*/
MODEL: DRM=TLK CKM=QECK
CELL: DNA=5.667D+09 NC=46
IRAD: CL=DSB
CLRP: RHT=HT4R BMR=2.75E-04 PHI=PML A0=PMR
CCKM: TCC=10 TPOT=20 GF=0.0 N0=1 KAP=1.0D+38 VOL=1
RBM: KX=6.0E+06 FMAX=1 !Analysis of PFGE data
! TLK model inputs (simple and complex double strand breaks)
DSB = 20 5 / !Radiation damage to DNA
HT4R = 0.1 3.9 / !Half-times for DSB repair
PML = 0.01 / !Probability a misrejoined DSB is lethal
PMR = 0.75 0.25 / !Probability DSB is rejoined correctly
! Parameters that impact on solution accuracy
SOLVER: DBLV=0 ETOL=1.0E-09 MXSS=999999 HMAX=10
! Parameters that control the time steps and stopping criteria
SIMCON: FSDX=1 TSAX=12 TCUT=96 FRDL=1.0D+00 RCUT=1.0D-09
BCONF: MITR=10000 MXFN=100000 SGT=1.0D-04 SST=1.0D-09 FCT=1.0D-09
MCAT: NPAR=3 !npar=2 or 3 for small datasets, npar=3-5 for large datasets
AMP1: CID=CLRP PNAM=BMR PLB=0.0 PUB=1 PIG=2.0E-04
AMP2: CID=CLRP PNAM=PHI PLB=0.0 PUB=0.25 PIG=0.01 LI=0 !Both DSB
AMP3: CID=CLRP PNAM=RHT PLB=0.01 PUB=12 PIG=1.5 LI=2 !Complex DSB
AMP4: CID=CLRP PNAM=RHT PLB=0.01 PUB=12 PIG=0.15 LI=1 !Simple DSB
AMP5: CID=IRAD PNAM=CL PLB=1 PUB=20.0 PIG=5 LI=2 !Complex DSB
/*
Figure of Merit (FOM) Weight
1: cell survival data
2: DSB rejoining data (FAR)
3: DSB rejoining data (Avg. DSB/cell)
4: Transformed cells per survivor
5: Transformed cells per irradiated cell
*/
FOM: UW=LFWT
LFWT = 1 0 0 0 0 / |
