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Recent Publications

Johnson EK, Zhang L, Adams, ME, Phillips A, Freitas MA, Froehner SC, Green-Church KB, Montanaro F. (2012) Proteomic analysis reveals new cardiac-specific dystrophin-associated proteins. PLoS ONE, 7(8):e43515.

Percival JM, Whitehead NP, Adams ME, Adamo CM, Beavo JA, Froehner SC. (2012) Sildenafil reduces respiratory muscle weakness and fibrosis in the mdx mouse model of Duchenne muscular dystrophy. J. Pathology 228(1):77-87.

Kim MJ, Froehner SC, Adams ME, Kim HS. (2011). α-syntrophin is required for the hepatocyte growth factor-induced migration of cultured myoblasts. Exp Cell Res, 317(20):2914-24.

Lyssand JS, Whiting JL, Lee KS, Kastl R, Wacker JL, Bruchas MR, Miyatake M, Langeberg LK, Chavkin C, Scott JD, Gardner RG, Adams ME, Hague C. (2010). α-dystrobrevin-1 recruits α-catulin to the α1D-adrenergic receptor/dystrophin-associated protein complex signalosome. PNAS, 107(50):21854-9, doi: 10.1073/pnas.101081910

Schubert S, Knoch KP, Ouwendijk J, Mohammed S, Bodrov Y, Jäger M, Altkrüger A, Wegbrod C, Adams ME, Kim Y, Froehner SC, Jensen ON, Kalaidzidis Y, Solimena M. (2010). β2-syntrophin is a Cdk5 substrate that restrains the motility of insulin secretory granules. PLoS ONE, 5(9):e12929, doi:10.1371/journal.pone.0012929

Adams ME, Anderson KNE, Froehner SC. (2010). The α-syntrophin PH and PDZ domains scaffold acetylcholine receptors, utrophin, and neuronal nitric oxide synthase at the neuromuscular junction. The Journal of Neuroscience, 30(33): 11004-11010; doi: 10.1523/​JNEUROSCI

Bragg AD, Das SS, Froehner SC. (2010) Dystrophin-associated protein scaffolding in brain requires α-dystrobrevin. NeuroReport, 21:695-699. doi: 10.1097/WNR.0b013e32833b0a3b

Whitehead NP, Yeung EW, Froehner SC, Allen DG. (2010). Skeletal muscle NADPH oxidase is increased and triggers stretch-induced damage in the mdx mouse. PLoS ONE, 5(12): e15354. doi:10.1371/journal.pone.0015354

Kim MJ, Hwang SH, Lim JA, Froehner SC, Adams ME, Kim HS. (2010). α-syntrophin modulates myogenin expression in differentiating myoblasts. PLoS ONE, 5(12): e15355. doi:10.1371/journal.pone.0015355

Lyssand JS, Whiting JL, Lee KS, Kastl R, Wacker JL, Bruchas MR, Miyatake M, Langeberg LK, Chavkin C, Scott JD, Gardner RG, Adams ME, Hague C. (2010). α-Dystrobrevin-1 recruits α-catulin to the α1D-adrenergic receptor/dystrophin-associated protein complex signalosome. PNAS, 107(50):21854-21859. doi:10.1073/pnas.1010819107

Adamo CM, Dai DF, Percival JM, Minami E, Willis MS, Patrucco E, Froehner SC, Beavo JA. (2010). Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy. PNAS, doi:10.1073/pnas.1013077107

Schubert S, Knoch KP, Ouwendijk J, Mohammed S, Bodrov Y, Jäger M, Altkrüger A, Wegbrod C, Adams ME, Kim Y, Froehner SC, Jensen ON, Kalaidzidis Y, Solimena M. (2010). β2-Syntrophin is a Cdk5 Substrate That Restrains the Motility of Insulin Secretory Granules. PLoS ONE, 5(9): e12929. doi:10.1371/journal.pone.0012929

Adams ME, Anderson KN, Froehner SC. (2010). The α-syntrophin PH and PDZ domains scaffold acetylcholine receptors, utrophin, and neuronal nitric oxide synthase at the neuromuscular junction. The Journal of Neuroscience, 30(33):11004-11010; doi:10.1523/JNEUROSCI.1930-10.2010

Bragg AD, Das SS, Froehner SC. (2010). Dystrophin-associated protein scaffolding in brain requires α-dystrobrevin. Neuroreport, 21(10):695-699. doi: 10.1097/WNR.0b013e32833b0a3b

Migliati ER, Amiry-Moghaddam M, Froehner SC, Adams ME, Ottersen OP, Bhardwaj A. (2010).Na(+)-K (+)-2Cl (-) Cotransport Inhibitor Attenuates Cerebral Edema Following Experimental Stroke via the Perivascular Pool of Aquaporin-4. Neurocritical Care, PMID: 20458553.

Percival JM, Anderson KN, Huang P, Adams ME, Froehner SC. (2010). Golgi and sarcolemmal neuronal NOS differentially regulate contraction-induced fatigue and vasoconstriction in exercising mouse skeletal muscle. Journal of Clinical Investigation, doi: 10.1172/JCI40736

Banks GB, Chamberlain JS, Froehner SC. (2009). Truncated dystrophins can influence neuromuscular synapse structure. Molecular and Cellular Neuroscience, 40(4):433-41. PMID: 19171194

Steen MS, Adams ME, Tesch Y, Froehner SC. (2009). Amelioration of muscular dystrophy by transgenic expression of Niemann-Pick C1. Molecular Biology of the Cell, 20: 146-152; published as 10.1091/mbc.E08-08-0811

Liu X, Zhang W, Alkayed NJ, Froehner SC, Adams ME, Amiry-Moghaddam M, Ottersen OP, Hurn PD, Bhardwaj A. (2008). Lack of sex-linked differences in cerebral edema and aquaporin-4 expression after experimental stroke. Journal of Cerebral Blood Flow & Metabolism, 28: 1898-1906. doi:10.1038/jcbfm.2008.83

Lyssand JS, DeFino MC, Tang XB, Hertz AL, Feller DB, Wacker JL, Adams ME, Hague C. (2008). Blood pressure is regulated by an α1D-adrenergic receptor/dystrophin signalosome. The Journal of Biological Chemistry,279: 28387-28392. doi:10.1074/jbc.M402604200

Compton AG, Albrecht DE, Seto JT, Cooper ST, Ilkovski B, Jones KJ, Challis D, Mowat D, Ranscht B, Bahlo M, Froehner SC, North KN. (2008). Mutations in contactin-1, a neural adhesion and neuromuscular junction protein, cause a familial form of lethal congenital myopathy. American Journal of Human Genetics, 83(6):714-724. PMID: 19026398

Percival JM, Anderson KN, Gregorevic P, Chamberlain JS, Froehner SC. (2008). Functional deficits in nNOSμ-deficient skeletal muscle: myopathy in nNOS knockout mice. PLoS ONE, 3(10): e3387. doi:10.1371/journal.pone.0003387

Zeynalov E, Chen CH, Froehner SC, Adams ME, Ottersen OP, Amiry-Moghaddam M, Bhardwaj A. (2008). The perivascular pool of aquaporin-4 mediates the effect of osmotherapy in postischemic cerebral edema. Critical Care Medicine, 36(9):2634-2640. doi: 10.1097/CCM.0b013e3181847853

Albrecht DE, Sherman DL, Brophy PJ, Froehner SC. (2008). The ABCA1 cholesterol transporter associates with one of two distinct dystrophin-based scaffolds in Schwann cells. Glia., 56(6):611-618. PMID: 18286648

Adams ME, Tesch Y, Percival JM, Albrecht DE, Conhaim JI, Anderson K, Froehner SC. (2008). Differential targeting of nNOS and AQP4 to dystrophin-deficient sarcolemma by membrane-directed α-dystrobrevin. Journal of Cell Science, Jan 1;121(Pt 1):48-54. PMID: 18057022

Wang D, Kelly BB, Albrecht DE, Adams ME, Froehner SC, Feng G. (2007). Complete deletion of all α-dystrobrevin isoforms does not reveal new neuromuscular junction phenotype. Gene Expression, 14(1):47-57. PMID: 17933218

Percival JM, Gregorevic P, Odom GL, Banks GB, Chamberlain JS, Froehner SC. (2007). rAAV6-microdystrophin rescues aberrant Golgi complex organization in mdx skeletal muscles. Traffic., Oct;8(10):1424-39. PMID: 17714427

Percival JM, Froehner SC. (2007). Golgi complex organization in skeletal muscle: a role for Golgi-mediated glycosylation in muscular dystrophies? Traffic., Mar;8(3):184-94. PMID: 17319799

Alessi A, Bragg AD, Percival JM, Yoo J, Albrecht DE, Froehner SC, Adams ME. (2006). Gamma-Syntrophin scaffolding is spatially and functionally distinct from that of the alpha/beta syntrophins. Experimental Cell Research, 312(16):3084-95. PMID: 16857187

Gregorevic P, Allen JM, Minami E, Blankinship MJ, Haraguchi M, Meuse L, Finn E, Adams ME, Froehner SC, Murry CE, Chamberlain JS. (2006). rAAV6-microdystrophin preserves muscle function and extends lifespan in severely dystrophic mice. Nature Medicine, Jul;12(7):787-9. PMID: 16819550

Bragg AD, Amiry-Moghaddam M, Ottersen OP, Adams ME, Froehner SC. (2006). Assembly of a perivascular astrocyte protein scaffold at the mammalian blood-brain barrier is dependent on α-syntrophin. Glia., 53(8):879-90. PMID: 16609960

Puwarawuttipanit, W., Bragg, A.D., Frydenlund, D.S., Mylonakou, M.N., Nagelhus, E.A., Peters, M. F., Kotchabhakdi, N., Adams, M.E., Froehner, S.C., Haug, F., Ottersen, O.P., and Amiry-Moghaddam, M. (2006). Differential effect of α-syntrophin knockout on AQP4 and Kir4.1 expression in retinal macroglial cells in mice. Neuroscience, 137:165-175. PMID: 16257493

Yan, J., Wen, W., Xu, W., Long, J., Adams, M.E., Froehner, S.C., and Zhang, M. (2005). Structure of the split PH domain and distinct lipid binding properties of the split PH-PDZ supramodule of α-syntrophin. The EMBO Journal, 24:3985-95. PMID: 16252003

Luo, S., Chen, Y., Lai, K., Arevalo, J.C., Froehner, S.C., Adams, M.E., Chao, M.V., and Ip, N.Y. (2005). α-Syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner. The Journal of Cell Biology, 169:813-824. PMID: 15939763

Compton AG, Cooper ST, Hill PM, Yang N, Froehner SC, North KN. (2005). The syntrophin-dystrobrevin subcomplex in human neuromuscular disorders. Journal of Neuropathology & Experimental Neurology, 64(4):350-61. PMID: 15835271

Adams, M.E., Kramarcy, N., Fukuda, T., Engel, A., Sealock, R., and Froehner, S.C. (2004). Structural abnormalities at neuromuscular synapses lacking multiple syntrophin isoforms. The Journal of Neuroscience, 24:10302-10309. doi:10.1523/JNEUROSCI.3408-04.2004

Shiao T., Fond, A., Deng, B., Wehling-Henricks, M., Adams, M.E., Froehner, S.C. and Tidball, J.G. (2004). Defects in neuromuscular junction structure in dystrophic muscle are corrected by expression of a NOS transgene in dystrophin-deficient muscles, but not in muscles lacking α- and β1-syntrophins. Human Molecular Genetics, 13:1873-84.

Connors, N.C., Adams, M.E., Froehner, S.C., and Kofuji, P. (2004). The potassium channel Kir4.1 associates with the dystrophin glycoprotein complex via α-syntrophin in glia. The Journal of Biological Chemistry, 279:28387-92. PMID: 15102837

Leonoudakis, D., Conti, L.R., Anderson, S., Radeke , C.M., McGuire, L.M., Adams, M.E., Froehner, S.C., Yates, J.R. 3rd, and Vandenberg, C.A. (2004). Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins. The Journal of Biological Chemisrty, 279(21):22331-46. PMID: 15024025

Amiry-Moghaddam, M., Xue, R., Haug F.M., Neely, J.D., Bhardwaj, A., Agre, P., Adams, M.E., Froehner, S.C. Mori S, Ottersen OP. (2004). α-syntrophin deletion removes the perivascular but not the endothelial pool of aquaporin-4 at the blood-brain barrier and delays the development of brain edema in an experimental model of acute hyponatremia. The FASEB Journal, 18:542-4. PMID: 14734638