003 09:14:58 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: u:\usr\bin\vc.exe u:\archive\ncih69\tlk\ncih69.inp FNI: U:\archive\ncih69\tlk\ncih69.inp FNO: U:\archive\ncih69\tlk\ncih69.out RADX: U:\archive\ncih69\tlk\ncih69.radx (44 exposures) -------------------------------------------------------------------------------- QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 1.72268E-11 1.05876E-02 60.000000 Complex DSB = 5.74228E-12 3.52920E-03 20.000000 Total DSB = 2.29691E-11 1.41168E-02 80.000000 DAMAGE REPAIR/MISREPAIR: A1= 7.500000E-01 (=75.000%) A2= 2.500000E-01 (=25.000%) PHI1= 3.015202E-02 (=3.015%) PHI2= 3.015202E-02 (=3.015%) (1-A1)*PHI1= 7.538004E-03 (=0.754%) (1-A2)*PHI2= 2.261401E-02 (=2.261%) (1-A1)*(1-PHI1)= 2.424620E-01 (=24.246%) (1-A2)*(1-PHI2)= 7.273860E-01 (=72.739%) RHT1= 0.007223 h (=0.43 minute) RHT2= 0.007223 h (=0.43 minute) LAM1= 9.5958390E+01 (1/h) LAM2= 9.5964455E+01 (1/h) BMR= 2.7500000E-04 (1/h) LAM1/BMR= 3.4893960E+05 LAM2/BMR= 3.4896165E+05 (LAM1+LAM2)/BMR= 6.9790126E+05 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 4.5228E-01 + 4.5228E-01 = 9.0456051E-01 (1/Gy) beta: 1.6547E-03 + 5.3426E-04 = 2.1889341E-03 (1/Gy^2) alpha/beta: 413.2424563 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg DFAR TABLE: Cell survival as a function of dose and dose rate (FRDL=100.0%). ====================================================================================================== --- Duration (h) --- Dose Dose Rate ---- LETHAL DAMAGE PER CELL ---- SIM ID Exposure Sim (Gy) (Gy/h) Mutations Residual Total SF(dose) ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 2 1.667E-01 2.417E+01 1.000E-01 6.000E-01 9.046E-02 0.000E+00 9.0459E-02 9.135121E-01 3 4.167E-01 2.442E+01 2.500E-01 6.000E-01 2.261E-01 0.000E+00 2.2615E-01 7.976010E-01 4 8.333E-01 2.483E+01 5.000E-01 6.000E-01 4.523E-01 0.000E+00 4.5229E-01 6.361673E-01 5 1.667E+00 2.567E+01 1.000E+00 6.000E-01 9.046E-01 0.000E+00 9.0459E-01 4.047087E-01 6 2.500E+00 2.650E+01 1.500E+00 6.000E-01 1.357E+00 0.000E+00 1.3569E+00 2.574624E-01 7 3.333E+00 2.733E+01 2.000E+00 6.000E-01 1.809E+00 0.000E+00 1.8092E+00 1.637891E-01 8 5.000E+00 2.900E+01 3.000E+00 6.000E-01 2.714E+00 0.000E+00 2.7138E+00 6.628687E-02 9 6.667E+00 3.067E+01 4.000E+00 6.000E-01 3.618E+00 0.000E+00 3.6184E+00 2.682687E-02 10 8.333E+00 3.233E+01 5.000E+00 6.000E-01 4.523E+00 0.000E+00 4.5229E+00 1.085707E-02 11 1.000E+01 3.400E+01 6.000E+00 6.000E-01 5.428E+00 0.000E+00 5.4275E+00 4.393948E-03 12 1.167E+01 3.567E+01 7.000E+00 6.000E-01 6.332E+00 0.000E+00 6.3321E+00 1.778269E-03 13 1.333E+01 3.733E+01 8.000E+00 6.000E-01 7.237E+00 0.000E+00 7.2367E+00 7.196807E-04 14 1.500E+01 3.900E+01 9.000E+00 6.000E-01 8.141E+00 0.000E+00 8.1413E+00 2.912610E-04 15 1.667E+01 4.067E+01 1.000E+01 6.000E-01 9.046E+00 0.000E+00 9.0459E+00 1.178758E-04 16 2.083E+01 4.483E+01 1.250E+01 6.000E-01 1.131E+01 0.000E+00 1.1307E+01 1.228234E-05 17 2.500E+01 4.900E+01 1.500E+01 6.000E-01 1.357E+01 0.000E+00 1.3569E+01 1.279785E-06 18 2.917E+01 5.317E+01 1.750E+01 6.000E-01 1.583E+01 0.000E+00 1.5830E+01 1.333501E-07 19 3.333E+01 5.733E+01 2.000E+01 6.000E-01 1.809E+01 0.000E+00 1.8092E+01 1.389471E-08 20 4.167E+01 6.567E+01 2.500E+01 6.000E-01 2.261E+01 0.000E+00 2.2615E+01 1.508558E-10 21 5.000E+01 7.400E+01 3.000E+01 6.000E-01 2.714E+01 0.000E+00 2.7138E+01 1.637851E-12 22 5.833E+01 8.233E+01 3.500E+01 6.000E-01 3.166E+01 0.000E+00 3.1661E+01 1.778225E-14 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 24 8.333E-04 2.400E+01 1.000E-01 1.200E+02 9.048E-02 1.004E-22 9.0477E-02 9.134950E-01 25 2.083E-03 2.400E+01 2.500E-01 1.200E+02 2.263E-01 0.000E+00 2.2627E-01 7.975041E-01 26 4.167E-03 2.400E+01 5.000E-01 1.200E+02 4.528E-01 0.000E+00 4.5276E-01 6.358699E-01 27 8.333E-03 2.401E+01 1.000E+00 1.200E+02 9.063E-01 0.000E+00 9.0627E-01 4.040301E-01 28 1.250E-02 2.401E+01 1.500E+00 1.200E+02 1.360E+00 0.000E+00 1.3603E+00 2.565918E-01 29 1.667E-02 2.402E+01 2.000E+00 1.200E+02 1.815E+00 0.000E+00 1.8146E+00 1.629021E-01 30 2.500E-02 2.402E+01 3.000E+00 1.200E+02 2.724E+00 7.302E-25 2.7239E+00 6.561980E-02 31 3.333E-02 2.403E+01 4.000E+00 1.200E+02 3.634E+00 0.000E+00 3.6336E+00 2.642174E-02 32 4.167E-02 2.404E+01 5.000E+00 1.200E+02 4.543E+00 1.122E-21 4.5434E+00 1.063668E-02 33 5.000E-02 2.405E+01 6.000E+00 1.200E+02 5.453E+00 0.000E+00 5.4534E+00 4.281680E-03 34 5.833E-02 2.406E+01 7.000E+00 1.200E+02 6.363E+00 0.000E+00 6.3634E+00 1.723478E-03 35 6.667E-02 2.407E+01 8.000E+00 1.200E+02 7.273E+00 0.000E+00 7.2734E+00 6.937291E-04 36 7.500E-02 2.407E+01 9.000E+00 1.200E+02 8.183E+00 0.000E+00 8.1835E+00 2.792356E-04 37 8.333E-02 2.408E+01 1.000E+01 1.200E+02 9.093E+00 0.000E+00 9.0935E+00 1.123958E-04 38 1.042E-01 2.410E+01 1.250E+01 1.200E+02 1.137E+01 0.000E+00 1.1369E+01 1.155304E-05 39 1.250E-01 2.412E+01 1.500E+01 1.200E+02 1.364E+01 0.000E+00 1.3644E+01 1.187522E-06 40 1.458E-01 2.415E+01 1.750E+01 1.200E+02 1.592E+01 0.000E+00 1.5919E+01 1.220638E-07 41 1.667E-01 2.417E+01 2.000E+01 1.200E+02 1.819E+01 0.000E+00 1.8194E+01 1.254678E-08 42 2.083E-01 2.421E+01 2.500E+01 1.200E+02 2.274E+01 0.000E+00 2.2744E+01 1.325632E-10 43 2.500E-01 2.425E+01 3.000E+01 1.200E+02 2.729E+01 0.000E+00 2.7294E+01 1.400598E-12 44 2.917E-01 2.429E+01 3.500E+01 1.200E+02 3.184E+01 0.000E+00 3.1844E+01 1.479804E-14 ------------------------------------------------------------------------------------------------------ NOTE: SF=EXP{-(lethal residual damage + lethal mutations)}. QECK TABLE: Cell survival, corrected for repopulation effects, as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. ===================================================================================================================== TSIM DOSE DOSE RATE - SURVIVING FRACTION - --------- EXPECTED NUMBER OF CELLS ----------- SIM ID (day) (Gy) (Gy/h) no repop repop N(t)/N(0) N(0)*S(D) N(t)*S(D) NSC(t) --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 2 1.007E+00 1.000E-01 6.000E-01 9.1351E-01 9.1351E-01 1.0000E+00 9.1351E-01 9.1351E-01 9.1351E-01 3 1.017E+00 2.500E-01 6.000E-01 7.9760E-01 7.9760E-01 1.0000E+00 7.9760E-01 7.9760E-01 7.9760E-01 4 1.035E+00 5.000E-01 6.000E-01 6.3617E-01 6.3617E-01 1.0000E+00 6.3617E-01 6.3617E-01 6.3617E-01 5 1.069E+00 1.000E+00 6.000E-01 4.0471E-01 4.0471E-01 1.0000E+00 4.0471E-01 4.0471E-01 4.0471E-01 6 1.104E+00 1.500E+00 6.000E-01 2.5746E-01 2.5746E-01 1.0000E+00 2.5746E-01 2.5746E-01 2.5746E-01 7 1.139E+00 2.000E+00 6.000E-01 1.6379E-01 1.6379E-01 1.0000E+00 1.6379E-01 1.6379E-01 1.6379E-01 8 1.208E+00 3.000E+00 6.000E-01 6.6287E-02 6.6287E-02 1.0000E+00 6.6287E-02 6.6287E-02 6.6287E-02 9 1.278E+00 4.000E+00 6.000E-01 2.6827E-02 2.6827E-02 1.0000E+00 2.6827E-02 2.6827E-02 2.6827E-02 10 1.347E+00 5.000E+00 6.000E-01 1.0857E-02 1.0857E-02 1.0000E+00 1.0857E-02 1.0857E-02 1.0857E-02 11 1.417E+00 6.000E+00 6.000E-01 4.3939E-03 4.3939E-03 1.0000E+00 4.3939E-03 4.3939E-03 4.3939E-03 12 1.486E+00 7.000E+00 6.000E-01 1.7783E-03 1.7783E-03 1.0000E+00 1.7783E-03 1.7783E-03 1.7783E-03 13 1.556E+00 8.000E+00 6.000E-01 7.1968E-04 7.1968E-04 1.0000E+00 7.1968E-04 7.1968E-04 7.1968E-04 14 1.625E+00 9.000E+00 6.000E-01 2.9126E-04 2.9126E-04 1.0000E+00 2.9126E-04 2.9126E-04 2.9126E-04 15 1.694E+00 1.000E+01 6.000E-01 1.1788E-04 1.1788E-04 1.0000E+00 1.1788E-04 1.1788E-04 1.1788E-04 16 1.868E+00 1.250E+01 6.000E-01 1.2282E-05 1.2282E-05 1.0000E+00 1.2282E-05 1.2282E-05 1.2282E-05 17 2.042E+00 1.500E+01 6.000E-01 1.2798E-06 1.2798E-06 1.0000E+00 1.2798E-06 1.2798E-06 1.2798E-06 18 2.215E+00 1.750E+01 6.000E-01 1.3335E-07 1.3335E-07 1.0000E+00 1.3335E-07 1.3335E-07 1.3335E-07 19 2.389E+00 2.000E+01 6.000E-01 1.3895E-08 1.3895E-08 1.0000E+00 1.3895E-08 1.3895E-08 1.3895E-08 20 2.736E+00 2.500E+01 6.000E-01 1.5086E-10 1.5086E-10 1.0000E+00 1.5086E-10 1.5086E-10 1.5086E-10 21 3.083E+00 3.000E+01 6.000E-01 1.6379E-12 1.6379E-12 1.0000E+00 1.6379E-12 1.6379E-12 1.6379E-12 22 3.431E+00 3.500E+01 6.000E-01 1.7782E-14 1.7782E-14 1.0000E+00 1.7782E-14 1.7782E-14 1.7782E-14 23 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 24 1.000E+00 1.000E-01 1.200E+02 9.1350E-01 9.1350E-01 1.0000E+00 9.1350E-01 9.1350E-01 9.1350E-01 25 1.000E+00 2.500E-01 1.200E+02 7.9750E-01 7.9750E-01 1.0000E+00 7.9750E-01 7.9750E-01 7.9750E-01 26 1.000E+00 5.000E-01 1.200E+02 6.3587E-01 6.3587E-01 1.0000E+00 6.3587E-01 6.3587E-01 6.3587E-01 27 1.000E+00 1.000E+00 1.200E+02 4.0403E-01 4.0403E-01 1.0000E+00 4.0403E-01 4.0403E-01 4.0403E-01 28 1.001E+00 1.500E+00 1.200E+02 2.5659E-01 2.5659E-01 1.0000E+00 2.5659E-01 2.5659E-01 2.5659E-01 29 1.001E+00 2.000E+00 1.200E+02 1.6290E-01 1.6290E-01 1.0000E+00 1.6290E-01 1.6290E-01 1.6290E-01 30 1.001E+00 3.000E+00 1.200E+02 6.5620E-02 6.5620E-02 1.0000E+00 6.5620E-02 6.5620E-02 6.5620E-02 31 1.001E+00 4.000E+00 1.200E+02 2.6422E-02 2.6422E-02 1.0000E+00 2.6422E-02 2.6422E-02 2.6422E-02 32 1.002E+00 5.000E+00 1.200E+02 1.0637E-02 1.0637E-02 1.0000E+00 1.0637E-02 1.0637E-02 1.0637E-02 33 1.002E+00 6.000E+00 1.200E+02 4.2817E-03 4.2817E-03 1.0000E+00 4.2817E-03 4.2817E-03 4.2817E-03 34 1.002E+00 7.000E+00 1.200E+02 1.7235E-03 1.7235E-03 1.0000E+00 1.7235E-03 1.7235E-03 1.7235E-03 35 1.003E+00 8.000E+00 1.200E+02 6.9373E-04 6.9373E-04 1.0000E+00 6.9373E-04 6.9373E-04 6.9373E-04 36 1.003E+00 9.000E+00 1.200E+02 2.7924E-04 2.7924E-04 1.0000E+00 2.7924E-04 2.7924E-04 2.7924E-04 37 1.003E+00 1.000E+01 1.200E+02 1.1240E-04 1.1240E-04 1.0000E+00 1.1240E-04 1.1240E-04 1.1240E-04 38 1.004E+00 1.250E+01 1.200E+02 1.1553E-05 1.1553E-05 1.0000E+00 1.1553E-05 1.1553E-05 1.1553E-05 39 1.005E+00 1.500E+01 1.200E+02 1.1875E-06 1.1875E-06 1.0000E+00 1.1875E-06 1.1875E-06 1.1875E-06 40 1.006E+00 1.750E+01 1.200E+02 1.2206E-07 1.2206E-07 1.0000E+00 1.2206E-07 1.2206E-07 1.2206E-07 41 1.007E+00 2.000E+01 1.200E+02 1.2547E-08 1.2547E-08 1.0000E+00 1.2547E-08 1.2547E-08 1.2547E-08 42 1.009E+00 2.500E+01 1.200E+02 1.3256E-10 1.3256E-10 1.0000E+00 1.3256E-10 1.3256E-10 1.3256E-10 43 1.010E+00 3.000E+01 1.200E+02 1.4006E-12 1.4006E-12 1.0000E+00 1.4006E-12 1.4006E-12 1.4006E-12 44 1.012E+00 3.500E+01 1.200E+02 1.4798E-14 1.4798E-14 1.0000E+00 1.4798E-14 1.4798E-14 1.4798E-14 --------------------------------------------------------------------------------------------------------------------- NOTE: N(0) is the initial number of cells (time=0 day), N(t) is the expected number of unirradiated (control) cells at TSIM, i.e., N(t)=N(0)*EXP[LN(2)*TSIM/TPOT]. The surviving fraction S(D) is the expected number of cells, per irradiated cell, that has not sustained lethal DNA damage (no corrections for repopulation effects). NSC(t) is the expected number of cells that survive irradiation, including repopulation effects (recommended method). The product N(t)*S(D) is an alternate method of estimating the surviving fraction with repopulation effects. DFAR TABLE: Mutagenesis and the induction of enhanced genetic instability (GI). Key GI model parameters are: (1-FRDL)=0.0%, NCM=1, NCG=1, and NCG*PGH*PGA=4.250E-06. ====================================================================================================== Dose Dose Rate -- NON-LETHAL MUTATIONS PER CELL -- **** PROBABILITY PER CELL **** SIM ID (Gy) (Gy/h) Mutations Residual Total AGF EGI EGI/SF ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 2 1.000E-01 6.000E-01 2.910E+00 0.00E+00 2.90955E+00 1.130E-05 1.130E-05 1.237E-05 3 2.500E-01 6.000E-01 7.274E+00 0.00E+00 7.27387E+00 2.466E-05 2.466E-05 3.091E-05 4 5.000E-01 6.000E-01 1.455E+01 0.00E+00 1.45477E+01 3.933E-05 3.933E-05 6.183E-05 5 1.000E+00 6.000E-01 2.910E+01 0.00E+00 2.90955E+01 5.004E-05 5.004E-05 1.236E-04 6 1.500E+00 6.000E-01 4.364E+01 0.00E+00 4.36432E+01 4.775E-05 4.775E-05 1.855E-04 7 2.000E+00 6.000E-01 5.819E+01 0.00E+00 5.81910E+01 4.050E-05 4.050E-05 2.473E-04 8 3.000E+00 6.000E-01 8.729E+01 0.00E+00 8.72865E+01 2.459E-05 2.459E-05 3.709E-04 9 4.000E+00 6.000E-01 1.164E+02 0.00E+00 1.16382E+02 1.327E-05 1.327E-05 4.945E-04 10 5.000E+00 6.000E-01 1.455E+02 0.00E+00 1.45477E+02 6.711E-06 6.711E-06 6.181E-04 11 6.000E+00 6.000E-01 1.746E+02 0.00E+00 1.74573E+02 3.259E-06 3.259E-06 7.417E-04 12 7.000E+00 6.000E-01 2.037E+02 0.00E+00 2.03668E+02 1.539E-06 1.539E-06 8.652E-04 13 8.000E+00 6.000E-01 2.328E+02 0.00E+00 2.32764E+02 7.116E-07 7.116E-07 9.888E-04 14 9.000E+00 6.000E-01 2.619E+02 0.00E+00 2.61859E+02 3.240E-07 3.240E-07 1.112E-03 15 1.000E+01 6.000E-01 2.910E+02 0.00E+00 2.90955E+02 1.457E-07 1.457E-07 1.236E-03 16 1.250E+01 6.000E-01 3.637E+02 0.00E+00 3.63694E+02 1.897E-08 1.897E-08 1.545E-03 17 1.500E+01 6.000E-01 4.364E+02 0.00E+00 4.36432E+02 2.372E-09 2.372E-09 1.853E-03 18 1.750E+01 6.000E-01 5.092E+02 0.00E+00 5.09171E+02 2.883E-10 2.883E-10 2.162E-03 19 2.000E+01 6.000E-01 5.819E+02 0.00E+00 5.81910E+02 3.432E-11 3.432E-11 2.470E-03 20 2.500E+01 6.000E-01 7.274E+02 0.00E+00 7.27387E+02 4.656E-13 4.656E-13 3.087E-03 21 3.000E+01 6.000E-01 8.729E+02 0.00E+00 8.72865E+02 6.065E-15 6.065E-15 3.703E-03 22 3.500E+01 6.000E-01 1.018E+03 0.00E+00 1.01834E+03 7.679E-17 7.679E-17 4.319E-03 23 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 24 1.000E-01 1.200E+02 2.910E+00 0.00E+00 2.90958E+00 1.130E-05 1.130E-05 1.237E-05 25 2.500E-01 1.200E+02 7.274E+00 0.00E+00 7.27407E+00 2.465E-05 2.465E-05 3.091E-05 26 5.000E-01 1.200E+02 1.455E+01 0.00E+00 1.45485E+01 3.932E-05 3.932E-05 6.183E-05 27 1.000E+00 1.200E+02 2.910E+01 0.00E+00 2.90982E+01 4.996E-05 4.996E-05 1.237E-04 28 1.500E+00 1.200E+02 4.365E+01 0.00E+00 4.36487E+01 4.760E-05 4.760E-05 1.855E-04 29 2.000E+00 1.200E+02 5.820E+01 0.00E+00 5.81998E+01 4.029E-05 4.029E-05 2.473E-04 30 3.000E+00 1.200E+02 8.730E+01 0.00E+00 8.73028E+01 2.434E-05 2.434E-05 3.710E-04 31 4.000E+00 1.200E+02 1.164E+02 0.00E+00 1.16407E+02 1.307E-05 1.307E-05 4.946E-04 32 5.000E+00 1.200E+02 1.455E+02 0.00E+00 1.45511E+02 6.576E-06 6.576E-06 6.182E-04 33 6.000E+00 1.200E+02 1.746E+02 0.00E+00 1.74615E+02 3.176E-06 3.176E-06 7.418E-04 34 7.000E+00 1.200E+02 2.037E+02 0.00E+00 2.03719E+02 1.492E-06 1.492E-06 8.654E-04 35 8.000E+00 1.200E+02 2.328E+02 0.00E+00 2.32823E+02 6.861E-07 6.861E-07 9.890E-04 36 9.000E+00 1.200E+02 2.619E+02 0.00E+00 2.61928E+02 3.107E-07 3.107E-07 1.113E-03 37 1.000E+01 1.200E+02 2.910E+02 0.00E+00 2.91032E+02 1.389E-07 1.389E-07 1.236E-03 38 1.250E+01 1.200E+02 3.638E+02 0.00E+00 3.63793E+02 1.785E-08 1.785E-08 1.545E-03 39 1.500E+01 1.200E+02 4.366E+02 0.00E+00 4.36553E+02 2.201E-09 2.201E-09 1.854E-03 40 1.750E+01 1.200E+02 5.093E+02 0.00E+00 5.09314E+02 2.639E-10 2.639E-10 2.162E-03 41 2.000E+01 1.200E+02 5.821E+02 0.00E+00 5.82075E+02 3.100E-11 3.100E-11 2.471E-03 42 2.500E+01 1.200E+02 7.276E+02 0.00E+00 7.27596E+02 4.093E-13 4.093E-13 3.088E-03 43 3.000E+01 1.200E+02 8.731E+02 0.00E+00 8.73118E+02 5.188E-15 5.188E-15 3.704E-03 44 3.500E+01 1.200E+02 1.019E+03 0.00E+00 1.01864E+03 6.393E-17 6.393E-17 4.320E-03 ------------------------------------------------------------------------------------------------------ AGF: function or expression of at least 1 of the 1 critical gene targets is altered. EGI: altered gene function or expression causes enhanced genetic instability. NEOM TABLE: Neoplastic transformation as a function of dose and dose rate at t=42.000 days. Parameters: TFS=1.1500E-05 (1/wk), TFU=2.0000E-03 (1/wk), NCM=1, NCG=1, and NCG*PGH*PGA=4.3E-06. ====================================================================================================== Dose Dose Rate Non-Lethal Genetic Instability *** TRANSFORMATION FREQUENCY *** SIM ID (Gy) (Gy/h) Mutations EGI EGI/SF BKG TPS TPI ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 2 1.000E-01 6.000E-01 2.910E+00 1.130E-05 1.237E-05 6.8994E-05 6.9142E-05 6.3162E-05 3 2.500E-01 6.000E-01 7.274E+00 2.466E-05 3.091E-05 6.8993E-05 6.9362E-05 5.5323E-05 4 5.000E-01 6.000E-01 1.455E+01 3.933E-05 6.183E-05 6.8991E-05 6.9728E-05 4.4359E-05 5 1.000E+00 6.000E-01 2.910E+01 5.004E-05 1.236E-04 6.8987E-05 7.0462E-05 2.8516E-05 6 1.500E+00 6.000E-01 4.364E+01 4.775E-05 1.855E-04 6.8982E-05 7.1195E-05 1.8330E-05 7 2.000E+00 6.000E-01 5.819E+01 4.050E-05 2.473E-04 6.8978E-05 7.1928E-05 1.1781E-05 8 3.000E+00 6.000E-01 8.729E+01 2.459E-05 3.709E-04 6.8970E-05 7.3394E-05 4.8650E-06 9 4.000E+00 6.000E-01 1.164E+02 1.327E-05 4.945E-04 6.8961E-05 7.4860E-05 2.0082E-06 10 5.000E+00 6.000E-01 1.455E+02 6.711E-06 6.181E-04 6.8953E-05 7.6325E-05 8.2867E-07 11 6.000E+00 6.000E-01 1.746E+02 3.259E-06 7.417E-04 6.8944E-05 7.7791E-05 3.4181E-07 12 7.000E+00 6.000E-01 2.037E+02 1.539E-06 8.652E-04 6.8936E-05 7.9256E-05 1.4094E-07 13 8.000E+00 6.000E-01 2.328E+02 7.116E-07 9.888E-04 6.8927E-05 8.0721E-05 5.8093E-08 14 9.000E+00 6.000E-01 2.619E+02 3.240E-07 1.112E-03 6.8918E-05 8.2186E-05 2.3938E-08 15 1.000E+01 6.000E-01 2.910E+02 1.457E-07 1.236E-03 6.8910E-05 8.3651E-05 9.8604E-09 16 1.250E+01 6.000E-01 3.637E+02 1.897E-08 1.545E-03 6.8889E-05 8.7312E-05 1.0724E-09 17 1.500E+01 6.000E-01 4.364E+02 2.372E-09 1.853E-03 6.8867E-05 9.0972E-05 1.1642E-10 18 1.750E+01 6.000E-01 5.092E+02 2.883E-10 2.162E-03 6.8846E-05 9.4631E-05 1.2619E-11 19 2.000E+01 6.000E-01 5.819E+02 3.432E-11 2.470E-03 6.8825E-05 9.8288E-05 1.3657E-12 20 2.500E+01 6.000E-01 7.274E+02 4.656E-13 3.087E-03 6.8782E-05 1.0560E-04 1.5930E-14 21 3.000E+01 6.000E-01 8.729E+02 6.065E-15 3.703E-03 6.8740E-05 1.1291E-04 1.8493E-16 22 3.500E+01 6.000E-01 1.018E+03 7.679E-17 4.319E-03 6.8697E-05 1.2021E-04 2.1376E-18 23 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 24 1.000E-01 1.200E+02 2.910E+00 1.130E-05 1.237E-05 6.8994E-05 6.9142E-05 6.3161E-05 25 2.500E-01 1.200E+02 7.274E+00 2.465E-05 3.091E-05 6.8993E-05 6.9362E-05 5.5316E-05 26 5.000E-01 1.200E+02 1.455E+01 3.932E-05 6.183E-05 6.8991E-05 6.9728E-05 4.4338E-05 27 1.000E+00 1.200E+02 2.910E+01 4.996E-05 1.237E-04 6.8987E-05 7.0462E-05 2.8469E-05 28 1.500E+00 1.200E+02 4.365E+01 4.760E-05 1.855E-04 6.8982E-05 7.1195E-05 1.8268E-05 29 2.000E+00 1.200E+02 5.820E+01 4.029E-05 2.473E-04 6.8978E-05 7.1928E-05 1.1717E-05 30 3.000E+00 1.200E+02 8.730E+01 2.434E-05 3.710E-04 6.8970E-05 7.3395E-05 4.8161E-06 31 4.000E+00 1.200E+02 1.164E+02 1.307E-05 4.946E-04 6.8961E-05 7.4861E-05 1.9780E-06 32 5.000E+00 1.200E+02 1.455E+02 6.576E-06 6.182E-04 6.8953E-05 7.6327E-05 8.1187E-07 33 6.000E+00 1.200E+02 1.746E+02 3.176E-06 7.418E-04 6.8944E-05 7.7793E-05 3.3308E-07 34 7.000E+00 1.200E+02 2.037E+02 1.492E-06 8.654E-04 6.8936E-05 7.9259E-05 1.3660E-07 35 8.000E+00 1.200E+02 2.328E+02 6.861E-07 9.890E-04 6.8927E-05 8.0724E-05 5.6001E-08 36 9.000E+00 1.200E+02 2.619E+02 3.107E-07 1.113E-03 6.8918E-05 8.2190E-05 2.2950E-08 37 1.000E+01 1.200E+02 2.910E+02 1.389E-07 1.236E-03 6.8910E-05 8.3655E-05 9.4024E-09 38 1.250E+01 1.200E+02 3.638E+02 1.785E-08 1.545E-03 6.8889E-05 8.7317E-05 1.0088E-09 39 1.500E+01 1.200E+02 4.366E+02 2.201E-09 1.854E-03 6.8867E-05 9.0978E-05 1.0804E-10 40 1.750E+01 1.200E+02 5.093E+02 2.639E-10 2.162E-03 6.8846E-05 9.4638E-05 1.1552E-11 41 2.000E+01 1.200E+02 5.821E+02 3.100E-11 2.471E-03 6.8825E-05 9.8297E-05 1.2333E-12 42 2.500E+01 1.200E+02 7.276E+02 4.093E-13 3.088E-03 6.8782E-05 1.0561E-04 1.4000E-14 43 3.000E+01 1.200E+02 8.731E+02 5.188E-15 3.704E-03 6.8740E-05 1.1292E-04 1.5816E-16 44 3.500E+01 1.200E+02 1.019E+03 6.393E-17 4.320E-03 6.8697E-05 1.2023E-04 1.7791E-18 ------------------------------------------------------------------------------------------------------ TPS: Transformation frequency per survivor, TPI: Transformation frequency per irradiated cell EGI: Probabilty random mutational events caused enhanced genetic instability (EGI). BKG: Background (spontaneous) cell transformation frequency TLKM TABLE: LQ model dose protraction factor(s) and cell survival estimates (FRDL=100.0%). LQ model parameters are: alpha = 0.9046 (1/Gy), alpha/beta = 413.2425 (Gy), lamda1 = 9.596E+01 (1/h), lamda2 = 9.596E+01 (1/h). ================================================================================================================= --- Duration (h) --- Dose Dose Rate* *********** G FACTOR *********** ******* SF(dose) ******* SIM ID Exposure Sim (Gy) (Gy/h) GL1 GL2 GEFF SF1 SF2 ----------------------------------------------------------------------------------------------------------------- 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 2 1.667E-01 2.417E+01 1.000E-01 6.000E-01 1.172E-01 1.172E-01 1.172E-01 9.1351E-01 9.135121E-01 3 4.167E-01 2.442E+01 2.500E-01 6.000E-01 4.877E-02 4.877E-02 4.877E-02 7.9760E-01 7.976010E-01 4 8.333E-01 2.483E+01 5.000E-01 6.000E-01 2.470E-02 2.470E-02 2.470E-02 6.3617E-01 6.361673E-01 5 1.667E+00 2.567E+01 1.000E+00 6.000E-01 1.243E-02 1.243E-02 1.243E-02 4.0471E-01 4.047087E-01 6 2.500E+00 2.650E+01 1.500E+00 6.000E-01 8.302E-03 8.302E-03 8.302E-03 2.5746E-01 2.574624E-01 7 3.333E+00 2.733E+01 2.000E+00 6.000E-01 6.233E-03 6.233E-03 6.233E-03 1.6379E-01 1.637891E-01 8 5.000E+00 2.900E+01 3.000E+00 6.000E-01 4.160E-03 4.160E-03 4.160E-03 6.6287E-02 6.628687E-02 9 6.667E+00 3.067E+01 4.000E+00 6.000E-01 3.121E-03 3.121E-03 3.121E-03 2.6827E-02 2.682687E-02 10 8.333E+00 3.233E+01 5.000E+00 6.000E-01 2.498E-03 2.498E-03 2.498E-03 1.0857E-02 1.085707E-02 11 1.000E+01 3.400E+01 6.000E+00 6.000E-01 2.082E-03 2.082E-03 2.082E-03 4.3939E-03 4.393948E-03 12 1.167E+01 3.567E+01 7.000E+00 6.000E-01 1.785E-03 1.785E-03 1.785E-03 1.7783E-03 1.778269E-03 13 1.333E+01 3.733E+01 8.000E+00 6.000E-01 1.562E-03 1.562E-03 1.562E-03 7.1968E-04 7.196807E-04 14 1.500E+01 3.900E+01 9.000E+00 6.000E-01 1.389E-03 1.388E-03 1.389E-03 2.9126E-04 2.912610E-04 15 1.667E+01 4.067E+01 1.000E+01 6.000E-01 1.250E-03 1.250E-03 1.250E-03 1.1788E-04 1.178758E-04 16 2.083E+01 4.483E+01 1.250E+01 6.000E-01 9.999E-04 9.999E-04 9.999E-04 1.2282E-05 1.228234E-05 17 2.500E+01 4.900E+01 1.500E+01 6.000E-01 8.333E-04 8.333E-04 8.333E-04 1.2798E-06 1.279785E-06 18 2.917E+01 5.317E+01 1.750E+01 6.000E-01 7.143E-04 7.143E-04 7.143E-04 1.3335E-07 1.333501E-07 19 3.333E+01 5.733E+01 2.000E+01 6.000E-01 6.251E-04 6.250E-04 6.251E-04 1.3895E-08 1.389471E-08 20 4.167E+01 6.567E+01 2.500E+01 6.000E-01 5.001E-04 5.001E-04 5.001E-04 1.5086E-10 1.508558E-10 21 5.000E+01 7.400E+01 3.000E+01 6.000E-01 4.168E-04 4.167E-04 4.168E-04 1.6379E-12 1.637851E-12 22 5.833E+01 8.233E+01 3.500E+01 6.000E-01 3.572E-04 3.572E-04 3.572E-04 1.7782E-14 1.778225E-14 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 24 8.333E-04 2.400E+01 1.000E-01 1.200E+02 9.739E-01 9.739E-01 9.739E-01 9.1350E-01 9.134950E-01 25 2.083E-03 2.400E+01 2.500E-01 1.200E+02 9.366E-01 9.366E-01 9.365E-01 7.9750E-01 7.975041E-01 26 4.167E-03 2.400E+01 5.000E-01 1.200E+02 8.790E-01 8.790E-01 8.790E-01 6.3587E-01 6.358699E-01 27 8.333E-03 2.401E+01 1.000E+00 1.200E+02 7.792E-01 7.792E-01 7.791E-01 4.0403E-01 4.040301E-01 28 1.250E-02 2.401E+01 1.500E+00 1.200E+02 6.962E-01 6.962E-01 6.961E-01 2.5659E-01 2.565918E-01 29 1.667E-02 2.402E+01 2.000E+00 1.200E+02 6.266E-01 6.266E-01 6.264E-01 1.6290E-01 1.629021E-01 30 2.500E-02 2.402E+01 3.000E+00 1.200E+02 5.177E-01 5.177E-01 5.176E-01 6.5620E-02 6.561980E-02 31 3.333E-02 2.403E+01 4.000E+00 1.200E+02 4.378E-01 4.378E-01 4.376E-01 2.6422E-02 2.642174E-02 32 4.167E-02 2.404E+01 5.000E+00 1.200E+02 3.774E-01 3.774E-01 3.772E-01 1.0637E-02 1.063668E-02 33 5.000E-02 2.405E+01 6.000E+00 1.200E+02 3.307E-01 3.307E-01 3.305E-01 4.2816E-03 4.281680E-03 34 5.833E-02 2.406E+01 7.000E+00 1.200E+02 2.937E-01 2.937E-01 2.936E-01 1.7235E-03 1.723478E-03 35 6.667E-02 2.407E+01 8.000E+00 1.200E+02 2.638E-01 2.638E-01 2.637E-01 6.9372E-04 6.937291E-04 36 7.500E-02 2.407E+01 9.000E+00 1.200E+02 2.393E-01 2.393E-01 2.392E-01 2.7923E-04 2.792356E-04 37 8.333E-02 2.408E+01 1.000E+01 1.200E+02 2.188E-01 2.188E-01 2.187E-01 1.1239E-04 1.123958E-04 38 1.042E-01 2.410E+01 1.250E+01 1.200E+02 1.801E-01 1.801E-01 1.800E-01 1.1553E-05 1.155304E-05 39 1.250E-01 2.412E+01 1.500E+01 1.200E+02 1.528E-01 1.528E-01 1.528E-01 1.1875E-06 1.187522E-06 40 1.458E-01 2.415E+01 1.750E+01 1.200E+02 1.327E-01 1.327E-01 1.326E-01 1.2206E-07 1.220638E-07 41 1.667E-01 2.417E+01 2.000E+01 1.200E+02 1.172E-01 1.172E-01 1.172E-01 1.2546E-08 1.254678E-08 42 2.083E-01 2.421E+01 2.500E+01 1.200E+02 9.504E-02 9.503E-02 9.499E-02 1.3255E-10 1.325632E-10 43 2.500E-01 2.425E+01 3.000E+01 1.200E+02 7.989E-02 7.989E-02 7.985E-02 1.4005E-12 1.400598E-12 44 2.917E-01 2.429E+01 3.500E+01 1.200E+02 6.891E-02 6.890E-02 6.887E-02 1.4797E-14 1.479804E-14 ----------------------------------------------------------------------------------------------------------------- GL=[2*[x+exp(-x)-1]/(x*x), where x = {lamda}*{irradiation time} and GEFF=-(alpha+LOG(SF)/dose)/(beta*dose). In the formula for GEFF, SF is surviving fraction as computed using the TLK model. The effects of lethal residual damage are included in the GEFF dose protraction factor but not GL1 or GL2. The estimates of the surviving fraction are SF1 = EXP{-dose*[alpha+(gl1*beta1+gl2*beta2)*dose]} and SF2 = EXP{-dose*(alpha+geff*beta*dose)}. QECK TABLE: Tumor control probability (TCP) estimates as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. The *MAX* estimate is recommended (the other TCP estimates are mainly included in the table for diagnostic purposes). ===================================================================================================================== TSIM DOSE ---- EXPECTED NUMBER OF CELLS ---- ------ TUMOR CONTROL PROBABILITY (TCP) ------- SIM ID (day) (Gy) N(0)*S(D) N(t)*S(D) NSC(t) N(0)*S(D) N(t)*S(D) NSC(t) *MAX* --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 2 1.007E+00 1.000E-01 9.1351E-01 9.1351E-01 9.1351E-01 4.0111E-01 4.0111E-01 4.0111E-01 4.0111E-01 3 1.017E+00 2.500E-01 7.9760E-01 7.9760E-01 7.9760E-01 4.5041E-01 4.5041E-01 4.5041E-01 4.5041E-01 4 1.035E+00 5.000E-01 6.3617E-01 6.3617E-01 6.3617E-01 5.2932E-01 5.2932E-01 5.2932E-01 5.2932E-01 5 1.069E+00 1.000E+00 4.0471E-01 4.0471E-01 4.0471E-01 6.6717E-01 6.6717E-01 6.6717E-01 6.6717E-01 6 1.104E+00 1.500E+00 2.5746E-01 2.5746E-01 2.5746E-01 7.7301E-01 7.7301E-01 7.7301E-01 7.7301E-01 7 1.139E+00 2.000E+00 1.6379E-01 1.6379E-01 1.6379E-01 8.4892E-01 8.4892E-01 8.4892E-01 8.4892E-01 8 1.208E+00 3.000E+00 6.6287E-02 6.6287E-02 6.6287E-02 9.3586E-01 9.3586E-01 9.3586E-01 9.3586E-01 9 1.278E+00 4.000E+00 2.6827E-02 2.6827E-02 2.6827E-02 9.7353E-01 9.7353E-01 9.7353E-01 9.7353E-01 10 1.347E+00 5.000E+00 1.0857E-02 1.0857E-02 1.0857E-02 9.8920E-01 9.8920E-01 9.8920E-01 9.8920E-01 11 1.417E+00 6.000E+00 4.3939E-03 4.3939E-03 4.3939E-03 9.9562E-01 9.9562E-01 9.9562E-01 9.9562E-01 12 1.486E+00 7.000E+00 1.7783E-03 1.7783E-03 1.7783E-03 9.9822E-01 9.9822E-01 9.9822E-01 9.9822E-01 13 1.556E+00 8.000E+00 7.1968E-04 7.1968E-04 7.1968E-04 9.9928E-01 9.9928E-01 9.9928E-01 9.9928E-01 14 1.625E+00 9.000E+00 2.9126E-04 2.9126E-04 2.9126E-04 9.9971E-01 9.9971E-01 9.9971E-01 9.9971E-01 15 1.694E+00 1.000E+01 1.1788E-04 1.1788E-04 1.1788E-04 9.9988E-01 9.9988E-01 9.9988E-01 9.9988E-01 16 1.868E+00 1.250E+01 1.2282E-05 1.2282E-05 1.2282E-05 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 17 2.042E+00 1.500E+01 1.2798E-06 1.2798E-06 1.2798E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 18 2.215E+00 1.750E+01 1.3335E-07 1.3335E-07 1.3335E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 19 2.389E+00 2.000E+01 1.3895E-08 1.3895E-08 1.3895E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 20 2.736E+00 2.500E+01 1.5086E-10 1.5086E-10 1.5086E-10 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 21 3.083E+00 3.000E+01 1.6379E-12 1.6379E-12 1.6379E-12 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 22 3.431E+00 3.500E+01 1.7782E-14 1.7782E-14 1.7782E-14 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 23 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 24 1.000E+00 1.000E-01 9.1350E-01 9.1350E-01 9.1350E-01 4.0112E-01 4.0112E-01 4.0112E-01 4.0112E-01 25 1.000E+00 2.500E-01 7.9750E-01 7.9750E-01 7.9750E-01 4.5045E-01 4.5045E-01 4.5045E-01 4.5045E-01 26 1.000E+00 5.000E-01 6.3587E-01 6.3587E-01 6.3587E-01 5.2947E-01 5.2947E-01 5.2947E-01 5.2947E-01 27 1.000E+00 1.000E+00 4.0403E-01 4.0403E-01 4.0403E-01 6.6762E-01 6.6762E-01 6.6762E-01 6.6762E-01 28 1.001E+00 1.500E+00 2.5659E-01 2.5659E-01 2.5659E-01 7.7368E-01 7.7368E-01 7.7368E-01 7.7368E-01 29 1.001E+00 2.000E+00 1.6290E-01 1.6290E-01 1.6290E-01 8.4967E-01 8.4967E-01 8.4967E-01 8.4967E-01 30 1.001E+00 3.000E+00 6.5620E-02 6.5620E-02 6.5620E-02 9.3649E-01 9.3649E-01 9.3649E-01 9.3649E-01 31 1.001E+00 4.000E+00 2.6422E-02 2.6422E-02 2.6422E-02 9.7392E-01 9.7392E-01 9.7392E-01 9.7392E-01 32 1.002E+00 5.000E+00 1.0637E-02 1.0637E-02 1.0637E-02 9.8942E-01 9.8942E-01 9.8942E-01 9.8942E-01 33 1.002E+00 6.000E+00 4.2817E-03 4.2817E-03 4.2817E-03 9.9573E-01 9.9573E-01 9.9573E-01 9.9573E-01 34 1.002E+00 7.000E+00 1.7235E-03 1.7235E-03 1.7235E-03 9.9828E-01 9.9828E-01 9.9828E-01 9.9828E-01 35 1.003E+00 8.000E+00 6.9373E-04 6.9373E-04 6.9373E-04 9.9931E-01 9.9931E-01 9.9931E-01 9.9931E-01 36 1.003E+00 9.000E+00 2.7924E-04 2.7924E-04 2.7924E-04 9.9972E-01 9.9972E-01 9.9972E-01 9.9972E-01 37 1.003E+00 1.000E+01 1.1240E-04 1.1240E-04 1.1240E-04 9.9989E-01 9.9989E-01 9.9989E-01 9.9989E-01 38 1.004E+00 1.250E+01 1.1553E-05 1.1553E-05 1.1553E-05 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 39 1.005E+00 1.500E+01 1.1875E-06 1.1875E-06 1.1875E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 40 1.006E+00 1.750E+01 1.2206E-07 1.2206E-07 1.2206E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 41 1.007E+00 2.000E+01 1.2547E-08 1.2547E-08 1.2547E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 42 1.009E+00 2.500E+01 1.3256E-10 1.3256E-10 1.3256E-10 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 43 1.010E+00 3.000E+01 1.4006E-12 1.4006E-12 1.4006E-12 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 44 1.012E+00 3.500E+01 1.4798E-14 1.4798E-14 1.4798E-14 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 --------------------------------------------------------------------------------------------------------------------- NOTE: TCP={probability no cells survive}=EXP{-(expected number of surviving cells)}. TCP estimates are based on the expected number of surviving cells with and without corrections for repopulation effects. The *MAX* TCP is the peak (all time points after irradiation) estimate derived from NSC(t). RADX EXPOSURE SUMMARY ============================================================================== SCENARIO ----- DURATION ----- ------ DOSE (Gy) ----- -- DOSE RATE (Gy/h) -- NUMBER hours days Background Total Background Total* ------------------------------------------------------------------------------ 1 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 2 1.667E-01 6.944E-03 0.0000E+00 1.0000E-01 0.0000E+00 6.0000E-01 3 4.167E-01 1.736E-02 0.0000E+00 2.5000E-01 0.0000E+00 6.0000E-01 4 8.333E-01 3.472E-02 0.0000E+00 5.0000E-01 0.0000E+00 6.0000E-01 5 1.667E+00 6.944E-02 0.0000E+00 1.0000E+00 0.0000E+00 6.0000E-01 6 2.500E+00 1.042E-01 0.0000E+00 1.5000E+00 0.0000E+00 6.0000E-01 7 3.333E+00 1.389E-01 0.0000E+00 2.0000E+00 0.0000E+00 6.0000E-01 8 5.000E+00 2.083E-01 0.0000E+00 3.0000E+00 0.0000E+00 6.0000E-01 9 6.667E+00 2.778E-01 0.0000E+00 4.0000E+00 0.0000E+00 6.0000E-01 10 8.333E+00 3.472E-01 0.0000E+00 5.0000E+00 0.0000E+00 6.0000E-01 11 1.000E+01 4.167E-01 0.0000E+00 6.0000E+00 0.0000E+00 6.0000E-01 12 1.167E+01 4.861E-01 0.0000E+00 7.0000E+00 0.0000E+00 6.0000E-01 13 1.333E+01 5.556E-01 0.0000E+00 8.0000E+00 0.0000E+00 6.0000E-01 14 1.500E+01 6.250E-01 0.0000E+00 9.0000E+00 0.0000E+00 6.0000E-01 15 1.667E+01 6.944E-01 0.0000E+00 1.0000E+01 0.0000E+00 6.0000E-01 16 2.083E+01 8.681E-01 0.0000E+00 1.2500E+01 0.0000E+00 6.0000E-01 17 2.500E+01 1.042E+00 0.0000E+00 1.5000E+01 0.0000E+00 6.0000E-01 18 2.917E+01 1.215E+00 0.0000E+00 1.7500E+01 0.0000E+00 6.0000E-01 19 3.333E+01 1.389E+00 0.0000E+00 2.0000E+01 0.0000E+00 6.0000E-01 20 4.167E+01 1.736E+00 0.0000E+00 2.5000E+01 0.0000E+00 6.0000E-01 21 5.000E+01 2.083E+00 0.0000E+00 3.0000E+01 0.0000E+00 6.0000E-01 22 5.833E+01 2.431E+00 0.0000E+00 3.5000E+01 0.0000E+00 6.0000E-01 23 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 24 8.333E-04 3.472E-05 0.0000E+00 1.0000E-01 0.0000E+00 1.2000E+02 25 2.083E-03 8.681E-05 0.0000E+00 2.5000E-01 0.0000E+00 1.2000E+02 26 4.167E-03 1.736E-04 0.0000E+00 5.0000E-01 0.0000E+00 1.2000E+02 27 8.333E-03 3.472E-04 0.0000E+00 1.0000E+00 0.0000E+00 1.2000E+02 28 1.250E-02 5.208E-04 0.0000E+00 1.5000E+00 0.0000E+00 1.2000E+02 29 1.667E-02 6.944E-04 0.0000E+00 2.0000E+00 0.0000E+00 1.2000E+02 30 2.500E-02 1.042E-03 0.0000E+00 3.0000E+00 0.0000E+00 1.2000E+02 31 3.333E-02 1.389E-03 0.0000E+00 4.0000E+00 0.0000E+00 1.2000E+02 32 4.167E-02 1.736E-03 0.0000E+00 5.0000E+00 0.0000E+00 1.2000E+02 33 5.000E-02 2.083E-03 0.0000E+00 6.0000E+00 0.0000E+00 1.2000E+02 34 5.833E-02 2.431E-03 0.0000E+00 7.0000E+00 0.0000E+00 1.2000E+02 35 6.667E-02 2.778E-03 0.0000E+00 8.0000E+00 0.0000E+00 1.2000E+02 36 7.500E-02 3.125E-03 0.0000E+00 9.0000E+00 0.0000E+00 1.2000E+02 37 8.333E-02 3.472E-03 0.0000E+00 1.0000E+01 0.0000E+00 1.2000E+02 38 1.042E-01 4.340E-03 0.0000E+00 1.2500E+01 0.0000E+00 1.2000E+02 39 1.250E-01 5.208E-03 0.0000E+00 1.5000E+01 0.0000E+00 1.2000E+02 40 1.458E-01 6.076E-03 0.0000E+00 1.7500E+01 0.0000E+00 1.2000E+02 41 1.667E-01 6.944E-03 0.0000E+00 2.0000E+01 0.0000E+00 1.2000E+02 42 2.083E-01 8.681E-03 0.0000E+00 2.5000E+01 0.0000E+00 1.2000E+02 43 2.500E-01 1.042E-02 0.0000E+00 3.0000E+01 0.0000E+00 1.2000E+02 44 2.917E-01 1.215E-02 0.0000E+00 3.5000E+01 0.0000E+00 1.2000E+02 ------------------------------------------------------------------------------ * Dose rate is the delivered dose divided by the duration of the exposure scenario. Total VC execution time (min): 6.25000E-03 VC 2.00I 15-JUL-2003 02-AUG-2003 09:14:58 PM