I. Parvovirus B19 causes a number of clinical syndromes
- Fifth disease (erythema infectiosum)--Fever and constitutional sx
followed about 2wks later by a red facial "slapped-cheek" rash,
which may wax and wane before resolving
- Inflammatory arthritis (mostly in adults; symmmetric involvement of hands
and, occasionally, wrists, knees, and ankles; may be associated with
elevated rheumatoid factor; resolves over several weeks), often with reticular rash on trunk
- Aplastic anemia in sickle-cell patients and/or immunocompromised pts (e.g.
- Fetal infection-Can be associated with hydrops fetalis and/or congenital
II. Transmitted mostly through respiratory secretions
III. Infected person is contagious 5-10d after exposure, i.e.
usually before getting sick
IV. Epidemiology in pregnancy
35% of preg. women are seropositive; acute infection
occurs in 1-4% of pregnancies
Maternal-fetal transmission occurs in about 20% of cases
but rarely causes fetal or neonatal disease; can be
associated with fetal hydrops & death, prob. in about
10% of congenital infections (though perhaps less: J.
Inf. Dis 171:1360, 1995)
Don't need to keep pregnant women out of situations where
they could be exposed, e.g. day-care