Degrees

 
• 2001 - PhD in Biochemistry, Microbiology and Molecular Biology

Dept. of Biochemistry and Molecular Biology
The Pennsylvania State University
Thesis:  "Role of histones and transcriptional activators in the regulation of eukaryotic gene expression"

• 1995 - MS in Molecular and Cellular Biology

PEDECIBA/Universidad de la República,  Uruguay.
(Research performed at Dr. Paolo Amati's lab, Università di Roma "La Sapienza", Italy).
Thesis:"Transgenic mice that express an antisense RNA complementary to the early mRNA of polyomavirus acquire resistance to experimental infection"

• 1991 - BS in Biology (Molecular and Cellular Biology)

Facultad de Ciencias Exactas y Naturales, Universidad de la República, Uruguay.

Publications

1. Hassan, A.H., Neely, K.E., Vignali, M., Reese, J.C., and J.L. Workman. (2001) Promoter targeting of chromatin -modifying complexes. Frontiers in Bioscience , 6: D1054-64.
2. Vignali, M., Steger, D.J., Neely, K.E. and J.L. Workman. (2000) Distribution of acetylated histones resulting from Gal4-VP16 recruitment of SAGA and NuA4 complexes. EMBO J., 19(11): 2629-40. (see cartoon)
3. Vignali, M., Hassan, A.H., Neely, K.E. and J.L. Workman. (2000) ATP-dependent chromatin remodeling complexes. Mol. Cell Biol., 20(6): 1899-1910.
4. Vignali, M. and J.L.Workman. (1998) Location and function of linker histones. Nat. Struct. Biol. 5(12):1025-8.
5. Juan, L-J., Utley, R.T., Vignali, M., Bohm, L. and J.L. Workman. (1997) H1-mediated repression of transcription factor binding to a stably positioned nucleosome. J. Biol.Chem, 272(6): 3635-40.
6. Vignali, M., Acosta, D., Rossi, S., Lanzzeri, S., Gama, S., Maisonave, J. and J. Cristina. (1996) Humoral immune response against Fasciola hepatica in bovines: primary characterization of protection induced by irradiated metacercariae. Parasitol. al día 29: 32-37.
7. Alvarez, F., Robello, C. and M. Vignali. (1994) Evolution of codon usage and base contents in kinetoplastid protozoans. Mol. Biol. Evol. 11(5): 790-802.

Currently

Developing yeast-based assays for studying protein-protein and protein-DNA interactions in the parasitic protozoan Plasmodium falciparum ,the causative agent of malaria (link to the lab page).