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MIQIN ZHANG Associate Professor Ph.D. UC Berkeley, 1999 Telephone: (206) 616-9356  Fax: (206) 543-3100  Email: mzhang@u.washington.edu  Office: 302L Roberts Hall

Research Group Research Interests

RESEARCH INTERESTS: Protein and cell and biomaterial interactions, protein immobilization, biocompatibility assessment, surface bioengineering by self-assembled films, protein and cell micropatterning for BioMEMS applications, tissue engineering for bone regeneration, controlled drug delivery, bionanotechnology for cancer diagnostics and therapeutics.

Professional Experience

• 2005 - Associate Professor, Dept of Materials Science and Engineering, University of Washington, Seattle, WA
  • Adjunct Associate Professor, Dept of Orthopaedics and Sports Medicine, UW School of Medicine
  • Adjunct Associate Professor, Dept of Radiology, UW School of Medicine
  • Adjunct Associate Professor, Dept of Neurological Surgery, UW School of Medicine
• 1999 - 2005, Assistant Professor, Dept. of Materials Science and Engineering, University of Washington, Seattle, WA
• 1994 - 1999, Graduate Student Researcher, Dept. of Mat. Sci. & Eng., University of California at Berkeley, Berkeley, CA
• 1991 - 1993, Graduate Student Researcher, Dept. of Mech. Eng., University of Victoria, Victoria, B.C.

Professional Activities and Responsibilities

• Member of Materials Research Society (MRS), The International Society for Optical Engineering (SPIE), American Chemical Society (ACS), Minerals.Metals.Materials (TMS).
• Principal Investigator for Biocompatibility Assessment of Biomedical Microdevices at the Advanced Light Source at Lawrence Berkeley National Laboratory (1998/1999, 1999/2000)
• Editorial Board for Biomedical Microdevices (1999-)
• Editorial Board for Journal of Biomedical Nanotechnology (2004-)

Research Labs

Our research is geared toward developing materials and devices for biological and medical applications, and conducted in three labs within the group:
• Nanoparticle Lab focuses its research on cancer diagnosis and treatment through imaging enhancement and targeted and controlled therapeutic payload delivery. This is accomplished by use of nanoconjugates or multifunctional nanovectors.

• Tissue Engineering Lab concentrates on development of biocompatible porous and nanofibrous matrices serving as biodegradable scaffolds and/or drug delivery depots for tissue repair and regeneration.

• Biosensor Lab targets the detection and identification of chemical and biological agents and development of drug screening techniques using protein and cell based sensors.

Selected Publications

N. Kohler, C. Sun, A. Fichtenholtz, J. Gunn, C. Fang, and M. Zhang "Methotrexate Immobilized Poly(ethylene glycol) Magnetic Nanoparticles for MR Imaging and Drug Delivery", Small 2 (6), 785-792 (2006).

C. Sun, R. Sze, and M. Zhang "Folate acid-PEG conjugated superparamagnetic nanoparticles for targeted cellular uptake and detection by MRI", Journal of Biomedical Materials Research, in press.

N. Bhattarai, Z. Li, D. Edmondson, and M. Zhang "Alginate-Based Nanofibrous Scaffolds: Structural, Mechanical and Biological Properties", Advanced Materials 18 (11), 1463-1467 (2006).

M. Veiseh, and M. Zhang "Effect of silicon oxidation on long-term cell selectivity of cell-patterned Au/SiO2 platforms", Journal of the American Chemical Society 128 (4), 1197-1203 (2006).

N. Bhattara, H. R. Ramay, S. H. Chou, and M. Zhang "Chitosan and lactic acid grafted chitosan nanoparticles as carriers for prolonged drug delivery", International Journal of Nanomedicine 1 (2), 181-187 (2006).

N. Kohler, C. Sun, J. Wang, and M. Zhang "Methotrexate-modified superparamagnetic nanoparticles and their intracellular uptake into human cancer cells”, Langmuir 21 (19), 8858-8864 (2005).

N. Bhattarai, D. Edmondson, O. Veiseh, F. A. Matsen, and M. Zhang "Electrospun chitosan-based nanofibers and their cellular compatibility”, Biomaterials 26 (31), 6176-6184 (2005).

Z. Li, and M. Zhang “Chitosan-alginate as scaffolding material for cartilage tissue engineering”, Journal of Biomedical Materials Research 75A (2), 485-493 (2005).

O. Veiseh, C. Sun, J. Gunn, N. Kohler, P. Gabikian, D.Lee, N. Bhattarai, R.Ellenbogen, R. Sze, A. Hallahan, J. Olson, and M. Zhang "An optical and MRI multifunctional nanoprobe for targeting gliomas”, Nano Letters 5 (6), 1003-1008 (2005).

H. R. Ramay, Z. Li, E. Shum, and M. Zhang “Chitosan-alginate porous scaffolds reinforced by hydroxyapatite nano- and micro-particles—structural, mechanical, and biological properties”, Journal of Biomedical Nanotechnology 1 (2), 151-160 (2005).

N. Bhattarai, H. R. Ramay, J. Gunn, F. A. Matsen, and M. Zhang “PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release”, Journal of Controlled Release 103, 609-624 (2005).

N. Bhattarai, F. A. Matsen, and M. Zhang “PEG-grafted chitosan as an injectable thermoreversible hydrogel”, Macromolecular Bioscience 5, 107-111 (2005).

Z. Li, H. Ramay, K. Hauch, D. Xiao, and M. Zhang “Chitosan-alginate hybrid scaffolds for bone tissue engineering”, Biomaterials 26 (18), 3919-3928 (2005).

S. Lan, M. Veiseh, and M. Zhang "Surface modification of silicon and gold-patterned silicon surfaces for improved biocompatibility and cell patterning selectivity", Biosensors & Bioelectronics 20 (9), 1697-1708 (2005).

N. Kohler, G. E. Fryxell, and M. Zhang "A bifunctional poly(ethylene glycol) silane immobilized on metallic oxide based nanoparticles for conjugating with cell targeting agents", Journal of the American Chemical Society 126 (23), 7206-7211 (2004).

M. Veiseh, B. T. Wickes, D. G. Castner, and M. Zhang "Guided cell patterning on gold-silicon dioxide substrates by surface molecular engineering", Biomaterials 25 (16), 3315-3324 (2004).

H. Ramay and M. Zhang "Biphasic calcium phosphate nanocomposite porous scaffolds for load-bearing bone tissue engineering", Biomaterials 25 (21), 5171-5180 (2004).

M. Zhang, Chapter 2, "Biocompatibility of Materials", in Biomaterials and Tissue Engineering, D. Shi(ed), pp 83-143, Springer-Verlag, New York, (2004).

Y. Zhang and M. Zhang "Cell growth and function on calcium phosphate reinforced chitosan scaffolds", Journal of Materials Science, Materials in Medicine 15 (3), 255-260 (2004).

Y. Zhang, C. Sun, N. Kohler, and M. Zhang "Self-assembled coatings on individual monodisperse magnetite nanoparticles for efficient intracellular uptake", Biomedical Microdevices 6 (1), 33-40 (2004).

H. Ramay and M. Zhang "Preparation of Porous Hydroxyapatite Scaffolds by Combination of the Gel-casting and Polymer Sponge Methods", Biomaterials 24 (19), 3293-3302 (2003).

Y. Zhang, M. Ni, M. Zhang and B. Ratner, "Calcium Phosphate/Chitosan Composite Scaffolds for Bone Tissue Engineering", Tissue Engineering 9 (2), 337-345 (2003).

M. Veiseh, M. Zareie and M. Zhang, "Highly Selective Protein Patterning on Gold-Silicon Substrates for Biosensor Applications", Langmuir 18 (17), 6671-6678 (2002).

Y. Zhang and M. Zhang, "Three-Dimentional Macroporous Calcium Phosphate Bioceramics with Nested Chitosan Sponges for Load-Bearing Bone Implants", Journal of Biomedical Materials Research 61 (1), 1-8 (2002).

Y. Zhang, N. Kohler and M. Zhang, "Surface modification of superparamagnetic magnetite nanoparticles and their intracellular uptake", Biomaterials 23 (7), 1553-1561 (2002).

Y. Zhang and M. Zhang, "Calcium phosphate/chitosan composite scaffolds for controlled in vitro antibiotic drug release", Journal of Biomedical Materials Research 62 (3), 378-386 (2002).

S. Lee, M. Zhang, and J. Baker, eds "Special issue on biologic nanotechnology", Biomedical Microdevices 3 (1), (2001).

Y. Zhang and M. Zhang, "Synthesis and characterization of Macroporous Chitosan/Calcium Phosphate Composite Scaffolds for Tissue Engineering", Journal of Biomedical Materials Research 55, 304-312 (2001).

M. Veiseh, Y. Zhang, K. Hinkley and M. Zhang, "Two-dimensional Protein Micropatterning for Sensor Applications through Chemical Selectivity Technique", Biomedical Microdevices 3, 45-51 (2001).

Y. Zhang and M. Zhang, "Microstructural and Mechanical Characterization of Chitosan Scaffolds Reinforced by Calcium Phosphates", Journal of Non-Crystalline Solids 282 (2), 159-64 (2001).

S. Lee, J. Baker, and M. Zhang, "Interfaces", Biomedical Microdevices 3 (1), 5-6 (2001).

T. Desai, D. Hansford, L. Kulinsky, A. H. Nashat, G. Rasi, J. Tu, Y. Wang, M. Zhang and M. Ferrari, "Nanopore Technology for Biomedical Applications", Biomedical Microdevices 2 (1), 11-40 (1999).

M. Zhang, T. Desai and M. Ferrari, "Proteins and Cells on PEG Immobilized Silicon", Biomaterials 19 (10), 953-960 (1998).

M. Zhang and M. Ferrari, "Hemocompatible Polyethylene Glycol Films on Silicon", Biomedical Microdevices 1 (1), 81 (1998).

M. Zhang and M. Ferrari, "Reduction of Albumin Adsorption onto Silicon Surfaces by Tween 20", Biotech. & Bioeng. 56 (6), 618 - 625 (1997).

M. Zhang and M. Ferrari, Chapter 6, "Free Boundary Reflection of P- and S- Waves in Granular Media", in Advances in Doublet Mechanics, Ferrari, et al. (eds), pp 103-121, Springer-Verlag, Berlin, Heidelberg (1997).