VC 2.00I 15-JUL-2003 01-AUG-2003 01:49:57 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: u:\usr\bin\vc.exe u:\archive\a549\tlk\a549.inp FNI: U:\archive\a549\tlk\a549.inp FNO: U:\archive\a549\tlk\a549.out RADX: U:\archive\a549\tlk\a549.radx (44 exposures) -------------------------------------------------------------------------------- QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 5.74228E-12 3.52920E-03 20.000000 Complex DSB = 1.43557E-12 8.82301E-04 5.000000 Total DSB = 7.17785E-12 4.41151E-03 25.000000 DAMAGE REPAIR/MISREPAIR: A1= 7.500000E-01 (=75.000%) A2= 2.500000E-01 (=25.000%) PHI1= 1.000000E-02 (=1.000%) PHI2= 1.000000E-02 (=1.000%) (1-A1)*PHI1= 2.500000E-03 (=0.250%) (1-A2)*PHI2= 7.500000E-03 (=0.750%) (1-A1)*(1-PHI1)= 2.475000E-01 (=24.750%) (1-A2)*(1-PHI2)= 7.425000E-01 (=74.250%) RHT1= 0.250000 h (=15.00 minute) RHT2= 2.361807 h (=141.71 minute) LAM1= 2.7725887E+00 (1/h) LAM2= 2.9348176E-01 (1/h) BMR= 1.1528046E-03 (1/h) LAM1/BMR= 2.4050812E+03 LAM2/BMR= 2.5458066E+02 (LAM1+LAM2)/BMR= 2.6596619E+03 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 5.0000E-02 + 3.7500E-02 = 8.7500000E-02 (1/Gy) beta: 2.9793E-02 + 2.1119E-02 = 5.0911655E-02 (1/Gy^2) alpha/beta: 1.7186634 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg DFAR TABLE: Cell survival as a function of dose and dose rate (FRDL=100.0%). ====================================================================================================== --- Duration (h) --- Dose Dose Rate ---- LETHAL DAMAGE PER CELL ---- SIM ID Exposure Sim (Gy) (Gy/h) Mutations Residual Total SF(dose) ------------------------------------------------------------------------------------------------------ 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 2 1.667E-01 7.217E+01 1.000E-01 6.000E-01 9.214E-03 2.520E-10 9.2141E-03 9.908283E-01 3 4.167E-01 8.442E+01 2.500E-01 6.000E-01 2.445E-02 2.338E-11 2.4447E-02 9.758497E-01 4 8.333E-01 8.483E+01 5.000E-01 6.000E-01 5.250E-02 2.647E-10 5.2504E-02 9.488502E-01 5 1.667E+00 8.567E+01 1.000E+00 6.000E-01 1.154E-01 3.274E-10 1.1537E-01 8.910396E-01 6 2.500E+00 8.650E+01 1.500E+00 6.000E-01 1.847E-01 4.360E-10 1.8466E-01 8.313857E-01 7 3.333E+00 8.733E+01 2.000E+00 6.000E-01 2.587E-01 5.180E-10 2.5874E-01 7.720245E-01 8 5.000E+00 8.900E+01 3.000E+00 6.000E-01 4.170E-01 6.186E-10 4.1699E-01 6.590291E-01 9 6.667E+00 9.067E+01 4.000E+00 6.000E-01 5.839E-01 6.696E-10 5.8395E-01 5.576918E-01 10 8.333E+00 9.233E+01 5.000E+00 6.000E-01 7.560E-01 6.916E-10 7.5602E-01 4.695322E-01 11 1.000E+01 9.400E+01 6.000E+00 6.000E-01 9.311E-01 7.052E-10 9.3108E-01 3.941267E-01 12 1.167E+01 9.567E+01 7.000E+00 6.000E-01 1.108E+00 7.128E-10 1.1079E+00 3.302511E-01 13 1.333E+01 9.733E+01 8.000E+00 6.000E-01 1.286E+00 7.171E-10 1.2857E+00 2.764433E-01 14 1.500E+01 9.900E+01 9.000E+00 6.000E-01 1.464E+00 7.196E-10 1.4642E+00 2.312629E-01 15 1.667E+01 1.007E+02 1.000E+01 6.000E-01 1.643E+00 7.211E-10 1.6430E+00 1.933983E-01 16 2.083E+01 1.048E+02 1.250E+01 6.000E-01 2.091E+00 7.225E-10 2.0907E+00 1.235957E-01 17 2.500E+01 1.090E+02 1.500E+01 6.000E-01 2.539E+00 7.229E-10 2.5389E+00 7.895632E-02 18 2.917E+01 1.132E+02 1.750E+01 6.000E-01 2.987E+00 7.230E-10 2.9871E+00 5.043439E-02 19 3.333E+01 1.173E+02 2.000E+01 6.000E-01 3.435E+00 7.231E-10 3.4353E+00 3.221477E-02 20 4.167E+01 1.257E+02 2.500E+01 6.000E-01 4.332E+00 7.231E-10 4.3318E+00 1.314331E-02 21 5.000E+01 1.340E+02 3.000E+01 6.000E-01 5.228E+00 7.231E-10 5.2284E+00 5.362328E-03 22 5.833E+01 1.423E+02 3.500E+01 6.000E-01 6.125E+00 7.231E-10 6.1249E+00 2.187771E-03 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.0000E+00 1.000000E+00 24 8.333E-04 7.200E+01 1.000E-01 1.200E+02 9.258E-03 2.665E-10 9.2582E-03 9.907845E-01 25 2.083E-03 8.400E+01 2.500E-01 1.200E+02 2.504E-02 3.322E-11 2.5043E-02 9.752684E-01 26 4.167E-03 8.400E+01 5.000E-01 1.200E+02 5.636E-02 2.794E-10 5.6363E-02 9.451962E-01 27 8.333E-03 8.401E+01 1.000E+00 1.200E+02 1.375E-01 4.066E-10 1.3750E-01 8.715351E-01 28 1.250E-02 8.401E+01 1.500E+00 1.200E+02 2.427E-01 6.007E-10 2.4275E-01 7.844684E-01 29 1.667E-02 8.402E+01 2.000E+00 1.200E+02 3.715E-01 7.289E-10 3.7148E-01 6.897154E-01 30 2.500E-02 8.403E+01 3.000E+00 1.200E+02 6.969E-01 1.503E-10 6.9693E-01 4.981138E-01 31 3.333E-02 9.603E+01 4.000E+00 1.200E+02 1.109E+00 6.392E-11 1.1092E+00 3.298270E-01 32 4.167E-02 9.604E+01 5.000E+00 1.200E+02 1.604E+00 8.861E-11 1.6039E+00 2.011100E-01 33 5.000E-02 9.605E+01 6.000E+00 1.200E+02 2.177E+00 0.000E+00 2.1770E+00 1.133807E-01 34 5.833E-02 9.606E+01 7.000E+00 1.200E+02 2.825E+00 0.000E+00 2.8247E+00 5.932782E-02 35 6.667E-02 9.607E+01 8.000E+00 1.200E+02 3.543E+00 4.026E-12 3.5433E+00 2.891636E-02 36 7.500E-02 9.608E+01 9.000E+00 1.200E+02 4.330E+00 1.123E-11 4.3297E+00 1.317204E-02 37 8.333E-02 9.608E+01 1.000E+01 1.200E+02 5.180E+00 2.037E-11 5.1805E+00 5.625444E-03 38 1.042E-01 9.610E+01 1.250E+01 1.200E+02 7.570E+00 5.223E-11 7.5705E+00 5.154394E-04 39 1.250E-01 9.612E+01 1.500E+01 1.200E+02 1.030E+01 7.044E-11 1.0303E+01 3.351628E-05 40 1.458E-01 9.615E+01 1.750E+01 1.200E+02 1.334E+01 2.216E-10 1.3343E+01 1.603979E-06 41 1.667E-01 9.617E+01 2.000E+01 1.200E+02 1.666E+01 2.385E-10 1.6657E+01 5.831603E-08 42 2.083E-01 9.621E+01 2.500E+01 1.200E+02 2.400E+01 2.611E-10 2.4003E+01 3.764812E-11 43 2.500E-01 9.625E+01 3.000E+01 1.200E+02 3.215E+01 2.747E-10 3.2154E+01 1.085183E-14 44 2.917E-01 9.629E+01 3.500E+01 1.200E+02 4.097E+01 2.831E-10 4.0967E+01 1.614772E-18 ------------------------------------------------------------------------------------------------------ NOTE: SF=EXP{-(lethal residual damage + lethal mutations)}. QECK TABLE: Cell survival, corrected for repopulation effects, as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. ===================================================================================================================== TSIM DOSE DOSE RATE - SURVIVING FRACTION - --------- EXPECTED NUMBER OF CELLS ----------- SIM ID (day) (Gy) (Gy/h) no repop repop N(t)/N(0) N(0)*S(D) N(t)*S(D) NSC(t) --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 2 3.007E+00 1.000E-01 6.000E-01 9.9083E-01 9.9083E-01 1.0000E+00 9.9083E-01 9.9083E-01 9.9083E-01 3 3.517E+00 2.500E-01 6.000E-01 9.7585E-01 9.7585E-01 1.0000E+00 9.7585E-01 9.7585E-01 9.7585E-01 4 3.535E+00 5.000E-01 6.000E-01 9.4885E-01 9.4885E-01 1.0000E+00 9.4885E-01 9.4885E-01 9.4885E-01 5 3.569E+00 1.000E+00 6.000E-01 8.9104E-01 8.9104E-01 1.0000E+00 8.9104E-01 8.9104E-01 8.9104E-01 6 3.604E+00 1.500E+00 6.000E-01 8.3139E-01 8.3139E-01 1.0000E+00 8.3139E-01 8.3139E-01 8.3139E-01 7 3.639E+00 2.000E+00 6.000E-01 7.7202E-01 7.7202E-01 1.0000E+00 7.7202E-01 7.7202E-01 7.7202E-01 8 3.708E+00 3.000E+00 6.000E-01 6.5903E-01 6.5903E-01 1.0000E+00 6.5903E-01 6.5903E-01 6.5903E-01 9 3.778E+00 4.000E+00 6.000E-01 5.5769E-01 5.5769E-01 1.0000E+00 5.5769E-01 5.5769E-01 5.5769E-01 10 3.847E+00 5.000E+00 6.000E-01 4.6953E-01 4.6953E-01 1.0000E+00 4.6953E-01 4.6953E-01 4.6953E-01 11 3.917E+00 6.000E+00 6.000E-01 3.9413E-01 3.9413E-01 1.0000E+00 3.9413E-01 3.9413E-01 3.9413E-01 12 3.986E+00 7.000E+00 6.000E-01 3.3025E-01 3.3025E-01 1.0000E+00 3.3025E-01 3.3025E-01 3.3025E-01 13 4.056E+00 8.000E+00 6.000E-01 2.7644E-01 2.7644E-01 1.0000E+00 2.7644E-01 2.7644E-01 2.7644E-01 14 4.125E+00 9.000E+00 6.000E-01 2.3126E-01 2.3126E-01 1.0000E+00 2.3126E-01 2.3126E-01 2.3126E-01 15 4.194E+00 1.000E+01 6.000E-01 1.9340E-01 1.9340E-01 1.0000E+00 1.9340E-01 1.9340E-01 1.9340E-01 16 4.368E+00 1.250E+01 6.000E-01 1.2360E-01 1.2360E-01 1.0000E+00 1.2360E-01 1.2360E-01 1.2360E-01 17 4.542E+00 1.500E+01 6.000E-01 7.8956E-02 7.8956E-02 1.0000E+00 7.8956E-02 7.8956E-02 7.8956E-02 18 4.715E+00 1.750E+01 6.000E-01 5.0434E-02 5.0434E-02 1.0000E+00 5.0434E-02 5.0434E-02 5.0434E-02 19 4.889E+00 2.000E+01 6.000E-01 3.2215E-02 3.2215E-02 1.0000E+00 3.2215E-02 3.2215E-02 3.2215E-02 20 5.236E+00 2.500E+01 6.000E-01 1.3143E-02 1.3143E-02 1.0000E+00 1.3143E-02 1.3143E-02 1.3143E-02 21 5.583E+00 3.000E+01 6.000E-01 5.3623E-03 5.3623E-03 1.0000E+00 5.3623E-03 5.3623E-03 5.3623E-03 22 5.931E+00 3.500E+01 6.000E-01 2.1878E-03 2.1878E-03 1.0000E+00 2.1878E-03 2.1878E-03 2.1878E-03 23 4.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 24 3.000E+00 1.000E-01 1.200E+02 9.9078E-01 9.9078E-01 1.0000E+00 9.9078E-01 9.9078E-01 9.9078E-01 25 3.500E+00 2.500E-01 1.200E+02 9.7527E-01 9.7527E-01 1.0000E+00 9.7527E-01 9.7527E-01 9.7527E-01 26 3.500E+00 5.000E-01 1.200E+02 9.4520E-01 9.4520E-01 1.0000E+00 9.4520E-01 9.4520E-01 9.4520E-01 27 3.500E+00 1.000E+00 1.200E+02 8.7154E-01 8.7154E-01 1.0000E+00 8.7154E-01 8.7154E-01 8.7154E-01 28 3.501E+00 1.500E+00 1.200E+02 7.8447E-01 7.8447E-01 1.0000E+00 7.8447E-01 7.8447E-01 7.8447E-01 29 3.501E+00 2.000E+00 1.200E+02 6.8972E-01 6.8972E-01 1.0000E+00 6.8972E-01 6.8972E-01 6.8972E-01 30 3.501E+00 3.000E+00 1.200E+02 4.9811E-01 4.9811E-01 1.0000E+00 4.9811E-01 4.9811E-01 4.9811E-01 31 4.001E+00 4.000E+00 1.200E+02 3.2983E-01 3.2983E-01 1.0000E+00 3.2983E-01 3.2983E-01 3.2983E-01 32 4.002E+00 5.000E+00 1.200E+02 2.0111E-01 2.0111E-01 1.0000E+00 2.0111E-01 2.0111E-01 2.0111E-01 33 4.002E+00 6.000E+00 1.200E+02 1.1338E-01 1.1338E-01 1.0000E+00 1.1338E-01 1.1338E-01 1.1338E-01 34 4.002E+00 7.000E+00 1.200E+02 5.9328E-02 5.9328E-02 1.0000E+00 5.9328E-02 5.9328E-02 5.9328E-02 35 4.003E+00 8.000E+00 1.200E+02 2.8916E-02 2.8916E-02 1.0000E+00 2.8916E-02 2.8916E-02 2.8916E-02 36 4.003E+00 9.000E+00 1.200E+02 1.3172E-02 1.3172E-02 1.0000E+00 1.3172E-02 1.3172E-02 1.3172E-02 37 4.003E+00 1.000E+01 1.200E+02 5.6254E-03 5.6254E-03 1.0000E+00 5.6254E-03 5.6254E-03 5.6254E-03 38 4.004E+00 1.250E+01 1.200E+02 5.1544E-04 5.1544E-04 1.0000E+00 5.1544E-04 5.1544E-04 5.1544E-04 39 4.005E+00 1.500E+01 1.200E+02 3.3516E-05 3.3516E-05 1.0000E+00 3.3516E-05 3.3516E-05 3.3516E-05 40 4.006E+00 1.750E+01 1.200E+02 1.6040E-06 1.6040E-06 1.0000E+00 1.6040E-06 1.6040E-06 1.6040E-06 41 4.007E+00 2.000E+01 1.200E+02 5.8316E-08 5.8316E-08 1.0000E+00 5.8316E-08 5.8316E-08 5.8316E-08 42 4.009E+00 2.500E+01 1.200E+02 3.7648E-11 3.7648E-11 1.0000E+00 3.7648E-11 3.7648E-11 3.7648E-11 43 4.010E+00 3.000E+01 1.200E+02 1.0852E-14 1.0852E-14 1.0000E+00 1.0852E-14 1.0852E-14 1.0852E-14 44 4.012E+00 3.500E+01 1.200E+02 1.6148E-18 1.6148E-18 1.0000E+00 1.6148E-18 1.6148E-18 1.6148E-18 --------------------------------------------------------------------------------------------------------------------- NOTE: N(0) is the initial number of cells (time=0 day), N(t) is the expected number of unirradiated (control) cells at TSIM, i.e., N(t)=N(0)*EXP[LN(2)*TSIM/TPOT]. The surviving fraction S(D) is the expected number of cells, per irradiated cell, that has not sustained lethal DNA damage (no corrections for repopulation effects). NSC(t) is the expected number of cells that survive irradiation, including repopulation effects (recommended method). The product N(t)*S(D) is an alternate method of estimating the surviving fraction with repopulation effects. DFAR TABLE: Mutagenesis and the induction of enhanced genetic instability (GI). Key GI model parameters are: (1-FRDL)=0.0%, NCM=1, NCG=1, and NCG*PGH*PGA=4.250E-06. ====================================================================================================== Dose Dose Rate -- NON-LETHAL MUTATIONS PER CELL -- **** PROBABILITY PER CELL **** SIM ID (Gy) (Gy/h) Mutations Residual Total AGF EGI EGI/SF ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 2 1.000E-01 6.000E-01 8.668E-01 0.00E+00 8.66790E-01 3.650E-06 3.650E-06 3.684E-06 3 2.500E-01 6.000E-01 2.168E+00 0.00E+00 2.16848E+00 8.993E-06 8.993E-06 9.216E-06 4 5.000E-01 6.000E-01 4.340E+00 0.00E+00 4.34030E+00 1.750E-05 1.750E-05 1.845E-05 5 1.000E+00 6.000E-01 8.688E+00 0.00E+00 8.68832E+00 3.290E-05 3.290E-05 3.692E-05 6 1.500E+00 6.000E-01 1.304E+01 0.00E+00 1.30397E+01 4.607E-05 4.607E-05 5.542E-05 7 2.000E+00 6.000E-01 1.739E+01 0.00E+00 1.73934E+01 5.707E-05 5.707E-05 7.392E-05 8 3.000E+00 6.000E-01 2.611E+01 0.00E+00 2.61057E+01 7.311E-05 7.311E-05 1.109E-04 9 4.000E+00 6.000E-01 3.482E+01 0.00E+00 3.48223E+01 8.253E-05 8.253E-05 1.480E-04 10 5.000E+00 6.000E-01 4.354E+01 0.00E+00 4.35413E+01 8.688E-05 8.688E-05 1.850E-04 11 6.000E+00 6.000E-01 5.226E+01 0.00E+00 5.22618E+01 8.753E-05 8.753E-05 2.221E-04 12 7.000E+00 6.000E-01 6.098E+01 0.00E+00 6.09832E+01 8.558E-05 8.558E-05 2.591E-04 13 8.000E+00 6.000E-01 6.971E+01 0.00E+00 6.97050E+01 8.188E-05 8.188E-05 2.962E-04 14 9.000E+00 6.000E-01 7.843E+01 0.00E+00 7.84272E+01 7.707E-05 7.707E-05 3.333E-04 15 1.000E+01 6.000E-01 8.715E+01 0.00E+00 8.71495E+01 7.162E-05 7.162E-05 3.703E-04 16 1.250E+01 6.000E-01 1.090E+02 0.00E+00 1.08956E+02 5.722E-05 5.722E-05 4.630E-04 17 1.500E+01 6.000E-01 1.308E+02 0.00E+00 1.30762E+02 4.387E-05 4.387E-05 5.556E-04 18 1.750E+01 6.000E-01 1.526E+02 0.00E+00 1.52569E+02 3.269E-05 3.269E-05 6.482E-04 19 2.000E+01 6.000E-01 1.744E+02 0.00E+00 1.74375E+02 2.387E-05 2.387E-05 7.408E-04 20 2.500E+01 6.000E-01 2.180E+02 0.00E+00 2.17988E+02 1.217E-05 1.217E-05 9.260E-04 21 3.000E+01 6.000E-01 2.616E+02 0.00E+00 2.61601E+02 5.959E-06 5.959E-06 1.111E-03 22 3.500E+01 6.000E-01 3.052E+02 0.00E+00 3.05214E+02 2.836E-06 2.836E-06 1.296E-03 23 0.000E+00 0.000E+00 0.000E+00 0.00E+00 0.00000E+00 0.000E+00 0.000E+00 0.000E+00 24 1.000E-01 1.200E+02 8.669E-01 0.00E+00 8.66862E-01 3.650E-06 3.650E-06 3.684E-06 25 2.500E-01 1.200E+02 2.169E+00 0.00E+00 2.16944E+00 8.992E-06 8.992E-06 9.220E-06 26 5.000E-01 1.200E+02 4.346E+00 0.00E+00 4.34647E+00 1.746E-05 1.746E-05 1.847E-05 27 1.000E+00 1.200E+02 8.723E+00 0.00E+00 8.72290E+00 3.231E-05 3.231E-05 3.707E-05 28 1.500E+00 1.200E+02 1.313E+01 0.00E+00 1.31286E+01 4.377E-05 4.377E-05 5.580E-05 29 2.000E+00 1.200E+02 1.756E+01 0.00E+00 1.75630E+01 5.148E-05 5.148E-05 7.464E-05 30 3.000E+00 1.200E+02 2.651E+01 0.00E+00 2.65150E+01 5.613E-05 5.613E-05 1.127E-04 31 4.000E+00 1.200E+02 3.557E+01 0.00E+00 3.55739E+01 4.986E-05 4.986E-05 1.512E-04 32 5.000E+00 1.200E+02 4.474E+01 0.00E+00 4.47352E+01 3.823E-05 3.823E-05 1.901E-04 33 6.000E+00 1.200E+02 5.399E+01 0.00E+00 5.39943E+01 2.602E-05 2.602E-05 2.294E-04 34 7.000E+00 1.200E+02 6.335E+01 0.00E+00 6.33469E+01 1.597E-05 1.597E-05 2.692E-04 35 8.000E+00 1.200E+02 7.279E+01 0.00E+00 7.27891E+01 8.944E-06 8.944E-06 3.093E-04 36 9.000E+00 1.200E+02 8.232E+01 0.00E+00 8.23170E+01 4.607E-06 4.607E-06 3.498E-04 37 1.000E+01 1.200E+02 9.193E+01 0.00E+00 9.19269E+01 2.197E-06 2.197E-06 3.906E-04 38 1.250E+01 1.200E+02 1.163E+02 0.00E+00 1.16288E+02 2.547E-07 2.547E-07 4.941E-04 39 1.500E+01 1.200E+02 1.411E+02 0.00E+00 1.41092E+02 2.009E-08 2.009E-08 5.995E-04 40 1.750E+01 1.200E+02 1.663E+02 0.00E+00 1.66293E+02 1.133E-09 1.133E-09 7.065E-04 41 2.000E+01 1.200E+02 1.919E+02 0.00E+00 1.91852E+02 4.753E-11 4.753E-11 8.150E-04 42 2.500E+01 1.200E+02 2.439E+02 0.00E+00 2.43908E+02 3.901E-14 3.901E-14 1.036E-03 43 3.000E+01 1.200E+02 2.970E+02 0.00E+00 2.97023E+02 1.369E-17 1.369E-17 1.262E-03 44 3.500E+01 1.200E+02 3.510E+02 0.00E+00 3.51004E+02 2.407E-21 2.407E-21 1.491E-03 ------------------------------------------------------------------------------------------------------ AGF: function or expression of at least 1 of the 1 critical gene targets is altered. EGI: altered gene function or expression causes enhanced genetic instability. NEOM TABLE: Neoplastic transformation as a function of dose and dose rate at t=42.000 days. Parameters: TFS=1.1500E-05 (1/wk), TFU=2.0000E-03 (1/wk), NCM=1, NCG=1, and NCG*PGH*PGA=4.3E-06. ====================================================================================================== Dose Dose Rate Non-Lethal Genetic Instability *** TRANSFORMATION FREQUENCY *** SIM ID (Gy) (Gy/h) Mutations EGI EGI/SF BKG TPS TPI ------------------------------------------------------------------------------------------------------ 1 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 2 1.000E-01 6.000E-01 8.668E-01 3.650E-06 3.684E-06 6.8995E-05 6.9039E-05 6.8406E-05 3 2.500E-01 6.000E-01 2.168E+00 8.993E-06 9.216E-06 6.8995E-05 6.9105E-05 6.7436E-05 4 5.000E-01 6.000E-01 4.340E+00 1.750E-05 1.845E-05 6.8994E-05 6.9214E-05 6.5674E-05 5 1.000E+00 6.000E-01 8.688E+00 3.290E-05 3.692E-05 6.8993E-05 6.9433E-05 6.1868E-05 6 1.500E+00 6.000E-01 1.304E+01 4.607E-05 5.542E-05 6.8991E-05 6.9652E-05 5.7908E-05 7 2.000E+00 6.000E-01 1.739E+01 5.707E-05 7.392E-05 6.8990E-05 6.9872E-05 5.3943E-05 8 3.000E+00 6.000E-01 2.611E+01 7.311E-05 1.109E-04 6.8988E-05 7.0311E-05 4.6337E-05 9 4.000E+00 6.000E-01 3.482E+01 8.253E-05 1.480E-04 6.8985E-05 7.0750E-05 3.9457E-05 10 5.000E+00 6.000E-01 4.354E+01 8.688E-05 1.850E-04 6.8982E-05 7.1190E-05 3.3426E-05 11 6.000E+00 6.000E-01 5.226E+01 8.753E-05 2.221E-04 6.8980E-05 7.1629E-05 2.8231E-05 12 7.000E+00 6.000E-01 6.098E+01 8.558E-05 2.591E-04 6.8977E-05 7.2068E-05 2.3801E-05 13 8.000E+00 6.000E-01 6.971E+01 8.188E-05 2.962E-04 6.8975E-05 7.2508E-05 2.0044E-05 14 9.000E+00 6.000E-01 7.843E+01 7.707E-05 3.333E-04 6.8972E-05 7.2947E-05 1.6870E-05 15 1.000E+01 6.000E-01 8.715E+01 7.162E-05 3.703E-04 6.8970E-05 7.3387E-05 1.4193E-05 16 1.250E+01 6.000E-01 1.090E+02 5.722E-05 4.630E-04 6.8963E-05 7.4486E-05 9.2061E-06 17 1.500E+01 6.000E-01 1.308E+02 4.387E-05 5.556E-04 6.8957E-05 7.5584E-05 5.9678E-06 18 1.750E+01 6.000E-01 1.526E+02 3.269E-05 6.482E-04 6.8950E-05 7.6682E-05 3.8674E-06 19 2.000E+01 6.000E-01 1.744E+02 2.387E-05 7.408E-04 6.8944E-05 7.7781E-05 2.5057E-06 20 2.500E+01 6.000E-01 2.180E+02 1.217E-05 9.260E-04 6.8931E-05 7.9977E-05 1.0512E-06 21 3.000E+01 6.000E-01 2.616E+02 5.959E-06 1.111E-03 6.8919E-05 8.2173E-05 4.4064E-07 22 3.500E+01 6.000E-01 3.052E+02 2.836E-06 1.296E-03 6.8906E-05 8.4369E-05 1.8458E-07 23 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 6.8995E-05 6.8995E-05 6.8995E-05 24 1.000E-01 1.200E+02 8.669E-01 3.650E-06 3.684E-06 6.8995E-05 6.9039E-05 6.8403E-05 25 2.500E-01 1.200E+02 2.169E+00 8.992E-06 9.220E-06 6.8995E-05 6.9105E-05 6.7395E-05 26 5.000E-01 1.200E+02 4.346E+00 1.746E-05 1.847E-05 6.8994E-05 6.9214E-05 6.5421E-05 27 1.000E+00 1.200E+02 8.723E+00 3.231E-05 3.707E-05 6.8993E-05 6.9435E-05 6.0515E-05 28 1.500E+00 1.200E+02 1.313E+01 4.377E-05 5.580E-05 6.8991E-05 6.9657E-05 5.4644E-05 29 2.000E+00 1.200E+02 1.756E+01 5.148E-05 7.464E-05 6.8990E-05 6.9880E-05 4.8198E-05 30 3.000E+00 1.200E+02 2.651E+01 5.613E-05 1.127E-04 6.8987E-05 7.0332E-05 3.5033E-05 31 4.000E+00 1.200E+02 3.557E+01 4.986E-05 1.512E-04 6.8985E-05 7.0788E-05 2.3348E-05 32 5.000E+00 1.200E+02 4.474E+01 3.823E-05 1.901E-04 6.8982E-05 7.1250E-05 1.4329E-05 33 6.000E+00 1.200E+02 5.399E+01 2.602E-05 2.294E-04 6.8979E-05 7.1716E-05 8.1312E-06 34 7.000E+00 1.200E+02 6.335E+01 1.597E-05 2.692E-04 6.8977E-05 7.2188E-05 4.2827E-06 35 8.000E+00 1.200E+02 7.279E+01 8.944E-06 3.093E-04 6.8974E-05 7.2663E-05 2.1012E-06 36 9.000E+00 1.200E+02 8.232E+01 4.607E-06 3.498E-04 6.8971E-05 7.3143E-05 9.6345E-07 37 1.000E+01 1.200E+02 9.193E+01 2.197E-06 3.906E-04 6.8968E-05 7.3628E-05 4.1419E-07 38 1.250E+01 1.200E+02 1.163E+02 2.547E-07 4.941E-04 6.8961E-05 7.4855E-05 3.8583E-08 39 1.500E+01 1.200E+02 1.411E+02 2.009E-08 5.995E-04 6.8954E-05 7.6104E-05 2.5507E-09 40 1.750E+01 1.200E+02 1.663E+02 1.133E-09 7.065E-04 6.8946E-05 7.7374E-05 1.2411E-10 41 2.000E+01 1.200E+02 1.919E+02 4.753E-11 8.150E-04 6.8939E-05 7.8661E-05 4.5872E-12 42 2.500E+01 1.200E+02 2.439E+02 3.901E-14 1.036E-03 6.8924E-05 8.1282E-05 3.0601E-15 43 3.000E+01 1.200E+02 2.970E+02 1.369E-17 1.262E-03 6.8908E-05 8.3956E-05 9.1108E-19 44 3.500E+01 1.200E+02 3.510E+02 2.407E-21 1.491E-03 6.8892E-05 8.6673E-05 1.3996E-22 ------------------------------------------------------------------------------------------------------ TPS: Transformation frequency per survivor, TPI: Transformation frequency per irradiated cell EGI: Probabilty random mutational events caused enhanced genetic instability (EGI). BKG: Background (spontaneous) cell transformation frequency TLKM TABLE: LQ model dose protraction factor(s) and cell survival estimates (FRDL=100.0%). LQ model parameters are: alpha = 0.0875 (1/Gy), alpha/beta = 1.7187 (Gy), lamda1 = 2.773E+00 (1/h), lamda2 = 2.935E-01 (1/h). ================================================================================================================= --- Duration (h) --- Dose Dose Rate* *********** G FACTOR *********** ******* SF(dose) ******* SIM ID Exposure Sim (Gy) (Gy/h) GL1 GL2 GEFF SF1 SF2 ----------------------------------------------------------------------------------------------------------------- 1 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 2 1.667E-01 7.217E+01 1.000E-01 6.000E-01 8.622E-01 9.839E-01 9.115E-01 9.9083E-01 9.908283E-01 3 4.167E-01 8.442E+01 2.500E-01 6.000E-01 7.047E-01 9.605E-01 8.082E-01 9.7584E-01 9.758497E-01 4 8.333E-01 8.483E+01 5.000E-01 6.000E-01 5.281E-01 9.232E-01 6.878E-01 9.4880E-01 9.488502E-01 5 1.667E+00 8.567E+01 1.000E+00 6.000E-01 3.401E-01 8.551E-01 5.473E-01 8.9075E-01 8.910396E-01 6 2.500E+00 8.650E+01 1.500E+00 6.000E-01 2.470E-01 7.944E-01 4.663E-01 8.3064E-01 8.313857E-01 7 3.333E+00 8.733E+01 2.000E+00 6.000E-01 1.930E-01 7.403E-01 4.112E-01 7.7064E-01 7.720245E-01 8 5.000E+00 8.900E+01 3.000E+00 6.000E-01 1.339E-01 6.482E-01 3.372E-01 6.5599E-01 6.590291E-01 9 6.667E+00 9.067E+01 4.000E+00 6.000E-01 1.023E-01 5.736E-01 2.872E-01 5.5288E-01 5.576918E-01 10 8.333E+00 9.233E+01 5.000E+00 6.000E-01 8.282E-02 5.124E-01 2.503E-01 4.6315E-01 4.695322E-01 11 1.000E+01 9.400E+01 6.000E+00 6.000E-01 6.953E-02 4.616E-01 2.216E-01 3.8654E-01 3.941267E-01 12 1.167E+01 9.567E+01 7.000E+00 6.000E-01 5.992E-02 4.191E-01 1.986E-01 3.2186E-01 3.302511E-01 13 1.333E+01 9.733E+01 8.000E+00 6.000E-01 5.264E-02 3.831E-01 1.798E-01 2.6763E-01 2.764433E-01 14 1.500E+01 9.900E+01 9.000E+00 6.000E-01 4.693E-02 3.524E-01 1.641E-01 2.2234E-01 2.312629E-01 15 1.667E+01 1.007E+02 1.000E+01 6.000E-01 4.234E-02 3.259E-01 1.509E-01 1.8462E-01 1.933983E-01 16 2.083E+01 1.048E+02 1.250E+01 6.000E-01 3.403E-02 2.737E-01 1.253E-01 1.1586E-01 1.235957E-01 17 2.500E+01 1.090E+02 1.500E+01 6.000E-01 2.844E-02 2.355E-01 1.071E-01 7.2660E-02 7.895632E-02 18 2.917E+01 1.132E+02 1.750E+01 6.000E-01 2.443E-02 2.064E-01 9.337E-02 4.5559E-02 5.043439E-02 19 3.333E+01 1.173E+02 2.000E+01 6.000E-01 2.141E-02 1.835E-01 8.276E-02 2.8565E-02 3.221477E-02 20 4.167E+01 1.257E+02 2.500E+01 6.000E-01 1.716E-02 1.502E-01 6.739E-02 1.1229E-02 1.314331E-02 21 5.000E+01 1.340E+02 3.000E+01 6.000E-01 1.432E-02 1.270E-01 5.682E-02 4.4138E-03 5.362328E-03 22 5.833E+01 1.423E+02 3.500E+01 6.000E-01 1.229E-02 1.100E-01 4.910E-02 1.7350E-03 2.187771E-03 23 2.778E-13 9.600E+01 0.000E+00 0.000E+00 0.000E+00 0.000E+00 0.000E+00 1.0000E+00 1.000000E+00 24 8.333E-04 7.200E+01 1.000E-01 1.200E+02 9.992E-01 9.999E-01 9.982E-01 9.9078E-01 9.907845E-01 25 2.083E-03 8.400E+01 2.500E-01 1.200E+02 9.981E-01 9.998E-01 9.955E-01 9.7526E-01 9.752684E-01 26 4.167E-03 8.400E+01 5.000E-01 1.200E+02 9.962E-01 9.996E-01 9.910E-01 9.4512E-01 9.451962E-01 27 8.333E-03 8.401E+01 1.000E+00 1.200E+02 9.923E-01 9.992E-01 9.821E-01 8.7095E-01 8.715351E-01 28 1.250E-02 8.401E+01 1.500E+00 1.200E+02 9.885E-01 9.988E-01 9.734E-01 7.8272E-01 7.844684E-01 29 1.667E-02 8.402E+01 2.000E+00 1.200E+02 9.848E-01 9.984E-01 9.648E-01 6.8613E-01 6.897154E-01 30 2.500E-02 8.403E+01 3.000E+00 1.200E+02 9.773E-01 9.976E-01 9.481E-01 4.8961E-01 4.981138E-01 31 3.333E-02 9.603E+01 4.000E+00 1.200E+02 9.699E-01 9.967E-01 9.320E-01 3.1691E-01 3.298270E-01 32 4.167E-02 9.604E+01 5.000E+00 1.200E+02 9.626E-01 9.959E-01 9.164E-01 1.8632E-01 2.011100E-01 33 5.000E-02 9.605E+01 6.000E+00 1.200E+02 9.553E-01 9.951E-01 9.013E-01 9.9637E-02 1.133807E-01 34 5.833E-02 9.606E+01 7.000E+00 1.200E+02 9.482E-01 9.943E-01 8.868E-01 4.8525E-02 5.932782E-02 35 6.667E-02 9.607E+01 8.000E+00 1.200E+02 9.411E-01 9.935E-01 8.726E-01 2.1551E-02 2.891636E-02 36 7.500E-02 9.608E+01 9.000E+00 1.200E+02 9.341E-01 9.927E-01 8.589E-01 8.7392E-03 1.317204E-02 37 8.333E-02 9.608E+01 1.000E+01 1.200E+02 9.272E-01 9.919E-01 8.457E-01 3.2397E-03 5.625444E-03 38 1.042E-01 9.610E+01 1.250E+01 1.200E+02 9.103E-01 9.899E-01 8.142E-01 1.8452E-04 5.154394E-04 39 1.250E-01 9.612E+01 1.500E+01 1.200E+02 8.938E-01 9.879E-01 7.849E-01 6.1544E-06 3.351628E-05 40 1.458E-01 9.615E+01 1.750E+01 1.200E+02 8.778E-01 9.859E-01 7.576E-01 1.2230E-07 1.603979E-06 41 1.667E-01 9.617E+01 2.000E+01 1.200E+02 8.622E-01 9.839E-01 7.320E-01 1.4717E-09 5.831603E-08 42 2.083E-01 9.621E+01 2.500E+01 1.200E+02 8.323E-01 9.799E-01 6.856E-01 5.0322E-14 3.764812E-11 43 2.500E-01 9.625E+01 3.000E+01 1.200E+02 8.040E-01 9.760E-01 6.445E-01 2.7594E-19 1.085183E-14 44 2.917E-01 9.629E+01 3.500E+01 1.200E+02 7.772E-01 9.721E-01 6.078E-01 2.6908E-25 1.614772E-18 ----------------------------------------------------------------------------------------------------------------- GL=[2*[x+exp(-x)-1]/(x*x), where x = {lamda}*{irradiation time} and GEFF=-(alpha+LOG(SF)/dose)/(beta*dose). In the formula for GEFF, SF is surviving fraction as computed using the TLK model. The effects of lethal residual damage are included in the GEFF dose protraction factor but not GL1 or GL2. The estimates of the surviving fraction are SF1 = EXP{-dose*[alpha+(gl1*beta1+gl2*beta2)*dose]} and SF2 = EXP{-dose*(alpha+geff*beta*dose)}. QECK TABLE: Tumor control probability (TCP) estimates as a function of dose and dose rate. Cell kinetic parameters are: N(0)=F0*KAP*VOL=1.00000E+00, TCC=10.0000 h, Tpot=20.000 days. The *MAX* estimate is recommended (the other TCP estimates are mainly included in the table for diagnostic purposes). ===================================================================================================================== TSIM DOSE ---- EXPECTED NUMBER OF CELLS ---- ------ TUMOR CONTROL PROBABILITY (TCP) ------- SIM ID (day) (Gy) N(0)*S(D) N(t)*S(D) NSC(t) N(0)*S(D) N(t)*S(D) NSC(t) *MAX* --------------------------------------------------------------------------------------------------------------------- 1 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 2 3.007E+00 1.000E-01 9.9083E-01 9.9083E-01 9.9083E-01 3.7127E-01 3.7127E-01 3.7127E-01 3.7127E-01 3 3.517E+00 2.500E-01 9.7585E-01 9.7585E-01 9.7585E-01 3.7687E-01 3.7687E-01 3.7687E-01 3.7687E-01 4 3.535E+00 5.000E-01 9.4885E-01 9.4885E-01 9.4885E-01 3.8719E-01 3.8719E-01 3.8719E-01 3.8719E-01 5 3.569E+00 1.000E+00 8.9104E-01 8.9104E-01 8.9104E-01 4.1023E-01 4.1023E-01 4.1023E-01 4.1023E-01 6 3.604E+00 1.500E+00 8.3139E-01 8.3139E-01 8.3139E-01 4.3545E-01 4.3545E-01 4.3545E-01 4.3545E-01 7 3.639E+00 2.000E+00 7.7202E-01 7.7202E-01 7.7202E-01 4.6208E-01 4.6208E-01 4.6208E-01 4.6208E-01 8 3.708E+00 3.000E+00 6.5903E-01 6.5903E-01 6.5903E-01 5.1735E-01 5.1735E-01 5.1735E-01 5.1735E-01 9 3.778E+00 4.000E+00 5.5769E-01 5.5769E-01 5.5769E-01 5.7253E-01 5.7253E-01 5.7253E-01 5.7253E-01 10 3.847E+00 5.000E+00 4.6953E-01 4.6953E-01 4.6953E-01 6.2529E-01 6.2529E-01 6.2529E-01 6.2529E-01 11 3.917E+00 6.000E+00 3.9413E-01 3.9413E-01 3.9413E-01 6.7427E-01 6.7427E-01 6.7427E-01 6.7427E-01 12 3.986E+00 7.000E+00 3.3025E-01 3.3025E-01 3.3025E-01 7.1874E-01 7.1874E-01 7.1874E-01 7.1874E-01 13 4.056E+00 8.000E+00 2.7644E-01 2.7644E-01 2.7644E-01 7.5848E-01 7.5848E-01 7.5848E-01 7.5848E-01 14 4.125E+00 9.000E+00 2.3126E-01 2.3126E-01 2.3126E-01 7.9353E-01 7.9353E-01 7.9353E-01 7.9353E-01 15 4.194E+00 1.000E+01 1.9340E-01 1.9340E-01 1.9340E-01 8.2415E-01 8.2415E-01 8.2415E-01 8.2415E-01 16 4.368E+00 1.250E+01 1.2360E-01 1.2360E-01 1.2360E-01 8.8374E-01 8.8374E-01 8.8374E-01 8.8374E-01 17 4.542E+00 1.500E+01 7.8956E-02 7.8956E-02 7.8956E-02 9.2408E-01 9.2408E-01 9.2408E-01 9.2408E-01 18 4.715E+00 1.750E+01 5.0434E-02 5.0434E-02 5.0434E-02 9.5082E-01 9.5082E-01 9.5082E-01 9.5082E-01 19 4.889E+00 2.000E+01 3.2215E-02 3.2215E-02 3.2215E-02 9.6830E-01 9.6830E-01 9.6830E-01 9.6830E-01 20 5.236E+00 2.500E+01 1.3143E-02 1.3143E-02 1.3143E-02 9.8694E-01 9.8694E-01 9.8694E-01 9.8694E-01 21 5.583E+00 3.000E+01 5.3623E-03 5.3623E-03 5.3623E-03 9.9465E-01 9.9465E-01 9.9465E-01 9.9465E-01 22 5.931E+00 3.500E+01 2.1878E-03 2.1878E-03 2.1878E-03 9.9781E-01 9.9781E-01 9.9781E-01 9.9781E-01 23 4.000E+00 0.000E+00 1.0000E+00 1.0000E+00 1.0000E+00 3.6788E-01 3.6788E-01 3.6788E-01 3.6788E-01 24 3.000E+00 1.000E-01 9.9078E-01 9.9078E-01 9.9078E-01 3.7129E-01 3.7129E-01 3.7129E-01 3.7129E-01 25 3.500E+00 2.500E-01 9.7527E-01 9.7527E-01 9.7527E-01 3.7709E-01 3.7709E-01 3.7709E-01 3.7709E-01 26 3.500E+00 5.000E-01 9.4520E-01 9.4520E-01 9.4520E-01 3.8860E-01 3.8860E-01 3.8860E-01 3.8860E-01 27 3.500E+00 1.000E+00 8.7154E-01 8.7154E-01 8.7154E-01 4.1831E-01 4.1831E-01 4.1831E-01 4.1831E-01 28 3.501E+00 1.500E+00 7.8447E-01 7.8447E-01 7.8447E-01 4.5636E-01 4.5636E-01 4.5636E-01 4.5636E-01 29 3.501E+00 2.000E+00 6.8972E-01 6.8972E-01 6.8972E-01 5.0172E-01 5.0172E-01 5.0172E-01 5.0172E-01 30 3.501E+00 3.000E+00 4.9811E-01 4.9811E-01 4.9811E-01 6.0768E-01 6.0768E-01 6.0768E-01 6.0768E-01 31 4.001E+00 4.000E+00 3.2983E-01 3.2983E-01 3.2983E-01 7.1905E-01 7.1905E-01 7.1905E-01 7.1905E-01 32 4.002E+00 5.000E+00 2.0111E-01 2.0111E-01 2.0111E-01 8.1782E-01 8.1782E-01 8.1782E-01 8.1782E-01 33 4.002E+00 6.000E+00 1.1338E-01 1.1338E-01 1.1338E-01 8.9281E-01 8.9281E-01 8.9281E-01 8.9281E-01 34 4.002E+00 7.000E+00 5.9328E-02 5.9328E-02 5.9328E-02 9.4240E-01 9.4240E-01 9.4240E-01 9.4240E-01 35 4.003E+00 8.000E+00 2.8916E-02 2.8916E-02 2.8916E-02 9.7150E-01 9.7150E-01 9.7150E-01 9.7150E-01 36 4.003E+00 9.000E+00 1.3172E-02 1.3172E-02 1.3172E-02 9.8691E-01 9.8691E-01 9.8691E-01 9.8691E-01 37 4.003E+00 1.000E+01 5.6254E-03 5.6254E-03 5.6254E-03 9.9439E-01 9.9439E-01 9.9439E-01 9.9439E-01 38 4.004E+00 1.250E+01 5.1544E-04 5.1544E-04 5.1544E-04 9.9948E-01 9.9948E-01 9.9948E-01 9.9948E-01 39 4.005E+00 1.500E+01 3.3516E-05 3.3516E-05 3.3516E-05 9.9997E-01 9.9997E-01 9.9997E-01 9.9997E-01 40 4.006E+00 1.750E+01 1.6040E-06 1.6040E-06 1.6040E-06 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 41 4.007E+00 2.000E+01 5.8316E-08 5.8316E-08 5.8316E-08 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 42 4.009E+00 2.500E+01 3.7648E-11 3.7648E-11 3.7648E-11 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 43 4.010E+00 3.000E+01 1.0852E-14 1.0852E-14 1.0852E-14 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 44 4.012E+00 3.500E+01 1.6148E-18 1.6148E-18 1.6148E-18 1.0000E+00 1.0000E+00 1.0000E+00 1.0000E+00 --------------------------------------------------------------------------------------------------------------------- NOTE: TCP={probability no cells survive}=EXP{-(expected number of surviving cells)}. TCP estimates are based on the expected number of surviving cells with and without corrections for repopulation effects. The *MAX* TCP is the peak (all time points after irradiation) estimate derived from NSC(t). RADX EXPOSURE SUMMARY ============================================================================== SCENARIO ----- DURATION ----- ------ DOSE (Gy) ----- -- DOSE RATE (Gy/h) -- NUMBER hours days Background Total Background Total* ------------------------------------------------------------------------------ 1 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 2 1.667E-01 6.944E-03 0.0000E+00 1.0000E-01 0.0000E+00 6.0000E-01 3 4.167E-01 1.736E-02 0.0000E+00 2.5000E-01 0.0000E+00 6.0000E-01 4 8.333E-01 3.472E-02 0.0000E+00 5.0000E-01 0.0000E+00 6.0000E-01 5 1.667E+00 6.944E-02 0.0000E+00 1.0000E+00 0.0000E+00 6.0000E-01 6 2.500E+00 1.042E-01 0.0000E+00 1.5000E+00 0.0000E+00 6.0000E-01 7 3.333E+00 1.389E-01 0.0000E+00 2.0000E+00 0.0000E+00 6.0000E-01 8 5.000E+00 2.083E-01 0.0000E+00 3.0000E+00 0.0000E+00 6.0000E-01 9 6.667E+00 2.778E-01 0.0000E+00 4.0000E+00 0.0000E+00 6.0000E-01 10 8.333E+00 3.472E-01 0.0000E+00 5.0000E+00 0.0000E+00 6.0000E-01 11 1.000E+01 4.167E-01 0.0000E+00 6.0000E+00 0.0000E+00 6.0000E-01 12 1.167E+01 4.861E-01 0.0000E+00 7.0000E+00 0.0000E+00 6.0000E-01 13 1.333E+01 5.556E-01 0.0000E+00 8.0000E+00 0.0000E+00 6.0000E-01 14 1.500E+01 6.250E-01 0.0000E+00 9.0000E+00 0.0000E+00 6.0000E-01 15 1.667E+01 6.944E-01 0.0000E+00 1.0000E+01 0.0000E+00 6.0000E-01 16 2.083E+01 8.681E-01 0.0000E+00 1.2500E+01 0.0000E+00 6.0000E-01 17 2.500E+01 1.042E+00 0.0000E+00 1.5000E+01 0.0000E+00 6.0000E-01 18 2.917E+01 1.215E+00 0.0000E+00 1.7500E+01 0.0000E+00 6.0000E-01 19 3.333E+01 1.389E+00 0.0000E+00 2.0000E+01 0.0000E+00 6.0000E-01 20 4.167E+01 1.736E+00 0.0000E+00 2.5000E+01 0.0000E+00 6.0000E-01 21 5.000E+01 2.083E+00 0.0000E+00 3.0000E+01 0.0000E+00 6.0000E-01 22 5.833E+01 2.431E+00 0.0000E+00 3.5000E+01 0.0000E+00 6.0000E-01 23 2.778E-13 1.157E-14 0.0000E+00 0.0000E+00 0.0000E+00 0.0000E+00 24 8.333E-04 3.472E-05 0.0000E+00 1.0000E-01 0.0000E+00 1.2000E+02 25 2.083E-03 8.681E-05 0.0000E+00 2.5000E-01 0.0000E+00 1.2000E+02 26 4.167E-03 1.736E-04 0.0000E+00 5.0000E-01 0.0000E+00 1.2000E+02 27 8.333E-03 3.472E-04 0.0000E+00 1.0000E+00 0.0000E+00 1.2000E+02 28 1.250E-02 5.208E-04 0.0000E+00 1.5000E+00 0.0000E+00 1.2000E+02 29 1.667E-02 6.944E-04 0.0000E+00 2.0000E+00 0.0000E+00 1.2000E+02 30 2.500E-02 1.042E-03 0.0000E+00 3.0000E+00 0.0000E+00 1.2000E+02 31 3.333E-02 1.389E-03 0.0000E+00 4.0000E+00 0.0000E+00 1.2000E+02 32 4.167E-02 1.736E-03 0.0000E+00 5.0000E+00 0.0000E+00 1.2000E+02 33 5.000E-02 2.083E-03 0.0000E+00 6.0000E+00 0.0000E+00 1.2000E+02 34 5.833E-02 2.431E-03 0.0000E+00 7.0000E+00 0.0000E+00 1.2000E+02 35 6.667E-02 2.778E-03 0.0000E+00 8.0000E+00 0.0000E+00 1.2000E+02 36 7.500E-02 3.125E-03 0.0000E+00 9.0000E+00 0.0000E+00 1.2000E+02 37 8.333E-02 3.472E-03 0.0000E+00 1.0000E+01 0.0000E+00 1.2000E+02 38 1.042E-01 4.340E-03 0.0000E+00 1.2500E+01 0.0000E+00 1.2000E+02 39 1.250E-01 5.208E-03 0.0000E+00 1.5000E+01 0.0000E+00 1.2000E+02 40 1.458E-01 6.076E-03 0.0000E+00 1.7500E+01 0.0000E+00 1.2000E+02 41 1.667E-01 6.944E-03 0.0000E+00 2.0000E+01 0.0000E+00 1.2000E+02 42 2.083E-01 8.681E-03 0.0000E+00 2.5000E+01 0.0000E+00 1.2000E+02 43 2.500E-01 1.042E-02 0.0000E+00 3.0000E+01 0.0000E+00 1.2000E+02 44 2.917E-01 1.215E-02 0.0000E+00 3.5000E+01 0.0000E+00 1.2000E+02 ------------------------------------------------------------------------------ * Dose rate is the delivered dose divided by the duration of the exposure scenario. Total VC execution time (min): 7.81667E-03 VC 2.00I 15-JUL-2003 01-AUG-2003 01:49:57 PM