VC 2.00I 15-JUL-2003 02-AUG-2003 08:30:43 PM by RD Stewart (trebor@purdue.edu) PROGRAM FILE INPUT/OUTPUT AND RUN-TIME OPTIONS: ================================================================================ CMD: vc tlk.inp ..\xdat\hx156c.xdat -c FNI: tlk.inp FNO: tlk.out RADX: ..\xdat\hx156c.radx (11 exposures) XDAT: ..\xdat\hx156c.xdat (11 experiments) -------------------------------------------------------------------------------- MCAT SUMMARY: BEST-FIT MODEL PARAMETERS (method = BCONF): ========================================================================================== --- PARAMETER --- ----- CONSTRAINTS ----- INITIAL OPTIMAL PID CID NAM Minimum Maximum GUESS VALUE 2001 CLRP BMR 0.00000E+00 1.00000E+00 2.00000E-04 1.9214372E-03 2400 CLRP PHI 0.00000E+00 2.50000E-01 1.00000E-02 2.1784439E-02 2202 CLRP RHT 1.00000E-02 1.20000E+01 1.50000E+00 2.7893701E+00 ------------------------------------------------------------------------------------------ FIGURE OF MERIT (FOM): 6.52752E-03 (nfom=99, nsim=1089, nmx=11, nox=11, ndf=7, nap=3) COMBINED UNWEIGHTED RESIDUAL: Stats: min=-1.024E-01 max=1.662E-01, mean=-3.3161E-03, stdev=7.5227E-02, var=5.6591E-03 Student's T test (mean=0, NDF=7): Pr>ABS(0.14620)= 8.8788E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.93146)=4.068E-01 (passed normality test) COMBINED WEIGHTED RESIDUAL: Stats: min=-3.087E-02 max=5.011E-02, mean=-9.9984E-04, stdev=2.2682E-02, var=5.1446E-04 Student's T test (mean=0, NDF=7): Pr>ABS(0.14620)= 8.8788E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.93146)=4.068E-01 (passed normality test) QECK TABLE: Cell and tissue kinetic parameters. ================================================================================ Duration of cell cycle (TCC): 10.00000 h Potential doubling time (Tpot): 480.00000 h (= 20.000 days) Cell birth rate (AX): 1.6636E+00 cell/day (= LOG(2)/TCC) Cell death rate (BX): 1.6289E+00 cell/day [=AX-LOG(2)/TPOT] Net cell birth rate (AX-BX): 3.4657E-02 cell/day Initial Number of Cells: non-dividing: 1.00000E+00 (100.000% = 1-GF) dividing: 0.00000E+00 ( 0.000% = GF) total: 1.00000E+00 (100.000% total) Life Support Capacity of System: Initial system capacity utilization: 0.000000% (=F0) Peak cell density (cells/cm^3): 1.00000E+38 (=KAP) Tissue volume (cm^3): 1.00000E+00 (=VOL) Maximum number of cells (cells): 1.00000E+38 (=KAP*VOL) -------------------------------------------------------------------------------- TLKM TABLE: Summary of TLK parameters and related (derived) quantities. ======================================================================== G0/G1 DNA CONTENT: 5667.000 Mbp/cell = 3.482938E+12 Da/cell ENDOGENOUS DAMAGE: per (h-Da) per (h-Mbp) per (h-cell) Simple DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Complex DSB = 0.00000E+00 0.00000E+00 0.00000E+00 Total DSB = 0.00000E+00 0.00000E+00 0.00000E+00 DAMAGE FORMATION: per (Gy-Da) per (Gy-Mbp) per (Gy-cell) Simple DSB = 5.74228E-12 3.52920E-03 20.000000 Complex DSB = 1.43557E-12 8.82301E-04 5.000000 Total DSB = 7.17785E-12 4.41151E-03 25.000000 DAMAGE REPAIR/MISREPAIR: A1= 7.500000E-01 (=75.000%) A2= 2.500000E-01 (=25.000%) PHI1= 2.178444E-02 (=2.178%) PHI2= 2.178444E-02 (=2.178%) (1-A1)*PHI1= 5.446110E-03 (=0.545%) (1-A2)*PHI2= 1.633833E-02 (=1.634%) (1-A1)*(1-PHI1)= 2.445539E-01 (=24.455%) (1-A2)*(1-PHI2)= 7.336617E-01 (=73.366%) RHT1= 0.100000 h (=6.00 minute) RHT2= 2.789370 h (=167.36 minute) LAM1= 6.9314718E+00 (1/h) LAM2= 2.4849595E-01 (1/h) BMR= 1.9214372E-03 (1/h) LAM1/BMR= 3.6074412E+03 LAM2/BMR= 1.2932817E+02 (LAM1+LAM2)/BMR= 3.7367694E+03 GAM= 0.250 ************** EQUIVALENT LQ MODEL PARAMETERS ************************** Simple Complex Total alpha: 1.0892E-01 + 8.1692E-02 = 1.9061384E-01 (1/Gy) beta: 1.9957E-02 + 2.8983E-02 = 4.8940052E-02 (1/Gy^2) alpha/beta: 3.8948434 (Gy) ------------------------------------------------------------------------ NOTE: 1 bp = 614.6 Da (amu) = 1.0205E-09 pg MCAT FIT: CELL SURVIVAL AS A FUNCTION OF DOSE AND DOSE RATE (HX 156C cells). ===================================================================================================== -------- EXPOSURE SUMMARY -------- Duration Dose Dose Rate ---------------- SURVIVING FRACTION -------------- EXPERIMENT (h) (Gy) (Gy/h)* Measured Norm. Wt Predicted Residual ----------------------------------------------------------------------------------------------------- 1 1.0885E+00 2.0900E+00 1.9200E+00 6.49878E-01 9.09E-02 5.89515E-01 -1.0239E-01 2 2.1146E+00 4.0600E+00 1.9200E+00 3.14125E-01 9.09E-02 3.05988E-01 -2.6594E-02 3 3.1302E+00 6.0100E+00 1.9200E+00 1.41363E-01 9.09E-02 1.44800E-01 2.3739E-02 4 4.1510E+00 7.9700E+00 1.9200E+00 5.32060E-02 9.09E-02 6.38110E-02 1.6619E-01 5 5.1875E+00 9.9600E+00 1.9200E+00 2.65170E-02 9.09E-02 2.64961E-02 -7.8718E-04 6 6.2031E+00 1.1910E+01 1.9200E+00 1.15140E-02 9.09E-02 1.08542E-02 -6.0792E-02 7 3.5000E-02 2.1000E+00 6.0000E+01 5.80825E-01 9.09E-02 5.48448E-01 -5.9033E-02 8 6.7500E-02 4.0500E+00 6.0000E+01 2.27726E-01 9.09E-02 2.29756E-01 8.8333E-03 9 1.0000E-01 6.0000E+00 6.0000E+01 7.05970E-02 9.09E-02 7.52316E-02 6.1604E-02 10 1.3250E-01 7.9500E+00 6.0000E+01 2.15530E-02 9.09E-02 2.00596E-02 -7.4446E-02 11 1.6617E-01 9.9700E+00 6.0000E+01 4.13500E-03 9.09E-02 4.25061E-03 2.7198E-02 ----------------------------------------------------------------------------------------------------- RESIDUAL: Stats: min=-1.024E-01 max=1.662E-01, mean=-3.3161E-03, stdev=7.5227E-02, var=5.6591E-03 Student's T test (mean=0, NDF=7): Pr>ABS(0.14620)= 8.8788E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.93146)=4.068E-01 (passed normality test) WEIGHTED RESIDUAL: Stats: min=-3.087E-02 max=5.011E-02, mean=-9.9984E-04, stdev=2.2682E-02, var=5.1446E-04 Student's T test (mean=0, NDF=7): Pr>ABS(0.14620)= 8.8788E-01 (acceptable fit) Shapiro-Wilk's Test: (Pr<0.93146)=4.068E-01 (passed normality test) NOX=11, NPAR=3 CFE.SF: Cell survival data for HX 156C cells. ========================================================================================= -------- EXPOSURE SUMMARY -------- ------------ ENDPOINT ------------- DATASET ID Duration Dose Dose Rate Fraction Fraction Standard CFE RADX (h) (Gy) (Gy/h) Killed Viable Error (%) ----------------------------------------------------------------------------------------- 1 1 1.0885E+00 2.0900E+00 1.9200E+00 3.50122E-01 6.49878E-01 1.00E+01 2 2 2.1146E+00 4.0600E+00 1.9200E+00 6.85875E-01 3.14125E-01 1.00E+01 3 3 3.1302E+00 6.0100E+00 1.9200E+00 8.58637E-01 1.41363E-01 1.00E+01 4 4 4.1510E+00 7.9700E+00 1.9200E+00 9.46794E-01 5.32060E-02 1.00E+01 5 5 5.1875E+00 9.9600E+00 1.9200E+00 9.73483E-01 2.65170E-02 1.00E+01 6 6 6.2031E+00 1.1910E+01 1.9200E+00 9.88486E-01 1.15140E-02 1.00E+01 7 7 3.5000E-02 2.1000E+00 6.0000E+01 4.19175E-01 5.80825E-01 1.00E+01 8 8 6.7500E-02 4.0500E+00 6.0000E+01 7.72274E-01 2.27726E-01 1.00E+01 9 9 1.0000E-01 6.0000E+00 6.0000E+01 9.29403E-01 7.05970E-02 1.00E+01 10 10 1.3250E-01 7.9500E+00 6.0000E+01 9.78447E-01 2.15530E-02 1.00E+01 11 11 1.6617E-01 9.9700E+00 6.0000E+01 9.95865E-01 4.13500E-03 1.00E+01 ----------------------------------------------------------------------------------------- CFE.DXA: Additional details from the cell survival assay (HX 156C). ===================================================================================== DATASET ID ---------- TIME (h) ----------- DOSE ---- LETHAL DAMAGE --- CFE RADX RADX TTP ETSI (Gy) #/(cell Gy) #/(cell) ------------------------------------------------------------------------------------- 1 1 1.089E+00 1.200E+01 4.000E+02 2.0900E+00 2.0621E-01 4.3097E-01 2 2 2.115E+00 1.200E+01 4.000E+02 4.0600E+00 2.8521E-01 1.1580E+00 3 3 3.130E+00 1.200E+01 4.000E+02 6.0100E+00 3.2553E-01 1.9564E+00 4 4 4.151E+00 1.200E+01 4.000E+02 7.9700E+00 3.6808E-01 2.9336E+00 5 5 5.188E+00 1.200E+01 4.000E+02 9.9600E+00 3.6445E-01 3.6300E+00 6 6 6.203E+00 1.200E+01 4.000E+02 1.1910E+01 3.7483E-01 4.4642E+00 7 7 3.500E-02 1.200E+01 4.000E+02 2.1000E+00 2.5872E-01 5.4331E-01 8 8 6.750E-02 1.200E+01 4.000E+02 4.0500E+00 3.6534E-01 1.4796E+00 9 9 1.000E-01 1.200E+01 4.000E+02 6.0000E+00 4.4179E-01 2.6508E+00 10 10 1.325E-01 1.200E+01 4.000E+02 7.9500E+00 4.8267E-01 3.8372E+00 11 11 1.662E-01 1.200E+01 4.000E+02 9.9700E+00 5.5048E-01 5.4883E+00 ------------------------------------------------------------------------------------- ETSI: Total elapsed time (after irradiation) before colonies are counted. TTP: Time available for repair before cells are plated. Total VC execution time (min): 0.12735 VC 2.00I 15-JUL-2003 02-AUG-2003 08:30:51 PM