Causes cholestatic liver diseae

Etiology unclear as of 2010, though involves autoimmune processes

Antimitochondrial Ab used in diagnosis

Independent risk factors in one case-control study included the following (J. Hepatol. 53:162, 2010-JW)

Sertraline was reported to be associated with improvements in pruritis in a case series of patients with cholestasis from primary biliary cirrhosis (Am. J. Gastroent. 98:2736, 2003--abst)