POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME


Characterized by acute neurologic changes (e.g. seizure, headache, encephalopathy, visual disturbance, and/or focal neurologic deficits

Not exclusively localized to posterior parts of the brain (despite the name)

Associated with hypertension, cytotoxic drugs, sepsis, Thrombotic Thrombocytopenic Purpura, and Preeclampsia

Renal failure present in 57% of patients and autoimmune disease in 45% in one case series (Mayo Clin. Proc. 85:427, 2010-JW)

Neuroimaging generally shows focal vasogenic edema

Generally reversible