BENIGN BREAST DISEASE


I. Breast divided into about 18 lobes, each with its own duct

II. Cysts and fibroadenomas are lobular (not lobar) in origin

III. At puberty, estrogen stimulates duct development; progesterone stimulates dev. of acinii/lobules

IV. Montgomery's tubercules--supply lubricant for suckling

V. Conditions

  1. Plasma cell mastitis ("Mammary duct ectasia")--consists of fatty tissue blocking ducts; looks like bag of worms, after long time get scarring and retraction of nipple; predominance of plasma cells on hist. examination
  2. Fibroadenoma--lobular in origin; mobile; no capsule; typical histological appearance
  3. Fibrocystic change--exaggeration of monthly histol. changes of breast; very common. Starts with fine granular nodules, feels like "cobblestones"; later, coalesce into cysts, occ. "blue-domed"--filled with blue fluid
  1. *larger cysts more likely to be Ca*
  1. Mondor's dis.--thrombophlebitis of thoracoepigastric v.--cord can be felt, often retraction too; prob. traumatic in cause; can be mistaken for Ca
  2. Sclerosing adenosis--fibrosis displacing nl. glandular tissue; twice as likely to get breast Ca
  3. Fat necrosis--due to trauma; can present as a hard, Ca-like palpable nodule