Pharmacologic tx: Imipramine, SRI's

Psychological tx: Cognitive-behavioral therapy is most commonly used

In a randomized trial of imipramine (titrated to 300mg/d), cognitive-behavioral therapy, or both, in 312 pts with panic disorder, 6mo f/u showed slight advantage of imipramine-only (titrated to 300mg/d) (response rate 49%) vs. therapy-only (response rate 46%); combined therapy-plus-imipramine sig. better than either alone (response rate 60%) (JAMA 283:2529, 2000--abst)