I. Etiology

  1. Helicobacter Pylori
  2. Other factors

I. Treatment

  1. Surgical excision
    1. For patienst with limited disease, endoscopic mucosal resectino may be an option though data is still limited as of 2009.
  2. Postop chemo (5-FU & leucovorin) + XRT ass'd with sig. longer disease-free survival (30mo vs. 19mo) and overall survival (36mo vs. 27mo) over median 5y f/u (NEJM 345:725, 2001--JW)
  3. Treatment of Helicobacter pylori Infection may reduce rate of progression of gastric histologic abnormalities (click on link for details)