DIURETICS


Category Agent Dosing Comments (apply to all agents w/in category)
Thiazides Chlorothiazide
Chlorthalidone
Hydrochlorothiazide
Indapamide
Metolazone
125-500mg QD
12.5-50mg QD
12.5-50mg QD
1.25-5mg QD
0.5-1.0mg QD
May increase cholesterol levels
May increase glucose levels*
Lowers serum levels of K, Na, and Mg
Decreases renal excretion of Ca and may reduce risk of Osteoporosis
Associated with pancreatitis, sexual dysfunction, and photosensitivity
May increase Lithium levels in pts on Lithium
Loop Bumetanide
Ethacrynic acid
Furosemide
Torsemide
0.5-5mg divided BID-TID
25-100mg divided BID-TID
20-320mg divided BID-TID
5-20mg divided QD-BID
Shorter t-1/2 than thiazides
Less effective for HTN than thiazides
May increase cholesterol levels
May increase glucose levels
Lowers serum levels of K, Na, and Mg
Potassium-sparing Amiloride
Eplenerone (Inspra)
Spironolactone
Triamterine
5-10mg QD-BID
50mg QD-BID
12.5-100mg QD-BID
50-150mg QD-BID
Blocks the effect of Aldosterone
Weak antihypertensive effect when used alone
Used often in conjunction w/thiazide to avoid hypokalemia
Can cause hyperkalemia and hyponatremia
Use with caution in combination w/ACEIs
Spironolactone can cause gynecomastia in men & irregular menses in women
Eplenerone has less anti-androgenic effect than spironolactone

*--Evidence to support: