Recent Publications

Last modified on August 7, 2019. . 


Wilkerson BA. Chitsazan AD. VandenBosch LS. Wilken MS. Reh TA. Bermingham-McDonogh O. Open chromatin dynamics in prosensory cells of the embryonic mouse cochlea. Sci Rep. 2019 June, 9(1):9060.

Hoshino A. Horvath S. Sridhar A. Chitsazan A. Reh TA. Synchrony and asynchrony between an epigenetic clock and developmental timing. Sci Rep. March, 2019, 9(1):3770

Zhang C1. Yu WQ. Hoshino A. Huang J. Rieke F. Reh TA. Wong ROL. Development of ON and OFF cholinergic amacrine cells in the human fetal retina. Journal of Comparative Neurology. 2019 Jan, 527(1):174-186.


Reh TA. Hindges R. MicroRNAs in Retinal Development. Annual Review of Vision Science. 2018 September, 4(1):25-44


Hoshino A. Ratnapriya R. Brooks MJ. Chaitankar V. Wilken MS. Zhang C. Starostik MR, Gieser L. La Torre A. Nishio M. Bates O. Walton A. Bermingham-McDonogh O. Glass IA, Wong ROL. Swaroop A. Reh TA. Molecular Anatomy of the Developing Human Retina. Dev Cell. 2017 Dec, 43(6):763-779.

Wohl SG. Jorstad NL. Levine EM. Reh TA. Müller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture. Nat Commun. 2017 Nov, 8(1):1603.

Nakamura PA. Shimchuk AA. Tang S. Wang Z. DeGolier K. Ding S. Reh TA. Small molecule Photoregulin3 prevents retinal degeneration in the RhoP23H mouse model of retinitis pigmentosa. Elife. 2017 Nov 17;6.

Jorstad NL. Wilken MS. Grimes WN. Wohl SG. VandenBosch LS. Yoshimatsu T. Wong RO. Rieke F. Reh TA. Stimulation of functional neuronal regeneration from Müller glia in adult mice. Nature. 2017 Aug;548(7665):103-107.

Chao JR. Lamba DA. Klesert TR. Torre A. Hoshino A. Taylor RJ. Jayabalu A. Engel AL. Khuu TH. Wang RK. Neitz M. Neitz J. Reh TA. Transplantation of Human Embryonic Stem Cell-Derived Retinal Cells into the Subretinal Space of a Non-Human Primate. Transl Vis Sci Technol. 2017 May, 6(3):4.


Nakamura PA. Tang S. Shimchuk AA. Ding S. Reh TA. Potential of Small Molecule-Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis Pigmentosa. Invest Ophthalmol Vis Sci. 2016 Nov, 57(14):6407-6415.

Wohl SG. Reh TA. The microRNA expression profile of mouse Müller glia in vivo and in vitro. Sci Rep. 2016 Oct 14;6:35423.

Wilken, MS. Reh TA. Retinal Regeneration in Birds and Mice. Curr Opin Genet Dev. 2016 July, 40:57-64.

Wohl SG, Reh TA. miR-124- 9-9* potentiates Ascl1-induced reprogramming of cultured Müller glia. Glia. 2016 May;64(5):743-62.

Reh, TA. Photoreceptor Transplantation in Late Stage Retinal Degeneration. Invest Opthalmol Vis Sci. 2016 April; 57(5):ORSFg1-7.


La Torre A, Hoshino A, Cavanaugh C, Ware CB, Reh TA. The GIPC1-Akt1 Pathway Is Required for the Specification of the Eye Field in Mouse Embryonic Stem Cells. Stem Cells. 2015 Sep;33(9):2674-85.

Zhang J, Taylor RJ, La Torre A, Wilken MS, Cox KE, Reh TA, Vetter ML. Ezh2 maintains retinal progenitor proliferation, transcriptional integrity, and the timing of late differentiation. Dev Biol. 2015 Jul 15;403(2):128-38.

Wilken MS, Brzezinski JA, La Torre A, Siebenthall K, Thurman R, Sabo P, Sandstrom RS, Vierstra J, Canfield TK, Hansen RS, Bender MA, Stamatoyannopoulos J, Reh TA. DNase I hypersensitivity analysis of the mouse brain and retina identifies region-specific regulatory elements. Epigenetics Chromatin. 2015 Feb 28;8:8.

Ueki Y, Wilken MS, Cox KE, Chipman LB, Bermingham-McDonogh O, Reh TA. A transient wave of BMP signaling in the retina is necessary for Müller glial differentiation. Development. 2015 Feb 1;142(3):533-43.

Ueki, Y., Wilken, M., Cox, K., Chipman, L., Jorstad, N., Sternhagen, K., Simic, M., Ullom, K., Nakafuku, M., Reh, T.A. Transgenic expression of the proneural transcription factor Ascl1 in Müller glia stimulates retinal regeneration in young mice. PNAS 2015 Nov 3;112(44):13717-22


Hyde DR, Reh TA. The past, present, and future of retinal regeneration. Exp Eye Res. 2014 Jun;123:105-6.

Yue et al Mouse ENCODE Consortium. A comparative encyclopedia of DNA elements in the mouse genome. Nature. 2014 Nov 20;515(7527):355-64.

Stergachis et al, Conservation of trans-acting circuitry during mammalian regulatory evolution. Nature. 2014 Nov 20;515(7527):365-70.

Cheng et al Principles of regulatory information conservation between mouse and human. Nature. 2014 Nov 20;515(7527):371-5.

Vierstra et al Mouse regulatory DNA landscapes reveal global principles of cis-regulatory evolution. Science. 2014 Nov 21;346(6212):1007-12.


Brzezinski JA, Uoon park K, Reh TA. Blimp1 (Prdm1) prevents re-specification of photoreceptors into retinal bipolar cells by restricting competence. Dev Biol. 2013;384(2):194-204.

Mathieu J, Zhang Z, Nelson A, Lambda DA, Reh TA, Ware C, Ruohola-Baker H. Hypoxia induces re-entry of committed cells into pluripotency. Stem Cells. 2013;31(9):1737-48.

La Torre A, Georgi S, Reh TA. Conserved microRNA pathway regulates developmental timing of retinal neurogenesis. Proc Natl Acad Sci USA. 2013;110(26):E2362-70.

Pollak J, Wilken MS, Ueki Y, Cox KE, Sullivan JM, Taylor RJ, Levine EM, Reh TA. ASCL1 reprograms mouse Muller glia into neurogenic retinal progenitors. Development. 2013;140(12):2619-31.

Ueki Y, Reh TA. EGF stimulates müller glial proliferation via a BMP-dependent mechanism. Glia. 2013 Jan 30. doi: 10.1002/glia.22472. [Epub ahead of print].PMID:23362023


Bermingham-McDonogh O, Corwin JT, Hauswirth WW, Heller S, Reed R, Reh TA. Regenerative medicine for the special senses: restoring the inputs. J Neurosci. 2012 Oct 10;32(41):14053-7. PMID:23055472

Ueki Y, Karl MO, Sudar S, Pollak J, Taylor RJ, Loeffler K, Wilken MS, Reardon S, Reh TA. P53 is required for the developmental restriction in Müller glial proliferation in mouse retina. Glia. 2012 Oct;60(10):1579-89. PMID:22777914

Ueki Y, Reh TA. Activation of BMP-Smad1/5/8 signaling promotes survival of retinal ganglion cells after damage in vivo. PLoS One. 2012;7(6):e38690. PMID:22701694

La Torre A, Lamba DA, Jayabalu A, Reh TA. Production and transplantation of retinal cells from human and mouse embryonic stem cells. Methods Mol Biol. 2012;884:229-46. PubMed PMID:22688710

Karl MO, Reh TA. Studying the generation of regenerated retinal neuron from Müller glia in the mouse eye. Methods Mol Biol. 2012;884:213-27.  PubMed PMID:22688709

McUsic AC, Lamba DA, Reh TA.  Guiding the morphogenesis of dissociated newborn mouse retinal cells and hES cell-derived retinal cells by soft lithography-patterned microchannel PLGA scaffolds. Biomaterials. 2012 Feb;33(5):1396-405.  PubMed PMID:22115999


Lamba DA, Reh TA. Microarray characterization of human embryonic stem cell-derived retinal cultures. Invest Ophthalmol Vis Sci. 2011 52(7):4897-906.

Gust J, Reh TA. Adult donor rod photoreceptors integrate into the mature mouse retina. Invest Ophthalmol Vis Sci. 2011 Mar 24. PubMed PMID: 21436277.

Georgi SA, Reh TA. Dicer is required for the maintenance of Notch signaling and gliogenic competence during mouse retinal development. Dev Neurobiol. 2011 May 3. doi: 10.1002/dneu.20899.

Brzezinski JA 4th, Kim EJ, Johnson JE, Reh TA. Ascl1 expression defines a subpopulation of lineage-restricted progenitors in the mammalian retina. Development. 2011 Aug;138(16):3519-31.

Nelson BR, Ueki Y, Reardon S, Karl MO, Georgi S, Hartman BH, Lamba DA, Reh TA. Genome-wide analysis of müller glial differentiation reveals a requirement for notch signaling in postmitotic cells to maintain the glial fate. PLoS One. 2011;6(8):e22817. Epub 2011 Aug 2.

Bermingham-McDonogh O, Reh TA. Regulated reprogramming in the regeneration of sensory receptor cells. Neuron. 2011 Aug 11;71(3):389-405.


Georgi SA, Reh TA. Dicer is required for the transition from early to late progenitor state in the developing mouse retina. J Neurosci. 2010 Mar 17;30(11):4048-61.

Brzezinski JA 4th, Lamba DA, Reh TA. Blimp1 controls photoreceptor versus bipolar cell fate choice during retinal development. Development. 2010 137(4):619-29.

Karl MO, Reh TA. (2010) Regenerative medicine for retinal diseases: activating endogenous repair mechanisms. Trends Mol Med. 2010 Apr;16(4):193-202.

Lamba DA, McUsic A, Hirata RK, Wang PR, Russell D, Reh TA. Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells. PLoS One. 2010 5(1):e8763.

Hayashi T, Lamba DA, Slowik A, Reh TA, Bermingham-McDonogh O. A method for stabilizing RNA for transfection that allows control of expression duration. DevDyn. 2010 Jul;239(7):2034-40.

Hartman BH, Nelson BR, Reh TA, Bermingham-McDonogh O. 2010 Delta/notch-like EGF-related receptor (DNER) is expressed in hair cells and neurons in the developing and adult mouse inner ear. J Assoc Res Otolaryngol.  Jun;11(2):187-201.

Hartman BH, Reh, TA, Bermingham-McDonogh, O. 2010 Notch signaling specifies prosensory domains via lateral induction in the developing mammalian inner ear Proc Natl Acad Sci U S A. 107(36):15792-15797.


Lamba, DA, Gust, J and Reh, TA Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice.  Cell Stem Cell 2009; 4:1-7

Nelson BR, Hartman BH, Ray CA, Hayashi T, Bermingham-McDonogh O, Reh TA. Acheate-scute like 1 (Ascl1) is required for normal delta-like (Dll) gene expression and notch signaling during retinal development. Dev Dyn. 238:2163-78

Hartman BH, Basak O, Nelson BR, Taylor V, Bermingham-McDonogh O, Reh TA. Hes5 expression in the postnatal and adult mouse inner ear and the drug-damaged cochlea. J Assoc Res Otolaryngol. 2009 10(3):321-40.

Geng R, Geller SF, Hayashi T, Ray CA, Reh TA, Bermingham-McDonogh O, Jones SM, Wright CG, Melki S, Imanishi Y, Palczewski K, Alagramam KN, Flannery JG. Usher syndrome IIIA gene clarin-1 is essential for hair cell function and associated neural activation. Hum Mol Genet. 2009 Aug 1;18(15):2748-60.

Geller SF, Guerin KI, Visel M, Pham A, Lee ES, Dror AA, Avraham KB, Hayashi T, Ray CA, Reh TA, Bermingham-McDonogh O, Triffo WJ, Bao S, Isosomppi J, Vstinsalo H, Sankila EM, Flannery JG. CLRN1 is nonessential in the mouse retina but is required for cochlear hair cell development. PLoS Genet. 2009 Aug;5(8):e1000607.


Lamba D, Karl M, Reh T. Neural regeneration and cell replacement: a view from the eye. Cell Stem Cell. 2008 Jun 5;2(6):538-49.

Liu H, Etter P, Hayes S, Jones I, Nelson B, Hartman B, Forrest D, Reh TA. NeuroD1 regulates expression of thyroid hormone receptor 2 and cone opsins in the developing mouse retina. J Neurosci. 2008 28(3):749 56.

Hayashi T, Kokubo H, Hartman BH, Ray CA, Reh TA, Bermingham-McDonogh O. Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea. Dev Biol. 2008 Apr 1;316(1):87-99.

Nelson BR, Reh TA. Relationship between Delta-like and proneural bHLH genes during chick retinal development. Dev Dyn. 2008 Jun;237(6):1565-80.

Karl MO, Hayes S, Nelson BR, Tan K, Buckingham B, Reh TA. Stimulation of neural regeneration in the mouse retina. Proc Natl Acad Sci U S A. 2008 105(49):19508-13

Lamba DA, Hayes S, Karl MO, Reh T.  Baf60c is a component of the neural progenitor-specific BAF complex in developing retina. Dev Dyn. 2008 Oct;237(10):3016-23.


Lawrence JM, Singhal S, Bhatia B, Keegan DJ, Reh TA, Luthert PJ, Khaw PT, Limb GA. (2007) MIO-M1 cells and similar muller glial cell lines derived from adult human retina exhibit neural stem cell characteristics. Stem Cells.25(8):2033-43.

Nelson BR, Hartman BH, Georgi SA, Lan MS, Reh TA. (2007) Transient inactivation of Notch signaling synchronizes differentiation of neural progenitor cells. Dev Biol. 304(2):479-98.

Hayes S, Nelson BR, Buckingham B, Reh TA. (2007) Notch signaling regulates regeneration in the avian retina. Dev Biol. 312(1):300-11

Sakami S, Etter P, Reh TA. (2008) Activin signaling limits the competence for retinal regeneration from the pigmented epithelium.  Mech Dev. 125(1-2):106-16

Hartman BH, Hayashi T, Nelson BR, Bermingham-McDonogh O, Reh TA. (2007) Dll3 is expressed in developing hair cells in the mammalian cochlea. Dev Dyn. 236(10):2875-83.


Reh, T.A. (2006) Right timing for retinal repair.  Nature 444(7116):156-7

McCabe KL, McGuire C, Reh TA.  (2006) Pea3 expression is regulated by FGF signaling in developing retina.  Dev Dyn. 235(2):327-35.

Nelson, B, R. Gumuscu, B., T. A. Reh  (2006) Notch activity is down-regulated just prior to retinal ganglion cell differentiation.  Developmental Neuroscience 28(1-2):128-41

Roberts MR, Srinivas M, Forrest D, Morreale de Escobar G, Reh TA. (2006) Making the gradient: thyroid hormone regulates cone opsin expression in the developing mouse retina. Proc Natl Acad Sci U S A. 103(16):6218-23.

Close JL, Liu J, Gumuscu B, Reh TA. (2006) Epidermal growth factor receptor expression regulates proliferation in the postnatal rat retina.Glia.  54(2):94-104.

Lamba DA, Karl MO, Ware CB, Reh TA. (2006)  Efficient generation of retinal progenitor cells from human embryonic stem cells.  Proc Natl Acad Sci U S A.  103:12769-12774


Moshiri, A. , McGuire, C. and Reh, T.A. (2005) Sonic hedgehog regulates proliferation of the retinal ciliary marginal zone in post-hatch chicks.  Developmental Dynamics . 233(1):66-75

Sakami, S., Hisatomi, O., Sakakibara, S., Liu, J, Reh, T.A. and Tokunaga, F. (2005)  Expression of Otx2 during retinal regeneration in the newt. Developmental Brain Research  22:155(1):49-59.

Close, JL, Gumuscu, B, and T. A. Reh (2005) Retinal neurons regulate proliferation of postnatal progenitors and  Muller glia in the Rat Retina via TGFß signaling. Development Jul;132(13):3015-2

Roberts, M.R., A. Hendrickson, C. R. McGuire, and T. A. Reh(2005)Retinoid X Receptor gamma is necessary to establish the S-opsin gradient in cone photoreceptors of the developing mouse retina I.O.V.S Aug;46(8):2897-904


Fischer AJ, Schmidt M, Omar G, Reh TA. 2004  BMP4 and CNTF are neuroprotective and suppress damage-induced proliferation of Muller glia in the retina. Mol Cell Neurosci. Dec;27(4):531-42.

Fischer AJ, Omar G, Eubanks J, McGuire CR, Dierks BD, Reh TA. Different aspects of gliosis in retinal Muller glia can be induced by CNTF, insulin, and FGF2 in the absence of damage.Mol Vis. 2004 Dec 22;10:973-86.

Fischer, A.J., Wang, S-Z., and Reh, T.A. (2004) NeuroD Induces the Expression of Visinin and Calretinin by Proliferating Cells Derived From Toxin-Damaged Chicken Retina Development Dynamics 229(3):555-63.

Kubota, R. McGuire, C., Dierks, B., and Reh, T.A. (2004) Identification of ciliary epithelial specific genes in the avian eye using a subtractive differential screen.   Developmental Dynamics 229:529-540

Moshiri, A. and Reh, T.A.  (2004) Persistent neural progenitors at the retinal margin of ptc +/-mice.  Journal of Neuroscience. 24(1):229-37.

Ramamurthy V, Niemi GA, Reh TA, Hurley JB.  Leber congenital amaurosis linked to AIPL1: a mouse model reveals destabilization of cGMP phosphodiesterase. Proc Natl Acad Sci U S A. 2004 Sep 21;101(38):13897-902.


Liu, J. Wilson, S. and Reh, T.A.  (2003)  BMP receptor 1b is required for axon guidance and cell survival in the developing retina.  Developmental Biology  256:34-47

Fischer, A. and Reh, T.A.  (2003) Potential of Muller glia to become neurogenic retinal progenitor cells.  Glia  43:70-76.

Fischer, A.J. and Reh, T.A. (2003)  Growth factors induce neurogenesis in the ciliary body.  Developmental Biology. 259:225-240.

Ramamurthy, V., Roberts, M., van den Akker, F., Niemi, G., Reh, T.A., and Hurley, J.B. (2003) AIPL1, a protein implicated in Leber’s congenital amaurosis, interacts with and aids in processing of farnesylated proteins.  P.N.A.S. 100(22):12630-5


Kubota , R., J.N. Hokoc , A. Moshiri , C. McGuire , T.A. Reh (2002) A comparative study of neurogenesis in the retinal ciliary marginal zone of homeothermic vertebrates.  Developmental Brain Research .134:31-41

 Fischer, A. J.  Dierks, B. and T.A. Reh (2002) Exogenous growth factors induce the production of ganglion cells at the retinal margin.  Development 129, 2283-2291.

 Fischer, A.J. and Reh, T.A. (2002) Exogenous growth factors stimulate the regeneration of ganglion cells in the chicken retina.  Developmental Biology 251(2):367-79

Fischer, A.J., McGuire, C.R., Dierks, B.D., and Reh, T.A. (2002) Insulin and fibroblast growth factor2 activate a neurogenic program in Muller glia of the chicken retina.  Journal of Neuroscience 22:9387-9398.


Ng, L. Hurley, J.B., Dierks, B. Srinivas,M., Salto, C., Vennstrom, B., Reh, T. A. Forrest, D. (2001)  A thyroid hormone receptor that is necessary for the development of    green cone photoreceptors.  Nature Genetics 27:94-98.

Fischer, A.J. and Reh, TA (2001) Müller glia are a potential source of neural regeneration in the postnatal chicken retina.  Nature Neuroscience 4:247-252.

Fischer, A. J., A. Hendrickson and T.A. Reh (2001). Immunocytochemical characterization of cysts in the peripheral retina and pars plana of the adult primate eye. Investigative Ophthalmology and Visual Science 42(13):3256-63

Fischer, A. J.  and T.A. Reh (2001) Transdifferentiation of pigmented epithelial cells: a source of retinal stem cells. Developmental Neuroscience 23(4-5):268-76

Bermingham-McDonogh, O., J. S. Stone, T. A. Reh, E. W Rubel  (2001) FGFR3 Expression during Development and Regeneration of the Chick Inner Ear Sensory Epithelia. Developmental Biology 238(2):247-59


Fuhrmann S, Levine EM, Reh TA. Extraocular mesenchyme patterns the optic vesicle during early eye development in the embryonic chick. Development. 2000;127(21):4599-609.

Levine EM, Close J, Fero M, Ostrovsky A, Reh TA. p27(Kip1) regulates cell cycle withdrawal of late multipotent progenitor cells in the mammalian retina. Dev Biol. 2000;219(2):299-314.

Davis AA, Matzuk MM, Reh TA. Activin A promotes progenitor differentiation into photoreceptors in rodent retina. Mol Cell Neurosci. 2000;15(1):11-21.

Fischer AJ, Reh TA. Identification of a proliferating marginal zone of retinal progenitors in postnatal chickens. Dev Biol. 2000;220(2):197-210.

Some from the 1990’s

Mccabe KL, Gunther EC, Reh TA. The development of the pattern of retinal ganglion cells in the chick retina: mechanisms that control differentiation. Development. 1999;126(24):5713-24.

Pittack C, Grunwald GB, Reh TA. Fibroblast growth factors are necessary for neural retina but not pigmented epithelium differentiation in chick embryos. Development. 1997;124(4):805-16.

Levine EM, Roelink H, Turner J, Reh TA. Sonic hedgehog promotes rod photoreceptor differentiation in mammalian retinal cells in vitro. J Neurosci. 1997;17(16):6277-88.

Kelley MW, Turner JK, Reh TA. Ligands of steroid/thyroid receptors induce cone photoreceptors in vertebrate retina. Development. 1995;121(11):3777-85.

One from the 1970’s

Kalil K, Reh T. Regrowth of severed axons in the neonatal central nervous system: establishment of normal connections. Science. 1979;205(4411):1158-61.