TODD
L. RICHARDS
Date of revision:
Business address:
Department of Radiology,
(206-221-6894)
email:
Education
Post-Doc; NMR spectroscopy,
Ph.D.; Biophysics-Neuro, University of
B.S.; Physics,
Thesis title: NMR imaging and
spectroscopy of the mammalian central nervous system after heavy ion radiation.
Thesis committee members: Thomas F.
Budinger, Cornelius Tobias, Paola Timiras
Positions Held:
Professor, Radiology, University of Washington, 1998-present
Associate Professor, Radiology,
University of Washington, 1991-1998
Adjunct faculty, Bioengineering, Univ.
of Wash., 1990-present
MRI consultant, Marion Merrell Dow Inc,
1991-1993
Assistant Professor, Radiology,
University of Washington, 1985-1991
Affiliate,
Affiliate, Bloedel Hearing Research
Center, 1992-present
Affiliate, CDMRC, 1993- present
Consultant for chemical shift imaging,
Diasonics Inc., 1984-85
Post. Doc.; Hounsfield Research Fellow
(NMR Res. Physicist); UCSF, 1984-85
Organization MeMberships:
International Society for Magnetic
Resonance in Medicine
Human Brain Mapping
Cognitive Neuroscience Society
Editorial and Review Responsibilities:
National Correspondent, International
Journal of Neuroradiology
Reviewer, American Journal of
Neuroradiology
Reviewer, American Journal of
Roentgenology
Reviewer, NMR in Biomedicine
Reviewer, Magnetic Resonance in
Medicine
Grant Reviewer,
Grant Reviewer, National Institute of
Neurological Disorders and Stroke
Local Responsibilities:
UW Faculty Senator - 1989 - 1991
UW Faculty Senator - 2002-2003
Inventions
filed with the Office of Technology Transfer
Automatic detection of brain lesions on
MR images, 1992
NMR detection of Cancer cell response
to artemisinin, 2007
Patent
applications
Magnetic Resonance Neurography, 1993
Press
Releases
UW Press release
UW Press release, October, 1999 -
Dyslexic children use nearly five times the brain area
http://www.washington.edu/newsroom/news/1999archive/10-99archive/k100499a.html
Newsweek article on our research -
PUBLICATIONS
- 116
In
chronological order
ARTICLES:
1. Chen GTY, Pitluck S, Richards T, Castro JR,
Quivey JM, Saunders WM, Lyman JT, Utility of Three Dimensional Display of CT
Derived Contours in Charged Particle Treatment Planning, Int. J. Rad. Oncol. Bio. Phys. 7, 1250, 1981.
2. Chen GTY., Richards T, Pitluck S, Olsen AJ,
O'Donnell TJ, Application of 3 Dimensional Graphics to Charged Particle
Radiotherapy, Proc. IEEE Computer Society Conference on Pattern Recognition and
Image Processing 82CH1761-6, 303-305, 1982.
3. Moseley ME, Chew WM, Nishimura MC, Richards
TL, Murphy-Boesch J, Young GB, Marschner TM, Pitts LH, James TL, In vivo
sodium-23 magnetic resonance surface coil imaging: observing experimental
cerebral ischemia in the rat, Magn Reson Imaging 3, 383-387,1985.
4. Richards TL, Keniry MA, Weinstein PR, Pereira
BM, Andrews BT, Murphy EJ, James TL, Measurement of lactate accumulation by In
Vivo proton NMR spectroscopy during global cerebral ischemia in rats, Magn.
Res. Med., 5, 353-357, 1987.
5. Richards TL, Tscholakoff D, Higgins CB,
Proton NMR spectroscopy in canine myocardial infarction, Magn. Res. Med., 4,
555-566, 1987.
6. Richards TL, Davis CA, Barker BR, Beinert WD,
Genant HK, Lipid/water ratio of bone marrow measured by phased-encoded proton
NMR spectroscopy, Invest Radiol, 22, 741-746, 1987.
7. Richards, TL, Terrier F, Siever RE, Lipton
MJ, Moseley ME, Higgins CB, Lactate accumulation in ischemic and anoxic
isolated rat hearts assessed by H-1 spectroscopy, Invest Radiol, 22, 638-641,
1987.
8. Richards, TL, RN Golden, LM Rose, Localized
proton spectroscopy the primate brain with highlighting of selected region on
brain image, CSI Newsletter, General Electric Company NMR Instruments, Volume 1
No. 5, October, 1987.
9. Alvord EC, Jr., LM Rose, S Hruby, TL
Richards, R Petersen, C-M Shaw, EA Clark, LH Ericsson, WA Stewart, DW Paty, MW
Kies, Experimental allergic encephalomyelitis in non-human primates: an
excellent mode of multiple sclerosis, Symposium on Biomedical Research in
Primates, Amsterdam, The Netherlands, 10-11 March 1988, pp. 31-50, 1988.
10. Richards
T, Budinger TF, NMR imaging and spectroscopy of the mammalian central nervous
system after heavy ion radiation, Radiation Research, 113, 79-101, 1988.
11. Richards
TL, KM Bradshaw, DM Freeman, CH Sotak, PR Gavin, Boron-11 imaging of intact
tissues using magnetic resonance gradient echos, Strahlentherapie und
Onkologie, 165, 179-181, 1989.
12. Livesey
JC, RN Golden, EG Shankland, Z Grunbaum, TL Richards, RA Wade, KA Krohn,
Measurement of tissue oxidation-reduction state with carbon-13 nuclear magnetic
resonance spectroscopy, Cancer Res, 49, 1937-1940, 1989.
13. Rose LM,
TL Richards, EC Alvord, Jr., Magnetic resonance imaging and peripheral blood
abnormalilities in experimental allergic encephalomyelitis, Biomed Pharm, 43,
347, 1989.
14. Baron RL,
Shuman WP, Lee SP, Rohrmann CA Jr, Golden RN, Richards TL, Richardson ML, Nelson JA, MR appearance of
gallstones in vitro at 1.5 T: correlation with chemical composition, Am J
Roentgenol, 153, 497-504, 1989.
15. Richards
TL, Separation of lipids from lactate in experimental allergic
encephalomyelitis by zero quantum NMR techniques, Invest. Radiol., 24, 955-957,
1989.
16. Chen Y,
Richards TL, Izenberg S, Golden RN, Williams DL, Nelson JA, Steen RG, In vivo
phosphorus NMR spectroscopy of skin using a crossover surface coil, Magn Res
Med, 23, 46-54, 1992.
17. Rose LM,
Richards TL, Petersen R, Peterson J, Hruby S, Alvord EC, Short analytical
review, remitting-relapsing EAE in non-human primates: a valid model of
multiple sclerosis, Clinical Immunology and Immunopathology, 59, 1, 1991.
18. KM
Bradshaw, TL Richards, SL Kraft, In vivo pharmacokinetic evaluation of boron
compounds using magnetic resonance spectroscopy and imaging, In Progress in Neutron
Capture Therapy for Cancer. Allen ed., Plenum Press,
19. Dorn RV et
al., The Idaho power burst facility/ boron neutron capture therapy (PBF/BNCT)
program overview, In Progress in Neutron Capture Therapy for Cancer. Allen ed.,
Plenum Press,
20. Alvord EC
Jr., Rose LM, Richards TR, Chronic experimental allergic encephalomyelitis as a
model of multiple sclerosis, In Myelin: Biology and Biochemistry. Martenson
ed., CRC press, 849, 1992.
21. Dager SR,
Marro KI, Richards TL, Metzger GD, MRS detection of whole brain lactate rise during 1 M sodium
lactate infusion in rats, Biol-Psychiatry, 32, 913-921, 1992.
22. Dager SR,
Marro KI, Richards TL, Metzger GD.
Localized magnetic resonance spectroscopy measurement of brain lacte
during intravenous lactate infusion in healthy volunteers, Life Sciences, 51,
973-985, 1992.
23. Richards
TL, 1H NMR spectroscopic imaging of the monkey brain using binomial
water suppression, NMR in Biomedicine, 4, 187, 1991.
24. Richards
TL, Review. Proton MR spectroscopy in multiple sclerosis: value in establishing
diagnosis, monitoring progression, and evaluating therapy, Amer J Roent, 157,
1073, 1991.
25. Heide, AC,
Richards TL, Alvord EC, Peterson J, Rose LM, Diffusion Imaging of Experimental
Allergic Encephalomyelitis, Magn Res Med, 29, 478-484, 1993.
26. Rose LM,
Richards TL, Alvord EC, Remitting-relapsing experimental allergic
encephalomyelitis (EAE) in non-human primates,
Laboratory Animal Science, 44, 508-512, 1994.
27. Chang MW,
Wong E, Richards T, New cowboy boots make it hard to swallow: a case report of
severe dysphagia from a fall, Archives of Phys. Med. & Rehab., 75, 1266-8,
1994
28. Jimenez
JV, Richards TL, Heide AC, Grierson JR, Shankland EG, Incorporation of a
phosphonium analogue of choline into the rat brain as measured by magnetic
resonance spectroscopy, Magn Res Med, 33, 285-292, 1995.
29. Dager SR,
Marro KI, Richards TL, Metzger GD, Preliminary application of magnetic
resonance spectroscopy to investigate lactate-induced panic, American Journal
of Psychiatry, 151, 57-63, 1994.
30. Astley SJ,
Weinberger E, Shaw DWW, Richards TL,
31. Richards
TL, EC Alvord, J Peterson,
32. Strauss
WL, Tsuruda JS, Richards TL, Partial volume effects in volume localized
phased-array proton spectroscopy of the temporal lobe, JMRI, 4, 433-436, 1995.
33. Dager SR,
Strauss W, Marro KI, Richards TL, Metzger GD, Artru AA, Proton magnetic
resonance spectroscopy investigation of hyperventilation with panic disorder
and comparison subjects, American
Journal of Psychiatry, 152, 666-672, 1995.
34. Richards
TL, Alvord EC Jr, He Y, K Marro, K Petersen, Peterson J, Cosgrove S, Heide AC, Rose LM, Experimental
allergic encephalomyelitis in non human primates, diffusion imaging of acute
and chronic brain lesions, Multiple Sclerosis, 1,109-117, 1995.
35. Richards
TL, Bowen JD, Alvord EC Jr., Maravilla KR, Dager SR, Rose LM, Posse S, MR brain
spectroscopy: basic concepts with emphasis on multiple sclerosis, Int J
Neurorad, 2, 123-133, 1996.
36. Dager SR,
M Layton, TL Richards, Neuroimaging findings in anxiety disorders, Seminars in
Clinical Neuropsychiatry 1, 48-60, 1996.
37. Rose LM,
TL Richards, J Peterson, R Petersen, EC Alvord, Resolution of CNS lesions
following treatment of experimental allergic encephalomyelitis in macaques with
monoclonal antibody to the CD18 leukocyte integrin, Multiple Sclerosis, 2,
259-266, 1997.
38. Richards
TL, GA Gates, JC Gardner, T Merrill, CE Hayes, H Panagiotides, S Serafini, EW
Rubel, Functional magnetic resonance spectroscopy of the auditory cortex in
patients with sudden sensorineural hearing loss, American Journal of
Neuroradiology, 18, 611-620, 1997.
39. Posse S,
SR Dager, TL Richards, C Yuan, R Ogg, AA Artru, HW Müller-Gärtner, C Hayes, In
Vivo Measurement of Regional Brain Metabolic Response to Hyperventilation using
Magnetic Resonance Proton Echo Planar Spectroscopic Imaging (PEPSI), Mag Res
Med, 37, 858-865, 1997.
40. Richards
TL, MS Lappin, J Acosta-Urquidi, GH Kraft,
AC Heide, FW Lawrie, TE Merrill, GB Melton, CA Cunningham, Double-Blind
Study of Pulsing Magnetic Field Effects on Multiple Sclerosis, J Alt Comp Med, 3, 21-29, 1997
41. Conley K
E, ML Blei, TL Richards, MJ Kushmerick, SA Jubrias. Activation of glycolysis in human muscle in
vivo, Am J Physiol: Cell Physiol., 273,
C306-C315, 1997
42. Berninger,
V., Raskind, W., McCutchen, D., Richards, T., Cunningham, A., Nolen, S.,
Wijsman, E., Dager, S., Corina, D., & Abbott, R. Educational and biological
links to learning disabilities.
Perspectives, vol. 23, no. 4., 1997.
43. Heide AC
(student of TL Richards), Kraft GH, Slimp JC, Gardner JC, Posse S, Serafini S,
Bowen JD, Richards TL, Cerebral N-acetyl asparate is Low in MS patients with
Abnormal Visual Evoked Potentials, American Journal of Neuroradiology, 19,
1047-1054, 1998.
44. Richards
TL, SR Dager, HS Panagiotides, CE
Hayes, S Posse, S Serafini, J A Nelson,
KR Maravilla, Functional MR Spectroscopy
During Language Activation, a preliminary study using proton echo-planar
spectroscopic imaging (PEPSI), Int J Neurorad, 3, 490-495, 1997.
45. Dager SR,
A Heide, T Richards, A Artru, W Strauss, C Hayes, S Posse, Single-voxel H NMR
and two-dimensional proton echo-planar spectroscopic imaging (PEPSI) of brain
metabolic changes during lactate-induced panic, Psych Res Neuroimag, 76,89-99,
1998.
46. Bell KR,
MW Chang, TL Richards, The use of proton magnetic resonance spectroscopy to
predict outcome in severe traumatic brain injury: a pilot study, accepted pending revision, Brain Injury, 1998
47.
Bowen J, TL Richards, K Marravilla, Clinical, MRI and MR spectroscopy findings
in a patient with an A to G substitution at the nucleotide position 3234 of
leucine transfer RNA., AJNR, 19, 231-234, 1998
48. Richards
TL, M Lappin, F Wilson-Lawrie, KC Stegbauer, Bioelectromagnetic Applications
for Multiple Sclerosis, In:
49. Kraft GH,
Richards TL, Heide AC, Correlations of
evoked potentials with MR imaging and MR spectroscopy in multiple
sclerosis: In: Taylor RS, Kraft GH, eds., Multiple Sclerosis
Rehabilitation. Physical Medicine and
Rehabilitation Clinics of
50. Richards
TL, SR Dager, S Posse, Functional MR spectroscopy of the brain, In: Castillo M,
ed, Proton MR spectroscopy of the brain, Neuroimaging Clinics of North America,
Philadelphia: Saunders, vol 8, Nov 1998,
823-833.
51. Bowen JD,
SH Petersdorf, TL Richards, KR Maravilla, DC Dale, TH Price, TP St John, AS Yu,
Phase I study of a humanized anit-CD11/CD18 mAb in multiple sclerosis, Clinical
Pharmacology and Therapeutics, 64, 339-346, 1998.
52. Vallbona C, TL
Richards, Evolution of magnetic therapy
from alternative to traditional
medicine, Phys Med Rehabil Clin N Am 10(3):729-54,
1999
53. Newmark J,
TL Richards, Case report: Delayed
unilateral post-traumatic dystonic tremor: localization studies using single
photon computed tomography and magnetic resonance spectroscopy techniques,
Military Medicine, 164, 59-64, 1999.
54.
Richards TL, Dager SR, Corina D, Serafini S, Heide AC, Steury K, Strauss W, Hayes CE,
Abbott RD, Craft S, Shaw D, Posse S,
Berninger VW, Dyslexic children have abnormal
brain lactate on reading-related language tasks, AJNR, 20,1393-1398,
1999.
55. Dager SR, Layton ME, Strauss W, Richards TL,
Heide AC, Artru AA, Posse S, Human
brain metabolic response to caffeine
and the effects of tolerance. American Journal of
Psychiatry,
156, 229-237, 1999.
56 Dager SR,
SD Friedman, A Heide, ME Layton, T Richards, A Artru, W Strauss, C
Hayes, S
Posse, Two-dimensional proton
echo-planar spectroscopic imaging of brain metabolic
changes during lactate-induced panic,
Arch Gen Psychiatry, 56, 70-77, 1999.
57.
Posse, S.,
Wiese, S., Gembris, D., Mathiak, K., Kessler, C., Grosse-Ruyken, M.L.,
Elghahwagi, B., Richards, T., Dager, S.R. and Kiselev, V.G. Enhancement of BOLD-contrast
sensitivity by single-shot multi-echo functional MR imaging. Magn Reson Med, 1999, 42:
87-97.
58.
Richards, TL, Multinuclear magnetic resonance spectroscopic imaging, In:
Encyclopedia of
Analytical Chemistry: Instrumentation and Applications, Ed. Meyers
RA, John Wiley&
Sons,
59.
Richards TL, Corina D, Serafini S, Steury K, Echelard DR, Dager SR,
Marro K, Abbott RD,
Maravilla KR, Berninger VW, The Effects of a
Phonologically-Driven Treatment for
Dyslexia on Lactate Levels as Measured by
Proton MR Spectroscopic Imaging,
AJNR, 21,916-922, 2000
60. Friedman, S.D, Dager, S.R., Richards, T.,
Petropoulos, H., Posse, S,. Modeling brain
compartmental lactate
response to metabolic challenge: A feasibility study. Psychiatry Res 98(1):55-66, 2000.
61. Serafini S, Steury
K, Richards T, Corina D, Abbott R, Dager SR, Berninger V, Comparison of
fMRI and PEPSI during language
processing in children, Magn Reson Med 45, 217-225,
2001.
63.
Richards TL, Functional Magnetic Resonance Imaging and Spectroscopic
Imaging of the
Brain: Application of fMRI and
fMRS to Reading Disabilities and Education, Learning
Disabilities Quarterly, Special Issue, 24, 189 - 203, 2001.
64. Corina, D.P., Richards, T.L., Serafini, S.,
Richards, A.L., Steury, K., Abbott, R.D.,
Echelard,
D.R., Maravilla, K.R. and Berninger, V.W., fMRI auditory language
differences
between dyslexic and able reading children, Neuroreport, 12 1195-201. 2001
65. Ramon C, Haueisen J, Richards T, Maravilla
K, Panagiotides H: "Multimodal Imaging of
Somatosensory Evoked Cortical
Activity" Biomed Tech, vol 46, Suppl 2, pp 237 - 238, 2001.
66. Gillson G, Richards TL, Smith RB, Wright
JV, A double-blind pilot study of the effect of
Prokarin on fatigue in multiple
sclerosis, 8,30-35, Multiple Sclerosis, 2002.
67. Berninger VW, Abbott RD, Abbott SP, Graham
S, Richards T, Writing and reading:
Connections between language by hand
and language by eye, Journal of Learning
Disabilities, 35, 39-56, 2002.
68. Berninger VW, Richards TL, Brain Literacy
for Educators and Psychologists,
Academic Press, 2002.
69.
Dawson G, Webb S, Schellenberg GD, Dager S, Friedman S, Aylward E,
Richards T.
Defining the broader phenotype of autism: genetic, brain, and behavioral
perspectives. Dev
Psychopathol 2002;14:581-611.
70.
Richards TL, Berninger VW, Aylward EH, et al. Reproducibility of proton
MR
spectroscopic imaging (PEPSI):
comparison of dyslexic and normal-reading children and
effects of treatment on brain lactate
levels during language tasks. AJNR Am J Neuroradiol,
23:1678-85, 2002
71.
Standish LJ, Johnson LC, Kozak L,
Richards TL. . Evidence of correlated
functional
magnetic resonance imaging signals
between distant human brains. Altern Ther
Health Med,
9(1): 122-5, 2003
72. Lappin MS, Lawrie FW, Richards TL, Kramer
ED (2003), Effects of a pulse
electromagnetic therapy on multiple
sclerosis fatigue and quality of life: a double-blind,
placebo controlled trial, Altern Ther
Health Med, 9, 38-48.
73. Hoffman HG, Richards T, Coda B, Richards
A, Sharar SR. (2003), The illusion of
presence in immersive virtual
reality during an fMRI brain scan, Cyberpsychol Behav, 6,
127-131.
74. Eckert M, Leonard C, Richards T, Aylward
E, Thomson J, Berninger V. Anatomical Correlates of Dyslexia: Frontal and
Cerebellar Findings. Brain 126, 482-494, 2003
75. Hoffman, H.G., Richards, T.L., Magula,
J., Seibel, E.J., Hayes, C., Mathis, M., Sharar, S.R. and Maravilla, K. (2003)
A magnet-friendly virtual reality fiberoptic image delivery system.
Cyberpsychol Behav 6(6), 645-8.
76. Hoffman, H.G.,
Richards, T., Coda, B., Richards, A. and Sharar, S.R., The illusion of presence
in immersive virtual reality during an fMRI brain scan, Cyberpsychol Behav, 6,
127-31, 2003
77. Friedman, S.D.,
Shaw, D.W., Artru, A.A., Richards, T.L., Gardner, J., Dawson, G., Posse, S. and
Dager, S.R., Regional brain chemical alterations in young children with autism
spectrum disorder, Neurology, 60, 100-7, 2003
78.
Lee, P.L., Yiannoutsos, C.T., Ernst, T., Chang,
L., Marra, C.M., Jarvik, J.G., Richards, T.L., Kwok, E.W., Kolson, D.L.,
Simpson, D., Tang, C.Y., Schifitto, G., Ketonen, L.M., Meyerhoff, D.J.,
Lenkinski, R.E., Gonzalez, R.G. and Navia, B.A., A multi-center 1H MRS study of
the AIDS dementia complex: validation and preliminary analysis. J Magn Reson
Imaging 17(6), 625-33, 2003
79.
Aylward EH,
Richards TL, Berninger VW, Nagy WE, Field KM, Grimme AC, Richards AL, Thomson
JB, Cramer SC. Instructional treatment
associated with changes in brain activation in children with dyslexia. Neurology.
Jul 22;61(2):212-9. 2003
80. Standish, L.J., Kozak, L., Johnson, L.C.
and Richards, T. Electroencephalographic
evidence of correlated event-related signals between the brains of spatially
and sensory isolated human subjects. J Altern Complement Med 10(2), 307-14.
2004
81. Hunter G. Hoffman, Todd L. Richards, Sam R. Sharar, Aric R.
Bills, David Blough,
Anne L. Richards, Barbara Coda, Modulation
of thermal pain-related brain activity with virtual reality: evidence from
fMRI., Neuroreport, 15, 1245-1248. 2004
82. Hunter G. Hoffman, Sam
R. Sharar, Barbara Coda, John J. Everett, Marcia Ciol, Todd Richards, David R. Patterson, Manipulating presence influences the magnitude
of virtual reality analgesia, Pain
111, 162–168. 2004
83. Ramon C,
Haueisen J, Richards T, Maravilla K. Multimodal
imaging of somatosensory evoked cortical activity. Neurol Clin
Neurophysiol. Nov 30;96. 2004
84. Chang
L, Lee PI, Yiannoutsos CT, Ernst T, Marra CM, Richards T, Kolson D, Schifitto
G,
Jarvik JG, Miller EN, Lenkinski R, Gonzalez G, Navia BA, A
multicenter in vivo proton-MRS study of HIV-associated dementia and its
relationship to age, Neuroimage 23, 1336-1347, 2004
85. Richards,
T., Berninger, W. V., Nagy, W., Parsons, A., Field, K., Richards, A., Brain
activation during language task contrasts in children with and without
dyslexia: Inferring mapping processes and assessing response to spelling
instruction , Educational & Child Psychology, 22, 62-80, 2005
86. Thomson,
J., Chennault, B., Abbott, R., Raskind, W., Richards, T., Aylward, E., &
Berninger, V. Converging evidence for attentional influences
on the orthographic word form in child dyslexics. Journal
of Neurolinguistics. 18, 93-126, 2005
87. Eckert, M., Leonard, C., Wilke, M.,
Eckert, M., Richards, T., Richards, A., & Berninger, V. . Voxel-based morphometry and manual-based
neuroanatomical findings in dyslexic children. Cortex, 41, 304-315. 2005
88. Yiannoutsos
CT, Ernst T,
Chang L,
Lee PL,
Richards T,
Marra CM,
Meyerhoff
DJ, Jarvik JG,
Kolson D,
Schifitto G,
Ellis RJ,
Swindells S,
Simpson DM,
Miller EN,
Gonzalez RG,
Navia BA.,
Regional patterns of brain
metabolites in AIDS dementia complex. Neuroimage. Nov;23(3):928-35. 2004
89. Aylward EH,
Park JE, Field KM, Parsons AC, Richards TL, Cramer SC, Meltzoff AN. Brain activation during face perception: evidence of a
developmental change.
J Cogn Neurosci. Feb;17(2):308-319. 2005
90.. Achterberg, J., Cooke, K., Richards, T.,
Standish, L.J., Kozak, L. and Lake, J., Evidence for correlations between
distant intentionality and brain function in recipients: a functional magnetic
resonance imaging analysis, J Altern Complement Med, 11 965-971. 2005
91. Richards, T.L.,
Kozak, L., Johnson, L.C. and Standish, L.J., Replicable functional magnetic
resonance imaging evidence of correlated brain signals between physically and
sensory isolated subjects, J Altern Complement Med, 11 955-963. 2005
92. Richards,
T., Aylward, E., Raskind, W., Abbott, R., Field,. K., Parsons, A.,
Richards, A., Nagy, W., Eckert, M., Leonard, C., & Berninger, V. , Converging
Evidence for Triple Word Form Theory in Child Dyslexics. Special issue on brain imaging in Developmental Neuropsychology. 30,
547-590, 2006
93 Hoffman, H.G.,
Richards, T.L., Bills, A.R., Van Oostrom, T., Magula, J., Seibel, E.J. and
Sharar, S.R., Using FMRI to study the neural correlates of virtual reality
analgesia, CNS Spectr, 11 45-51, 2006
94. Richards,
T., Aylward, E., Berninger, V., Field, K., Parsons, A., Richards, A. and Nagy,
W., Individual fMRI activation in orthographic mapping and morpheme mapping
after orthographic or morphological spelling treatment in child dyslexics,
Journal of Neurolinguistics, 19, 56-86,
2006
95. Stanberry, L. I., Richards, T., Berninger
V. W., Nandy, R. R., Aylward, E., Maravilla, K., Cordes, D., Low-frequency
signal changes reflect differences in functional connectivity between good
readers and dyslexics during continuous phoneme mapping, Magnetic Resonance
Imaging, 24, 217-229, 2006
96. Johnson, L.C., Richards,
T.L., Archbold K.H., Landis C.A., Functional magnetic resonance imaging in
nursing research, Biological Research For Nursing, 8, 43-54, 2006
97. Natalia M. Kleinhans, Leonard C. Johnson,
Roderick Mahurin, Todd Richards, Keith C. Stegbauer, Jessica Greenson,
Geraldine Dawson and Elizabeth Aylward,
Increased amygdala activation to neutral faces is associated with better
face memory performance, Neuroreport, 18, 987-91, 2007
98 Todd Richards, Virginia Berninger,
William Winn, Pat Stock, Richard Wagner, Andrea Muse, and Kenneth Maravilla, FMRI
Activation in Children with and without Dyslexia during Pseudoword Aural Repeat
and Visual Decode: Before and After Treatment, Neuropsychology, 21, 732-741,
2007
99. Sandra
E. Juul, Elizabeth Aylward, Todd Richards, Ronald J. McPherson, John Kuratani,
Thomas M. Burbacher, Prenatal Cord Clamping in Newborn Macaca nemestrina: a
model of perinatal asphyxia, Developmental Neuroscience, 29, 311 - 320 , 2007
100. Hunter G. Hoffman, Todd L. Richards, Trevor
Van Oostrom, Barbara A. Coda, Mark P. Jensen, David K. Blough, Sam R. Sharar, Analgesic
effects of opioids and immersive virtual reality distraction: Evidence from
subjective and functional brain imaging assessments, Anesthesiology and
Analgesia, 105, 1776 –1783, 2007
101. Balasrinivasa
Rao Sajja, Ponnada A. Narayana, Jerry S.Wolinsky, Chul W. Ahn, and the PROMiSe
Trial MRSI Group (Richards TL was member of the PROMISE MRSI Group) Longitudinal
Magnetic Resonance Spectroscopic Imaging of Primary Progressive Multiple
Sclerosis Patients Treated with Glatiramer Acetate: Multi-Center Study, Multiple Sclerosis, 14,
73-80, 2008
102. Richards T., Berninger V., Abnormal fMRI connectivity in children with
dyslexia during a phoneme task: Before but not after treatment, Journal of Neurolinguistics
, 21, 294-304, 2008
103. Kleinhans
NM, Johnson LC, Mahurin R, Richards TL, Stegbauer KC, Greenson J, Dawson G Aylward EH Abnormal functional connectivity in autism spectrum disorders during
face processing, Brain, 131, 1000-12, 2008
104. Berninger VW, Raskind W, Richards T,
Abbott R, and Stock P. A multidisciplinary approach to understanding
developmental dyslexia within working-memory architecture: Genotypes,
phenotypes, brain, and instruction. Dev
Neuropsychol, 33: 707-44, 2008.
105.
106. Raizada RD, Richards TL, Meltzoff A, Kuhl PK.,
Socioeconomic status predicts hemispheric specialisation of the left
inferior frontal gyrus in young children, Neuroimage. 40:1392-401, 2008
107. Stephen
R. Dager, Neva M. Corrigan, Todd L. Richards, and Stefan Posse, Research Applications of Magnetic
Resonance Spectroscopy to Investigate Psychiatric Disorders, Top Magn Reson
Imaging, 19:81-96, 2008
108.
Todd
L. Richards,
109.
110.
Kleinhans
NM, Johnson LC, Richards T, Mahurin R, Greenson J, Dawson G, and Aylward E.
Reduced neural habituation in the amygdala and social impairments in autism
spectrum disorders. Am J Psychiatry,
2009.
111. Astley, S.J., Olson, H.C., Kerns, K., Brooks, A., Aylward, E.H., Coggins, T.E., Davies, J., Dorn, S., Gendler, B., Jirikowic, T., Kraegel, P., Maravilla, K. and Richards, T., Neuropyschological and behavioral outcomes from a comprehensive magnetic resonance study of children. Can J Clin Pharmacol 16(1), e178-201, 2009
112 . Astley, S.J., Richards, T., Aylward, E.H., Olson, H.C., Kerns, K., Brooks, A., Coggins, T.E., Davies, J., Dorn, S., Gendler, B., Jirikowic, T., Kraegel, P. and Maravilla, K. Magnetic resonance spectroscopy outcomes from a comprehensive magnetic resonance study of children with fetal alcohol spectrum disorders. Magn Reson Imaging, 2009
113. Borson, S., Scanlan, J., Friedman, S., Zuhr, E., Fields, J., Aylward, E., Mahurin, R., Richards, T., Anzai, Y., Yukawa, M. and Yeh, S., Modeling the impact of COPD on the brain. Int J Chron Obstruct Pulmon Dis 3(3), 429-34, 2008
114. Corrigan, N.M., Richards, T., Webb, S.J., Murias, M., Merkle, K., Kleinhans, N.M., Johnson, L.C., Poliakov, A., Aylward, E. and Dawson, G. , An Investigation of the Relationship Between fMRI and ERP Source Localized Measurements of Brain Activity during Face Processing. Brain Topogr., 2009
115. Richards, T.L., Berninger, V.W., Stock, P., Altemeier, L., Trivedi, P. and Maravilla, K., Functional magnetic resonance imaging sequential-finger movement activation differentiating good and poor writers. J Clin Exp Neuropsychol, 1-17, 2009
116. Weaver, K.E., Richards, T.L., Liang, O.,
Laurino, M.Y., Samii, A. and Aylward, E, Longitudinal diffusion tensor imaging
in Huntington's Disease. Exp Neurol 216(2), 525-9, 2009
Published
Abstracts/Presentations:
2005-2006
T.
Richards, N. Oskin, H. Panagiotides, S. Webb, A. Poliakov, N. Kleinhans, E. Aylward, G. Dawson, Face Processing in
Autism: fMRI/EEG source localization correlations, International Meeting
for Autism Research, 2006
N.
Oskin, S. Webb, T. Richards, H. Panagiotides, E. Aylward, DIPOLE SOURCE
LOCALIZATION OF FACE PROCESSING IN AUTISM, International Meeting for Autism
Research, 2006
Natalia
Kleinhans,
Richards,
TL et al, Differences in fMRI Activation between Children with and without
Dyslexia during Pseudoword Aural Repeat and Visual Decode, Annual Meeting for
Cognitive Neuroscience Society,
1998-2000
Serafini
S, Corina D, Richards T, Heide A, Dager S, Posse S, Hayes C, Berninger V. Functional MR Spectroscopy as a Tool to
Investigate Language Processing.
Cognitive Neuroscience Society 1998 Annual Meeting Abstract Program,
p.124. Presented as a poster at the
Cognitive Neuroscience Society Fifth Annual Meeting
S. Serafini, K. Steury, B. Floyd, D. Corina, T. Richards, S. Dager, S. Posse, C. Hayes, V. Berninger, Comparison of MR spectroscopy and functional MRI during language processing in children, Cognitive Neuroscience Society 1999 Annual Meeting Abstract Program, abstract 57b, Presented as a poster at the Cognitive Neuroscience Society Sixth Annual Meeting April 10-13, Washington, DC.
Berninger V, Richards T, Corina D, Serafini S, Abbott R,
Treatment-related changes in chemical activation of dyslexic brains during
phonological and lexical access tasks, Society for the Scientific Study of
Reading, Montreal, April, 1999.
Richards
TL, Corina D, Serafini S, Steury K,
Echelard DR, Dager SR,, Marro K,
Maravilla, KR, Abbott RD, Berninger VW, Functional MRI and functional
MR spectroscopic imaging of dyslexia, accepted to Human Brain Mapping 2000, San
Antonio Conference, June 2000.
Steury K, Corina D,
Richards T, Serafini S, Maravilla K, A comparison of fMRI and fMRS during an
auditory monitoring task, submitted to Cognitive Neuroscience Society Meeting
2000.
1997
Corina
DP, Craft S, Serafini S, Richards TL, Dager SR, Posse S,
Hayes
CE, Berninger V. A Functional MR
Spectroscopy Study of Language
Processing. Cognitive Neuroscience 4th Annual meeting,
American Academcy of Clinical
Neurophysiology, oral presentation, 1- 1st author, 1- coauthor,
Berninger,
V., Raskind, W., Dager, S., Richards, T., Corina, D., Abbott, R., &
McCutchen, D. (1997, April 21). Treatment of reading and writing
disabilities. Annual meeting of the
Learning Disabilities Association, Chicago.
International
Society for Magnetic Resonance in Medicine, Annual Meeting, 1997, 2 coauthor
presentations
1996
American Society of Neuroradiology,
34th Annual Meeting, 1st author, 2 co-author, 1996
International Society of Magnetic
Resonance in Medicine, 2- coauthor, 1996
Clinical Neurophysiology, 1-coauthor,
1996
1995
1. TL Richards, MR spectroscopy for
evaluating metabolic changes in the brain of MS patients, International
Business Communications, Conference on Multiple Sclerosis, 1995.
1994
- 5
Abstracts, 2nd Annual Meeting, Society of Magnetic
Resonance, 1994
TL Richards, LM Rose, K Maravilla, EC
Alvord Jr, CA Cunningham, JD Bowen, Multiple sclerosis: abnormally low
N-acetyl/creatine ratio in central gray matter,
Abstracts, 2nd Annual Meeting,
Society of Magnetic Resonance, p. 591, 1994
S-02-1624TH 1158. Diffusion-Weighted
Fluorine Spectroscopy. E.G. Shankland, T.L. Richards and K.A. Krohn.
S-05-1615T 1425. Incorporation
of a Phosphonium Analogue of Choline into the Rat Brain as Measured by NMR
Spectroscopy. J.V. Jimenez, T.L. Richards, A.C. Heide, J.R. Grierson and E.G.
Shankland.
1993
1. TL Richards, J Peterson, S Cosgrove,
K Petersen, LM Rose, EC Alvord Jr, Temporal relationships in N-acetyl
aspartate, choline, and MRI lesions in EAE, Conference proceedings, Advances in
understanding and treatment of multiple sclerosis, International Business
Communications, 1993.
2. E Weinberger, SJ Astley, TL Richards,
DW Shaw, SK Clarren, Hydrogen proton spectroscopy in nonhuman primates exposed
to ethanol during gestation, The Society for Pediatric Radiology, 36th Annual
Meeting, 1993.
3. EC Alvord, C Shaw, T Richards, The
relative rates of cellular proliferation and infiltration and the histologic
definition of gliomas, in press, Canad J Neur Sci, 1993.
4. Chang MW, TL Richards, New cowboy
boots make it hard to swallow: a case report of severe dysphagia from a fall,
5. TL Richards, C Yuan, CR Loomis, VP
Terry, JS Tsuruda, JD Bowen, Progress towards N-acetyl aspartate imaging of the
entire brain, Radiologic Society of North America, 1993 Annual Meeting.
6. AG Filler, RN Golden, FA Howe, JS
Tsuruda, TL Richards, High resolution diffusion gradient imaging for
neurography in human subjects, Society of Magnetic Resonance in Medicine, 1993
Annual Meeting.
7. EG Shankland, TL Richards, KA Krohn,
C-13 flow suppression spectroscopy to measure cellular redox, SMRM, 1993 Annual
Meeting.
8. SR Dager, KI Marro, TL Richards, GD
Metzger, H-1 MRS investigation of lactate-induced panic, SMRM, 1993 Annual
Meeting.
1992
1. TL Richards, AC Heide, K Marro, EC
Alvord, J Peterson, LM Rose, Volume-localized proton NMR spectroscopy and
histologic evaluation of demyelination in the monkey brain, Advances in Proton
Magnetic Resonance Spectroscopy of the Brain, Society of Magnetic Resonance in
Medicine,
2. TL Richards, J Tsuruda, AC Heidi,
Vector analysis of diffusion images in experimental allergic encephalomyelitis,
Society of Magnetic Resonance in Medicine, 11th Annual meeting, Berlin, 1992.
3. SR Dager, KI Marro,TL Richards, GD
Metzger, 1H MRS detection of increased brain lactate during intravenous lactate
infusion in humans, Society of Magnetic Resonance in Medicine, 11th Annual
meeting, Berlin, 1992.
4. KI Marro, SR Dager, TL Richards,
Attenuation of lactate signal due to coherent flow in volume localized MR
spectroscopy, Society of Magnetic Resonance in Medicine, 11th Annual meeting,
Berlin, 1992.
5. KI Marro, CE Hayes, TL Richards, An
inductively driven 200 MHz bird-cage resonator with built-in variable tuning
capacitors, Society of Magnetic Resonance in Medicine, 11th Annual meeting,
1992.
6. E Weinberger, D Shaw, S Ashley, TL
Richards, 1H MR spectroscopy of an animal model of fetal alcohol syndrome,
Society of Magnetic Resonance in Medicine, 11th Annual meeting, Berlin, 1992.
1982-1990
1. TL Richards, AC Heide, K Marro, LM Rose,
JR Peterson, R Petersen, EC Alvord, Jr., Changes in brain proton spectra
precede the onset of experimental allergic encephalomyelitis in macaques,
Society of Magnetic Resonance in Medicine, Tenth Annual meeting, San Francisco, 1991, pp 427.
2. AC Heide, TL Richards, LM Rose, JP
Peterson, EC Ellsworth Jr., Diffusion Imaging of Monkeys with Experimental
Allergic Encephalomyelitis, Society of
Magnetic Resonance in Medicine, Tenth Annual meeting, San Francisco, 1991, pp.
989
3. TL Richards, JR Peterson, LM Rose,
EC Alvord Jr., Proton chemical shift imaging of primates during experimental
allergic encephalomyelitis, Society of Magnetic Resonance in Medicine, Ninth
Annual meeting, New York, Aug 18-24, 1990, pp. 1043.
4. TL Richards, U Schmiedl, Dynamic changes
of proton resonances in the monkey brain following administration of
gadolinium, Society of Magnetic Resonance in Medicine, Ninth Annual meeting,
5. Richards
TL, KM Bradshaw, Boron-10 versus Boron-11 Signal to Noise Comparison of Compound used in Neutron Capture Therapy,
Society of Magnetic Resonance in Medicine, Eighth Annual meeting,
6. Richards
TL, RN Golden, EG Shankland, LM Rose, J Peterson, High signal intensity near magnetite
microspheres measured with magnetic resonance imaging, Invest. Radiol. 24, S90,
1989.
7. Richards
TL, KM Bradshaw, D Flamig, Boron chemical shift imaging of BNCT compound in
aqueous albumin solutions, Invest. Radiol. 24, S97, 1989.
8. Richards TL, JS Kenney, LM Rose, J
Hill, S Hruby, R Petersen, EC Alvord Jr, Detection of Brain Lipids in primates
with experimental allergic encephalomyelitis by in vivo proton spectroscopy and
in vitro histochemistry, Society of Magnetic Resonance in Medicine, Seventh
Annual meeting, San Francisco, Aug 21-26, 1988, pp. 467.
9. Kenney JS, TL Richards, Where in the
Macaca Fascicularis brain is the localized proton spectrum uncontaminated by
resonances in the 1.25+.2 ppm region?, Society of Magnetic Resonance in Medicine,
Seventh Annual meeting, San Francisco, Aug 21-26, pp. 468., 1988
10. Golden RN, JC Livesey, EG
Shankland, Z Grunbaum, TL Richards, RA Wade, KA Krohn, C-13 NMR tracer
technique for in vivo measurement of tissue redox state, Society of Magnetic
Resonance in Medicine, Seventh Annual meeting, "Works in Progress",
pp. 70, 1988.
11. Richards TL, KM Bradshaw, DM
Freeman, CH Sotak, PR Gavin, Boron-11 imaging of intact tissues using magnetic
resonance gradient echos, Third International Symposium on Neutron Capture
Therapy, Bremen, Germany, June, 1988.
12. Richards TL, PR Gavin, S Kraft, ML
Griebenow, RN Golden, Boron-11 NMR spectroscopy of excised mouse tissues after
infusion of boron compound used in neutron capture therapy, Radiology, 165(P),
346, 1987.
13. Richards TL, LM Rose, Rn Golden, EC
Alvord, In vivo proton spectroscopy of the primate brain after induction of
experimental allergic encephalomyelitis, "Works in Progress", Society
of Magnetic Resonance in Medicine, Sixth Annual meeting, New York, Aug 17-21,
pp. 64, 1987.
14. Golden RN, EG Shankland, Z
Grumbaum, JC Livesey, TL Richards, RA Wade, KA Krohn, Measurement of Tissue
Redox State with C-13 NMR, Conference on "Prediction of Tumor Treatment
Response", April 21-24, 1987, Banff, Canada.
15. Williams D, D Olson, B Porter, T
Richards, G Wesbey, Implanted dual coaxial transmission line balanced-matching
approach to NMR probe design for canine myocardial NMR spectroscopy, Society of Magnetic Resonance in Medicine,
Fifth Annual Meeting, August 19-22, 1986, Montreal, Canada, pp. 185-186.
16. Haynor DR, TL Richards, W See, G
Wesbey, Perfluorocarbons for detection of tissue perfusion use of pulsed field
gradients, Society of Magnetic Resonance in Medicine, Fifth Annual Meeting,
August 19-22, 1986, Montreal, Canada, pp. 325-326.
17. See WA, T Richards, LA Mack, WH
Chapman, GE Wesbey, P-31 NMR spectroscopy as a predictor of testicular
viability following ischemic injury, Society of Magnetic Resonance in Medicine,
Fifth Annual Meeting, August 19-22, 1986, Montreal, Canada, pp. 1013-1014.
18. Koretsky, Ap, T. Richards, ME
Moseley, Spatial localization of metabolites using spin-echo difference
spectroscopy, Society of Magnetic Resonance in Medicine, Fourth Annual Meeting,
August 19-23, 1985, London, United Kingdom, pp. 999-1000, 1985.
19. Richards, T., T. F. Budinger, and
R. Nunlist, Phase encoded proton spectroscopy and imaging of the rat brain in
vivo with the surface coil, In: Scientific program, Society of Magnetic
Resonance in Medicine, Third Annual Meeting,
20. Richards, T., T. F. Budinger, and
R. Nunlist, RF pulse energy optimization for proton spectroscopy using lipid
and n-acetyl aspartate peak characteristics of normal brain, In: Scientific
program, Society of Magnetic Resonance in Medicine, Third Annual Meeting,
21. Jones, R. M., T. Richards, and T.
F. Budinger, Proton and Carbon Spectroscopy of Lipids and Aqueous Metabolites
Extracted from Brain, In: Scientific program, Society of Magnetic Resonance in
Medicine, Third Annual Meeting, August 13-17, 1984, New York, New York, pp.
395-396, 1984.
22. Richards, T., T. F. Budinger, G.
Wesbey, B. Engelstad, Evaluation of Heavy Ion Radiation Damage to the Rat Brain
using Proton NMR Imaging, In: Scientific program, Society of Magnetic Resonance
in Medicine. Second Annual Meeting, pp. 198-99, 1983.
23. Richards, T., A. Hasenfeld, and T.
F. Budinger, A Computer Simulation of Surface Coil Selective Region
Spectroscopy, In: Works in Progress, Society of Magnetic Resonance in Medicine.
Second Annual Meeting, pp. 20, 1983.
24. Richards, T. L., T. F. Budinger,
and R. Nunlist, Proton NMR Relaxation Times of Gray and White Matter before and
after Tissue Preservation, In: Scientific program, Society of Magnetic
Resonance in Medicine. First Annual Meeting, pp. 131-32, 1982.
25.
Richards, T., G. T. Y. Chen, J. Llacer, C. A. Tobias, Determination of
the Effects of Respiration on Charged Particle Radiotherapy of Abdominal
Tumors, Med. Phys. 9:623, 1982.
Invited
Presentations:
Techniques for automatic brain lesion
detection in patients with multiple sclerosis,
Magnetic resonance imaging and
spectroscopy of multiple sclerosis,
Update on MS research,
Update on MS research,
Update on MS research,
Update on MS research,
Update on MS research, National
Multiple Sclerosis Society, Local Chapter, Annual Meeting, 1994.
Brain imaging and spectroscopy:
multiple sclerosis, Making connections - High School teacher training, 1994 -
2000
Magnetic resonance imaging and
spectroscopy of the monkey brain during experimental allergic
encephalomyelitis,
"Brain lipids become NMR visible
after experimental allergic encephalomyelitis" at the "MR
Spectroscopy in Humans" Symposium of the American Physiological Society ,
"Diffuse Brain
Abnormalities", AUR Research Symposium, MRS: new insights into organ
physiology, May 20-21,
Spectroscopy Evening Workshop, SMRI 7th
Annual meeting, New Visions, Feb 25- March 1,
"Proton in vivo spectroscopy of
CNS changes associated with radiation", given at: Workshop on
Pathophysiological Studies by NMR In Vivo Spectroscopy, University of
California, Berkeley, sponsored by the Society of Magnetic Resonance in
Medicine, August 15, 1983
"NMR in-vitro spectroscopy with
protons, phosphorus, and carbon on brain tissue", given at: Electrical
Engineering Department Seminar,
Current Research Support:
Active
1.
NICHD 1P50HD55782-01
NIH –
Structural and Chemical Brain Imaging of Autism
Project IV of the UW ACE
will pursue the three broad objectives: (1) Identification of early biomarkers
for autism, including the trajectory of head circumference growth, brain
structure and tissue-based patterns of neurochemical alterations that can
increase our ability to identify infants who will eventually develop autism or
autism-related symptoms; (2) Longitudinal characterization of brain development
in adolescents with autism previously studied since age 3; and (3)
identification of risk and protective brain biomarkers related to longer term
outcome in adolescents with autism, including development of seizure disorder
and behavioral decline.
Role: Co-investigator of
Program Project IV.
2. NIH 1R01 HD55741-01 (Piven)
Consortium Network $1,786,915
A Longitudinal MRI Study
of Infants at Risk for Autism
In this application we
propose to employ these new methods to conduct a longitudinal MRI/DTI study of
6 m old infant sibs of autistic individuals, with follow-up at 12 and 24 m of
age. This study will provide important, new information about the trajectory of
early post-natal brain overgrowth (regions, tissues, structures and fiber
tracts), as measured on MRI and DTI, and its potential relationship to clinical
features. It has the potential to provide
insights into developmental brain and behavioral phenotypes, and
neurobiological mechanisms, that will inform other levels of analysis during
what appears to be a critical period of development in the pathogenesis of
autism. A multicenter grant with the
Role: Co-investigator –
UW Site
3.
5R21HD049832-02 (Valilala) 7/1/05-6/30/09
NIH/NICHD $275,000
Cerebral
Edema in Pediatric Diabetic Ketoacidosis
The overall
goals of this study are to characterize cerebrovascular changes in children
critically ill with DKA, and to determine the relationship between laboratory
markers, cerebrovascular changes and the presence or absence of cerebral edema.
Role:
Co-investigator
4. RO1 EY-014645 (Fine)
08/2004-08/2009
NIH/NEI $340,256
The
neural and functional effects of long term visual deprivation.
The goal of
this project is to examine the neural and behavioral effects of long-term
bilateral visual deprivation in adults using a combination of psychophysics and
functional magnetic resonance imaging.
Role:
Co-investigator
5.
R01HD052820-01A2 (Juul) 9/17/07-6/30/12
NIH/NICHD $2,790,725
Optimizing
Neuroprotection Following Perinatal Asphyxia
Specific aims: Aim 1) To determine which therapeutic strategy is most
effective in decreasing the neurodevelopmental sequelae of perinatal asphyxia
in near-term M. nemestrina: rEpo alone, hypothermia alone, or rEpo plus
hypothermia (vs. vehicle controls); Aim 2) To determine which therapeutic
strategy is most effective in decreasing the structural consequences of
perinatal asphyxia in brains of near-term M. nemestrina: rEpo alone,
hypothermia alone, or rEpo plus hypothermia (vs. vehicle controls); Aim 3) To
establish the safety of high dose rEpo treatment, hypothermia, and rEpo plus
head cooling in near-term M. nemestrina exposed to perinatal asphyxia.
Evaluation will include EEG, cerebral function monitoring, MRI/MRS,
neurobehavioral evaluations, biochemical and immunohistochemical studies.
Role: Co-investigator
6. P01
CA042045-21 (Krohn) 05/10/04-02/28/09
NCI/NIH $1,337,893
Molecular
Imaging of Cancer and Its Response to Therapy.
The major
goals of this program project grant are to investigate ways of imaging cancer
with PET and MRI.
Role: Co-Investigator
7. R01CA065537-14 (Eary) 12/01/05-11/30/2010
NCI/NIH $2,175,446
PET in Sarcoma: A Clinical Trail
Patient outcome correlation with FDG PET studies and
advanced image analysis. All sarcoma
tumor types are studied.
Role:
Co-Investigator
Previous
Grants:
Eleven
years of Continuous Support from NIH/NINDS
NIH-
NINDS
NIH-RO1 NS-30722 (PI -Richards)
Multiple Sclerosis-- MR spectroscopy
and evoked potentials
The major goal of this project is to
correlate MR spectroscopy with visual and
somatosensory evoked potentials in
patients with multiple sclerosis.
High Q Foundation (Aylward) 6/1/06-08/1/08
Direct Cost for all years $422,938
Metabolic Spectroscopy as a Biomarker
in Huntington’s Disease
Subjects with Huntington’s Disease and
controls are scanned twice with MR spectroscopy, DTI, and structural scans to
understand disease progression.
Role: Co-investigator
NIH/NICHD P50 33812 (PI, Berninger) 03/01/96 - 11/30/06
Learning
Disabilities: Links to Schools and Biology
The major goal of this project is to
use MR spectroscopy and functional MRI to study brain-
language activation in children
with learning disabilities.
Role: PI of Project 4
Santa Fe Institute SFIC-W-01 (PIs,
Kuhl, Meltzoff)
Santa Fe Institute Consortium
(SFIC): Increasing Human Potential
The major goals of this project are
to acquire a solid understanding of both the neurobiological and
neuropsychological development of the normal human brain, with a
particular emphasis on cognition, memory, and language as well as emotion and
social interactions, and to use these insights to develop tools to enhance
the home and educational environments of infants and adolescents, thereby
optimizing plastic changes at these critical times in maturation
and ultimately enhancing and improving intellectual capacity.
Role: Co-investigator
NIH/NINDS 1RO1
NS 36524 (PI Marra) 4/1/97-3/31/00
In
vivo proton MRS studies of cerebral injury in HIV
dementia
This
project will use proton MR spectroscopy to measure brain chemicals
such
as NAA, choline, and myoinositol and correlate these with
clinical
disability in patients with HIV dementia
NIH/NIMH 1 R21 MH63647-01 (PI- Marra) 5/1/01-3/31/04
Title: Novel Methods to Assess Brain Function in
HIV-1
This
is a pilot study to estimate the magnitude of changes in brain activation as
measured by
functional
MRI and functional MRS and by neuropsychological test performance in response
to
potent
antiretroviral therapy in HIV-1-infected individuals. A memory task is used during the
functional
brain imaging.
Role: Co-Investigator
NIH 1 R21 HD040954-01 (PI
Shara)
Title: Virtual Reality Analgesia for Rehabiliation
in Children
The
goal of these investigations is to develop non-pharmacologic analgesic
techniques for subjects with subacute and chronic rehabilitation-induced pain
(e.g., postburn physical therapy, rehabilitation activities following spinal
cord injury, limb loss, and cerebral palsy), emphasizing virtual reality
analgesia, the combination of virtual reality and hypnotic analgesia, and the
analgesic mechanisms of these techniques.
Role: Co-Investigator
NIH - 5R01AA012915-02 (PI – Astley)
Title: MRI/S in Children with Prenatal
Alcoholic Exposure
This
project is to use MR spectroscopy and fMRI to study brain chemistry and brain activation
in
children
with fetal alcohol syndrome (FAS).
Role:
Co-Investigator
NIH/NICCAM R21 AT00287-01 (PI
Standish) (
Richards is PI at the UW site
Title: Transfer of neural energy
between human subjects
This project will use functional MRI
and electroencephalography to study brain activation
in humans during an energy transfer
technique.
Subcontract
with the
Serial
MRSI: Sub-study of Primary Progressive Multiple Sclerosis
This
project will use proton MR spectroscopic imaging as an outcome measure
during
a clinical trial to test the effectiveness of copaxone in primary progressive
multiple
sclerosis
Subcontract
with EDMS, LLC (PI Richards)
MR
Imaging and Spectroscopy Evaluation for the Procarin Trial
This
project uses proton MR spectroscopy and conventional MRI to evaluate changes in
brain
chemistry
and structure during the Procarin clinical trial for multiple sclerosis.
Multiple
Sclerosis Association of
Title
- Evaluation of a pulsed electromagnetic therapy (Enermed) on Multiple
Sclerosis
Patient
Symptoms and Quality of Life
PI
- T. Richards
The
primary purpose of this research is to test the effects of a novel
electromagnetic
treatment on physical function, cognitive function,
and
quality of life experienced by MS sufferers.
Higher Ground
for Humanity (PI- Richards)
Neurofeedback and bioelectric measurements
in multiple sclerosis
This project will measure the effect of
neurofeedback training in multiple
sclerosis
patients
NIH
R01 MH50579 (Dager) 1 0/1/94 - 9/30/97 20%
NIH/NIMH
MRS
investigation of lactate-induced panic
The major goal
of this project is to use proton MR spectroscopy to
study lactate
infusion in panic patients.
NCI
NMR assay of thiol redox predicts tumor
therapy response
PI - K Krohn
Coinvestigator - T Richards, 5%
period of support -
Source:
Confidential Drug Company
Title: Phase 1
safety and pharmacokinetic study of Huf2G in subjects with multiple sclerosis
PI - James Bowen, M.D.
Period of
Support: 10/94 - present
Role on the
project: Co-investigator, 5%
National Multiple Sclerosis Society
Total brain n-acetyl imaging in
multiple sclerosis
PI - T Richards, 10% time and salary
period of support -
Royalty Research Fund
Functional and biochemical changes in
sudden sensorineural hearging loss as measured by MRI and MRS
PI - T Richards
Period of support -
National INST of neurological disorders
and stroke
MR evaluation of a model of multiple
sclerosis
R01 NS30722-01
PI - T Richards,
period of support -
Priority percentile - 3.9
NIH
Axonal study for improved selective
nerve anesthesia
PI - R. Fink
Consultant -
T Richards
period of support 1991-1994
Magnetic resonance imaging of auditory
nuclei in the chick brain
PI - T Richards
period of support -
First investigator grant from NINDS
Title of grant: "NMR spectroscopy
of Demyelination in the Primate Brain"
R29 NS24622-01
PI - TL Richards
Period of support -
Priority percentile - 5
DOE INEL subcontract no. C85-110744,
Title of grant: "Boron NMR of
tumors"
PI- TL Richards, 10% time and salary
Title of program project -
"Neutron Capture Therapy: Brain Cancer Treatment Program Plan", PI -
Merle L. Griebenow,
Period of support -
National Cancer Institue of NIH
Title of program project: Metabolic
Imaging of Cancer and its Response to Therapy
Program director: Kenneth Krohn
Period of support -
Title of Project - Core G - NMR support
PI - Martin Kushmeric
Co-investigator - TL Richards, 5% time
RFA NIH87HL26H
Title of program project: SCOR in
vascular research; PI - DE Strandness
Title of project: "Evaluation of
the structure and composition of atherosclerotic plaques by magnetic resonance
imaging (MRI)"; PI- Alan Nelson
T Richards - consultant
Period of support -
UW School of Medicine in house grant -
Biomedical Research Support Grant
"NMR spectroscopy of Demyelination
in the Primate Brain",
Period of support -
Instructional
Activities
Students
Supervised:
Jo-Fu Lotus Lin, Graduate Student,
Department of Speech and Hearing, PhD committee, 2005-present
Leah Altemier, Graduate Student, Education,
Dyslexia, 2003-2007
Allison Brooks, Graduate Student, Education,
Neuroimaging, 1999-2004
KC Stegbauer, Graduate Student, Bioengineering, MR spectroscopy, 1997-present
Sandra Serafini, graduate student, Department of Speech and Hearing, Thesis
advisor, 1995- present
Brenden Boys, undergraduate, 1997.
Jilma Jimenez - visiting student,
Bioengineering,
Katrin Petersen - undergraduate student
- 1993 - 1996
Lori Arakaki- Bioengineering, An
optical method for myoglobin oxygenation measurements in the blood-perfused rat hind limb, Ph.D.
Thesis committee, 1991 - 1995
Wayne Strauss - medical student/
bioengineering -1993 - 1999
Aaron Heide - Medical student,
Diffusion imaging of experimental allergic encephalomyelitis, 1991- 1999
Ken Marro - Bioengineering, Lactate
signal attenuation due to coherent flow in volume-localized proton spectroscopy, 1991-1996
Dan Leotta - Qualifying exam committee,
1993
Alan DeSoto - Electrical Engineering,
Stereotaxic MR image registration.,1993
Ian Sweet - Bioengineering, P-31
spectroscopy of muscle in Diabetes, Ph.D., 1990.
Alex Hertzberg - Bioengineering,
Measurement of Bone Trabeculae and bone marrow with MRI, Ph.D. , 1990
Don Allen, Electrical Engineering,
Computer software for NMR spectral analysis, 1989.
Courses
Taught:
Lecture given to PET physics group, UW
on
Lecture given to Neuroradiology group,
UW on
Bioeng 565/Radgy 550, NMR in
Biomedicine, Winter quarter 1995, 1997, 1999, 2001, 2003, 2005
Summer Basic MR physics course for
radiology residents and staff, 1992 - 1999
Bioeng 599 I, NMR in Biomedicine,
Winter Quarter 1993
Bioeng 599 H, NMR in Biomedicine,
Spring Quarter 1992
RADGY 550/Bioengineering 599H spring
1991. MR physics
RADGY 550, Spring 1989, Spring 1990. In
vivo NMR in Biomedicine. Team taught
with Dr. Grant Steen.
MR physics taught to Radiology
residents, 1986-present
"Biophysical Interpretation of MRI
Image Intensity" as part of course on Magnetic Resonance Imaging: Its
function and promise, Radiology Northwest,