US Public Health Service recommendations for post-exposure prophylaxis for HIV:

  1. Start ASAP and continue x 28d
  2. Wash exposure sites with soap & water
  3. Consider screening for Hep B and Hep C as well

(See MMWR 2001;50 (No. RR-11) for the rather complex recommendations on what meds to use)

For non-occupational post-exposure prophylaxis, meds are recommended only if presenting 72h or less after exposure and source of exposure is known to be HIV-infected and exposure represents a "substantial risk" of infection; recommends 28d of HAART.  If HIV status of source is unknown, they advise doctor & pt decide on a case-by-case basis.

(Source: MMWR 54 (RR-2):1-28, 2005)