Publications
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Shi, J., Chou, B., Choi, J.L., Ta, A.L., and Pun, S.H. (2013) Investigation of polyethylenimine/DNA polyplex transfection to cultured cells using radiolabeling and subcellular fractionation methods. Mol Pharm, accepted.
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Zhang, L., Sinclair, A., Cao, Z., Ella-Menye, J-R., Xu, X., Carr, L., Pun, S.H., and Jiang, S. (2013) Hydrolytic cationic ester microparticles for highly efficient DNA vaccine delivery. Small, accepted.
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Chen, C-Y., Kim, T.H., Wu, W-C., Huang, C.M., Wei, H. Mount C.W., Tian, Y., Jang, S-H., Pun, S.H., and Jen, A.K-Y. (2013) pH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors. Biomaterials, accepted.
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Chan, L.W., Wang, Y-N., Lin, L.Y., Upton, M.P., Hwang, J.H., and Pun, S.H. (2013) Synthesis and characterization of anti-EGFR fluorescent nanoparticles for optical molecular imaging. Bioconjugate Chem, 24:167-175.
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Wei, H., Pahang, J.A., and Pun, S.H. (2013) Optimization of brush-like cationic copolymers for non-viral gene delivery. Biomacromolecules, 14:275-284.
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Schellinger, J.G., Pahang, J.A., Johnson, R.N., Chu, D.S.H., Sellers, D.L., Maris, D.O., Convertine, A.J., Stayton, P.S., Horner, P.J., and Pun, S.H. (2013) Melittin-grafted HPMA-oligolysine based copolymers for improved gene delivery. Biomaterials, 34:2318-2326.
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Berguig, G.Y., Convertine, A.J., Shi, J., Palanca-Wessels, M.C., Duvall, C.L., Pun, S.H., Press, O.W., and Stayton, P.S. (2012) Intracellular delivery and trafficking dynamics of a lymphoma-targeting antibody-polymer conjugate. Mol Pharm, 9:3506-3514.
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Wei, H., Schellinger, J.G., Chu, D.S.H., and Pun, S.H. (2012) Neuron-targeted copolymers with sheddable shielding blocks synthesized using a reducible, RAFT-ATRP double-head agent. J Am Chem Soc, 134:16554-16557.
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Kacherovsky, N., Harkey, M.A., Blau, C.A., Giachelli, C.M., and Pun, S.H. (2012) Combination of Sleeping Beauty transposition and Chemically Induced Dimerization selection for robust production of engineered cells. Nucleic Acids Res, 40(11):e85.
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Chu, D.S.H., Schellinger, J.G., Shi, J., Convertine, A.J., Stayton, P.S., and Pun, S.H. (2012) Application of controlled radical polymerization for nucleic acid delivery. Acc Chem Res, 45(7):1089-1099.
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Chu, D.S.H., Johnson, R.N., and Pun, S.H. (2012) Cathepsin B-sensitive polymers for compartment-specific degradation and nucleic acid release. J Control Release, 157:445-454.
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Shi, J., Johnson, R.N., Schellinger, J.G., Carlson, P.M., and Pun, S.H. (2012) Reducible HPMA-co-oligolysine copolymers for nucleic acid delivery. Int J Pharm, 427:113-122.
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Kim, T.H., Mount, C.W., Dulken, B.W., Ramos, J., Fu, C.J., Khant, H.A., Chiu, W., Gombotz, W., and Pun, S.H. (2012) Filamentous, mixed micelles of triblock copolymers enhance tumor localization of indocyanine green in a murine xenograft model. Mol Pharm, 9:135-143.
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Wang, C.H., Chan, L.W., Johnson, R.N., Chu, D.S.H., Shi, J., Schellinger, J.G., Lieber, A., and Pun, S.H. (2011) HPMA-co-oligolysine copolymer-coated adenovirus transduce CAR-negative cells through interaction with sulfate proteoglycans. Biomaterials, 32:9536-9545.
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Johnson, R.N., Chu, D.S.H., Shi, J., Schellinger, J.G., Carlson, P.M., and Pun, S.H. (2011) HPMA-oligolysine copolymers for gene delivery: optimization of peptide length and polymer molecular weight. J Control Release, 155:303-311.
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Kim, Y.S., Park, I.K., Kim, W.J., Yu, M.K., Jon, S., Pun, S.H., Jeong, M.H., and Ahn, Y. (2011) SPION nanoparticles as efficient probe and carrier of DNA to umbilical cord blood-derived mesenchymal stem cells. J Nanosci Nanotech, 11:1507-1510.
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Wang, C.H. and Pun, S.H. (2011) Substrate-mediated nucleic acid delivery from self-assembled monolayers. Trends Biotechnol, 29(3):119-126.
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Johnson, R.N., Burke, R.S., Convertine, A., Hoffman, A.S., Stayton, P.S., and Pun, S.H. (2010) Synthesis of statistical copolymers with multiple functional peptides via RAFT polymerization. Biomacromolecules, 11(11):3007-3013.
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Wang, C.H., Jiang, S., and Pun, S.H. (2010) Localized cell uptake of His-tagged polyplexes immobilized on NTA self-assembled monolayers. Langmuir, 26(19):15445-15452.
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Kim, T.H., Mount, C.W., Gombotz, W.R., and Pun, S.H. (2010) The delivery of doxorubicin to 3-D multicellular spheroids and tumors in a murine xenograft model using tumor-penetrating triblock polymeric micelles. Biomaterials, 31(28):7386-7397.
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Kim, T.H., Chen, Y.P., Mount, C.W. Gombotz, W.R., Li, X.D., and Pun, S.H. (2010) Evaluation of temperature-sensitive, indocyanine green-encapsulating micelles for noninvasive near-infrared tumor imaging. Pharm Res, 27(7):1900-1913.
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Wilson, B.K., Mentele, T., Bachar, S., Knouf, E., Bendoraite, A., Tewari, M., Pun, S.H., and Lin, L.Y. (2010) Nanostructure-enhanced laser tweezers for efficient trapping and alignment of particles. Opt Express, 18(15):16005-16013.
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Kwon, E.J., Liong, S., and Pun, S.H. (2010) A truncated HGP peptide sequence retains endosomolytic activity and improves gene delivery efficiencies. Mol Pharm, 7(4):1260-1265.
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Kwon, E.J., Lasiene, J., Jacobson, B., Park, I.K., Horner, P.J., and Pun, S.H. (2010) Targeted nonviral delivery vehicles to neural progenitor cells in the mouse subventricular zone. Biomaterials, 31(8):2417-2424.
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Burke, R.S. and Pun, S.H. (2010) Synthesis and characterization of biodegradable HPMA-oligolysine copolymers for improved gene delivery. Bioconj Chem, 21:140-150.
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Miao, X., Wilson, B.K., Cao, G., Pun, S.H., and Lin, L.Y. (2009) Long-range trapping and rotation of nanowires and nanotubes by plasmonic tweezers. IEEE Journal of Selected Topics in Quantum Electronics, 15(5):1515-1520.
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Kwon, J.S., Park, I.K., Cho, A.S., Shin, S.M., Hong, M.H., Jeong, S.Y., Kim, Y.S., Min, J.J., Kim, W.J., Jo, S., Pun, S.H., Cho, J.G., Park, J.C., Kang, J.C., and Ahn, Y. (2009) Enhanced angiogenesis mediated by vascular endothelial growth factor plasmid-loaded thermo-responsive amphiphilic polymer in a rat myocardial infarction model. J Control Release, 138(2):168-176.
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Ng, C.P., Goodman, T.T., Park, I.K., and Pun, S.H. (2009) Bio-mimetic surface engineering of plasmid-loaded nanoparticles for active intracellular trafficking by actin comet-tail motility. Biomaterials, 30(5):951-958.
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Miao, X., Wilson, B.K., Pun, S.H., and Lin, L.Y. (2008) Optical manipulation of micron/submicron particles and biomolecules through plasmonics. Opt Express, 16(18):13517-13525.
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Goodman, T.T., Ng, C.P., and Pun, S.H. (2008) 3-D tissue culture systems for the evaluation and optimization of nanoparticle-based drug carriers. Bioconj Chem, 19(10):1951-1959.
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Kwon, E.J., Bergen, J.M., Park, I.K., and Pun, S.H. (2008) Peptide-modified vectors for nucleic acid delivery to neurons. J Control Release, 132(3):230-235.
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Goodman, T.T., Chen, J., Matveev, K., and Pun, S.H. (2008) Spatio-temporal modeling of nanoparticle delivery to multicellular spheroids. Biotechnol Bioeng, 101(2):388-399.
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Kwon, E.J., Bergen, J.M., and Pun, S.H. (2008) Application of an HIV gp41-derived peptide for enhanced intracellular trafficking of synthetic gene and siRNA delivery vehicles. Bioconj Chem, 19(4):920-927.
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Burke, R.S. and Pun, S.H. (2008) Extracellular barriers to in vivo PEI and PEGylated PEI polyplex-mediated gene delivery to liver. Bioconj Chem, 19(3):693-704. |
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Park, I.K., Ng, C.P., Wang, J., Chu, B.C., Wang, C., and Pun, S.H. (2008) Determination of nanoparticle vehicle unpackaging by MR imaging of a T(2) magnetic relaxation switch. Biomaterials, 29(6):724-732. |
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Ng, C.P. and Pun, S.H. (2008) A perfusable 3D cell-matrix tissue culture chamber for in situ evaluation of nanoparticle vehicle penetration and transport. Biotechnol Bioeng, 99(6):1490-1501. |
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Bergen, J.M., Kwon, E.J., Shen, T.W., and Pun, S.H. (2008) Application of an environmentally sensitive fluorophore for rapid analysis of the binding and internalization of gene carriers. Bioconj Chem, 19(1):377-384. |
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Bergen, J.M. and Pun, S.H. (2008) Analysis of the intracellular barriers encountered by nonviral gene carriers in a model of spatially controlled delivery to neurons. J Gene Med, 10(2):187-197. |
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Saul, J.M., Wang, C.K., Ng, C.P., and Pun, S.H. (2008) Multilayer nanocomplexes of polymer and DNA exhibit enhanced gene delivery. Adv Mater, 20(1):19-25. |
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Bergen, J.M., Park, I.K., Horner, P.J., and Pun, S.H. (2008) Nonviral approaches for neuronal delivery of nucleic acids. Pharm Res, 25(5):983-998. |
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Rodriguez, V.B., Henry, S.M., Hoffman, A.S., Stayton, P.S., Li, X., and Pun, S.H. (2008) Encapsulation and stabilization of indocyanine green within poly(styrene-alt-maleic anhydride) block-poly(styrene) micelles for near-infrared imaging. J Biomed Opt, 13(1):014025. |
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Park, I.K., Lasiene, J., Chou, S.H., Horner, P.J., and Pun, S.H. (2007) Neuron-specific delivery of nucleic acids mediated by Tet1-modified poly(ethylenimine). J Gene Med, 9(8):691-702.
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Saul, J.M., Linnes, M.P., Ratner, B.D., Giachelli, C.M., and Pun, S.H. (2007) Delivery of non-viral gene carriers from sphere-templated fibrin scaffolds for sustained transgene expression. Biomaterials, 28(31):4705-4716.
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Housni, A., Cai, H., Liu, S., Pun, S.H, and Narain, R. (2007) Facile preparation of glyconanoparticles and their bioconjugation to streptavidin. Langmuir, 23(9):5056-5061.
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Goodman, T.T., Olive, P.L., and Pun, S.H. (2007) Increased nanoparticle penetration in collagenase-treated multicellular spheroids. Int J Nanomedicine, 2(2):265-274.
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Bergen, J.M. and Pun, S.H. (2007) Evaluation of an LC8-binding peptide for the attachment of artificial cargo to dynein. Mol Pharm, 4(1):119-128.
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Cheng, J., Zeidan, R., Mishra, S., Liu, A., Pun, S.H., Kulkarni, R.P., Jensen, G.S., Bellocq, N.C., and Davis M.E. (2006) Structure-Function Correlation of chloroquine and analogues as transgene expression enhancers in nonviral gene delivery. J Med Chem, 49(22):6522-6531.
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Park, I.K., von Recum, H.A., Jiang, S., and Pun, S.H. (2006) Supramolecular assembly of cyclodextrin-based nanoparticles on solid sufaces for gene delivery. Langmuir, 22(20):8478-8484.
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Bergen, J.M., von Recum, H.A., Goodman, T.T., Massey, A.P., and Pun, S.H. (2006) Gold nanoparticles as a versatile platform for optimizing physicochemical parameters for targeted drug delivery. Macromol Biosci, 6(7):506-516.
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Popielarski, S.R., Pun, S.H., and Davis, M.E. (2005) A nanoparticle-based model delivery system to guide the rational design of gene delivery to the liver. 1. Synthesis and characterization. Bioconj Chem, 16(5):1063-1070.
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Bergen, J.M. and Pun, S.H. (2005) Peptide-enhanced gene delivery. MRS Bulletin, 30:663-667.
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Pack, D.W., Hoffman, A.S., Pun, S.H., and Stayton, P.S. (2005) Design and development of polymers for gene delivery. Nat Rev Drug Discov, 4(7):581-593.
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Bellocq, N.C., Kang, D.W., Wang, X., Jensen, G.S., Pun, S.H., Schleup, T., Zepeda, M.L., and Davis, M.E. (2004) Synthetic biocompatible cyclodextrin-based constructs for local gene delivery to improve cutaneous wound healing. Bioconj Chem, 15(6):1201-1211.
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Pun, S.H., Bellocq, N.C., Liu, A., Jensen, G., Machemer, T., Quijano, E., Schluep, T., Wen, S., Engler, H., Heidel, J., and Davis, M.E. (2004) Cyclodextrin-modified polyethylenimine polymers for gene delivery. Bioconj Chem, 15(4):831-840.
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Pun, S.H. and Davis, M.E. (2004) Cyclodextrin polymers for gene delivery, Chapter in Polymeric Gene Delivery, CRC Press, Mansoor Amiji, Ed.
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Pun, S.H., Tack, F., Bellocq, N.C., Cheng, J., Grubbs, B.H., Jensen, G.S., Davis, M.E., Brewster, M., Janicot, M., Janssens, B., Floren, W., Bakker, A. (2004) Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles. Cancer Biol Ther, 3(7):641-650.
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Davis, M.E., Pun, S.H., Bellocq, N.C., Reineke, T.M., Popielarski, S.R., Mishra, S., and Heidel, J.D. (2004) Self-assembling nucleic acid delivery vehicles via linear, water-soluble, cyclodextrin-containing polymers. Curr Med Chem, 11(2):179-197.
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Bellocq, N.C., Pun, S.H., Jensen, G.S. and Davis, M.E. (2003) Transferrin-containing, cyclodextrin polymer-based particles for tumor-targeted gene delivery. Bioconj Chem, 14(6):1122-1132.
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Pun, S.H. and Davis, M.E. (2002) Development of a nonviral gene delivery vehicle for systemic application. Bioconj Chem, 13(3):630-639.
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Hwang, S.J. and Davis, M.E. (2001) Cationic polymers for gene delivery: designs for overcoming barriers to systemic administration. Curr Opin Mol Ther, 3(2): 183-191.
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Bellocq, N.C., Hwang, S.J., and Davis, M.E. (2001) Optimization of cyclodextrin-polymers specifically designed for gene delivery. Proceedings of the 221st American Chemical Society National Meeting, Polymeric Materials: Science & Engineering, 84:809-810.
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Hwang, S.J., Bellocq, N.C., and Davis, M.E. (2001) Effects of structure of beta-cyclodextrin-containing polymers on gene delivery. Bioconj Chem, 12(2):280-290.
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Gonzalez, H., Hwang, S.J., and Davis, M.E. (1999) New class of polymers for the delivery of macromolecular therapeutics. Bioconj Chem, 10(6):1068-1074.
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McDaniel, R., Kao, C., Hwang, S.J., and Khosla, C. (1997) Engineered intermodular and intramodular polyketide synthase fusions. Chem Biol, 4(9):667-674.
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