VC 2.00I 15-JUL-2003 02-AUG-2003 09:13:26 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: vc tlk.inp ..\xdat\ncih69.xdat -c FNI: tlk.inp FNO: tlk.out RADX: ..\xdat\ncih69.radx (7 exposures) XDAT: ..\xdat\ncih69.xdat (7 experiments) -------------------------------------------------------------------------------- MCAT SUMMARY: BEST-FIT MODEL PARAMETERS (method = BCONF): ========================================================================================== --- PARAMETER --- ----- CONSTRAINTS ----- INITIAL OPTIMAL PID CID NAM Minimum Maximum GUESS VALUE 2400 CLRP PHI 0.00000E+00 2.50000E-01 1.00000E-02 3.0152017E-02 2201 CLRP RHT 1.00000E-03 2.40000E+01 1.50000E-01 7.2234140E-03 2202 CLRP RHT 1.00000E-03 2.40000E+01 8.00000E+00 7.2229575E-03 ------------------------------------------------------------------------------------------ FIGURE OF MERIT (FOM): 4.92294E-02 (nfom=204, nsim=1428, nmx=7, nox=7, ndf=3, nap=3) COMBINED UNWEIGHTED RESIDUAL: Stats: min=-2.627E-01 max=6.379E-01, mean=1.5975E-01, stdev=3.2980E-01, var=1.0877E-01 Student's T test (mean=0, NDF=3): Pr>ABS(1.28158)= 2.9007E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.95255)=7.663E-01 (passed normality test) COMBINED WEIGHTED RESIDUAL: Stats: min=-9.928E-02 max=2.411E-01, mean=6.0381E-02, stdev=1.2465E-01, var=1.5539E-02 Student's T test (mean=0, NDF=3): Pr>ABS(1.28158)= 2.9007E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.95255)=7.663E-01 (passed normality test) QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 1.72268E-11 1.05876E-02 60.000000 Complex DSB = 5.74228E-12 3.52920E-03 20.000000 Total DSB = 2.29691E-11 1.41168E-02 80.000000 DAMAGE REPAIR/MISREPAIR: A1= 7.500000E-01 (=75.000%) A2= 2.500000E-01 (=25.000%) PHI1= 3.015202E-02 (=3.015%) PHI2= 3.015202E-02 (=3.015%) (1-A1)*PHI1= 7.538004E-03 (=0.754%) (1-A2)*PHI2= 2.261401E-02 (=2.261%) (1-A1)*(1-PHI1)= 2.424620E-01 (=24.246%) (1-A2)*(1-PHI2)= 7.273860E-01 (=72.739%) RHT1= 0.007223 h (=0.43 minute) RHT2= 0.007223 h (=0.43 minute) LAM1= 9.5958390E+01 (1/h) LAM2= 9.5964455E+01 (1/h) BMR= 2.7500000E-04 (1/h) LAM1/BMR= 3.4893960E+05 LAM2/BMR= 3.4896165E+05 (LAM1+LAM2)/BMR= 6.9790125E+05 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 4.5228E-01 + 4.5228E-01 = 9.0456051E-01 (1/Gy) beta: 1.6547E-03 + 5.3426E-04 = 2.1889341E-03 (1/Gy^2) alpha/beta: 413.2424561 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg MCAT FIT: CELL SURVIVAL AS A FUNCTION OF DOSE AND DOSE RATE (NCIH 69 cells). ===================================================================================================== -------- EXPOSURE SUMMARY -------- Duration Dose Dose Rate ---------------- SURVIVING FRACTION -------------- EXPERIMENT (h) (Gy) (Gy/h)* Measured Norm. Wt Predicted Residual ----------------------------------------------------------------------------------------------------- 1 3.9764E+00 2.3858E+00 6.0000E-01 1.27500E-01 1.43E-01 1.15534E-01 -1.0357E-01 2 1.1984E+01 7.1902E+00 6.0000E-01 1.56540E-03 1.43E-01 1.49723E-03 -4.5533E-02 3 1.2611E-02 1.5133E+00 1.2000E+02 1.69080E-01 1.43E-01 2.53513E-01 3.3305E-01 4 2.4924E-02 2.9909E+00 1.2000E+02 6.05080E-02 1.43E-01 6.61640E-02 8.5484E-02 5 3.7593E-02 4.5112E+00 1.2000E+02 6.00810E-03 1.43E-01 1.65942E-02 6.3794E-01 6 4.9908E-02 5.9890E+00 1.2000E+02 2.27670E-03 1.43E-01 4.32487E-03 4.7358E-01 7 6.2562E-02 7.5074E+00 1.2000E+02 1.37140E-03 1.43E-01 1.08611E-03 -2.6267E-01 ----------------------------------------------------------------------------------------------------- RESIDUAL: Stats: min=-2.627E-01 max=6.379E-01, mean=1.5975E-01, stdev=3.2980E-01, var=1.0877E-01 Student's T test (mean=0, NDF=3): Pr>ABS(1.28158)= 2.9007E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.95255)=7.663E-01 (passed normality test) WEIGHTED RESIDUAL: Stats: min=-9.928E-02 max=2.411E-01, mean=6.0381E-02, stdev=1.2465E-01, var=1.5539E-02 Student's T test (mean=0, NDF=3): Pr>ABS(1.28158)= 2.9007E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.95255)=7.663E-01 (passed normality test) NOX=7, NPAR=3 CFE.SF: Cell survival data for NCIH 69 cells. ========================================================================================= -------- EXPOSURE SUMMARY -------- ------------ ENDPOINT ------------- DATASET ID Duration Dose Dose Rate Fraction Fraction Standard CFE RADX (h) (Gy) (Gy/h) Killed Viable Error (%) ----------------------------------------------------------------------------------------- 1 1 3.9764E+00 2.3858E+00 6.0000E-01 8.72500E-01 1.27500E-01 1.00E+01 2 2 1.1984E+01 7.1902E+00 6.0000E-01 9.98435E-01 1.56540E-03 1.00E+01 3 3 1.2611E-02 1.5133E+00 1.2000E+02 8.30920E-01 1.69080E-01 1.00E+01 4 4 2.4924E-02 2.9909E+00 1.2000E+02 9.39492E-01 6.05080E-02 1.00E+01 5 5 3.7593E-02 4.5112E+00 1.2000E+02 9.93992E-01 6.00810E-03 1.00E+01 6 6 4.9908E-02 5.9890E+00 1.2000E+02 9.97723E-01 2.27670E-03 1.00E+01 7 7 6.2562E-02 7.5074E+00 1.2000E+02 9.98629E-01 1.37140E-03 1.00E+01 ----------------------------------------------------------------------------------------- CFE.DXA: Additional details from the cell survival assay (NCIH 69). ===================================================================================== DATASET ID ---------- TIME (h) ----------- DOSE ---- LETHAL DAMAGE --- CFE RADX RADX TTP ETSI (Gy) #/(cell Gy) #/(cell) ------------------------------------------------------------------------------------- 1 1 3.976E+00 1.200E+01 4.000E+02 2.3858E+00 8.6328E-01 2.0596E+00 2 2 1.198E+01 1.200E+01 4.000E+02 7.1902E+00 8.9840E-01 6.4596E+00 3 3 1.261E-02 1.200E+01 4.000E+02 1.5133E+00 1.1745E+00 1.7774E+00 4 4 2.492E-02 1.200E+01 4.000E+02 2.9909E+00 9.3783E-01 2.8050E+00 5 5 3.759E-02 1.200E+01 4.000E+02 4.5112E+00 1.1338E+00 5.1146E+00 6 6 4.991E-02 1.200E+01 4.000E+02 5.9890E+00 1.0160E+00 6.0850E+00 7 7 6.256E-02 1.200E+01 4.000E+02 7.5074E+00 8.7806E-01 6.5919E+00 ------------------------------------------------------------------------------------- ETSI: Total elapsed time (after irradiation) before colonies are counted. TTP: Time available for repair before cells are plated. Total VC execution time (min): 0.14922 VC 2.00I 15-JUL-2003 02-AUG-2003 09:13:35 PM