The Merz Laboratory is interested in subcellular organization and dynamics, with an emphasis on the membrane dynamics of organelles such as endosomes and lysosomes. The lab currently includes of four postdoctoral fellows, two graduate students, a research associate, and undergraduates. You can meet some of them on the People page. We employ a wide range of contemporary and classical approaches including yeast genetics, high-throughput screening, in vitro reconstitution, fluorescence spectroscopy, quasielastic light scattering, and high-sensitivity light and electron microscopy. Current projects include fundamental studies of SNARE-mediated membrane fusion, dissection of AP-3 mediated transport from the Golgi to the lysosome, and studies of the relationship between cellular metabolism and lysosomal physiology. For more information, check out the Research and Papers pages.