VC 2.00I 15-JUL-2003 02-AUG-2003 08:54:28 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: u:\usr\bin\vc.exe u:\archive\ncih69\lpl\ncih69.inp FNI: U:\archive\ncih69\lpl\ncih69.inp FNO: U:\archive\ncih69\lpl\ncih69.out RADX: U:\archive\ncih69\lpl\ncih69.radx (44 exposures) -------------------------------------------------------------------------------- QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- LPLM TABLE: Summary of LPL parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) DSB = 0.00000E+00 0.00000E+00 0.00000E+00 RADIATION DAMAGE: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) DSB = 2.29691E-11 1.41168E-02 80.000000 FL = 2.59691E-13 1.59606E-04 0.904488 DAMAGE REPAIR/MISREPAIR: A0= 9.500000E-01 (=95.000%) (1-A0)= 5.000000E-02 (=5.000%) RHT= 0.007139 h (=0.43 minute) LAM= 9.7097429E+01 (1/h) BMR= 2.7500000E-04 (1/h) LAM/BMR= 3.5308156E+05 GAM= 0.250 ***** EQUIVALENT LQ MODEL PARAMETERS ***** alpha = 0.904488 (1/Gy) beta = 0.002266 (1/Gy^2) alpha/beta = 399.197395 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg DFAR TABLE: Cell survival as a function of dose and dose rate (FRDL=100.0%). ====================================================================================================== --- Duration (h) --- Dose Dose Rate ---- LETHAL DAMAGE PER CELL ---- SIM ID Exposure Sim (Gy) (Gy/h) Mutations Residual Total SF(dose) ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 2 1.667E-01 2.417E+01 1.000E-01 6.000E-01 2.627E-06 9.045E-02 9.0451E-02 9.135187E-01 3 4.167E-01 2.442E+01 2.500E-01 6.000E-01 6.827E-06 2.261E-01 2.2613E-01 7.976154E-01 4 8.333E-01 2.483E+01 5.000E-01 6.000E-01 1.383E-05 4.522E-01 4.5226E-01 6.361902E-01 5 1.667E+00 2.567E+01 1.000E+00 6.000E-01 2.783E-05 9.045E-01 9.0452E-01 4.047379E-01 6 2.500E+00 2.650E+01 1.500E+00 6.000E-01 4.183E-05 1.357E+00 1.3568E+00 2.574903E-01 7 3.333E+00 2.733E+01 2.000E+00 6.000E-01 5.583E-05 1.809E+00 1.8090E+00 1.638128E-01 8 5.000E+00 2.900E+01 3.000E+00 6.000E-01 8.383E-05 2.713E+00 2.7135E+00 6.630123E-02 9 6.667E+00 3.067E+01 4.000E+00 6.000E-01 1.118E-04 3.618E+00 3.6181E+00 2.683462E-02 10 8.333E+00 3.233E+01 5.000E+00 6.000E-01 1.398E-04 4.522E+00 4.5226E+00 1.086099E-02 11 1.000E+01 3.400E+01 6.000E+00 6.000E-01 1.678E-04 5.427E+00 5.4271E+00 4.395852E-03 12 1.167E+01 3.567E+01 7.000E+00 6.000E-01 1.958E-04 6.331E+00 6.3316E+00 1.779168E-03 13 1.333E+01 3.733E+01 8.000E+00 6.000E-01 2.238E-04 7.236E+00 7.2361E+00 7.200966E-04 14 1.500E+01 3.900E+01 9.000E+00 6.000E-01 2.518E-04 8.140E+00 8.1406E+00 2.914504E-04 15 1.667E+01 4.067E+01 1.000E+01 6.000E-01 2.798E-04 9.045E+00 9.0452E+00 1.179610E-04 16 2.083E+01 4.483E+01 1.250E+01 6.000E-01 3.499E-04 1.131E+01 1.1306E+01 1.229343E-05 17 2.500E+01 4.900E+01 1.500E+01 6.000E-01 4.199E-04 1.357E+01 1.3568E+01 1.281172E-06 18 2.917E+01 5.317E+01 1.750E+01 6.000E-01 4.899E-04 1.583E+01 1.5829E+01 1.335187E-07 19 3.333E+01 5.733E+01 2.000E+01 6.000E-01 5.599E-04 1.809E+01 1.8090E+01 1.391479E-08 20 4.167E+01 6.567E+01 2.500E+01 6.000E-01 6.999E-04 2.261E+01 2.2613E+01 1.511284E-10 21 5.000E+01 7.400E+01 3.000E+01 6.000E-01 8.399E-04 2.713E+01 2.7135E+01 1.641403E-12 22 5.833E+01 8.233E+01 3.500E+01 6.000E-01 9.799E-04 3.166E+01 3.1658E+01 1.782725E-14 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 24 8.333E-04 2.400E+01 1.000E-01 1.200E+02 2.206E-05 9.045E-02 9.0471E-02 9.135010E-01 25 2.083E-03 2.400E+01 2.500E-01 1.200E+02 1.325E-04 2.261E-01 2.2625E-01 7.975152E-01 26 4.167E-03 2.400E+01 5.000E-01 1.200E+02 4.972E-04 4.522E-01 4.5274E-01 6.358828E-01 27 8.333E-03 2.401E+01 1.000E+00 1.200E+02 1.760E-03 9.045E-01 9.0625E-01 4.040373E-01 28 1.250E-02 2.401E+01 1.500E+00 1.200E+02 3.535E-03 1.357E+00 1.3603E+00 2.565924E-01 29 1.667E-02 2.402E+01 2.000E+00 1.200E+02 5.650E-03 1.809E+00 1.8146E+00 1.628989E-01 30 2.500E-02 2.402E+01 3.000E+00 1.200E+02 1.049E-02 2.713E+00 2.7240E+00 6.561503E-02 31 3.333E-02 2.403E+01 4.000E+00 1.200E+02 1.575E-02 3.618E+00 3.6337E+00 2.641833E-02 32 4.167E-02 2.404E+01 5.000E+00 1.200E+02 2.119E-02 4.522E+00 4.5436E+00 1.063471E-02 33 5.000E-02 2.405E+01 6.000E+00 1.200E+02 2.672E-02 5.427E+00 5.4536E+00 4.280653E-03 34 5.833E-02 2.406E+01 7.000E+00 1.200E+02 3.229E-02 6.331E+00 6.3637E+00 1.722972E-03 35 6.667E-02 2.407E+01 8.000E+00 1.200E+02 3.788E-02 7.236E+00 7.2738E+00 6.934881E-04 36 7.500E-02 2.407E+01 9.000E+00 1.200E+02 4.347E-02 8.140E+00 8.1839E+00 2.791237E-04 37 8.333E-02 2.408E+01 1.000E+01 1.200E+02 4.906E-02 9.045E+00 9.0939E+00 1.123448E-04 38 1.042E-01 2.410E+01 1.250E+01 1.200E+02 6.305E-02 1.131E+01 1.1369E+01 1.154627E-05 39 1.250E-01 2.412E+01 1.500E+01 1.200E+02 7.705E-02 1.357E+01 1.3644E+01 1.186669E-06 40 1.458E-01 2.415E+01 1.750E+01 1.200E+02 9.104E-02 1.583E+01 1.5920E+01 1.219600E-07 41 1.667E-01 2.417E+01 2.000E+01 1.200E+02 1.050E-01 1.809E+01 1.8195E+01 1.253445E-08 42 2.083E-01 2.421E+01 2.500E+01 1.200E+02 1.330E-01 2.261E+01 2.2745E+01 1.323979E-10 43 2.500E-01 2.425E+01 3.000E+01 1.200E+02 1.610E-01 2.713E+01 2.7296E+01 1.398481E-12 44 2.917E-01 2.429E+01 3.500E+01 1.200E+02 1.890E-01 3.166E+01 3.1846E+01 1.477176E-14 ------------------------------------------------------------------------------------------------------ NOTE: SF=EXP{-(lethal residual damage + lethal mutations)}. QECK TABLE: Cell survival, corrected for repopulation effects, as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. ===================================================================================================================== TSIM DOSE DOSE RATE - SURVIVING FRACTION - --------- EXPECTED NUMBER OF CELLS ----------- SIM ID (day) (Gy) (Gy/h) no repop repop N(t)/N(0) N(0)*S(D) N(t)*S(D) NSC(t) --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 2 1.007E+00 1.000E-01 6.000E-01 9.1352E-01 9.1352E-01 1.0000E+00 9.1352E-01 9.1352E-01 9.1352E-01 3 1.017E+00 2.500E-01 6.000E-01 7.9762E-01 7.9762E-01 1.0000E+00 7.9762E-01 7.9762E-01 7.9762E-01 4 1.035E+00 5.000E-01 6.000E-01 6.3619E-01 6.3619E-01 1.0000E+00 6.3619E-01 6.3619E-01 6.3619E-01 5 1.069E+00 1.000E+00 6.000E-01 4.0474E-01 4.0474E-01 1.0000E+00 4.0474E-01 4.0474E-01 4.0474E-01 6 1.104E+00 1.500E+00 6.000E-01 2.5749E-01 2.5749E-01 1.0000E+00 2.5749E-01 2.5749E-01 2.5749E-01 7 1.139E+00 2.000E+00 6.000E-01 1.6381E-01 1.6381E-01 1.0000E+00 1.6381E-01 1.6381E-01 1.6381E-01 8 1.208E+00 3.000E+00 6.000E-01 6.6301E-02 6.6301E-02 1.0000E+00 6.6301E-02 6.6301E-02 6.6301E-02 9 1.278E+00 4.000E+00 6.000E-01 2.6835E-02 2.6835E-02 1.0000E+00 2.6835E-02 2.6835E-02 2.6835E-02 10 1.347E+00 5.000E+00 6.000E-01 1.0861E-02 1.0861E-02 1.0000E+00 1.0861E-02 1.0861E-02 1.0861E-02 11 1.417E+00 6.000E+00 6.000E-01 4.3959E-03 4.3959E-03 1.0000E+00 4.3959E-03 4.3959E-03 4.3959E-03 12 1.486E+00 7.000E+00 6.000E-01 1.7792E-03 1.7792E-03 1.0000E+00 1.7792E-03 1.7792E-03 1.7792E-03 13 1.556E+00 8.000E+00 6.000E-01 7.2010E-04 7.2010E-04 1.0000E+00 7.2010E-04 7.2010E-04 7.2010E-04 14 1.625E+00 9.000E+00 6.000E-01 2.9145E-04 2.9145E-04 1.0000E+00 2.9145E-04 2.9145E-04 2.9145E-04 15 1.694E+00 1.000E+01 6.000E-01 1.1796E-04 1.1796E-04 1.0000E+00 1.1796E-04 1.1796E-04 1.1796E-04 16 1.868E+00 1.250E+01 6.000E-01 1.2293E-05 1.2293E-05 1.0000E+00 1.2293E-05 1.2293E-05 1.2293E-05 17 2.042E+00 1.500E+01 6.000E-01 1.2812E-06 1.2812E-06 1.0000E+00 1.2812E-06 1.2812E-06 1.2812E-06 18 2.215E+00 1.750E+01 6.000E-01 1.3352E-07 1.3352E-07 1.0000E+00 1.3352E-07 1.3352E-07 1.3352E-07 19 2.389E+00 2.000E+01 6.000E-01 1.3915E-08 1.3915E-08 1.0000E+00 1.3915E-08 1.3915E-08 1.3915E-08 20 2.736E+00 2.500E+01 6.000E-01 1.5113E-10 1.5113E-10 1.0000E+00 1.5113E-10 1.5113E-10 1.5113E-10 21 3.083E+00 3.000E+01 6.000E-01 1.6414E-12 1.6414E-12 1.0000E+00 1.6414E-12 1.6414E-12 1.6414E-12 22 3.431E+00 3.500E+01 6.000E-01 1.7827E-14 1.7827E-14 1.0000E+00 1.7827E-14 1.7827E-14 1.7827E-14 23 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 24 1.000E+00 1.000E-01 1.200E+02 9.1350E-01 9.1350E-01 1.0000E+00 9.1350E-01 9.1350E-01 9.1350E-01 25 1.000E+00 2.500E-01 1.200E+02 7.9752E-01 7.9752E-01 1.0000E+00 7.9752E-01 7.9752E-01 7.9752E-01 26 1.000E+00 5.000E-01 1.200E+02 6.3588E-01 6.3588E-01 1.0000E+00 6.3588E-01 6.3588E-01 6.3588E-01 27 1.000E+00 1.000E+00 1.200E+02 4.0404E-01 4.0404E-01 1.0000E+00 4.0404E-01 4.0404E-01 4.0404E-01 28 1.001E+00 1.500E+00 1.200E+02 2.5659E-01 2.5659E-01 1.0000E+00 2.5659E-01 2.5659E-01 2.5659E-01 29 1.001E+00 2.000E+00 1.200E+02 1.6290E-01 1.6290E-01 1.0000E+00 1.6290E-01 1.6290E-01 1.6290E-01 30 1.001E+00 3.000E+00 1.200E+02 6.5615E-02 6.5615E-02 1.0000E+00 6.5615E-02 6.5615E-02 6.5615E-02 31 1.001E+00 4.000E+00 1.200E+02 2.6418E-02 2.6418E-02 1.0000E+00 2.6418E-02 2.6418E-02 2.6418E-02 32 1.002E+00 5.000E+00 1.200E+02 1.0635E-02 1.0635E-02 1.0000E+00 1.0635E-02 1.0635E-02 1.0635E-02 33 1.002E+00 6.000E+00 1.200E+02 4.2807E-03 4.2807E-03 1.0000E+00 4.2807E-03 4.2807E-03 4.2807E-03 34 1.002E+00 7.000E+00 1.200E+02 1.7230E-03 1.7230E-03 1.0000E+00 1.7230E-03 1.7230E-03 1.7230E-03 35 1.003E+00 8.000E+00 1.200E+02 6.9349E-04 6.9349E-04 1.0000E+00 6.9349E-04 6.9349E-04 6.9349E-04 36 1.003E+00 9.000E+00 1.200E+02 2.7912E-04 2.7912E-04 1.0000E+00 2.7912E-04 2.7912E-04 2.7912E-04 37 1.003E+00 1.000E+01 1.200E+02 1.1234E-04 1.1234E-04 1.0000E+00 1.1234E-04 1.1234E-04 1.1234E-04 38 1.004E+00 1.250E+01 1.200E+02 1.1546E-05 1.1546E-05 1.0000E+00 1.1546E-05 1.1546E-05 1.1546E-05 39 1.005E+00 1.500E+01 1.200E+02 1.1867E-06 1.1867E-06 1.0000E+00 1.1867E-06 1.1867E-06 1.1867E-06 40 1.006E+00 1.750E+01 1.200E+02 1.2196E-07 1.2196E-07 1.0000E+00 1.2196E-07 1.2196E-07 1.2196E-07 41 1.007E+00 2.000E+01 1.200E+02 1.2534E-08 1.2534E-08 1.0000E+00 1.2534E-08 1.2534E-08 1.2534E-08 42 1.009E+00 2.500E+01 1.200E+02 1.3240E-10 1.3240E-10 1.0000E+00 1.3240E-10 1.3240E-10 1.3240E-10 43 1.010E+00 3.000E+01 1.200E+02 1.3985E-12 1.3985E-12 1.0000E+00 1.3985E-12 1.3985E-12 1.3985E-12 44 1.012E+00 3.500E+01 1.200E+02 1.4772E-14 1.4772E-14 1.0000E+00 1.4772E-14 1.4772E-14 1.4772E-14 --------------------------------------------------------------------------------------------------------------------- NOTE: N(0) is the initial number of cells (time=0 day), N(t) is the expected number of unirradiated (control) cells at TSIM, i.e., N(t)=N(0)*EXP[LN(2)*TSIM/TPOT]. The surviving fraction S(D) is the expected number of cells, per irradiated cell, that has not sustained lethal DNA damage (no corrections for repopulation effects). NSC(t) is the expected number of cells that survive irradiation, including repopulation effects (recommended method). The product N(t)*S(D) is an alternate method of estimating the surviving fraction with repopulation effects. DFAR TABLE: Mutagenesis and the induction of enhanced genetic instability (GI). Key GI model parameters are: (1-FRDL)=0.0%, NCM=1, NCG=1, and NCG*PGH*PGA=4.250E-06. ====================================================================================================== Dose Dose Rate -- NON-LETHAL MUTATIONS PER CELL -- **** PROBABILITY PER CELL **** SIM ID (Gy) (Gy/h) Mutations Residual Total AGF EGI EGI/SF ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 2 1.000E-01 6.000E-01 4.000E-01 0.00E+00 4.00007E-01 1.553E-06 1.553E-06 1.700E-06 3 2.500E-01 6.000E-01 1.000E+00 0.00E+00 1.00002E+00 3.390E-06 3.390E-06 4.250E-06 4 5.000E-01 6.000E-01 2.000E+00 0.00E+00 2.00004E+00 5.408E-06 5.408E-06 8.500E-06 5 1.000E+00 6.000E-01 4.000E+00 0.00E+00 4.00008E+00 6.881E-06 6.881E-06 1.700E-05 6 1.500E+00 6.000E-01 6.000E+00 0.00E+00 6.00012E+00 6.566E-06 6.566E-06 2.550E-05 7 2.000E+00 6.000E-01 8.000E+00 0.00E+00 8.00016E+00 5.570E-06 5.570E-06 3.400E-05 8 3.000E+00 6.000E-01 1.200E+01 0.00E+00 1.20002E+01 3.381E-06 3.381E-06 5.100E-05 9 4.000E+00 6.000E-01 1.600E+01 0.00E+00 1.60003E+01 1.825E-06 1.825E-06 6.800E-05 10 5.000E+00 6.000E-01 2.000E+01 0.00E+00 2.00004E+01 9.232E-07 9.232E-07 8.500E-05 11 6.000E+00 6.000E-01 2.400E+01 0.00E+00 2.40005E+01 4.484E-07 4.484E-07 1.020E-04 12 7.000E+00 6.000E-01 2.800E+01 0.00E+00 2.80005E+01 2.117E-07 2.117E-07 1.190E-04 13 8.000E+00 6.000E-01 3.200E+01 0.00E+00 3.20006E+01 9.793E-08 9.793E-08 1.360E-04 14 9.000E+00 6.000E-01 3.600E+01 0.00E+00 3.60007E+01 4.459E-08 4.459E-08 1.530E-04 15 1.000E+01 6.000E-01 4.000E+01 0.00E+00 4.00008E+01 2.005E-08 2.005E-08 1.700E-04 16 1.250E+01 6.000E-01 5.000E+01 0.00E+00 5.00010E+01 2.612E-09 2.612E-09 2.125E-04 17 1.500E+01 6.000E-01 6.000E+01 0.00E+00 6.00012E+01 3.267E-10 3.267E-10 2.550E-04 18 1.750E+01 6.000E-01 7.000E+01 0.00E+00 7.00014E+01 3.972E-11 3.972E-11 2.975E-04 19 2.000E+01 6.000E-01 8.000E+01 0.00E+00 8.00016E+01 4.730E-12 4.730E-12 3.399E-04 20 2.500E+01 6.000E-01 1.000E+02 0.00E+00 1.00002E+02 6.422E-14 6.422E-14 4.249E-04 21 3.000E+01 6.000E-01 1.200E+02 0.00E+00 1.20002E+02 8.369E-16 8.369E-16 5.099E-04 22 3.500E+01 6.000E-01 1.400E+02 0.00E+00 1.40003E+02 1.060E-17 1.060E-17 5.948E-04 23 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 24 1.000E-01 1.200E+02 4.001E-01 0.00E+00 4.00062E-01 1.553E-06 1.553E-06 1.700E-06 25 2.500E-01 1.200E+02 1.000E+00 0.00E+00 1.00037E+00 3.391E-06 3.391E-06 4.252E-06 26 5.000E-01 1.200E+02 2.001E+00 0.00E+00 2.00139E+00 5.409E-06 5.409E-06 8.506E-06 27 1.000E+00 1.200E+02 4.005E+00 0.00E+00 4.00493E+00 6.877E-06 6.877E-06 1.702E-05 28 1.500E+00 1.200E+02 6.010E+00 0.00E+00 6.00990E+00 6.554E-06 6.554E-06 2.554E-05 29 2.000E+00 1.200E+02 8.016E+00 0.00E+00 8.01582E+00 5.549E-06 5.549E-06 3.407E-05 30 3.000E+00 1.200E+02 1.203E+01 0.00E+00 1.20294E+01 3.354E-06 3.354E-06 5.112E-05 31 4.000E+00 1.200E+02 1.604E+01 0.00E+00 1.60441E+01 1.801E-06 1.801E-06 6.819E-05 32 5.000E+00 1.200E+02 2.006E+01 0.00E+00 2.00593E+01 9.066E-07 9.066E-07 8.525E-05 33 6.000E+00 1.200E+02 2.407E+01 0.00E+00 2.40748E+01 4.380E-07 4.380E-07 1.023E-04 34 7.000E+00 1.200E+02 2.809E+01 0.00E+00 2.80904E+01 2.057E-07 2.057E-07 1.194E-04 35 8.000E+00 1.200E+02 3.211E+01 0.00E+00 3.21061E+01 9.462E-08 9.462E-08 1.364E-04 36 9.000E+00 1.200E+02 3.612E+01 0.00E+00 3.61217E+01 4.285E-08 4.285E-08 1.535E-04 37 1.000E+01 1.200E+02 4.014E+01 0.00E+00 4.01374E+01 1.916E-08 1.916E-08 1.706E-04 38 1.250E+01 1.200E+02 5.018E+01 0.00E+00 5.01765E+01 2.462E-09 2.462E-09 2.132E-04 39 1.500E+01 1.200E+02 6.022E+01 0.00E+00 6.02157E+01 3.036E-10 3.036E-10 2.559E-04 40 1.750E+01 1.200E+02 7.025E+01 0.00E+00 7.02549E+01 3.641E-11 3.641E-11 2.985E-04 41 2.000E+01 1.200E+02 8.029E+01 0.00E+00 8.02941E+01 4.277E-12 4.277E-12 3.412E-04 42 2.500E+01 1.200E+02 1.004E+02 0.00E+00 1.00372E+02 5.647E-14 5.647E-14 4.265E-04 43 3.000E+01 1.200E+02 1.205E+02 0.00E+00 1.20451E+02 7.157E-16 7.157E-16 5.118E-04 44 3.500E+01 1.200E+02 1.405E+02 0.00E+00 1.40529E+02 8.820E-18 8.820E-18 5.971E-04 ------------------------------------------------------------------------------------------------------ AGF: function or expression of at least 1 of the 1 critical gene targets is altered. EGI: altered gene function or expression causes enhanced genetic instability. NEOM TABLE: Neoplastic transformation as a function of dose and dose rate at t=42.000 days. Parameters: TFS=1.1500E-05 (1/wk), TFU=2.0000E-03 (1/wk), NCM=1, NCG=1, and NCG*PGH*PGA=4.3E-06. ====================================================================================================== Dose Dose Rate Non-Lethal Genetic Instability *** TRANSFORMATION FREQUENCY *** SIM ID (Gy) (Gy/h) Mutations EGI EGI/SF BKG TPS TPI ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 2 1.000E-01 6.000E-01 4.000E-01 1.553E-06 1.700E-06 6.8995E-05 6.9015E-05 6.3047E-05 3 2.500E-01 6.000E-01 1.000E+00 3.390E-06 4.250E-06 6.8995E-05 6.9046E-05 5.5072E-05 4 5.000E-01 6.000E-01 2.000E+00 5.408E-06 8.500E-06 6.8995E-05 6.9096E-05 4.3958E-05 5 1.000E+00 6.000E-01 4.000E+00 6.881E-06 1.700E-05 6.8994E-05 6.9197E-05 2.8007E-05 6 1.500E+00 6.000E-01 6.000E+00 6.566E-06 2.550E-05 6.8993E-05 6.9298E-05 1.7843E-05 7 2.000E+00 6.000E-01 8.000E+00 5.570E-06 3.400E-05 6.8993E-05 6.9398E-05 1.1368E-05 8 3.000E+00 6.000E-01 1.200E+01 3.381E-06 5.100E-05 6.8992E-05 6.9600E-05 4.6146E-06 9 4.000E+00 6.000E-01 1.600E+01 1.825E-06 6.800E-05 6.8991E-05 6.9802E-05 1.8731E-06 10 5.000E+00 6.000E-01 2.000E+01 9.232E-07 8.500E-05 6.8989E-05 7.0003E-05 7.6030E-07 11 6.000E+00 6.000E-01 2.400E+01 4.484E-07 1.020E-04 6.8988E-05 7.0205E-05 3.0861E-07 12 7.000E+00 6.000E-01 2.800E+01 2.117E-07 1.190E-04 6.8987E-05 7.0406E-05 1.2526E-07 13 8.000E+00 6.000E-01 3.200E+01 9.793E-08 1.360E-04 6.8986E-05 7.0608E-05 5.0845E-08 14 9.000E+00 6.000E-01 3.600E+01 4.459E-08 1.530E-04 6.8985E-05 7.0810E-05 2.0637E-08 15 1.000E+01 6.000E-01 4.000E+01 2.005E-08 1.700E-04 6.8983E-05 7.1011E-05 8.3765E-09 16 1.250E+01 6.000E-01 5.000E+01 2.612E-09 2.125E-04 6.8981E-05 7.1515E-05 8.7917E-10 17 1.500E+01 6.000E-01 6.000E+01 3.267E-10 2.550E-04 6.8978E-05 7.2019E-05 9.2269E-11 18 1.750E+01 6.000E-01 7.000E+01 3.972E-11 2.975E-04 6.8975E-05 7.2523E-05 9.6832E-12 19 2.000E+01 6.000E-01 8.000E+01 4.730E-12 3.399E-04 6.8972E-05 7.3027E-05 1.0162E-12 20 2.500E+01 6.000E-01 1.000E+02 6.422E-14 4.249E-04 6.8966E-05 7.4034E-05 1.1189E-14 21 3.000E+01 6.000E-01 1.200E+02 8.369E-16 5.099E-04 6.8960E-05 7.5042E-05 1.2317E-16 22 3.500E+01 6.000E-01 1.400E+02 1.060E-17 5.948E-04 6.8954E-05 7.6050E-05 1.3558E-18 23 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 24 1.000E-01 1.200E+02 4.001E-01 1.553E-06 1.700E-06 6.8995E-05 6.9015E-05 6.3046E-05 25 2.500E-01 1.200E+02 1.000E+00 3.391E-06 4.252E-06 6.8995E-05 6.9046E-05 5.5065E-05 26 5.000E-01 1.200E+02 2.001E+00 5.409E-06 8.506E-06 6.8995E-05 6.9096E-05 4.3937E-05 27 1.000E+00 1.200E+02 4.005E+00 6.877E-06 1.702E-05 6.8994E-05 6.9197E-05 2.7958E-05 28 1.500E+00 1.200E+02 6.010E+00 6.554E-06 2.554E-05 6.8993E-05 6.9298E-05 1.7781E-05 29 2.000E+00 1.200E+02 8.016E+00 5.549E-06 3.407E-05 6.8993E-05 6.9399E-05 1.1305E-05 30 3.000E+00 1.200E+02 1.203E+01 3.354E-06 5.112E-05 6.8992E-05 6.9602E-05 4.5669E-06 31 4.000E+00 1.200E+02 1.604E+01 1.801E-06 6.819E-05 6.8991E-05 6.9804E-05 1.8441E-06 32 5.000E+00 1.200E+02 2.006E+01 9.066E-07 8.525E-05 6.8989E-05 7.0006E-05 7.4450E-07 33 6.000E+00 1.200E+02 2.407E+01 4.380E-07 1.023E-04 6.8988E-05 7.0209E-05 3.0054E-07 34 7.000E+00 1.200E+02 2.809E+01 2.057E-07 1.194E-04 6.8987E-05 7.0411E-05 1.2132E-07 35 8.000E+00 1.200E+02 3.211E+01 9.462E-08 1.364E-04 6.8986E-05 7.0613E-05 4.8969E-08 36 9.000E+00 1.200E+02 3.612E+01 4.285E-08 1.535E-04 6.8985E-05 7.0816E-05 1.9766E-08 37 1.000E+01 1.200E+02 4.014E+01 1.916E-08 1.706E-04 6.8983E-05 7.1018E-05 7.9785E-09 38 1.250E+01 1.200E+02 5.018E+01 2.462E-09 2.132E-04 6.8981E-05 7.1524E-05 8.2583E-10 39 1.500E+01 1.200E+02 6.022E+01 3.036E-10 2.559E-04 6.8978E-05 7.2030E-05 8.5476E-11 40 1.750E+01 1.200E+02 7.025E+01 3.641E-11 2.985E-04 6.8975E-05 7.2536E-05 8.8465E-12 41 2.000E+01 1.200E+02 8.029E+01 4.277E-12 3.412E-04 6.8972E-05 7.3042E-05 9.1554E-13 42 2.500E+01 1.200E+02 1.004E+02 5.647E-14 4.265E-04 6.8966E-05 7.4053E-05 9.8045E-15 43 3.000E+01 1.200E+02 1.205E+02 7.157E-16 5.118E-04 6.8960E-05 7.5065E-05 1.0498E-16 44 3.500E+01 1.200E+02 1.405E+02 8.820E-18 5.971E-04 6.8954E-05 7.6076E-05 1.1238E-18 ------------------------------------------------------------------------------------------------------ TPS: Transformation frequency per survivor, TPI: Transformation frequency per irradiated cell EGI: Probabilty random mutational events caused enhanced genetic instability (EGI). BKG: Background (spontaneous) cell transformation frequency LPLM TABLE: LQ model dose protraction factor(s) and cell survival estimates (FRDL=100.0%). LQ model parameters are: alpha = 0.904 (1/Gy), alpha/beta = 399.197 (Gy), lamda = 9.710E+01 (1/h). ====================================================================================================== --- Duration (h) --- Dose Dose Rate* ***** G FACTOR ***** ******* SF(dose) ******* SIM ID Exposure Sim (Gy) (Gy/h) GL GEFF SF1 SF2 ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 2 1.667E-01 2.417E+01 1.000E-01 6.000E-01 1.160E-01 1.160E-01 9.1352E-01 9.135187E-01 3 4.167E-01 2.442E+01 2.500E-01 6.000E-01 4.821E-02 4.821E-02 7.9762E-01 7.976154E-01 4 8.333E-01 2.483E+01 5.000E-01 6.000E-01 2.441E-02 2.441E-02 6.3619E-01 6.361902E-01 5 1.667E+00 2.567E+01 1.000E+00 6.000E-01 1.228E-02 1.228E-02 4.0474E-01 4.047379E-01 6 2.500E+00 2.650E+01 1.500E+00 6.000E-01 8.205E-03 8.205E-03 2.5749E-01 2.574903E-01 7 3.333E+00 2.733E+01 2.000E+00 6.000E-01 6.160E-03 6.160E-03 1.6381E-01 1.638128E-01 8 5.000E+00 2.900E+01 3.000E+00 6.000E-01 4.111E-03 4.111E-03 6.6301E-02 6.630123E-02 9 6.667E+00 3.067E+01 4.000E+00 6.000E-01 3.085E-03 3.085E-03 2.6835E-02 2.683462E-02 10 8.333E+00 3.233E+01 5.000E+00 6.000E-01 2.469E-03 2.469E-03 1.0861E-02 1.086099E-02 11 1.000E+01 3.400E+01 6.000E+00 6.000E-01 2.058E-03 2.058E-03 4.3959E-03 4.395852E-03 12 1.167E+01 3.567E+01 7.000E+00 6.000E-01 1.764E-03 1.764E-03 1.7792E-03 1.779168E-03 13 1.333E+01 3.733E+01 8.000E+00 6.000E-01 1.544E-03 1.544E-03 7.2010E-04 7.200966E-04 14 1.500E+01 3.900E+01 9.000E+00 6.000E-01 1.372E-03 1.372E-03 2.9145E-04 2.914504E-04 15 1.667E+01 4.067E+01 1.000E+01 6.000E-01 1.235E-03 1.235E-03 1.1796E-04 1.179610E-04 16 2.083E+01 4.483E+01 1.250E+01 6.000E-01 9.882E-04 9.882E-04 1.2293E-05 1.229343E-05 17 2.500E+01 4.900E+01 1.500E+01 6.000E-01 8.236E-04 8.236E-04 1.2812E-06 1.281172E-06 18 2.917E+01 5.317E+01 1.750E+01 6.000E-01 7.060E-04 7.060E-04 1.3352E-07 1.335187E-07 19 3.333E+01 5.733E+01 2.000E+01 6.000E-01 6.177E-04 6.177E-04 1.3915E-08 1.391479E-08 20 4.167E+01 6.567E+01 2.500E+01 6.000E-01 4.942E-04 4.942E-04 1.5113E-10 1.511284E-10 21 5.000E+01 7.400E+01 3.000E+01 6.000E-01 4.119E-04 4.119E-04 1.6414E-12 1.641403E-12 22 5.833E+01 8.233E+01 3.500E+01 6.000E-01 3.530E-04 3.530E-04 1.7827E-14 1.782725E-14 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 24 8.333E-04 2.400E+01 1.000E-01 1.200E+02 9.736E-01 9.736E-01 9.1350E-01 9.135010E-01 25 2.083E-03 2.400E+01 2.500E-01 1.200E+02 9.358E-01 9.358E-01 7.9752E-01 7.975152E-01 26 4.167E-03 2.400E+01 5.000E-01 1.200E+02 8.777E-01 8.777E-01 6.3588E-01 6.358828E-01 27 8.333E-03 2.401E+01 1.000E+00 1.200E+02 7.771E-01 7.770E-01 4.0404E-01 4.040373E-01 28 1.250E-02 2.401E+01 1.500E+00 1.200E+02 6.935E-01 6.934E-01 2.5659E-01 2.565924E-01 29 1.667E-02 2.402E+01 2.000E+00 1.200E+02 6.236E-01 6.234E-01 1.6290E-01 1.628989E-01 30 2.500E-02 2.402E+01 3.000E+00 1.200E+02 5.145E-01 5.143E-01 6.5615E-02 6.561503E-02 31 3.333E-02 2.403E+01 4.000E+00 1.200E+02 4.345E-01 4.344E-01 2.6418E-02 2.641833E-02 32 4.167E-02 2.404E+01 5.000E+00 1.200E+02 3.743E-01 3.741E-01 1.0635E-02 1.063471E-02 33 5.000E-02 2.405E+01 6.000E+00 1.200E+02 3.278E-01 3.276E-01 4.2806E-03 4.280653E-03 34 5.833E-02 2.406E+01 7.000E+00 1.200E+02 2.910E-01 2.909E-01 1.7229E-03 1.722972E-03 35 6.667E-02 2.407E+01 8.000E+00 1.200E+02 2.613E-01 2.612E-01 6.9348E-04 6.934881E-04 36 7.500E-02 2.407E+01 9.000E+00 1.200E+02 2.370E-01 2.368E-01 2.7912E-04 2.791237E-04 37 8.333E-02 2.408E+01 1.000E+01 1.200E+02 2.166E-01 2.165E-01 1.1234E-04 1.123448E-04 38 1.042E-01 2.410E+01 1.250E+01 1.200E+02 1.782E-01 1.781E-01 1.1546E-05 1.154627E-05 39 1.250E-01 2.412E+01 1.500E+01 1.200E+02 1.512E-01 1.511E-01 1.1866E-06 1.186669E-06 40 1.458E-01 2.415E+01 1.750E+01 1.200E+02 1.313E-01 1.312E-01 1.2195E-07 1.219600E-07 41 1.667E-01 2.417E+01 2.000E+01 1.200E+02 1.160E-01 1.159E-01 1.2534E-08 1.253445E-08 42 2.083E-01 2.421E+01 2.500E+01 1.200E+02 9.398E-02 9.393E-02 1.3239E-10 1.323979E-10 43 2.500E-01 2.425E+01 3.000E+01 1.200E+02 7.900E-02 7.895E-02 1.3984E-12 1.398481E-12 44 2.917E-01 2.429E+01 3.500E+01 1.200E+02 6.813E-02 6.809E-02 1.4770E-14 1.477176E-14 ------------------------------------------------------------------------------------------------------ GL=[2*[x+exp(-x)-1]/(x*x), where x = {lamda}*{irradiation time} and GEFF=-(alpha+LOG(SF)/D)/(beta*D). In the formula for GEFF, SF is surviving fraction as computed using the LPL model. The effects of lethal residual damage are included in the GEFF dose protraction factor but not GL. The SF estimates are: SF1=EXP{-dose*[alpha+gl*beta*dose]} and SF2=EXP{-dose*(alpha+geff*beta*dose)}. QECK TABLE: Tumor control probability (TCP) estimates as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. The *MAX* estimate is recommended (the other TCP estimates are mainly included in the table for diagnostic purposes). ===================================================================================================================== TSIM DOSE ---- EXPECTED NUMBER OF CELLS ---- ------ TUMOR CONTROL PROBABILITY (TCP) ------- SIM ID (day) (Gy) N(0)*S(D) N(t)*S(D) NSC(t) N(0)*S(D) N(t)*S(D) NSC(t) *MAX* --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 2 1.007E+00 1.000E-01 9.1352E-01 9.1352E-01 9.1352E-01 4.0111E-01 4.0111E-01 4.0111E-01 4.0111E-01 3 1.017E+00 2.500E-01 7.9762E-01 7.9762E-01 7.9762E-01 4.5040E-01 4.5040E-01 4.5040E-01 4.5040E-01 4 1.035E+00 5.000E-01 6.3619E-01 6.3619E-01 6.3619E-01 5.2931E-01 5.2931E-01 5.2931E-01 5.2931E-01 5 1.069E+00 1.000E+00 4.0474E-01 4.0474E-01 4.0474E-01 6.6715E-01 6.6715E-01 6.6715E-01 6.6715E-01 6 1.104E+00 1.500E+00 2.5749E-01 2.5749E-01 2.5749E-01 7.7299E-01 7.7299E-01 7.7299E-01 7.7299E-01 7 1.139E+00 2.000E+00 1.6381E-01 1.6381E-01 1.6381E-01 8.4890E-01 8.4890E-01 8.4890E-01 8.4890E-01 8 1.208E+00 3.000E+00 6.6301E-02 6.6301E-02 6.6301E-02 9.3585E-01 9.3585E-01 9.3585E-01 9.3585E-01 9 1.278E+00 4.000E+00 2.6835E-02 2.6835E-02 2.6835E-02 9.7352E-01 9.7352E-01 9.7352E-01 9.7352E-01 10 1.347E+00 5.000E+00 1.0861E-02 1.0861E-02 1.0861E-02 9.8920E-01 9.8920E-01 9.8920E-01 9.8920E-01 11 1.417E+00 6.000E+00 4.3959E-03 4.3959E-03 4.3959E-03 9.9561E-01 9.9561E-01 9.9561E-01 9.9561E-01 12 1.486E+00 7.000E+00 1.7792E-03 1.7792E-03 1.7792E-03 9.9822E-01 9.9822E-01 9.9822E-01 9.9822E-01 13 1.556E+00 8.000E+00 7.2010E-04 7.2010E-04 7.2010E-04 9.9928E-01 9.9928E-01 9.9928E-01 9.9928E-01 14 1.625E+00 9.000E+00 2.9145E-04 2.9145E-04 2.9145E-04 9.9971E-01 9.9971E-01 9.9971E-01 9.9971E-01 15 1.694E+00 1.000E+01 1.1796E-04 1.1796E-04 1.1796E-04 9.9988E-01 9.9988E-01 9.9988E-01 9.9988E-01 16 1.868E+00 1.250E+01 1.2293E-05 1.2293E-05 1.2293E-05 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 17 2.042E+00 1.500E+01 1.2812E-06 1.2812E-06 1.2812E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 18 2.215E+00 1.750E+01 1.3352E-07 1.3352E-07 1.3352E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 19 2.389E+00 2.000E+01 1.3915E-08 1.3915E-08 1.3915E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 20 2.736E+00 2.500E+01 1.5113E-10 1.5113E-10 1.5113E-10 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 21 3.083E+00 3.000E+01 1.6414E-12 1.6414E-12 1.6414E-12 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 22 3.431E+00 3.500E+01 1.7827E-14 1.7827E-14 1.7827E-14 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 23 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 24 1.000E+00 1.000E-01 9.1350E-01 9.1350E-01 9.1350E-01 4.0112E-01 4.0112E-01 4.0112E-01 4.0112E-01 25 1.000E+00 2.500E-01 7.9752E-01 7.9752E-01 7.9752E-01 4.5045E-01 4.5045E-01 4.5045E-01 4.5045E-01 26 1.000E+00 5.000E-01 6.3588E-01 6.3588E-01 6.3588E-01 5.2947E-01 5.2947E-01 5.2947E-01 5.2947E-01 27 1.000E+00 1.000E+00 4.0404E-01 4.0404E-01 4.0404E-01 6.6762E-01 6.6762E-01 6.6762E-01 6.6762E-01 28 1.001E+00 1.500E+00 2.5659E-01 2.5659E-01 2.5659E-01 7.7368E-01 7.7368E-01 7.7368E-01 7.7368E-01 29 1.001E+00 2.000E+00 1.6290E-01 1.6290E-01 1.6290E-01 8.4968E-01 8.4968E-01 8.4968E-01 8.4968E-01 30 1.001E+00 3.000E+00 6.5615E-02 6.5615E-02 6.5615E-02 9.3649E-01 9.3649E-01 9.3649E-01 9.3649E-01 31 1.001E+00 4.000E+00 2.6418E-02 2.6418E-02 2.6418E-02 9.7393E-01 9.7393E-01 9.7393E-01 9.7393E-01 32 1.002E+00 5.000E+00 1.0635E-02 1.0635E-02 1.0635E-02 9.8942E-01 9.8942E-01 9.8942E-01 9.8942E-01 33 1.002E+00 6.000E+00 4.2807E-03 4.2807E-03 4.2807E-03 9.9573E-01 9.9573E-01 9.9573E-01 9.9573E-01 34 1.002E+00 7.000E+00 1.7230E-03 1.7230E-03 1.7230E-03 9.9828E-01 9.9828E-01 9.9828E-01 9.9828E-01 35 1.003E+00 8.000E+00 6.9349E-04 6.9349E-04 6.9349E-04 9.9931E-01 9.9931E-01 9.9931E-01 9.9931E-01 36 1.003E+00 9.000E+00 2.7912E-04 2.7912E-04 2.7912E-04 9.9972E-01 9.9972E-01 9.9972E-01 9.9972E-01 37 1.003E+00 1.000E+01 1.1234E-04 1.1234E-04 1.1234E-04 9.9989E-01 9.9989E-01 9.9989E-01 9.9989E-01 38 1.004E+00 1.250E+01 1.1546E-05 1.1546E-05 1.1546E-05 9.9999E-01 9.9999E-01 9.9999E-01 9.9999E-01 39 1.005E+00 1.500E+01 1.1867E-06 1.1867E-06 1.1867E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 40 1.006E+00 1.750E+01 1.2196E-07 1.2196E-07 1.2196E-07 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 41 1.007E+00 2.000E+01 1.2534E-08 1.2534E-08 1.2534E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 42 1.009E+00 2.500E+01 1.3240E-10 1.3240E-10 1.3240E-10 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 43 1.010E+00 3.000E+01 1.3985E-12 1.3985E-12 1.3985E-12 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 44 1.012E+00 3.500E+01 1.4772E-14 1.4772E-14 1.4772E-14 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 --------------------------------------------------------------------------------------------------------------------- NOTE: TCP={probability no cells survive}=EXP{-(expected number of surviving cells)}. TCP estimates are based on the expected number of surviving cells with and without corrections for repopulation effects. The *MAX* TCP is the peak (all time points after irradiation) estimate derived from NSC(t). RADX EXPOSURE SUMMARY ============================================================================== SCENARIO ----- DURATION ----- ------ DOSE (Gy) ----- -- DOSE RATE (Gy/h) -- NUMBER hours days Background Total Background Total* ------------------------------------------------------------------------------ 1 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 2 1.667E-01 6.944E-03 0.0000E+00 1.0000E-01 0.0000E+00 6.0000E-01 3 4.167E-01 1.736E-02 0.0000E+00 2.5000E-01 0.0000E+00 6.0000E-01 4 8.333E-01 3.472E-02 0.0000E+00 5.0000E-01 0.0000E+00 6.0000E-01 5 1.667E+00 6.944E-02 0.0000E+00 1.0000E+00 0.0000E+00 6.0000E-01 6 2.500E+00 1.042E-01 0.0000E+00 1.5000E+00 0.0000E+00 6.0000E-01 7 3.333E+00 1.389E-01 0.0000E+00 2.0000E+00 0.0000E+00 6.0000E-01 8 5.000E+00 2.083E-01 0.0000E+00 3.0000E+00 0.0000E+00 6.0000E-01 9 6.667E+00 2.778E-01 0.0000E+00 4.0000E+00 0.0000E+00 6.0000E-01 10 8.333E+00 3.472E-01 0.0000E+00 5.0000E+00 0.0000E+00 6.0000E-01 11 1.000E+01 4.167E-01 0.0000E+00 6.0000E+00 0.0000E+00 6.0000E-01 12 1.167E+01 4.861E-01 0.0000E+00 7.0000E+00 0.0000E+00 6.0000E-01 13 1.333E+01 5.556E-01 0.0000E+00 8.0000E+00 0.0000E+00 6.0000E-01 14 1.500E+01 6.250E-01 0.0000E+00 9.0000E+00 0.0000E+00 6.0000E-01 15 1.667E+01 6.944E-01 0.0000E+00 1.0000E+01 0.0000E+00 6.0000E-01 16 2.083E+01 8.681E-01 0.0000E+00 1.2500E+01 0.0000E+00 6.0000E-01 17 2.500E+01 1.042E+00 0.0000E+00 1.5000E+01 0.0000E+00 6.0000E-01 18 2.917E+01 1.215E+00 0.0000E+00 1.7500E+01 0.0000E+00 6.0000E-01 19 3.333E+01 1.389E+00 0.0000E+00 2.0000E+01 0.0000E+00 6.0000E-01 20 4.167E+01 1.736E+00 0.0000E+00 2.5000E+01 0.0000E+00 6.0000E-01 21 5.000E+01 2.083E+00 0.0000E+00 3.0000E+01 0.0000E+00 6.0000E-01 22 5.833E+01 2.431E+00 0.0000E+00 3.5000E+01 0.0000E+00 6.0000E-01 23 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 24 8.333E-04 3.472E-05 0.0000E+00 1.0000E-01 0.0000E+00 1.2000E+02 25 2.083E-03 8.681E-05 0.0000E+00 2.5000E-01 0.0000E+00 1.2000E+02 26 4.167E-03 1.736E-04 0.0000E+00 5.0000E-01 0.0000E+00 1.2000E+02 27 8.333E-03 3.472E-04 0.0000E+00 1.0000E+00 0.0000E+00 1.2000E+02 28 1.250E-02 5.208E-04 0.0000E+00 1.5000E+00 0.0000E+00 1.2000E+02 29 1.667E-02 6.944E-04 0.0000E+00 2.0000E+00 0.0000E+00 1.2000E+02 30 2.500E-02 1.042E-03 0.0000E+00 3.0000E+00 0.0000E+00 1.2000E+02 31 3.333E-02 1.389E-03 0.0000E+00 4.0000E+00 0.0000E+00 1.2000E+02 32 4.167E-02 1.736E-03 0.0000E+00 5.0000E+00 0.0000E+00 1.2000E+02 33 5.000E-02 2.083E-03 0.0000E+00 6.0000E+00 0.0000E+00 1.2000E+02 34 5.833E-02 2.431E-03 0.0000E+00 7.0000E+00 0.0000E+00 1.2000E+02 35 6.667E-02 2.778E-03 0.0000E+00 8.0000E+00 0.0000E+00 1.2000E+02 36 7.500E-02 3.125E-03 0.0000E+00 9.0000E+00 0.0000E+00 1.2000E+02 37 8.333E-02 3.472E-03 0.0000E+00 1.0000E+01 0.0000E+00 1.2000E+02 38 1.042E-01 4.340E-03 0.0000E+00 1.2500E+01 0.0000E+00 1.2000E+02 39 1.250E-01 5.208E-03 0.0000E+00 1.5000E+01 0.0000E+00 1.2000E+02 40 1.458E-01 6.076E-03 0.0000E+00 1.7500E+01 0.0000E+00 1.2000E+02 41 1.667E-01 6.944E-03 0.0000E+00 2.0000E+01 0.0000E+00 1.2000E+02 42 2.083E-01 8.681E-03 0.0000E+00 2.5000E+01 0.0000E+00 1.2000E+02 43 2.500E-01 1.042E-02 0.0000E+00 3.0000E+01 0.0000E+00 1.2000E+02 44 2.917E-01 1.215E-02 0.0000E+00 3.5000E+01 0.0000E+00 1.2000E+02 ------------------------------------------------------------------------------ * Dose rate is the delivered dose divided by the duration of the exposure scenario. Total VC execution time (min): 3.65000E-03 VC 2.00I 15-JUL-2003 02-AUG-2003 08:54:29 PM