Publications

Goodman, T.T., Chen, J., Matveev, K., and Pun, S.H. (2008) Spatio-temporal modeling of nanoparticle delivery to multicellular spheroids. Biotech and Bioeng, in press.
Kwon, E.J., Bergen, J.M., and Pun, S.H. (2008) Application of an HIV gp41-derived peptide for enhanced intracellular trafficking of synthetic gene and siRNA delivery vehicles. Bioconj Chem v19(4):920-927.
Burke, R.S. and Pun, S.H. (2008) Extracellular barriers to in vivo PEI and PEGylated PEI polyplex-mediated gene delivery to liver. Bioconj Chem v19(3):693-704.
Park, I.K., Ng, C.P., Wang, J., Chu, B.C., Wang, C., and Pun, S.H. (2008) Determination of nanoparticle vehicle unpackaging by MR imaging of a T2 magnetic relaxation switch. Biomaterials v29(6):724-732.
Ng, C.P. and Pun, S.H. (2008) A versatile 3-D soft tissue perfusion chamber for mimicking tissue microenvironments. Biotech and Bioeng v99(6):1490-1501.
Bergen, J.M., Kwon, E.J., Shen, T.W., and Pun, S.H. (2008) Application of an environmentally-sensitive fluorophore for rapid analysis of the binding and internalization of gene carriers. Bioconj Chem v19(1):377-384.
Bergen, J.M. and Pun, S.H. (2008) Analysis of intracellular barriers encountered by non-viral gene carriers in a model of spatially-controlled delivery to neurons. J Gene Med v10(2):187-197.
Saul, J.M., Wang, C.K., Ng, C.P., and Pun, S.H. (2008) Multilayer nanocomplexes of polymer and DNA exhibit enhanced gene delivery Advanced Materials v20(1):19-25.
Bergen, J.M., Park, I.K., Horner, P.J., and Pun, S.H. (2008) Nonviral approaches for neuronal delivery of nucleic acids. Pharm Res v25(5):983-998.
Rodriguez, V., Henry, S., Hoffman, A.S., Stayton, P.S., Li, X., and Pun, S.H. (2008) Polymeric micelle encapsulation of indocyanine green. J. Biomed Optics v13(1) 014025.
Park, I.K., Lasiene, J., Chou, S.H., Horner, P.J., and Pun, S.H. (2007) Neuron-specific delivery of nucleic acids mediated by Tet1-modified poly(ethylenimine). J Gene Med v9:691-702.
Saul, J.M., Linnes, M.P., Ratner, B.D., Giachelli, C.M., and Pun, S.H. (2007) Delivery of non-viral gene carriers from sphere-templated fibrin scaffolds for sustained transgene expression. Biomaterials v28(31):4705-4716.
Housni, A., Cai, H., Liu, S., Pun, S.H, and Narain, R. (2007) Facile preparation of glyconanoparticles and their bioconjugation to streptavidin. Langmuir 23(9):5056-5061.
Goodman, T., Olive, P.L., Pun, S.H. (2007) Increased nanoparticle penetration in collagenase-treated multicellular spheroids. Int J Nanomed v2(2):265-274.
Bergen, J.M. and Pun, S.H. (2007) Evaluation of an LC8-binding motif for cargo attachment to dynein. Mol Pharm 4(1):119-128.
Cheng, J., Zeidan, R., Mishra, S., Liu, A., Pun, S.H., Kulkarni, R.P., Jensen, G.S., Bellocq, N.C., and Davis M.E. (2006) Structure-Function Correlation of Chloroquine and Analogues as Transgene Expression Enhancers in Nonviral Gene Delivery. Journal of Medicinal Chemistry, 49(22), 6522-6531.
Park, I.K., von Recum, H.A., and Pun, S.H. (2006) Supramolecular assembly of cyclodextrin-based nanoparticles on solid sufaces for gene delivery. Langmuir 22:8478-8484.
Bergen, J.M., von Recum, H.A., Goodman, T.T., Massey, A.P., and Pun, S.H. (2006) Gold nanoparticles as a versatile platform for optimizing physicochemical parameters for targeted drug delivery. Macromolecular Bioscience 6:506-516.
Popielarski, S.R., Pun, S.H., and Davis , M.E. (2005) A nanoparticle-based model delivery system to guide the rational design of gene delivery to the liver. 1. Synthesis and Characterization. Bioconjugate Chemistry 16:1063-1070.
Bergen, J.M. and Pun, S.H. (2005) Peptide-enhanced gene delivery. MRS Bulletin 30:663-667.
Pack, D.W., Hoffman, A.S., Pun, S.H., and Stayton, P.S. (2005) Design and Development of Polymers for Gene Delivery. Nature Reviews Drug Discovery 5:581-593.
Bellocq, N.C., Kang, D.W., Wang, X., Jensen, G.S., Pun, S.H., Schleup, T., Zepeda, M.L., and Davis, M.E. (2004) Synthetic biocompatible cyclodextrin-based constructs for local gene delivery to improve cutaneous wound healing. Bioconjugate Chemistry 15:1201-1211.
Pun, S.H., Bellocq, N.C., Liu, A., Machemer, T., Maneval, D.C., Quijano, E., Schluep, T., Wen, S., Engler, H., Heidel, J., and Davis, M.E. (2004) Cyclodextrin-poly(ethylenimine) polymers for gene delivery. Bioconjugate Chemistry 15:831-840.
Pun, S.H. and Davis, M.E. (2004) Cyclodextrin polymers for gene delivery, Chapter in Polymeric Gene Delivery, CRC Press, Mansoor Amiji, Ed.
Pun, S.H., Bellocq, N.C., Cheng, J., Grubbs, B.H., Jensen, G.S., Davis, M.E., Tack, F., Brewster, M., Janicot, M., Janssens, B., Floren, W., Bakker, A. (2004) Biodistribution of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles. Cancer Biology and Therapy 7:641-650.
Davis, M.E., Pun, S.H., Bellocq, N.C., Reineke, T.M., Popielarski, S.R., Mishra, S., and Heidel, J. (2004) Self-assemblying nucleic acid delivery vehicles via linear, water-soluble, cyclodextrin-containing polymers. Current Medicinal Chemistry 11(2):179-197
Bellocq, N.C., Pun, S.H., Jensen, G.S. and Davis, M.E. (2003) Synthesis of transferrin-PEG conjugates and preparation of transferrin-modified polyplexes for tumor-targeted gene delivery. Bioconjugate Chemistry 14:1122-1132.
Pun, S.H. and Davis, M.E. (2002) Development of a Non-viral Gene Delivery Vehicle for Systemic Application. Bioconjugate Chemistry 13:630-639.
Hwang, S.J. and Davis, M.E. (2001) Cationic Polymers for Gene Delivery: Designs for Overcoming Barriers to Systemic Administration. Current Opinions in Molecular Therapeutics 3(2): 183-191.
Bellocq, N.C., Hwang, S.J., and Davis, M.E. (2001) Optimization of Cyclodextrin-Polymers Specifically Designed for Gene Delivery. Proceedings of the 221st American Chemical Society National Meeting, Polymeric Materials: Science & Engineering 84: 809-810.
Hwang, S.J., Bellocq, N.C., and Davis, M.E. (2001) Effects of Structure of beta-cyclodextrin-containing Polymers on Gene Delivery. Bioconjugate Chemistry 12(2): 280-290.
Gonzalez, H., Hwang, S.J., and Davis, M.E. (1999) New Class of Polymers for the Delivery of Macromolecular Therapeutics. Bioconjugate Chemistry 10: 1068-1074.
McDaniel, R., Kao, C., Hwang, S.J., and Khosla, C. (1997) Engineered Intermodular and Intramodular Polyketide Synthase Fusions. Chem. & Bio. v.4: 667-674.
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