MONOCLONAL GAMMOPATHIES


See also Multiple Myeloma

I. Monoclonal gammopathy of undetermined significance (MGUS)

  1. Defined as serum monoclonal Ig concentration 3g/dl or lower and no other evidence of multiple myeloma or related disorders.
  2. In pts with MGUS, 10y incidence of progression to multiple myeloma, lymphoma, or other serious disorders in one prospective study was 6% for those with initial monoclonal protein concentration of 0.5 g/dL or lower and 34% among those with initial monoclonal protein concentration of 2.51-3.0 g/dL.
  3. Prevalence was 1.7% in community-dwellers 50-59yo and 6.6% in those > 80yo in one community-based study (NEJM 354:1362, 2006--JW)