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MIQIN ZHANG Professor Ph.D. UC Berkeley Telephone: (206) 616-9356  Fax: (206) 543-3100  Email: mzhang@u.washington.edu  Office: 302L Roberts Hall

Research Group Research Interests

RESEARCH INTERESTS: Protein, cell, and biomaterial interactions; biocompatibility assessment; protein and cell micropatterning for biosensing and BioMEMS applications; biomaterials for tissue engineering and regenerative medicine; controlled drug delivery; nanotechnology for cancer diagnosis and therapy. -more

Professional Experience

• 2008 - Professor, Dept of Materials Science and Engineering, University of Washington, Seattle, WA
  • Adjunct Professor, Dept of Orthopaedics and Sports Medicine, UW School of Medicine
  • Adjunct Professor, Dept of Radiology, UW School of Medicine
  • Adjunct Professor, Dept of Neurological Surgery, UW School of Medicine
• 2005 - 2008, Associate Professor, Dept of Materials Science and Engineering, University of Washington, Seattle, WA
• 1999 - 2005, Assistant Professor, Dept of Materials Science and Engineering, University of Washington, Seattle, WA
• 1994 - 1999, Graduate Student Researcher, Dept of Mat. Sci. & Eng., University of California at Berkeley, Berkeley, CA
• 1991 - 1993, Graduate Student Researcher, Dept of Mech. Eng., University of Victoria, Victoria, B.C.

Professional Activities and Responsibilities

• Editorial Board for Biomedical Microdevices (1999-)
• Editorial Board for Journal of Biomedical Nanotechnology (2004-)
• Editorial Board for Clinical Medicine: Pediatrics (2007-)
• Editorial Board for International Journal of Clinical and Experimental Medicine (2007-)

Research Labs (- see details)

Our research is geared toward developing materials and devices for biological and medical applications, and is conducted in three labs within the group:
• Nanoparticle Lab focuses its research on cancer diagnosis and treatment through imaging enhancement and targeted and controlled therapeutic payload delivery using nanoconjugates or multifunctional nanovectors.

• Tissue Engineering Lab concentrates on development of biocompatible porous and nanofibrous matrices serving as biodegradable scaffolds and/or drug delivery depots for tissue repair and regeneration.

• Biosensor Lab targets the detection and identification of chemical and biological agents and the development of drug screening techniques using protein and cell based sensors.

Selected Publications

O. Veiseh, J. Gunn, and M. Zhang “Design and fabrication of magnetic nanoparticles for targeted drug delivery and imaging", Advanced Drug Delivery Reviews, accepted.

Z. Li, M. Leung, R. Hopper, R. Ellenbogen, and M. Zhang “Feeder-free self-renewal of human embryonic stem cells in 3D porous natural polymer scaffolds", Biomaterials 31 (3), 404-412 (2010).

J. Gunn, R. K. Paranji, and M. Zhang “A simple and highly sensitive method for magnetic nanoparticle quantitation using ¹H-NMR spectroscopy", Biophysical Journal, accepted.

N. Bhattarai, J. Gunn, and M. Zhang “Chitosan-based hydrogels for controlled, localized drug delivery", Advanced Drug Delivery Reviews, accepted.

C. Fang, and M. Zhang “Multifunctional magnetic nanoparticles for medical imaging applications", Journal of Materials Chemistry 19 (35), 6258-6266 (2009).

O. Veiseh, C. Sun, C. Fang, N. Bhattarai, J. Gunn, F. Kievit, K. Du, B. Pullar, D. Lee, R. Ellenbogen, J. Olson, and M. Zhang “Specific targeting of brain tumors with an optical/magnetic resonance imaging nanoprobe across the blood-brain barrier", Cancer Research 69 (15), 6200-6207 (2009).

F. Kievit, O. Veiseh, N. Bhattarai, C. Fang, J. W. Gunn, D. Lee, R. G. Ellenbogen, J. Olson, and M. Zhang “PEI-PEG-chitosan copolymer coated iron oxide nanoparticles for safe gene delivery: synthesis, complexation, and transfection", Advanced Functional Materials 19 (14), 2244-2251 (2009).

C. Fang, N. Bhattarai, C. Sun, and M. Zhang “Functionalized nanoparticles with long-term stability in biological media", Small 5 (14), 1637-1641 (2009).

N. Bhattarai, Z. Li, J. Gunn, M. Leung, A. Cooper, D. Edmondson, O. Veiseh, M. Chen, Y. Zhang, R. Ellenbogen, and M. Zhang “Natural-synthetic polyblend nanofibers for biomedical applications", Advanced Materials 21 (27), 2792-2797 (2009).

W. Lin, T. Hyeon, G. M. Lanza, M. Zhang, and T. J. Meade “Magnetic nanoparticles for early detection of cancer by magnetic resonance imaging", MRS Bulletin 34 (6), 441-448 (2009).

R. Buckmaster, F. Asphahani, M. Thein, J. Xu, and M. Zhang “Detection of drug-induced cellular changes using confocal raman spectroscopy on patterned single-cell biosensors", The Analyst 134 (7), 1440-1446 (2009).

D. Edmondson, N. Bhattarai, S. Jana, A. Kim, and M. Zhang “Design and evaluation of a nano-scale differential tensile test device for nanofibers", Applied Physics Letters 94 (10), 103101 (2009).

O. Veiseh, J. W. Gunn, F. Kievit, C. Sun, C. Fang, J. S. H. Lee, and M. Zhang “Inhibition of tumor cell invasion with chlorotoxin-bound superparamagnetic nanoparticles", Small 5 (2), 256-264 (2009).

O. Veiseh, F. Kievit, J. Gunn, B. Ratner, and M. Zhang “A ligand-mediated nanovector for targeted gene delivery and transfection in cancer cells", Biomaterials 30 (4), 649-657 (2009).

C. Sun, J. S. H. Lee, and M. Zhang "Magnetic nanoparticles in MR imaging and drug delivery", Advanced Drug Delivery Reviews 60 (11), 1252-65 (2008).

J. Gunn, H. Wallen, O. Veiseh, C. Sun, C. Fang, J. Cao, C, Yee, and M. Zhang “A multimodal targeting nanoparticle for selectively labeling T cells”, Small 4 (6), 712-15 (2008).

Z. Li, J. Gunn, M. H. Chen, A. Cooper and M. Zhang “On-site alginate gelation for enhanced cell proliferation and uniform distribution in porous scaffolds”, Journal of Biomedical Materials Research 86A (2), 552-59 (2008).

F. Asphahani, M. Thein, O. Veiseh, D. Edmondson, R. Kosai, M. Veiseh, J. Xu, and M. Zhang “Influence of cell patterning and spreading on impedance characteristics in cell-based sensors”, Biosensors & Bioelectronics 23 (8), 1307-13 (2008).

J. Yang, J. Gunn, S. Dave, M. Zhang, A. Wang and X. Gao “Ultrasensitive Detection and Molecular Imaging with magnetic nanoparticles”, The Analyst 133 (2), 154-60 (2008).

C. Sun, O. Veiseh, D. Lee, N. Bhattarai, J. Gunn, C. Fang, R. Ellenbogen, J. Olson and M. Zhang “In vivo MRI detection of gliomas by chlorotoxin-conjugated superparamagnetic nanoprobes”, Small 4 (3), 372-79 (2008).

C. Sun, C. Fang, Z. Stephen, O. Veiseh, S. Hansen, D. Lee, R. Ellenbogen, J. Olson, and M. Zhang “Tumor-targeted drug delivery and MRI contrast enhancement by chlorotoxin-conjugated iron oxide nanoparticles”, Nanomedicine 3 (4), 495-505 (2008).

J. Gunn and M. Zhang “Superparamagnetic Iron Oxide Nanoparticles: Next generation MR contrast agents and intracranial imaging enhancers”, in Nanotechnology in Cancer, Chapter 4, American Scientific Publishers, 2007.

N. Bhattarai and M Zhang “Controlled synthesis and structural stability of alginate based nanofibers”, Nanotechnology 18 (45) 455601 (2007).

F. Asphahani and M. Zhang “Cellular impedance biosensors: the future lies with single-cell detection”, The Analyst 132 (10), 835-41 (2007).

M. Veiseh, P. Gabikian, B. Bahrami, O. Veiseh, M. Zhang, R. C. Hackman, W. J. Levin, S. J. Hansen, D. Kwok, N. M. Munoz, R. W. Sze, P. S. Nelson, W. M. Grady, N. M. Greenberg, R. G. Ellenbogen, J. M. Olson “Tumor Paint: a chlorotoxin: Cy5.5 bioconjugate for intra-operative visualization of cancer foci”, Cancer research 67 (14), 6882-88 (2007).

M. Veiseh, O Veiseh, M. C. Martin, C. Bertozzi and M. Zhang “Single cell based sensors and synchrotron FTIR spectroscopy: a hybrid system towards bacterial detection”, Biosensors and Bioelectronics 2 (6), 785-792 (2007).

M. Veiseh, O. Veiseh, M. Martin, F. Asphahani and M. Zhang “Short peptides enhance single cell adhesion and viability on microarrays”, Langmuir 23 (8), 4472-79 (2007).

L. L. Muldoon, P. Tratnyek, P. M. Jacobs, N. D. Doolittle, G. A. Christoforidis, J. Frank, M. Lindau, P. R. Lockman, S. Manninger, Y. Qiang, A. M. Spence, S. I. Stupp, M. Zhang, E. A. Neuwelt “Imaging and nanomedicine for diagnosis and therapy in the central nervous system”, American Journal of Neuroradiology 27 (3), 715-21 (2006).

C. Allan, J. M. Clark, R. J. Fernandes, P. Fleckman, B. Hager, J. James, A. Norman, A. Pirrone, H. R. Ramay, B. P. Rubin, F. K. Satterstrom, Z. Wisecarver and M. Zhang “Human fetal digit tip regeneration in vitro”, Wound Repair and Regeneration 14, 398-404 (2006).

Y. Nie, Y. Zhang, J. Zhang and M. Zhang ""Immobilization of polydiacetylene onto silica microbeads for colorimetric detection", Journal of Materials Chemistry 16 (6), 546-549 (2006).

N. Kohler, C. Sun, A. Fichtenholtz, J. Gunn, C. Fang, and M. Zhang "Methotrexate Immobilized Poly(ethylene glycol) Magnetic Nanoparticles for MR Imaging and Drug Delivery", Small 2 (6), 785-792 (2006).

C. Sun, R. Sze, and M. Zhang "Folate acid-PEG conjugated superparamagnetic nanoparticles for targeted cellular uptake and detection by MRI", Journal of Biomedical Materials Research, 78A (3), 550-7 (2006).

N. Bhattarai, Z. Li, D. Edmondson, and M. Zhang "Alginate-Based Nanofibrous Scaffolds: Structural, Mechanical and Biological Properties", Advanced Materials 18 (11), 1463-1467 (2006).

M. Veiseh, and M. Zhang "Effect of silicon oxidation on long-term cell selectivity of cell-patterned Au/SiO2 platforms", Journal of the American Chemical Society 128 (4), 1197-1203 (2006).

N. Bhattara, H. R. Ramay, S. H. Chou, and M. Zhang "Chitosan and lactic acid grafted chitosan nanoparticles as carriers for prolonged drug delivery", International Journal of Nanomedicine 1 (2), 181-187 (2006).

N. Kohler, C. Sun, J. Wang, and M. Zhang "Methotrexate-modified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells”, Langmuir 21 (19), 8858-8864 (2005).

N. Bhattarai, D. Edmondson, O. Veiseh, F. A. Matsen, and M. Zhang "Electrospun chitosan-based nanofibers and their cellular compatibility”, Biomaterials 26 (31), 6176-6184 (2005).

Z. Li, and M. Zhang “Chitosan-alginate as scaffolding material for cartilage tissue engineering”, Journal of Biomedical Materials Research 75A (2), 485-493 (2005).

O. Veiseh, C. Sun, J. Gunn, N. Kohler, P. Gabikian, D.Lee, N. Bhattarai, R.Ellenbogen, R. Sze, A. Hallahan, J. Olson, and M. Zhang "An optical and MRI multifunctional nanoprobe for targeting gliomas”, Nano Letters 5 (6), 1003-1008 (2005).

H. R. Ramay, Z. Li, E. Shum, and M. Zhang “Chitosan-alginate porous scaffolds reinforced by hydroxyapatite nano- and micro-particles—structural, mechanical, and biological properties”, Journal of Biomedical Nanotechnology 1 (2), 151-160 (2005).

N. Bhattarai, H. R. Ramay, J. Gunn, F. A. Matsen, and M. Zhang “PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release”, Journal of Controlled Release 103, 609-624 (2005).

N. Bhattarai, F. A. Matsen, and M. Zhang “PEG-grafted chitosan as an injectable thermoreversible hydrogel”, Macromolecular Bioscience 5, 107-111 (2005).

Z. Li, H. Ramay, K. Hauch, D. Xiao, and M. Zhang “Chitosan-alginate hybrid scaffolds for bone tissue engineering”, Biomaterials 26 (18), 3919-3928 (2005).

S. Lan, M. Veiseh, and M. Zhang "Surface modification of silicon and gold-patterned silicon surfaces for improved biocompatibility and cell patterning selectivity", Biosensors & Bioelectronics 20 (9), 1697-1708 (2005).

N. Kohler, G. E. Fryxell, and M. Zhang "A bifunctional poly(ethylene glycol) silane immobilized on metallic oxide based nanoparticles for conjugating with cell targeting agents", Journal of the American Chemical Society 126 (23), 7206-7211 (2004).

M. Veiseh, B. T. Wickes, D. G. Castner, and M. Zhang "Guided cell patterning on gold-silicon dioxide substrates by surface molecular engineering", Biomaterials 25 (16), 3315-3324 (2004).

H. Ramay and M. Zhang "Biphasic calcium phosphate nanocomposite porous scaffolds for load-bearing bone tissue engineering", Biomaterials 25 (21), 5171-5180 (2004).

M. Zhang, Chapter 2, "Biocompatibility of Materials", in Biomaterials and Tissue Engineering, D. Shi(ed), pp 83-143, Springer-Verlag, New York, (2004).

Y. Zhang and M. Zhang "Cell growth and function on calcium phosphate reinforced chitosan scaffolds", Journal of Materials Science, Materials in Medicine 15 (3), 255-260 (2004).

Y. Zhang, C. Sun, N. Kohler, and M. Zhang "Self-assembled coatings on individual monodisperse magnetite nanoparticles for efficient intracellular uptake", Biomedical Microdevices 6 (1), 33-40 (2004).

H. Ramay and M. Zhang "Preparation of Porous Hydroxyapatite Scaffolds by Combination of the Gel-casting and Polymer Sponge Methods", Biomaterials 24 (19), 3293-3302 (2003).

Y. Zhang, M. Ni, M. Zhang and B. Ratner, "Calcium Phosphate/Chitosan Composite Scaffolds for Bone Tissue Engineering", Tissue Engineering 9 (2), 337-345 (2003).

M. Veiseh, M. Zareie and M. Zhang, "Highly Selective Protein Patterning on Gold-Silicon Substrates for Biosensor Applications", Langmuir 18 (17), 6671-6678 (2002).

Y. Zhang and M. Zhang, "Three-Dimentional Macroporous Calcium Phosphate Bioceramics with Nested Chitosan Sponges for Load-Bearing Bone Implants", Journal of Biomedical Materials Research 61 (1), 1-8 (2002).

Y. Zhang, N. Kohler and M. Zhang, "Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake", Biomaterials 23 (7), 1553-1561 (2002).

Y. Zhang and M. Zhang, "Calcium phosphate/chitosan composite scaffolds for controlled in vitro antibiotic drug release", Journal of Biomedical Materials Research 62 (3), 378-386 (2002).

S. Lee, M. Zhang, and J. Baker, eds "Special issue on biologic nanotechnology", Biomedical Microdevices 3 (1), (2001).

Y. Zhang and M. Zhang, "Synthesis and characterization of Macroporous Chitosan/Calcium Phosphate Composite Scaffolds for Tissue Engineering", Journal of Biomedical Materials Research 55, 304-312 (2001).

M. Veiseh, Y. Zhang, K. Hinkley and M. Zhang, "Two-dimensional Protein Micropatterning for Sensor Applications through Chemical Selectivity Technique", Biomedical Microdevices 3, 45-51 (2001).

Y. Zhang and M. Zhang, "Microstructural and Mechanical Characterization of Chitosan Scaffolds Reinforced by Calcium Phosphates", Journal of Non-Crystalline Solids 282 (2), 159-64 (2001).

S. Lee, J. Baker, and M. Zhang, "Interfaces", Biomedical Microdevices 3 (1), 5-6 (2001).

T. Desai, D. Hansford, L. Kulinsky, A. H. Nashat, G. Rasi, J. Tu, Y. Wang, M. Zhang and M. Ferrari, "Nanopore Technology for Biomedical Applications", Biomedical Microdevices 2 (1), 11-40 (1999).

M. Zhang, T. Desai and M. Ferrari, "Proteins and Cells on PEG Immobilized Silicon", Biomaterials 19 (10), 953-960 (1998).

M. Zhang and M. Ferrari, "Hemocompatible Polyethylene Glycol Films on Silicon", Biomedical Microdevices 1 (1), 81 (1998).

M. Zhang and M. Ferrari, "Reduction of Albumin Adsorption onto Silicon Surfaces by Tween 20", Biotech. & Bioeng. 56 (6), 618 - 625 (1997).

M. Zhang and M. Ferrari, Chapter 6, "Free Boundary Reflection of P- and S- Waves in Granular Media", in Advances in Doublet Mechanics, Ferrari, et al. (eds), pp 103-121, Springer-Verlag, Berlin, Heidelberg (1997).