Publications

Shi, J., Chou, B., Choi, J.L., Ta, A.L., and Pun, S.H. (2013) Investigation of polyethylenimine/DNA polyplex transfection to cultured cells using radiolabeling and subcellular fractionation methods. Mol Pharm, accepted.

Zhang, L., Sinclair, A., Cao, Z., Ella-Menye, J-R., Xu, X., Carr, L., Pun, S.H., and Jiang, S. (2013) Hydrolytic cationic ester microparticles for highly efficient DNA vaccine delivery. Small, accepted.

Chen, C-Y., Kim, T.H., Wu, W-C., Huang, C.M., Wei, H. Mount C.W., Tian, Y., Jang, S-H., Pun, S.H., and Jen, A.K-Y. (2013) pH-dependent, thermosensitive polymeric nanocarriers for drug delivery to solid tumors. Biomaterials, accepted.

Chan, L.W., Wang, Y-N., Lin, L.Y., Upton, M.P., Hwang, J.H., and Pun, S.H. (2013) Synthesis and characterization of anti-EGFR fluorescent nanoparticles for optical molecular imaging. Bioconjugate Chem, 24:167-175.

Wei, H., Pahang, J.A., and Pun, S.H. (2013) Optimization of brush-like cationic copolymers for non-viral gene delivery. Biomacromolecules, 14:275-284.

Schellinger, J.G., Pahang, J.A., Johnson, R.N., Chu, D.S.H., Sellers, D.L., Maris, D.O., Convertine, A.J., Stayton, P.S., Horner, P.J., and Pun, S.H. (2013) Melittin-grafted HPMA-oligolysine based copolymers for improved gene delivery. Biomaterials, 34:2318-2326.

Berguig, G.Y., Convertine, A.J., Shi, J., Palanca-Wessels, M.C., Duvall, C.L., Pun, S.H., Press, O.W., and Stayton, P.S. (2012) Intracellular delivery and trafficking dynamics of a lymphoma-targeting antibody-polymer conjugate. Mol Pharm, 9:3506-3514.

Wei, H., Schellinger, J.G., Chu, D.S.H., and Pun, S.H. (2012) Neuron-targeted copolymers with sheddable shielding blocks synthesized using a reducible, RAFT-ATRP double-head agent. J Am Chem Soc, 134:16554-16557.

Kacherovsky, N., Harkey, M.A., Blau, C.A., Giachelli, C.M., and Pun, S.H. (2012) Combination of Sleeping Beauty transposition and Chemically Induced Dimerization selection for robust production of engineered cells. Nucleic Acids Res, 40(11):e85.

Chu, D.S.H., Schellinger, J.G., Shi, J., Convertine, A.J., Stayton, P.S., and Pun, S.H. (2012) Application of controlled radical polymerization for nucleic acid delivery. Acc Chem Res, 45(7):1089-1099.

Chu, D.S.H., Johnson, R.N., and Pun, S.H. (2012) Cathepsin B-sensitive polymers for compartment-specific degradation and nucleic acid release. J Control Release, 157:445-454.

Shi, J., Johnson, R.N., Schellinger, J.G., Carlson, P.M., and Pun, S.H. (2012) Reducible HPMA-co-oligolysine copolymers for nucleic acid delivery. Int J Pharm, 427:113-122.

Kim, T.H., Mount, C.W., Dulken, B.W., Ramos, J., Fu, C.J., Khant, H.A., Chiu, W., Gombotz, W., and Pun, S.H. (2012) Filamentous, mixed micelles of triblock copolymers enhance tumor localization of indocyanine green in a murine xenograft model. Mol Pharm, 9:135-143.

Wang, C.H., Chan, L.W., Johnson, R.N., Chu, D.S.H., Shi, J., Schellinger, J.G., Lieber, A., and Pun, S.H. (2011) HPMA-co-oligolysine copolymer-coated adenovirus transduce CAR-negative cells through interaction with sulfate proteoglycans. Biomaterials, 32:9536-9545.

Johnson, R.N., Chu, D.S.H., Shi, J., Schellinger, J.G., Carlson, P.M., and Pun, S.H. (2011) HPMA-oligolysine copolymers for gene delivery: optimization of peptide length and polymer molecular weight. J Control Release, 155:303-311.

Kim, Y.S., Park, I.K., Kim, W.J., Yu, M.K., Jon, S., Pun, S.H., Jeong, M.H., and Ahn, Y. (2011) SPION nanoparticles as efficient probe and carrier of DNA to umbilical cord blood-derived mesenchymal stem cells. J Nanosci Nanotech, 11:1507-1510.

Wang, C.H. and Pun, S.H. (2011) Substrate-mediated nucleic acid delivery from self-assembled monolayers. Trends Biotechnol, 29(3):119-126.

Johnson, R.N., Burke, R.S., Convertine, A., Hoffman, A.S., Stayton, P.S., and Pun, S.H. (2010) Synthesis of statistical copolymers with multiple functional peptides via RAFT polymerization. Biomacromolecules, 11(11):3007-3013.

Wang, C.H., Jiang, S., and Pun, S.H. (2010) Localized cell uptake of His-tagged polyplexes immobilized on NTA self-assembled monolayers. Langmuir, 26(19):15445-15452.

Kim, T.H., Mount, C.W., Gombotz, W.R., and Pun, S.H. (2010) The delivery of doxorubicin to 3-D multicellular spheroids and tumors in a murine xenograft model using tumor-penetrating triblock polymeric micelles. Biomaterials, 31(28):7386-7397.

Kim, T.H., Chen, Y.P., Mount, C.W. Gombotz, W.R., Li, X.D., and Pun, S.H. (2010) Evaluation of temperature-sensitive, indocyanine green-encapsulating micelles for noninvasive near-infrared tumor imaging. Pharm Res, 27(7):1900-1913.

Wilson, B.K., Mentele, T., Bachar, S., Knouf, E., Bendoraite, A., Tewari, M., Pun, S.H., and Lin, L.Y. (2010) Nanostructure-enhanced laser tweezers for efficient trapping and alignment of particles. Opt Express, 18(15):16005-16013.

Kwon, E.J., Liong, S., and Pun, S.H. (2010) A truncated HGP peptide sequence retains endosomolytic activity and improves gene delivery efficiencies. Mol Pharm, 7(4):1260-1265.

Kwon, E.J., Lasiene, J., Jacobson, B., Park, I.K., Horner, P.J., and Pun, S.H. (2010) Targeted nonviral delivery vehicles to neural progenitor cells in the mouse subventricular zone. Biomaterials, 31(8):2417-2424.

Burke, R.S. and Pun, S.H. (2010) Synthesis and characterization of biodegradable HPMA-oligolysine copolymers for improved gene delivery. Bioconj Chem, 21:140-150.

Miao, X., Wilson, B.K., Cao, G., Pun, S.H., and Lin, L.Y. (2009) Long-range trapping and rotation of nanowires and nanotubes by plasmonic tweezers. IEEE Journal of Selected Topics in Quantum Electronics, 15(5):1515-1520.

Kwon, J.S., Park, I.K., Cho, A.S., Shin, S.M., Hong, M.H., Jeong, S.Y., Kim, Y.S., Min, J.J., Kim, W.J., Jo, S., Pun, S.H., Cho, J.G., Park, J.C., Kang, J.C., and Ahn, Y. (2009) Enhanced angiogenesis mediated by vascular endothelial growth factor plasmid-loaded thermo-responsive amphiphilic polymer in a rat myocardial infarction model. J Control Release, 138(2):168-176.

Ng, C.P., Goodman, T.T., Park, I.K., and Pun, S.H. (2009) Bio-mimetic surface engineering of plasmid-loaded nanoparticles for active intracellular trafficking by actin comet-tail motility. Biomaterials, 30(5):951-958.

Miao, X., Wilson, B.K., Pun, S.H., and Lin, L.Y. (2008) Optical manipulation of micron/submicron particles and biomolecules through plasmonics. Opt Express, 16(18):13517-13525.

Goodman, T.T., Ng, C.P., and Pun, S.H. (2008) 3-D tissue culture systems for the evaluation and optimization of nanoparticle-based drug carriers. Bioconj Chem, 19(10):1951-1959.

Kwon, E.J., Bergen, J.M., Park, I.K., and Pun, S.H. (2008) Peptide-modified vectors for nucleic acid delivery to neurons. J Control Release, 132(3):230-235.

Goodman, T.T., Chen, J., Matveev, K., and Pun, S.H. (2008) Spatio-temporal modeling of nanoparticle delivery to multicellular spheroids. Biotechnol Bioeng, 101(2):388-399.

Kwon, E.J., Bergen, J.M., and Pun, S.H. (2008) Application of an HIV gp41-derived peptide for enhanced intracellular trafficking of synthetic gene and siRNA delivery vehicles. Bioconj Chem, 19(4):920-927.

Burke, R.S. and Pun, S.H. (2008) Extracellular barriers to in vivo PEI and PEGylated PEI polyplex-mediated gene delivery to liver. Bioconj Chem, 19(3):693-704.

Park, I.K., Ng, C.P., Wang, J., Chu, B.C., Wang, C., and Pun, S.H. (2008) Determination of nanoparticle vehicle unpackaging by MR imaging of a T(2) magnetic relaxation switch. Biomaterials, 29(6):724-732.

Ng, C.P. and Pun, S.H. (2008) A perfusable 3D cell-matrix tissue culture chamber for in situ evaluation of nanoparticle vehicle penetration and transport. Biotechnol Bioeng, 99(6):1490-1501.

Bergen, J.M., Kwon, E.J., Shen, T.W., and Pun, S.H. (2008) Application of an environmentally sensitive fluorophore for rapid analysis of the binding and internalization of gene carriers. Bioconj Chem, 19(1):377-384.

Bergen, J.M. and Pun, S.H. (2008) Analysis of the intracellular barriers encountered by nonviral gene carriers in a model of spatially controlled delivery to neurons. J Gene Med, 10(2):187-197.

Saul, J.M., Wang, C.K., Ng, C.P., and Pun, S.H. (2008) Multilayer nanocomplexes of polymer and DNA exhibit enhanced gene delivery. Adv Mater, 20(1):19-25.

Bergen, J.M., Park, I.K., Horner, P.J., and Pun, S.H. (2008) Nonviral approaches for neuronal delivery of nucleic acids. Pharm Res, 25(5):983-998.

Rodriguez, V.B., Henry, S.M., Hoffman, A.S., Stayton, P.S., Li, X., and Pun, S.H. (2008) Encapsulation and stabilization of indocyanine green within poly(styrene-alt-maleic anhydride) block-poly(styrene) micelles for near-infrared imaging. J Biomed Opt, 13(1):014025.

Park, I.K., Lasiene, J., Chou, S.H., Horner, P.J., and Pun, S.H. (2007) Neuron-specific delivery of nucleic acids mediated by Tet1-modified poly(ethylenimine). J Gene Med, 9(8):691-702.

Saul, J.M., Linnes, M.P., Ratner, B.D., Giachelli, C.M., and Pun, S.H. (2007) Delivery of non-viral gene carriers from sphere-templated fibrin scaffolds for sustained transgene expression. Biomaterials, 28(31):4705-4716.

Housni, A., Cai, H., Liu, S., Pun, S.H, and Narain, R. (2007) Facile preparation of glyconanoparticles and their bioconjugation to streptavidin. Langmuir, 23(9):5056-5061.

Goodman, T.T., Olive, P.L., and Pun, S.H. (2007) Increased nanoparticle penetration in collagenase-treated multicellular spheroids. Int J Nanomedicine, 2(2):265-274.

Bergen, J.M. and Pun, S.H. (2007) Evaluation of an LC8-binding peptide for the attachment of artificial cargo to dynein. Mol Pharm, 4(1):119-128.

Cheng, J., Zeidan, R., Mishra, S., Liu, A., Pun, S.H., Kulkarni, R.P., Jensen, G.S., Bellocq, N.C., and Davis M.E. (2006) Structure-Function Correlation of chloroquine and analogues as transgene expression enhancers in nonviral gene delivery. J Med Chem, 49(22):6522-6531.

Park, I.K., von Recum, H.A., Jiang, S., and Pun, S.H. (2006) Supramolecular assembly of cyclodextrin-based nanoparticles on solid sufaces for gene delivery. Langmuir, 22(20):8478-8484.

Bergen, J.M., von Recum, H.A., Goodman, T.T., Massey, A.P., and Pun, S.H. (2006) Gold nanoparticles as a versatile platform for optimizing physicochemical parameters for targeted drug delivery. Macromol Biosci, 6(7):506-516.

Popielarski, S.R., Pun, S.H., and Davis, M.E. (2005) A nanoparticle-based model delivery system to guide the rational design of gene delivery to the liver. 1. Synthesis and characterization. Bioconj Chem, 16(5):1063-1070.

Bergen, J.M. and Pun, S.H. (2005) Peptide-enhanced gene delivery. MRS Bulletin, 30:663-667.

Pack, D.W., Hoffman, A.S., Pun, S.H., and Stayton, P.S. (2005) Design and development of polymers for gene delivery. Nat Rev Drug Discov, 4(7):581-593.

Bellocq, N.C., Kang, D.W., Wang, X., Jensen, G.S., Pun, S.H., Schleup, T., Zepeda, M.L., and Davis, M.E. (2004) Synthetic biocompatible cyclodextrin-based constructs for local gene delivery to improve cutaneous wound healing. Bioconj Chem, 15(6):1201-1211.

Pun, S.H., Bellocq, N.C., Liu, A., Jensen, G., Machemer, T., Quijano, E., Schluep, T., Wen, S., Engler, H., Heidel, J., and Davis, M.E. (2004) Cyclodextrin-modified polyethylenimine polymers for gene delivery. Bioconj Chem, 15(4):831-840.

Pun, S.H. and Davis, M.E. (2004) Cyclodextrin polymers for gene delivery, Chapter in Polymeric Gene Delivery, CRC Press, Mansoor Amiji, Ed.

Pun, S.H., Tack, F., Bellocq, N.C., Cheng, J., Grubbs, B.H., Jensen, G.S., Davis, M.E., Brewster, M., Janicot, M., Janssens, B., Floren, W., Bakker, A. (2004) Targeted delivery of RNA-cleaving DNA enzyme (DNAzyme) to tumor tissue by transferrin-modified, cyclodextrin-based particles. Cancer Biol Ther, 3(7):641-650.

Davis, M.E., Pun, S.H., Bellocq, N.C., Reineke, T.M., Popielarski, S.R., Mishra, S., and Heidel, J.D. (2004) Self-assembling nucleic acid delivery vehicles via linear, water-soluble, cyclodextrin-containing polymers. Curr Med Chem, 11(2):179-197.

Bellocq, N.C., Pun, S.H., Jensen, G.S. and Davis, M.E. (2003) Transferrin-containing, cyclodextrin polymer-based particles for tumor-targeted gene delivery. Bioconj Chem, 14(6):1122-1132.

Pun, S.H. and Davis, M.E. (2002) Development of a nonviral gene delivery vehicle for systemic application. Bioconj Chem, 13(3):630-639.

Hwang, S.J. and Davis, M.E. (2001) Cationic polymers for gene delivery: designs for overcoming barriers to systemic administration. Curr Opin Mol Ther, 3(2): 183-191.

Bellocq, N.C., Hwang, S.J., and Davis, M.E. (2001) Optimization of cyclodextrin-polymers specifically designed for gene delivery. Proceedings of the 221st American Chemical Society National Meeting, Polymeric Materials: Science & Engineering, 84:809-810.

Hwang, S.J., Bellocq, N.C., and Davis, M.E. (2001) Effects of structure of beta-cyclodextrin-containing polymers on gene delivery. Bioconj Chem, 12(2):280-290.

Gonzalez, H., Hwang, S.J., and Davis, M.E. (1999) New class of polymers for the delivery of macromolecular therapeutics. Bioconj Chem, 10(6):1068-1074.

McDaniel, R., Kao, C., Hwang, S.J., and Khosla, C. (1997) Engineered intermodular and intramodular polyketide synthase fusions. Chem Biol, 4(9):667-674.