Etiology and Prognosis of Anogenital Cancer

Human papillomaviruses (HPV) are the necessary cause of all, or nearly all, cervical carcinoma. These agents also are major etiologic factors in the etiology of other anogenital carcinomas in men and women, such as vulvar, vaginal, anal, and penile carcinomas. While HPV infection is widespread, the great majority of exposed persons do not develop anogenital cancers. This suggests that there exist contributing factors that act to enhance the carcinogenic effects of HPV. As part of a team of multidisciplinary collaboration investigators at the Fred Hutchinson Cancer Research Center (Janet Daling, Margaret Madeleine, Denise Galloway, and the late Jim McDougall, Peggy Porter, Chu Chen), I have been investigating factors other than HPV that contribute to the pathogenesis of anogenital cancer. Among the factors we have been investigating are cigarette smoking, oral contraceptive use, and genetic susceptibility.

In addition to etiologic studies, we have been examining how characteristics of the anogenital cancer patients influence patient prognosis. In particular, for cervical carcinoma we have been studying the role of HPV type, cell cycle control proteins, and serologic response to HPV proteins in outcome of cervical cancer patients.

Related Publications

Daling JR, Madeleine MM, Johnson LG, Schwartz SM, Shera KA, Wurscher MA, Carter JJ, Porter PL, Galloway DA, McDougall JK, Krieger JN. Penile cancer: importance of circumcision, human papillomavirus and smoking in in situ and invasive disease. Int J Cancer In Press

Johnson LG, Madeleine MM, Newcomer LM, Schwartz SM, Daling JR. Anal cancer incidence and survival: the SEER experience, 1973-2000. Cancer 2004 Jul 15;101(2):281-8.

Madeleine MM, Brumback B, Cushing-Haugen K, Schwartz SM, Daling JR, Smith AG, Nelson JL, Porter P, Shera KA, McDougall JK, Galloway DA. Human leukocyte antigen class II and cervical cancer risk: a population-based study. J Infect Dis 2002; 186:1565-74.

Daling JR, Madeleine MM, Schwartz SM, Shera KA, Carter JJ, McKnight B, Porter P, Galloway DA, McDougall JK, Tamimi H. Population-based study of squamous cell vaginal cancer: HPV and co-factors. Gynecol Oncol 2002;84:263-270.

Schwartz SM, Daling JR, Shera KA, Madeleine MM, McKnight B, Galloway DA, Porter PL, McDougall JK. Human papillomavirus and prognosis of invasive cervical cancer: a population-based study. J Clin Oncol 2001;19:1906-1915.

Carter JJ, Madeleine MM, Shera K, Schwartz SM, Cushing-Haugen KL, Wipf GC, Porter P, Daling JR, McDougall JK, Galloway DA. Human papillomavirus 16 and 18L1 serology compared across anogenital cancer sites. Cancer Research 2001;61:1934-1940.

Madeleine MM, Daling JR, Schwartz SM, Shera K, McKnight B, Carter JJ, Wipf GC, Critchlow CW, McDougall JK, Porter P, Galloway DA. Human papillomavirus and long-term oral contraceptive use increase the risk of adenocarcinoma in situ of the cervix. Cancer Epidemiol Biom Prev 2001;10: 171-177.

Madeleine MM, Shera K, Schwartz SM, Daling JR, Galloway DA, Wipf GC, Carter JJ, McKnight B, McDougall JK. The p53 Arg72Pro polymorphism, HPV, and invasive squamous cell cervical cancer: a population-based study. Cancer Epidemiol Biom Prev 2000; 9:225-229.

Madeleine MM, Daling JR, Carter JJ, Wipf GC, Schwartz SM, McKnight B, Kurman RJ, Beckmann AM, Hagansee ME, Galloway DA. Co-factors with HPV in a population-based study of vulvar cancer. JNCI 1997; 89:1516-23.

Daling JR, Madeleine MM, McKnight B, Carter JJ, Wipf GC, Ashley R, Schwartz SM, Beckmann AM, Hagansee ME, Mandelson MT, Galloway DA. The relationship of human papillomavirus-related cervical tumors to cigarette smoking, oral contraceptive use, and prior herpes simplex-2 infection. Cancer Epid Biom Prev 1996; 5:541-548.