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MIQIN ZHANG

Kyocera Professor

Ph.D. UC Berkeley (1999)

Telephone: (206) 616-9356 

Fax: (206) 543-3100 

Email: mzhang@u.washington.edu 

Office: 302L Roberts Hall


RESEARCH INTERESTS: Protein, cell, and biomaterial interactions; biocompatibility assessment; protein and cell micropatterning for biosensing and BioMEMS applications; biomaterials for tissue engineering and regenerative medicine; controlled drug delivery; nanotechnology for cancer diagnosis and therapy.

Research Labs (- see details)

Selected Publications

    Z. R. Stephen, F. M. Kievit, O. Veiseh, P. A Chiarelli, C. Fang, S. Hatzinger, K. Wang, R. G. Ellenbogen, J. R. Silber, and M. Zhang “Redox-Responsive Magnetic Nanoparticle for Targeted Convection-Enhanced Delivery of O6-Benzylguanine to Brain Tumors", ACS Nano, 8 (10), 10383-10395 (2014).

    F. M. Kievit, S. J. Florczyk, M. C. Leung, K. Wang, J. D. Wu, J. R. Silber, R. G. Ellenbogen, J. S. H. Lee, and M. Zhang “Proliferation and enrichment of CD133+ glioblastoma cancer stem cells on 3D chitosan-alginate scaffolds", Biomaterials, 35 (33), 9137-9143 (2014).

    S. Jana, M. Leung, J. Chang, and M. Zhang “Biomimicking the Micro/nano-environment for Skeletal Muscle Tissue Engineering", Biofabrication, 6 (3), 035012 (2014).

    J. G. Sham, F. M. Kievit, J. R. Grierson, R. S. Miyaoka, M. M. Yeh, M. Zhang, R. S. Yeung, S. Minoshima, J. O. Park “Anti-Glypican-3 F(ab’)2 Fragments for 89Zr-PET in Hepatocellular Carcinoma", The Journal of Nuclear Medicine, 55 (12), 2032-2037 (2014).

    C. T. Tsao, A. Ravanpay, F. Kievit, M. Jensen, R. Ellenbogen, and M. Zhang “Thermo-reversible PEG-g-chitosan hydrogel as a therapeutic T lymphocyte depot for local glioblastoma immunotherapy", Biomacromolecules, 15 (7), 2656-2662 (2014).

    C. T. Tsao, M. Leung, J. Y. F. Chang, and M. Zhang “A simple material model to generate epidermal and dermal layers in vitro for skin regeneration", Journal of Materials Chemistry B, 2 (32), 5256-5264 (2014).

    C. T. Tsao, F. M. Kievit, K. Wang, R. Ellenbogen, and M. Zhang “Chitosan-Based Thermoreversible Hydrogel as an in vitro tumor microenvironment for testing breast cancer therapies", Molecular Pharmaceutics, 11 (7), 2134-2142 (2014).

    S. L. Levengood, and M. Zhang “Chitosan-based scaffolds for bone tissue engineering", Journal of Materials Chemistry B, 2 (21), 3161-3184 (2014).

    G.M. Lanza, C. Moonen, J. Baker, Jr, E. Chang, Z. Cheng, P. Grodzinski, K. Ferrara, K. Hynynen, G. Kelloff, Y. Lee, A. Patri, D. Sept, J.E. Schnitzer, B. J. Wood, M. Zhang, G. Zhang, K. Farahani “Assessing the barriers to image-guided drug delivery", Wires Nanomed Nanobiotechnology, 6 (1), 1-14 (2014).

    V. P. Lai, F. M. Kievit, S. J. Florczyk, K. Wang, M. L. Disis, and M. Zhang “CCL21 and IFNγ recruit and activate tumor specific T cells in 3D scaffold model of breast cancer", Anti-cancer Agents in Medicinal Chemistry, 14 (2), 204-210 (2014).

    T. Low, M. Leung, X. Wang, J. J. F. Chang, C. T. Tsao, J. Sham, D. Edmondson, and M. Zhang “Bi-layer scaffold of chitosan/PCL-nanofibrous mat and PLLA-microporous disc for skin tissue engineering", Journal of Biomedical Nanotechnology, 10 (6), 1105-1113 (2014).

    J. G. Sham, F. M. Kievit, J.R. Grierson, R. S. Miyaoka, M. M. Yeh, M. Zhang, R.S. Yeung, S. Minoshima, J. O. Park “Glypican-3 Targeted Zirconium-PET Imaging of Hepatocellular Carcinoma", The Journal of Nuclear Medicine, 55 (5), 799-804 (2014).

    F. M. Kievit, A. Cooper, S. Jana, M. C. Leung, K. Wang, D. Edmondson, D. Wood, J. S. H. Lee, R. G. Ellenbogen, and M. Zhang “Aligned chitosan-polycaprolactone polyblend nanofibers promote the migration of glioblastoma cells", Advanced Healthcare Materials, 2 (12), 1651-1659 (2013).

    M. Leung, A. Cooper, S. Jana, C. T. Tsao, T. Petrie, and M. Zhang “Nanofiber-based in vitro system for high myogenic differentiation of human embryonic stem cells", Biomacromolecules, 14 (12), 4207-4216 (2013).

    M. Leung, S. Jana, C. T. Tsao, and M. Zhang “Tenogenic differentiation of human bone marrow stem cells via combinatory effect of aligned chitosan-poly-caprolactone nanofibers and TGF-β3", Journal of Materials Chemistry B, 1 (47), 6516-6524 (2013).

    O. Veiseh, F, M. Kievit, V. Liu, C. Fang, Z. Stephen, R.G. Ellenbogen, and M. Zhang “In vivo safety evaluation of polyarginine coated magnetic nanovectors: safety and clearance", Molecular Pharmaceutics, 10 (11), 4099-4106 (2013).

    D. Edmondson, S. Jana, D. Wood, C. Fang, and M. Zhang “Uniaxially-aligned nanofibers as sensor and transmitter for biotelemetry", Analyst, 138 (23), 7135-7139 (2013).

    S. J. Florczyk, K. Wang, S. Jana, D. L. Wood, S. k. Sytsma, J. Sham, F. M. Kievit, and M. Zhang “Porous chitosan-hyaluronic acid scaffolds as a mimic of glioblastoma microenvironment ECM", Biomaterials, 34 (38), 10143-10150 (2013).

    S. Florczyk, M. Leung, Z. Li, J. Huang, R. Hopper, and M. Zhang “Evaluation of 3D porous chitosan-alginate scaffolds in rat calvarial defects for bone regeneration applications", Journal of Biomedical Materials Research A, 101 (10), 2974-2983 (2013).

    T. Wang, F. M. Kievit, O. Veiseh, H. Arami, Z. R. Stephen, C. Fang, Y. Liu, R. G. Ellenbogen, and M. Zhang “Targeted cell uptake of a non-internalizing antibody through conjugation to iron oxide nanoparticles in primary central nervous system lymphoma", World Neurosurgery, 80 (1), 134-141 (2013)

    Vy Pan-Lai , S. J. Florczyc , F. M. Kievit , K. Wang , E. Gad , M. L. Disis, and M. Zhang “Three-Dimensional Scaffolds to Evaluate Tumor Associated Fibroblast-Mediated Suppression of Breast Tumor Specific T Cells", Biomacromolecules, 14 (5), 1330-1337 (2013).

    A. Galperin, R. A. Oldinski, S. J. Florczyk, J.D. Bryers, M. Zhang, B.D. Ratner “Integrated bi-layered scaffold for osteochondral tissue engineering", Advanced Healthcare Materials, 2 (6), 872-883 (2013).

    S. Jana, A. Cooper, and M. Zhang “Chitosan scaffolds with unidirectional microtubular pores for large skeletal myotube generation", Advanced Healthcare Materials, 2 (4), 557-561 (2013).

    S. Jana, and M. Zhang “Fabrication of 3D Aligned Nanofibrous Tubes by Direct Electrospinning", Journal of Materials Chemistry B, 1 (20), 2575-2581 (2013).

    K. Wang, J. Park, and M. Zhang “Treatment of glioblastoma multiforme using combination of siRNA targeting EGFR and ß-catenin", The journal of Gene Medicine, 15 (1), 42-50 (2013).

    H. Mok, and M. Zhang “Superparamagnetic Iron Oxide Nanoparticle-Based Delivery Systems for Biotherapeutics", Expert Opinion on Drug Delivery, 10 (1), 73-87 (2013).

    A. Cooper, R. Oldinski, H. Ma, J. D. Bryers, and M. Zhang “Chitosan-based nanofibrous membranes for antibacterial filter", Carbohydrate Polymers, 92 (1), 254-259 (2013).

    C. Fang, F. Kievit, Y. Cho, H. Mok, O. Press, and M. Zhang “Effect of cationic side-chains on intracellular delivery and cytotoxicity of pH sensitive polymer-doxorubicin nanocarriers", Nanoscale, 4 (22), 4012-4020 (2012).

    S. Jana, A Cooper, F Ohuchi, and M. Zhang “Uniaxially aligned nanofibrous cylinders by electrospinning", ACS Applied Materials & Interfaces, 4 (9), 4817-4824 (2012).

    S. J. Florczyk, M. Leung, S. Jana, Z. Li, N. Bhattarai, J. I. Huang, R. A. Hopper, and M. Zhang “Enhanced bone tissue formation by alginate gel-assisted cell seeding in porous ceramic scaffolds and sustained release of growth factor", Journal of Biomedical Materials Research A, 100A (12), 3408-3415 (2012)

    D. Edmondson, A. Cooper, S. Jana, D. Wood, and M. Zhang “Centrifugal Electrospinning of Highly-Aligned Polymer Nanofibers over Large Area", Journal of Materials Chemistry, 22 (35), 18646-18652 (2012)

    C. Fang, F. M. Kievit, O. Veiseh, Z. R. Stephen, T. Wang, D. Lee, R. G. Ellenbogen, and M. Zhang “Fabrication of Magnetic Nanoparticles with Controllable Drug Loading and Release through a Simple Assembly Approach", Journal of Controlled Release, 162 (1), 233-241 (2012).

    S. J. Florczyk, G. Liu, F. M. Kievit, A. M. Lewis, J. D. Wu, and M. Zhang “3D Porous Chitosan-Alginate Scaffolds: New Matrix for Studying Prostate Cancer Cell-Lymphocyte Interactions In Vitro", Advanced Healthcare Materials, 1 (5), 590-599 (2012).

    A. Cooper, M. Leung, and M. Zhang “Polymeric Fibrous Matrices for Substrate-Mediated Human Embryonic Stem Cell Lineage Differentiation", Macromolecular Bioscience, 12 (7), 882-892 (2012).

    F. Asphahani, M. Thein, K. Wang, D. Wood, S. Wong, J. Xu, and M. Zhang “Real-time characterization of cytotoxicity using single-cell impedance monitoring", Analyst, 137 (13), 3011-3019 (2012).

    F. M. Kievit, Z. R. Stephen, O. Veiseh, H. Arami, T. Wang, Vy P. Lai, J. O. Park, R. G. Ellenbogen, M. L. Disis, and M. Zhang “Targeting of Primary Breast Cancers and Metastases in a Transgenic Mouse Model Using Rationally Designed Multifunctional SPIONs", ACS Nano, 6 (3), 2591-1601 (2012).

    S. Jana, S. J. Florczyk, M. Leung, and M. Zhang “High-Strength Pristine Porous Chitosan Scaffolds for Tissue Engineering", Journal of Materials Chemistry, 22 (13), 6291-6299 (2012).

    A. Cooper, C. Zhong, Y. Kinoshita, R. S. Morrison, M. Rolandi, and M. Zhang “Self-assembled chitin nanofiber templates for artificial neural networks", Journal of Materials Chemistry, 22 (7), 3105-3109 (2012).

    F. M. Kievit, and M. Zhang “Cancer Nanotheranostics: Improving Imaging and Therapy by Targeted Delivery across Biological Barriers", Advanced Materials, 23 (36), H217-H247 (2011).

    F. M. Kievit, and M. Zhang “Surface engineering of iron oxide nanoparticles for targeted cancer therapy", Accounts of Chemical Research, 44 (10), 853-862 (2011).

    S. J. Florczyk, D. Kim, D. Wood, and M. Zhang “Influence of processing parameters on pore structure of 3D porous chitosan-alginate polyelectrolyte complex scaffolds", Journal of Biomedical Materials Research, 98A (4), 614-620 (2011).

    H. Arami, Z. Stephen, O. Veiseh, and M. Zhang “Chitosan Coated Iron Oxide Nanoparticles for Molecular Imaging and Drug Delivery", Advances in Polymer Science, 243, 169-184 (2011).

    Z. R. Stephen, F. M. Kievit, and M. Zhang “Magnetite nanoparticles for medical MR imaging", Materials Today, 14 (7-8), 330-338 (2011).

    O. Veiseh, F. Kievit, R. G. Ellenbogen, and M. Zhang “Cancer Cell Invasion: Treatment and Monitoring Opportunities in Nanomedicine", Advanced Drug Delivery Reviews, 8 (18), 582-596 (2011).

    O. Veiseh, F. M. Kievit, H. Mok, J. Ayesh, C. Clark, C. Fang, M. Leung, H. Arami, J. O. Park, and M. Zhang “Cell transcytosing poly-arginine coated magnetic nanovector for safe and effective siRNA delivery", Biomaterials, 32 (24), 5717-5725 (2011).

    A. Cooper, N. Bhattarai, F. M. Kievit, M. Rossol, and M. Zhang “Electrospinning of chitosan derivative nanofibers with structural stability in an aqueous environment", Physical Chemistry Chemical Physics, 13 (21), 9969-9972 (2011).

    F. M. Kievit, F. Y. Wang, C. Fang, H. Mok, K. Wang, J. R. Silber, R. G. Ellenbogen, and M. Zhang “Doxorubicin loaded iron oxide nanoparticles overcome multidrug resistance in cancer in vitro", Journal of Controlled Release, 152 (1), 76-83 (2011).

    F. Asphahani, X. Zheng, O. Veiseh, M. Thein, J. Xu, F. Ohuchi, and M. Zhang “Effects of electrode surface modification with chlorotoxin on patterning single glioma cells", Physical Chemistry Chemical Physics, 13 (19), 8953-8960 (2011).

    A. Cooper, N. Bhattarai, and M. Zhang “Fabrication and cellular compatibility of aligned chitosan-PCL fibers for nerve tissue regeneration", Carbohydrate Polymers, 85 (1), 149-156 (2011).

    J. Gunn, S. I. Park, O. Veiseh, O. W. Press, and M. Zhang “A pretargeted nanoparticle system for tumor cell labeling", Molecular Biosystems, 7 (3), 743-748 (2011).

    F. Asphahani, K. Wang, M. Thein, O. Veiseh, S. Yung, J. Xu, and M. Zhang “Single-cell bioelectrical impedance platform for monitoring cellular response to drug treatment", Physical Biology, 8 (1), 015006 (2011).

    J. Park, Z. Stephen, C. Sun, O. Veiseh, F. Kievit, C. Fang, M. Leung, H. Mok, and M. Zhang “Glypican-3 Targeting of Liver Cancer Cells Using Multifunctional Nanoparticles", Molecular Imaging, 10 (1), 69-77 (2011).

    A. Rojas, G. Liu, I. Coleman, P.S. Nelson, M. Zhang, R. Dash, P.B. Fisher, S. R. Plymate, J. Wu “IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR", Oncogene, 30 (20), 2345-2355 (2011).

    V. Phan, D. Cecil, G. Holt, D. Herendeen, F. Kievit, M. Zhang, and M. L. Disis, Chapter 10, "Epitope-based vaccines for cancer", in Cancer vaccines: From Research to Clinical Practice, CRC Press, (2011).

    Khanna, C. Zhang, E. Park, D. Ahmed, C. J. Goodrich, N. B. Smith , C. Dong, F. Asphahani, X. Jiang, M. Zhang, and J. Xu “Site–specific sonoporation of human melanoma cells at the cellular level using high lateral–resolution ultrasonic micro–transducer arrays", Biosensors & Bioelectronics, 27 (1), 25-33 (2011).

    H. Mok, O. Veiseh, C. Fang, F. M. Kievit, F. Y. Wang, J. O. Park, and M. Zhang “pH-sensitive siRNA Nanovector for Targeted Gene Silencing and Cytotoxic Effect in Cancer Cells", Molecular Pharmaceutics, 7 (6), 1930-1939 (2010).

    C. Fang, O. Veiseh, F. Kievit, N. Bhattarai, F. Wang, Z. Stephen, C. Li, D. Lee, R. G. Ellenbogen, and M. Zhang “Functionalization of iron oxide magnetic nanoparticles with targeting ligands: their physicochemical properties and in vivo behavior", Nanomedicine, 5 (9), 1357-1369 (2010).

    O. Veiseh, F. M. Kievit, C. Fang, N. Mu, S. Jana, M. Leung, H. Mok, R. G. Ellenbogen, J. O. Park, and M. Zhang “Chlorotoxin bound magnetic nanovector tailored for cancer cell targeting, imaging, and siRNA delivery", Biomaterials, 31 (31), 8032-8042 (2010).

    A. Cooper, S. Jana, N. Bhattarai, and M. Zhang “Aligned chitosan-based nanofibers for enhanced myogenesis", Journal of Materials Chemistry, 20 (40), 8904-8911 (2010).

    F. M. Kievit, O. Veiseh, C. Fang, N. Bhattarai, D. Lee, R. G. Ellenbogen, and M. Zhang “Chlorotoxin labeled magnetic nanovectors for targeted gene delivery to glioma", ACS Nano, 4 (8), 4587-4594 (2010).

    M. Leung, F. M. Kievit, S. J. Florczyk, O. Veiseh, J. Wu, J. O. Park, and M. Zhang “Chitosan-alginate scaffold culture system for hepatocellular carcinoma increases malignancy and drug resistance", Pharmaceutical Research, 27 (9), 1939-1948 (2010).

    C. Fang, and M. Zhang “Nanoparticle-based theragnostics: integrating diagnostic and therapeutic potentials in nanomedicine", Journal of Controlled Release, 146 (1), 2-5 (2010).

    F. M. Kievit, S. J. Florczyk, M. Leung, O. Veiseh, J. O. Park, M. L. Disis, and M. Zhang “Chitosan-alginate 3D scaffolds as a mimic of the glioma tumor microenvironment", Biomaterials, 31 (22), 5903-5910 (2010).

    C. Sun, K. Du, C. Fang, N. Bhattarai, O. Veiseh, F. Kievit, Z. Stephen, D. Lee, R. G. Ellenbogen, B. Ratner, and M. Zhang “PEG-mediated synthesis of highly dispersive multifunctional superparamagnetic nanoparticles: their physicochemical properties and function in vivo", ACS Nano, 4 (4), 2402-2410 (2010).

    J. Gunn, and M. Zhang “Poly-blend nanofibers for biomedical applications: perspectives and challenges", Trends in Biotechnology, 28 (4), 189-197 (2010).

    M. Thein, F. Asphahani, A. Cheng, R. Buckmaster, M. Zhang, and J. Xu “Response characteristics of single-cell impedance sensors employed with surface-modified microelectrodes", Biosensors & Bioelectronics, 25 (8), 1963-1969 (2010).

    N. Bhattarai, J. Gunn, and M. Zhang “Chitosan-based hydrogels for controlled, localized drug delivery", Advanced Drug Delivery Reviews, 62 (1), 83-99 (2010).

    O. Veiseh, J. Gunn, and M. Zhang “Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging", Advanced Drug Delivery Reviews, 62 (3), 284-304 (2010).

    Z. Li, M. Leung, R. Hopper, R. Ellenbogen, and M. Zhang “Feeder-free self-renewal of human embryonic stem cells in 3D porous natural polymer scaffolds", Biomaterials 31 (3), 404-412 (2010).

    M. Lee, O. Veiseh, N. Bhattarai, C. Sun, S. Hansen, S. Ditzler, S. Knoblaugh, D. Lee, R. Ellenbogen, M. Zhang, and M. Olson “Rapid pharmacokinetic and biodistribution studies using cholorotoxin-conjugated iron oxide nanoparticles: a novel non-radioactive method", PLOS One 5 (3), e9538 (2010).

    C. Zhong, A. Cooper, A. Kapetanovic, Z. Fang, M. Zhang, and M. Rolandi “A facile bottom-up route to self-assembled biogenic chitin nanofibers", Soft Matter 6 (21), 5298-5301 (2010).

    J. Gunn, R. K. Paranji, and M. Zhang “A simple and highly sensitive method for magnetic nanoparticle quantitation using 1H-NMR spectroscopy", Biophysical Journal 97 (9), 2640-2647 (2009).

    C. Fang, and M. Zhang “Multifunctional magnetic nanoparticles for medical imaging applications", Journal of Materials Chemistry 19 (35), 6258-6266 (2009).

    O. Veiseh, C. Sun, C. Fang, N. Bhattarai, J. Gunn, F. Kievit, K. Du, B. Pullar, D. Lee, R. Ellenbogen, J. Olson, and M. Zhang “Specific targeting of brain tumors with an optical/magnetic resonance imaging nanoprobe across the blood-brain barrier", Cancer Research 69 (15), 6200-6207 (2009).

    F. Kievit, O. Veiseh, N. Bhattarai, C. Fang, J. W. Gunn, D. Lee, R. G. Ellenbogen, J. Olson, and M. Zhang “PEI-PEG-chitosan copolymer coated iron oxide nanoparticles for safe gene delivery: synthesis, complexation, and transfection", Advanced Functional Materials 19 (14), 2244-2251 (2009).

    C. Fang, N. Bhattarai, C. Sun, and M. Zhang “Functionalized nanoparticles with long-term stability in biological media", Small 5 (14), 1637-1641 (2009).

    N. Bhattarai, Z. Li, J. Gunn, M. Leung, A. Cooper, D. Edmondson, O. Veiseh, M. Chen, Y. Zhang, R. Ellenbogen, and M. Zhang “Natural-synthetic polyblend nanofibers for biomedical applications", Advanced Materials 21 (27), 2792-2797 (2009).

    W. Lin, T. Hyeon, G. M. Lanza, M. Zhang, and T. J. Meade “Magnetic nanoparticles for early detection of cancer by magnetic resonance imaging", MRS Bulletin 34 (6), 441-448 (2009).

    R. Buckmaster, F. Asphahani, M. Thein, J. Xu, and M. Zhang “Detection of drug-induced cellular changes using confocal raman spectroscopy on patterned single-cell biosensors", The Analyst 134 (7), 1440-1446 (2009).

    D. Edmondson, N. Bhattarai, S. Jana, A. Kim, and M. Zhang “Design and evaluation of a nano-scale differential tensile test device for nanofibers", Applied Physics Letters 94 (10), 103101 (2009).

    O. Veiseh, J. W. Gunn, F. Kievit, C. Sun, C. Fang, J. S. H. Lee, and M. Zhang “Inhibition of tumor cell invasion with chlorotoxin-bound superparamagnetic nanoparticles", Small 5 (2), 256-264 (2009).

    O. Veiseh, F. Kievit, J. Gunn, B. Ratner, and M. Zhang “A ligand-mediated nanovector for targeted gene delivery and transfection in cancer cells", Biomaterials 30 (4), 649-657 (2009).

    C. Sun, J. S. H. Lee, and M. Zhang "Magnetic nanoparticles in MR imaging and drug delivery", Advanced Drug Delivery Reviews 60 (11), 1252-65 (2008).

    J. Gunn, H. Wallen, O. Veiseh, C. Sun, C. Fang, J. Cao, C, Yee, and M. Zhang “A multimodal targeting nanoparticle for selectively labeling T cells”, Small 4 (6), 712-15 (2008).

    Z. Li, J. Gunn, M. H. Chen, A. Cooper and M. Zhang “On-site alginate gelation for enhanced cell proliferation and uniform distribution in porous scaffolds”, Journal of Biomedical Materials Research 86A (2), 552-59 (2008).

    F. Asphahani, M. Thein, O. Veiseh, D. Edmondson, R. Kosai, M. Veiseh, J. Xu, and M. Zhang “Influence of cell patterning and spreading on impedance characteristics in cell-based sensors”, Biosensors & Bioelectronics 23 (8), 1307-13 (2008).

    J. Yang, J. Gunn, S. Dave, M. Zhang, A. Wang and X. Gao “Ultrasensitive Detection and Molecular Imaging with magnetic nanoparticles”, The Analyst 133 (2), 154-60 (2008).

    C. Sun, O. Veiseh, D. Lee, N. Bhattarai, J. Gunn, C. Fang, R. Ellenbogen, J. Olson and M. Zhang “In vivo MRI detection of gliomas by chlorotoxin-conjugated superparamagnetic nanoprobes”, Small 4 (3), 372-79 (2008).

    C. Sun, C. Fang, Z. Stephen, O. Veiseh, S. Hansen, D. Lee, R. Ellenbogen, J. Olson, and M. Zhang “Tumor-targeted drug delivery and MRI contrast enhancement by chlorotoxin-conjugated iron oxide nanoparticles”, Nanomedicine 3 (4), 495-505 (2008).

    J. Gunn and M. Zhang “Superparamagnetic Iron Oxide Nanoparticles: Next generation MR contrast agents and intracranial imaging enhancers”, in Nanotechnology in Cancer, Chapter 4, American Scientific Publishers, 2007.

    N. Bhattarai and M Zhang “Controlled synthesis and structural stability of alginate based nanofibers”, Nanotechnology 18 (45) 455601 (2007).

    F. Asphahani and M. Zhang “Cellular impedance biosensors for drug screening and toxin detection”, The Analyst 132 (10), 835-41 (2007).

    M. Veiseh, P. Gabikian, B. Bahrami, O. Veiseh, M. Zhang, R. C. Hackman, W. J. Levin, S. J. Hansen, D. Kwok, N. M. Munoz, R. W. Sze, P. S. Nelson, W. M. Grady, N. M. Greenberg, R. G. Ellenbogen, J. M. Olson “Tumor Paint: a chlorotoxin: Cy5.5 bioconjugate for intra-operative visualization of cancer foci”, Cancer research 67 (14), 6882-88 (2007).

    M. Veiseh, O Veiseh, M. C. Martin, C. Bertozzi and M. Zhang “Single cell based sensors and synchrotron FTIR spectroscopy: a hybrid system towards bacterial detection”, Biosensors and Bioelectronics 2 (6), 785-792 (2007).

    M. Veiseh, O. Veiseh, M. Martin, F. Asphahani and M. Zhang “Short peptides enhance single cell adhesion and viability on microarrays”, Langmuir 23 (8), 4472-79 (2007).

    L. L. Muldoon, P. Tratnyek, P. M. Jacobs, N. D. Doolittle, G. A. Christoforidis, J. Frank, M. Lindau, P. R. Lockman, S. Manninger, Y. Qiang, A. M. Spence, S. I. Stupp, M. Zhang, E. A. Neuwelt “Imaging and nanomedicine for diagnosis and therapy in the central nervous system”, American Journal of Neuroradiology 27 (3), 715-21 (2006).

    C. Allan, J. M. Clark, R. J. Fernandes, P. Fleckman, B. Hager, J. James, A. Norman, A. Pirrone, H. R. Ramay, B. P. Rubin, F. K. Satterstrom, Z. Wisecarver and M. Zhang “Human fetal digit tip regeneration in vitro”, Wound Repair and Regeneration 14, 398-404 (2006).

    Y. Nie, Y. Zhang, J. Zhang and M. Zhang ""Immobilization of polydiacetylene onto silica microbeads for colorimetric detection", Journal of Materials Chemistry 16 (6), 546-549 (2006).

    N. Kohler, C. Sun, A. Fichtenholtz, J. Gunn, C. Fang, and M. Zhang "Methotrexate Immobilized Poly(ethylene glycol) Magnetic Nanoparticles for MR Imaging and Drug Delivery", Small 2 (6), 785-792 (2006).

    C. Sun, R. Sze, and M. Zhang "Folate acid-PEG conjugated superparamagnetic nanoparticles for targeted cellular uptake and detection by MRI", Journal of Biomedical Materials Research, 78A (3), 550-7 (2006).

    N. Bhattarai, Z. Li, D. Edmondson, and M. Zhang "Alginate-Based Nanofibrous Scaffolds: Structural, Mechanical and Biological Properties", Advanced Materials 18 (11), 1463-1467 (2006).

    M. Veiseh, and M. Zhang "Effect of silicon oxidation on long-term cell selectivity of cell-patterned Au/SiO2 platforms", Journal of the American Chemical Society 128 (4), 1197-1203 (2006).

    N. Bhattara, H. R. Ramay, S. H. Chou, and M. Zhang "Chitosan and lactic acid grafted chitosan nanoparticles as carriers for prolonged drug delivery", International Journal of Nanomedicine 1 (2), 181-187 (2006).

    N. Kohler, C. Sun, J. Wang, and M. Zhang "Methotrexate-modified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells”, Langmuir 21 (19), 8858-8864 (2005).

    N. Bhattarai, D. Edmondson, O. Veiseh, F. A. Matsen, and M. Zhang "Electrospun chitosan-based nanofibers and their cellular compatibility”, Biomaterials 26 (31), 6176-6184 (2005).

    Z. Li, and M. Zhang “Chitosan-alginate as scaffolding material for cartilage tissue engineering”, Journal of Biomedical Materials Research 75A (2), 485-493 (2005).

    O. Veiseh, C. Sun, J. Gunn, N. Kohler, P. Gabikian, D.Lee, N. Bhattarai, R.Ellenbogen, R. Sze, A. Hallahan, J. Olson, and M. Zhang "An optical and MRI multifunctional nanoprobe for targeting gliomas”, Nano Letters 5 (6), 1003-1008 (2005).

    H. R. Ramay, Z. Li, E. Shum, and M. Zhang “Chitosan-alginate porous scaffolds reinforced by hydroxyapatite nano- and micro-particles—structural, mechanical, and biological properties”, Journal of Biomedical Nanotechnology 1 (2), 151-160 (2005).

    N. Bhattarai, H. R. Ramay, J. Gunn, F. A. Matsen, and M. Zhang “PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release”, Journal of Controlled Release 103, 609-624 (2005).

    N. Bhattarai, F. A. Matsen, and M. Zhang “PEG-grafted chitosan as an injectable thermoreversible hydrogel”, Macromolecular Bioscience 5, 107-111 (2005).

    Z. Li, H. Ramay, K. Hauch, D. Xiao, and M. Zhang “Chitosan-alginate hybrid scaffolds for bone tissue engineering”, Biomaterials 26 (18), 3919-3928 (2005).

    S. Lan, M. Veiseh, and M. Zhang "Surface modification of silicon and gold-patterned silicon surfaces for improved biocompatibility and cell patterning selectivity", Biosensors & Bioelectronics 20 (9), 1697-1708 (2005).

    N. Kohler, G. E. Fryxell, and M. Zhang "A bifunctional poly(ethylene glycol) silane immobilized on metallic oxide based nanoparticles for conjugating with cell targeting agents", Journal of the American Chemical Society 126 (23), 7206-7211 (2004).

    M. Veiseh, B. T. Wickes, D. G. Castner, and M. Zhang "Guided cell patterning on gold-silicon dioxide substrates by surface molecular engineering", Biomaterials 25 (16), 3315-3324 (2004).

    H. Ramay and M. Zhang "Biphasic calcium phosphate nanocomposite porous scaffolds for load-bearing bone tissue engineering", Biomaterials 25 (21), 5171-5180 (2004).

    M. Zhang, Chapter 2, "Biocompatibility of Materials", in Biomaterials and Tissue Engineering, D. Shi(ed), pp 83-143, Springer-Verlag, New York, (2004).

    Y. Zhang and M. Zhang "Cell growth and function on calcium phosphate reinforced chitosan scaffolds", Journal of Materials Science, Materials in Medicine 15 (3), 255-260 (2004).

    Y. Zhang, C. Sun, N. Kohler, and M. Zhang "Self-assembled coatings on individual monodisperse magnetite nanoparticles for efficient intracellular uptake", Biomedical Microdevices 6 (1), 33-40 (2004).

    H. Ramay and M. Zhang "Preparation of Porous Hydroxyapatite Scaffolds by Combination of the Gel-casting and Polymer Sponge Methods", Biomaterials 24 (19), 3293-3302 (2003).

    Y. Zhang, M. Ni, M. Zhang and B. Ratner, "Calcium Phosphate/Chitosan Composite Scaffolds for Bone Tissue Engineering", Tissue Engineering 9 (2), 337-345 (2003).

    M. Veiseh, M. Zareie and M. Zhang, "Highly Selective Protein Patterning on Gold-Silicon Substrates for Biosensor Applications", Langmuir 18 (17), 6671-6678 (2002).

    Y. Zhang and M. Zhang, "Three-Dimentional Macroporous Calcium Phosphate Bioceramics with Nested Chitosan Sponges for Load-Bearing Bone Implants", Journal of Biomedical Materials Research 61 (1), 1-8 (2002).

    Y. Zhang, N. Kohler and M. Zhang, "Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake", Biomaterials 23 (7), 1553-1561 (2002).

    Y. Zhang and M. Zhang, "Calcium phosphate/chitosan composite scaffolds for controlled in vitro antibiotic drug release", Journal of Biomedical Materials Research 62 (3), 378-386 (2002).

    Y. Zhang and M. Zhang, "Synthesis and characterization of Macroporous Chitosan/Calcium Phosphate Composite Scaffolds for Tissue Engineering", Journal of Biomedical Materials Research 55, 304-312 (2001).

    M. Veiseh, Y. Zhang, K. Hinkley and M. Zhang, "Two-dimensional Protein Micropatterning for Sensor Applications through Chemical Selectivity Technique", Biomedical Microdevices 3, 45-51 (2001).

    Y. Zhang and M. Zhang, "Microstructural and Mechanical Characterization of Chitosan Scaffolds Reinforced by Calcium Phosphates", Journal of Non-Crystalline Solids 282 (2), 159-64 (2001).

    S. Lee, J. Baker, and M. Zhang, "Interfaces", Biomedical Microdevices 3 (1), 5-6 (2001).

    T. Desai, D. Hansford, L. Kulinsky, A. H. Nashat, G. Rasi, J. Tu, Y. Wang, M. Zhang and M. Ferrari, "Nanopore Technology for Biomedical Applications", Biomedical Microdevices 2 (1), 11-40 (1999).

    M. Zhang, T. Desai and M. Ferrari, "Proteins and Cells on PEG Immobilized Silicon", Biomaterials 19 (10), 953-960 (1998).

    M. Zhang and M. Ferrari, "Hemocompatible Polyethylene Glycol Films on Silicon", Biomedical Microdevices 1 (1), 81-90 (1998).

    M. Zhang and M. Ferrari, "Reduction of Albumin Adsorption onto Silicon Surfaces by Tween 20", Biotech. & Bioeng. 56 (6), 618 - 625 (1997).

    M. Zhang and M. Ferrari, Chapter 6, "Free Boundary Reflection of P- and S- Waves in Granular Media", in Advances in Doublet Mechanics, Ferrari, et al. (eds), pp 103-121, Springer-Verlag, Berlin, Heidelberg (1997).


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