/*
  TLK Model Input File for Human Bladder Carcinoma Cells (RT112)

  REFERENCE:
      Ruiz de Almodovar JM, Bush C, Peacock JH, Steel GG, Whitaker SJ, McMillan TJ.
      Dose-rate effect for DNA damage induced by ionizing radiation in human tumor
      cells. Radiat. Res. 138, S93-S96 (1994)

  PREPARED BY: RD STEWART (trebor@purdue.edu)
  DATE: 14-JUL-2003
*/
  MODEL: DRM=TLK CKM=QECK
  CELL: DNA=5.667D+09 NC=46
  IRAD: CL=DSB
  CLRP: RHT=HT4R BMR=1.1452726E-03 PHI=PML A0=PMR
  CCKM: TCC=10 TPOT=20 GF=0.0 N0=1 KAP=1.0D+38 VOL=1
  RBM: KX=6.0E+06 FMAX=1   !Analysis of PFGE data

! TLK model inputs (simple and complex double strand breaks)
  DSB = 20 5 /                                 
  HT4R = 2.1975690E-01 2.2534392E-01 /         
  PML = 1.8240273E-02 /                        
  PMR = 0.75 0.25 /

! Parameters that impact on solution accuracy
  SOLVER: DBLV=0 ETOL=1.0E-09 MXSS=999999 HMAX=10

! Parameters that control the time steps and stopping criteria
  SIMCON: FSDX=1 TSAX=12 TCUT=96 FRDL=1.0D+00 RCUT=1.0D-09

 !IRRADIATION CONDITIONS (single fraction)
  RADX: ADR=RX1 AD=RX2
  RX1 = 0.6 1.2 3.0 6.0 12 30 76.8 /  !dose rate (Gy/h)
  RX2 = 0 0.1 0.25 0.5 1 1.5 2 3 4 5 6 7 8 9 10 12.5
        15 17.5 20 25 30 35 /

Last updated: 10 June, 2011
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