INTERFERONS


Alpha-interferon--2 forms in US:

Side f/x:

  1. Flu-like sx (fever, chills, malaise, HA, arthralgias, myalgia, tachycardia)
  2. Alopecia
  3. Myelosuppression
  4. Infection
  5. Autoimmunity (rare; mostly thyroid)
  6. Seizures (rare)
  7. Cardiac failure (rare)
  8. Renal failure (rare)
  9. Retinopathy
  10. Interstitial pulmonary fibrosis
  11. Hearing impairment
  12. Psychiatric (20-30% of pts--apathy, cognitive changes, depression)
    1. Paroxetine 10mg QD titrated upward starting 2wks before and continuing to end of IFN treatment was ass'd with sig. lower incidence of depression in a randomized trial of 38 pts with malignant melanoma receiving IFN (NEJM 344:961, 2001--JW)
  13. Paradoxical worsening of HCV hepatitis

Pegylated IFN