VC 2.00H 10-JUL-2003 20-JUL-2003 03:41:59 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: vc tlk.inp ..\xdat\ag1522.xdat -c FNI: tlk.inp FNO: tlk.out RADX: ..\xdat\ag1522.radx (30 exposures) XDAT: ..\xdat\ag1522.xdat (30 experiments) -------------------------------------------------------------------------------- MCAT SUMMARY: BEST-FIT MODEL PARAMETERS (method = BCONF): ========================================================================================== --- PARAMETER --- ----- CONSTRAINTS ----- INITIAL OPTIMAL PID CID NAM Minimum Maximum GUESS VALUE 2001 CLRP BMR 0.00000E+00 1.00000E-02 2.00000E-04 4.3976503E-04 2400 CLRP PHI 0.00000E+00 2.50000E-01 1.00000E-02 2.1429799E-02 2201 CLRP RHT 1.00000E-02 1.20000E+01 1.50000E-01 8.6179242E-01 2202 CLRP RHT 1.00000E-02 1.20000E+01 8.00000E+00 8.7735334E-01 ------------------------------------------------------------------------------------------ FIGURE OF MERIT (FOM): 7.91585E-03 (nfom=565, nsim=16950, nmx=30, nox=30, ndf=25, nap=4) COMBINED UNWEIGHTED RESIDUAL: Stats: min=-4.601E-01 max=4.656E-01, mean=6.6121E-02, stdev=2.3198E-01, var=5.3817E-02 Student's T test (NDF=25): Pr>ABS(1.56114)= 1.3106E-01 (accept fit) Shapiro-Wilk's Test: (Pr<0.97864)=8.138E-01 (accept normality) COMBINED WEIGHTED RESIDUAL: Stats: min=-8.400E-02 max=8.501E-02, mean=1.2072E-02, stdev=4.2354E-02, var=1.7939E-03 Student's T test (NDF=25): Pr>ABS(1.56114)= 1.3106E-01 (accept fit) Shapiro-Wilk's Test: (Pr<0.97864)=8.138E-01 (accept normality) QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 5.74228E-12 3.52920E-03 20.000000 Complex DSB = 1.43557E-12 8.82301E-04 5.000000 Total DSB = 7.17785E-12 4.41151E-03 25.000000 DAMAGE REPAIR/MISREPAIR: A1= 7.500000E-01 (=75.000%) A2= 2.500000E-01 (=25.000%) PHI1= 2.142980E-02 (=2.143%) PHI2= 2.142980E-02 (=2.143%) (1-A1)*PHI1= 5.357450E-03 (=0.536%) (1-A2)*PHI2= 1.607235E-02 (=1.607%) (1-A1)*(1-PHI1)= 2.446426E-01 (=24.464%) (1-A2)*(1-PHI2)= 7.339277E-01 (=73.393%) RHT1= 0.861792 h (=51.71 minute) RHT2= 0.877353 h (=52.64 minute) LAM1= 8.0430875E-01 (1/h) LAM2= 7.9004336E-01 (1/h) BMR= 4.3976503E-04 (1/h) LAM1/BMR= 1.8289511E+03 LAM2/BMR= 1.7965125E+03 (LAM1+LAM2)/BMR= 3.6254636E+03 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 1.0715E-01 + 8.0362E-02 = 1.8751074E-01 (1/Gy) beta: 3.3352E-02 + 8.2278E-03 = 4.1580123E-02 (1/Gy^2) alpha/beta: 4.5096245 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg MCAT FIT: CELL SURVIVAL AS A FUNCTION OF DOSE AND DOSE RATE (AG 1522 cells). ===================================================================================================== -------- EXPOSURE SUMMARY -------- Duration Dose Dose Rate ---------------- SURVIVING FRACTION -------------- EXPERIMENT (h) (Gy) (Gy/h)* Measured Norm. Wt Predicted Residual ----------------------------------------------------------------------------------------------------- 1 1.6938E+01 4.0650E+00 2.4000E-01 3.76391E-01 3.33E-02 4.25155E-01 1.1470E-01 2 1.8675E+01 4.4820E+00 2.4000E-01 4.58897E-01 3.33E-02 3.89149E-01 -1.7923E-01 3 2.4113E+01 5.7870E+00 2.4000E-01 2.86135E-01 3.33E-02 2.95015E-01 3.0100E-02 4 3.9200E+01 9.4080E+00 2.4000E-01 1.54421E-01 3.33E-02 1.36812E-01 -1.2871E-01 5 6.6646E+01 1.5995E+01 2.4000E-01 3.10940E-02 3.33E-02 3.38105E-02 8.0346E-02 6 9.0883E+01 2.1812E+01 2.4000E-01 9.50500E-03 3.33E-02 9.83886E-03 3.3933E-02 7 1.6938E+01 5.7590E+00 3.4000E-01 3.56144E-01 3.33E-02 2.81932E-01 -2.6323E-01 8 1.8153E+01 6.1720E+00 3.4000E-01 2.23658E-01 3.33E-02 2.57191E-01 1.3038E-01 9 2.3818E+01 8.0980E+00 3.4000E-01 9.83700E-02 3.33E-02 1.67587E-01 4.1302E-01 10 4.0418E+01 1.3742E+01 3.4000E-01 6.97450E-02 3.33E-02 4.77683E-02 -4.6007E-01 11 4.0503E+01 1.3771E+01 3.4000E-01 6.20880E-02 3.33E-02 4.74612E-02 -3.0818E-01 12 6.7726E+01 2.3027E+01 3.4000E-01 4.79500E-03 3.33E-02 6.05881E-03 2.0859E-01 13 6.7809E+01 2.3055E+01 3.4000E-01 3.98600E-03 3.33E-02 6.02120E-03 3.3801E-01 14 1.8301E+01 1.2994E+01 7.1000E-01 3.26530E-02 3.33E-02 3.65531E-02 1.0670E-01 15 1.8304E+01 1.2996E+01 7.1000E-01 4.03640E-02 3.33E-02 3.65341E-02 -1.0483E-01 16 2.3903E+01 1.6971E+01 7.1000E-01 1.40600E-02 3.33E-02 1.30261E-02 -7.9370E-02 17 2.3942E+01 1.6999E+01 7.1000E-01 1.12190E-02 3.33E-02 1.29318E-02 1.3245E-01 18 3.8737E+01 2.7503E+01 7.1000E-01 8.84000E-04 3.33E-02 8.47461E-04 -4.3116E-02 19 3.8776E+01 2.7531E+01 7.1000E-01 7.15000E-04 3.33E-02 8.41327E-04 1.5015E-01 20 2.4864E-02 2.0140E+00 8.1000E+01 3.51755E-01 3.33E-02 5.81482E-01 3.9507E-01 21 2.5247E-02 2.0450E+00 8.1000E+01 4.49952E-01 3.33E-02 5.75205E-01 2.1775E-01 22 4.9370E-02 3.9990E+00 8.1000E+01 1.34009E-01 3.33E-02 2.50772E-01 4.6561E-01 23 4.9395E-02 4.0010E+00 8.1000E+01 1.77384E-01 3.33E-02 2.50523E-01 2.9194E-01 24 7.3136E-02 5.9240E+00 8.1000E+01 4.96770E-02 3.33E-02 8.46274E-02 4.1299E-01 25 7.4259E-02 6.0150E+00 8.1000E+01 6.22530E-02 3.33E-02 7.98874E-02 2.2074E-01 26 7.4284E-02 6.0170E+00 8.1000E+01 8.88420E-02 3.33E-02 7.97858E-02 -1.1351E-01 27 9.9099E-02 8.0270E+00 8.1000E+01 1.63930E-02 3.33E-02 1.94509E-02 1.5721E-01 28 9.9111E-02 8.0280E+00 8.1000E+01 1.94500E-02 3.33E-02 1.94360E-02 -7.2224E-04 29 1.2320E-01 9.9790E+00 8.1000E+01 3.79100E-03 3.33E-02 3.88039E-03 2.3036E-02 30 1.2358E-01 1.0010E+01 8.1000E+01 4.75000E-03 3.33E-02 3.77539E-03 -2.5815E-01 ----------------------------------------------------------------------------------------------------- RESIDUAL: Stats: min=-4.601E-01 max=4.656E-01, mean=6.6121E-02, stdev=2.3198E-01, var=5.3817E-02 Student's T test (NDF=25): Pr>ABS(1.56114)= 1.3106E-01 (accept fit) Shapiro-Wilk's Test: (Pr<0.97864)=8.138E-01 (accept normality) WEIGHTED RESIDUAL: Stats: min=-8.400E-02 max=8.501E-02, mean=1.2072E-02, stdev=4.2354E-02, var=1.7939E-03 Student's T test (NDF=25): Pr>ABS(1.56114)= 1.3106E-01 (accept fit) Shapiro-Wilk's Test: (Pr<0.97864)=8.138E-01 (accept normality) NOX=30, NPAR=4 CFE.SF: Cell survival data for AG 1522 cells. ========================================================================================= -------- EXPOSURE SUMMARY -------- ------------ ENDPOINT ------------- DATASET ID Duration Dose Dose Rate Fraction Fraction Standard CFE RADX (h) (Gy) (Gy/h) Killed Viable Error (%) ----------------------------------------------------------------------------------------- 1 1 1.6938E+01 4.0650E+00 2.4000E-01 6.23609E-01 3.76391E-01 1.00E+01 2 2 1.8675E+01 4.4820E+00 2.4000E-01 5.41103E-01 4.58897E-01 1.00E+01 3 3 2.4113E+01 5.7870E+00 2.4000E-01 7.13865E-01 2.86135E-01 1.00E+01 4 4 3.9200E+01 9.4080E+00 2.4000E-01 8.45579E-01 1.54421E-01 1.00E+01 5 5 6.6646E+01 1.5995E+01 2.4000E-01 9.68906E-01 3.10940E-02 1.00E+01 6 6 9.0883E+01 2.1812E+01 2.4000E-01 9.90495E-01 9.50500E-03 1.00E+01 7 7 1.6938E+01 5.7590E+00 3.4000E-01 6.43856E-01 3.56144E-01 1.00E+01 8 8 1.8153E+01 6.1720E+00 3.4000E-01 7.76342E-01 2.23658E-01 1.00E+01 9 9 2.3818E+01 8.0980E+00 3.4000E-01 9.01630E-01 9.83700E-02 1.00E+01 10 10 4.0418E+01 1.3742E+01 3.4000E-01 9.30255E-01 6.97450E-02 1.00E+01 11 11 4.0503E+01 1.3771E+01 3.4000E-01 9.37912E-01 6.20880E-02 1.00E+01 12 12 6.7726E+01 2.3027E+01 3.4000E-01 9.95205E-01 4.79500E-03 1.00E+01 13 13 6.7809E+01 2.3055E+01 3.4000E-01 9.96014E-01 3.98600E-03 1.00E+01 14 14 1.8301E+01 1.2994E+01 7.1000E-01 9.67347E-01 3.26530E-02 1.00E+01 15 15 1.8304E+01 1.2996E+01 7.1000E-01 9.59636E-01 4.03640E-02 1.00E+01 16 16 2.3903E+01 1.6971E+01 7.1000E-01 9.85940E-01 1.40600E-02 1.00E+01 17 17 2.3942E+01 1.6999E+01 7.1000E-01 9.88781E-01 1.12190E-02 1.00E+01 18 18 3.8737E+01 2.7503E+01 7.1000E-01 9.99116E-01 8.84000E-04 1.00E+01 19 19 3.8776E+01 2.7531E+01 7.1000E-01 9.99285E-01 7.15000E-04 1.00E+01 20 20 2.4864E-02 2.0140E+00 8.1000E+01 6.48245E-01 3.51755E-01 1.00E+01 21 21 2.5247E-02 2.0450E+00 8.1000E+01 5.50048E-01 4.49952E-01 1.00E+01 22 22 4.9370E-02 3.9990E+00 8.1000E+01 8.65991E-01 1.34009E-01 1.00E+01 23 23 4.9395E-02 4.0010E+00 8.1000E+01 8.22616E-01 1.77384E-01 1.00E+01 24 24 7.3136E-02 5.9240E+00 8.1000E+01 9.50323E-01 4.96770E-02 1.00E+01 25 25 7.4259E-02 6.0150E+00 8.1000E+01 9.37747E-01 6.22530E-02 1.00E+01 26 26 7.4284E-02 6.0170E+00 8.1000E+01 9.11158E-01 8.88420E-02 1.00E+01 27 27 9.9099E-02 8.0270E+00 8.1000E+01 9.83607E-01 1.63930E-02 1.00E+01 28 28 9.9111E-02 8.0280E+00 8.1000E+01 9.80550E-01 1.94500E-02 1.00E+01 29 29 1.2320E-01 9.9790E+00 8.1000E+01 9.96209E-01 3.79100E-03 1.00E+01 30 30 1.2358E-01 1.0010E+01 8.1000E+01 9.95250E-01 4.75000E-03 1.00E+01 ----------------------------------------------------------------------------------------- CFE.DXA: Additional details from the cell survival assay (AG 1522). ===================================================================================== DATASET ID ---------- TIME (h) ----------- DOSE ---- LETHAL DAMAGE --- CFE RADX RADX TTP ETSI (Gy) #/(cell Gy) #/(cell) ------------------------------------------------------------------------------------- 1 1 1.694E+01 1.200E+01 4.000E+02 4.0650E+00 2.4038E-01 9.7713E-01 2 2 1.868E+01 1.200E+01 4.000E+02 4.4820E+00 1.7379E-01 7.7893E-01 3 3 2.411E+01 1.200E+01 4.000E+02 5.7870E+00 2.1622E-01 1.2513E+00 4 4 3.920E+01 1.200E+01 4.000E+02 9.4080E+00 1.9856E-01 1.8681E+00 5 5 6.665E+01 1.200E+01 4.000E+02 1.5995E+01 2.1699E-01 3.4707E+00 6 6 9.088E+01 1.200E+01 4.000E+02 2.1812E+01 2.1346E-01 4.6559E+00 7 7 1.694E+01 1.200E+01 4.000E+02 5.7590E+00 1.7927E-01 1.0324E+00 8 8 1.815E+01 1.200E+01 4.000E+02 6.1720E+00 2.4265E-01 1.4976E+00 9 9 2.382E+01 1.200E+01 4.000E+02 8.0980E+00 2.8637E-01 2.3190E+00 10 10 4.042E+01 1.200E+01 4.000E+02 1.3742E+01 1.9378E-01 2.6629E+00 11 11 4.050E+01 1.200E+01 4.000E+02 1.3771E+01 2.0182E-01 2.7792E+00 12 12 6.773E+01 1.200E+01 4.000E+02 2.3027E+01 2.3191E-01 5.3402E+00 13 13 6.781E+01 1.200E+01 4.000E+02 2.3055E+01 2.3964E-01 5.5250E+00 14 14 1.830E+01 1.200E+01 4.000E+02 1.2994E+01 2.6334E-01 3.4218E+00 15 15 1.830E+01 1.200E+01 4.000E+02 1.2996E+01 2.4698E-01 3.2098E+00 16 16 2.390E+01 1.200E+01 4.000E+02 1.6971E+01 2.5128E-01 4.2644E+00 17 17 2.394E+01 1.200E+01 4.000E+02 1.6999E+01 2.6414E-01 4.4901E+00 18 18 3.874E+01 1.200E+01 4.000E+02 2.7503E+01 2.5565E-01 7.0311E+00 19 19 3.878E+01 1.200E+01 4.000E+02 2.7531E+01 2.6309E-01 7.2432E+00 20 20 2.486E-02 1.200E+01 4.000E+02 2.0140E+00 5.1878E-01 1.0448E+00 21 21 2.525E-02 1.200E+01 4.000E+02 2.0450E+00 3.9052E-01 7.9861E-01 22 22 4.937E-02 1.200E+01 4.000E+02 3.9990E+00 5.0259E-01 2.0098E+00 23 23 4.940E-02 1.200E+01 4.000E+02 4.0010E+00 4.3225E-01 1.7294E+00 24 24 7.314E-02 1.200E+01 4.000E+02 5.9240E+00 5.0679E-01 3.0022E+00 25 25 7.426E-02 1.200E+01 4.000E+02 6.0150E+00 4.6160E-01 2.7765E+00 26 26 7.428E-02 1.200E+01 4.000E+02 6.0170E+00 4.0234E-01 2.4209E+00 27 27 9.910E-02 1.200E+01 4.000E+02 8.0270E+00 5.1213E-01 4.1109E+00 28 28 9.911E-02 1.200E+01 4.000E+02 8.0280E+00 4.9077E-01 3.9399E+00 29 29 1.232E-01 1.200E+01 4.000E+02 9.9790E+00 5.5869E-01 5.5751E+00 30 30 1.236E-01 1.200E+01 4.000E+02 1.0010E+01 5.3443E-01 5.3496E+00 ------------------------------------------------------------------------------------- ETSI: Total elapsed time (after irradiation) before colonies are counted. TTP: Time available for repair before cells are plated. Total VC execution time (min): 2.2938 VC 2.00H 10-JUL-2003 20-JUL-2003 03:44:17 PM