An agonist for the transient receptor potential vanilloid 1 receptor (TRPV1)

In a meta-analysis of 6 randomized trials of topical capsaicin for chronic pain from neuropathic or musculoskeletal disorders, incidence of 50% or greater reduction in pain was sig. more frequent for treatment of neuropathic pain (60% vs. 42% at 8wks) and musculoskeletal pain (38% vs. 25% at 4wks) (BMJ 328:991, 2004--JW)


Qutenza (8% patch; can cut patch to match size/shape of area for treatment; pretreat with topical anesthetic (comes with?); can use up to 4 patches at a time and apply for 60min; repeat Q3mos)