I. Etiology

  1. Caused by Neisseria gonorrheae

II. Clinical Features

  1. Men: urethritis (with dysuria and urethral discharge; sometimes asymptomatic)
  2. Women: Cervicitis (with vaginal discharge, lower abdominal discomfort, and dyspareunia); Salpingitis (Pelvic Inflammatory Disease)
  3. Men and women: Local complications (lymphangitis, periurethral abscess), disseminated disease (petechial or pustular skin lesions, asymmetrical arthritis, tenosynovitis, and raraely, meningitis or endocarditis)
  4. Coinfection w/Chlamydia Trachomatis seen in 20-40% of pts with gonorrhea

Single-dose regimens (e.g. with ceftriaxone, ciprofloxacin, gatifloxacin, spectinomycin, azithromycin, ofloxacin, or cefixime) have been shown to have high cure rates in uncomplicated urogenital or rectal infection; pharyngeal or disseminated infection generally requires longer treatment.

Antimicrobial resistance to quinolones is very common in the U.S. as of 2006.