Whole integration of neural connectomics, dynamics and bio-mechanics for identification of behavioral sensorimotor pathways in Caenorhabditis elegans

Jimin Kim1   Julia A. Santos2   Mark J. Alkema3   Eli Shlizerman1,2
1Electrical & Computer Engineering,     2Applied Mathematics,    University of Washington
3Neurobiology, University of Massachusetts Medical School

Whole Integration Blog: additional scenarios and code (coming out soon!) will be published in CelegansWholeIntegration Github repository and blog. Check it out! Through the blog we aim to create a detailed collection of computationally generated scenarios with #celegans experimental and computational community.

Forward


Experimental (Youtube, credit: MIT)

Wave Force

Feedback - Wave Force Initiation

Feedback - Neural Initiation


Backward


Experimental (Youtube, credit: MIT)

Wave Force

Feedback - Wave Force Initiation

Feedback - Neural Initiation


Motor Neurons Ablations


DD Ablation (Experiment: Donnelly et al, 2013)

DD Ablation

VD Ablation (Experiment: Donnelly et al, 2013)

VD Ablation

GABA Reversed (VD/DD) (Prediction)




Avoidance (ALM+AVM induced)

Turn (RIV induced)

Avoidance

Wild

SMDV Ablated


Asymmetric Stimulation (AWC+AIY)


Healthy

AIZ Ablation

AVER Ablation

RIM Ablation | AIZ Ablated