# |
Name |
RefSeq |
WormBase |
E-Value |
%ID |
Genome Position |
Pfam Domains |
Gene Ontology |
Description |
| 1 |
T01H10.1 |
NM_077622 |
T01H10.1 |
0 |
100 |
chrX 12,100,776 |
'Neurotransmitter-gated ion-channel ligand binding domain' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'synaptic transmission' 'membrane' 'integral to membrane' |
nitcotinic acetylcholine receptor |
| 2 |
T01H10.3 |
NM_077624 |
T01H10.3 |
6e-109 |
63.23 |
chrX 12,105,751 |
'Neurotransmitter-gated ion-channel ligand binding domain' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'synaptic transmission' 'membrane' 'integral to membrane' |
nicotinic acetylcholine receptor |
| 3 |
Y105C5B.16 |
NM_070504 |
Y105C5B.16 |
8e-108 |
59.27 |
chrIV 15,959,608 |
'Neurotransmitter-gated ion-channel ligand binding domain' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'synaptic transmission' 'membrane' 'integral to membrane' |
|
| 4 |
T01H10.7 |
NM_077628 |
T01H10.7 |
4e-103 |
55.52 |
chrX 12,117,401 |
'Neurotransmitter-gated ion-channel ligand binding domain' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'synaptic transmission' 'membrane' 'integral to membrane' |
nicotininc acetylcholine receptor |
| 5 |
T01H10.2 |
NM_077623 |
T01H10.2 |
3.5e-95 |
63.64 |
chrX 12,103,004 |
'Neurotransmitter-gated ion-channel ligand binding domain' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'synaptic transmission' 'membrane' 'integral to membrane' |
nicotinic acetylcholine receptor |
| 6 |
T01H10.5 |
NM_077626 |
T01H10.5 |
1.5e-93 |
69.53 |
chrX 12,110,320 |
'Neurotransmitter-gated ion-channel ligand binding domain' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'synaptic transmission' 'membrane' 'integral to membrane' |
nicotinic acetylcholine receptor |
| 7 |
T01H10.6 |
NM_077627 |
T01H10.6 |
4.3e-93 |
67.69 |
chrX 12,114,063 |
'Neurotransmitter-gated ion-channel ligand binding domain' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'synaptic transmission' 'membrane' 'integral to membrane' |
nicotinic acetylcholine receptor |
| 8 |
C04C3.2 |
NM_067940 |
C04C3.2 |
1.3e-28 |
28.22 |
chrIV 3,417,401 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
channel protein |
| 9 |
T05B4.1 |
NM_071753 |
T05B4.1 |
1.9e-27 |
29.35 |
chrV 4,136,901 |
n/a |
n/a |
ionic channel protein |
| 10 |
acr-17 |
NM_071314 |
F53E10.2 |
3.9e-25 |
27.68 |
chrV 2,611,244 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'membrane' 'neurotransmitter receptor activity' |
an ortholog of alpha subunit of nicotinic acetylcholine receptor (nAChR). |
| 11 |
Y57G11C.2 |
NM_070376 |
Y57G11C.2 |
1.6e-23 |
27.62 |
chrIV 14,714,984 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
neurotransmitter-gated ion-channel |
| 12 |
Y44A6E.1 |
NM_075636 |
Y44A6E.1 |
2.1e-23 |
25.62 |
chrV 20,917,081 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'membrane' 'neurotransmitter receptor activity' |
Neurotransmitter-gated ion-channel |
| 13 |
acr-22 |
NM_076869 |
F48E3.7 |
4.7e-23 |
28.52 |
chrX 7,495,691 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
acr-22 encodes a predicted member of the nicotinic acetylcholine receptor nonalpha subunit family with highest similarity to human neuronal acetylcholine receptor alpha-9 subunit. |
| 14 |
F17E9.7 |
NM_069010 |
F17E9.7 |
4e-22 |
27.05 |
chrIV 8,343,519 |
'Neurotransmitter-gated ion-channel ligand binding domain' |
'extracellular ligand-gated ion channel activity' 'transport' 'membrane' |
contains similarity to Pfam domain PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) |
| 15 |
F17E9.8 |
NM_069009 |
F17E9.8 |
4.4e-21 |
27.76 |
chrIV 8,341,211 |
'Neurotransmitter-gated ion-channel ligand binding domain' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'synaptic transmission' 'membrane' 'integral to membrane' |
contains similarity to Pfam domain PF02931 (Neurotransmitter-gated ion-channel ligand binding domain) |
| 16 |
acr-21 |
NM_066051 |
F27B3.2 |
2.9e-20 |
24.1 |
chrIII 6,584,064 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'membrane' 'neurotransmitter receptor activity' |
acr-21 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR); ACR-21 is a highly divergent member of the 'ACR-16' class of nAChR subunits, which includes ACR-7, ACR-9, ACR-10, ACR-11, ACR-14, ACR-15, ACR-16, and ACR-19, and is most closely related to the alpha-7 subunits of vertebrate nAChRs. |
| 17 |
F18G5.4 |
NM_077155 |
F18G5.4 |
3.7e-20 |
28.07 |
chrX 9,229,244 |
n/a |
n/a |
member of the ligand-gated ionic channels family |
| 18 |
Y73B6BL.26 |
NM_068584 |
Y73B6BL.26 |
6.4e-20 |
30.62 |
chrIV 6,448,617 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'membrane' 'neurotransmitter receptor activity' |
contains similarity to Pfam domains PF02931 (Neurotransmitter-gated ion-channel ligand binding domain), PF02932 (Neurotransmitter-gated ion-channel transmembrane region) |
| 19 |
acr-7 |
NM_063246 |
T09A5.3 |
1.9e-19 |
24.29 |
chrII 7,847,611 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'receptor activity' 'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
acr-7 encodes an alpha-7-like homomer-forming subunit of the nicotinic acetylcholine receptor (nAChR) superfamily which encode ligand-gated ion channels that regulate fast action of acetylcholine at neuromuscular junctions and in the nervous system; ACR-7 is expressed pharyngeal muscle and in tail neurons distal to the anus, and is a member of the ACR-16-like group of nAChR subunits. |
| 20 |
acr-20 |
NM_064589 |
R06A4.10 |
3.2e-19 |
23.33 |
chrII 14,375,814 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
acr-20 encodes an alpha 7-like homomer-forming subunit of the nicotinic acetylcholine receptor (nAChR) superfamily which encode ligand-gated ion channels that regulate fast action of acetylcholine at neuromuscular junctions and in the nervous system; ACR-20 is a member of the DEG-3-like group of nAChR subunits which appears to be unique to nematodes. |
| 21 |
des-2 |
n/a |
T26H10.1 |
5.4e-19 |
24.51 |
chrV 11,420,249 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
des-2 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR), predicted to be a ligand-gated ion channel regulating the fast action of acetylcholine at neuromuscular junctions and in the nervous system; DES-2 is coexpressed with and genetically interacts with DEG-3, which which it probably forms heteromultimers, and DES-2 falls into the 'DEG-3' class of nAChR subunits, probably unique to nematodes, which includes DEG-3, ACR-5, ACR-17, ACR-18 ACR-20, and ACR-23. |
| 22 |
acr-2 |
NM_076727 |
K11G12.2 |
3.5e-18 |
21.99 |
chrX 6,696,454 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'receptor activity' 'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
A homolog of a non-alpha type nicotinic acetylcholine receptor subunit that forms a functional channel when co-expressed with the unc-38 alpha subunit. |
| 23 |
F11C7.1 |
NM_078423 |
F11C7.1 |
1.7e-17 |
24.71 |
chrX 17,416,579 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'membrane' 'neurotransmitter receptor activity' |
ligand-gated ionic channel |
| 24 |
acr-23 |
NM_071623 |
F59B1.9 |
3e-17 |
22.07 |
chrV 3,655,434 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
acr-23 encodes an alpha 7-like homomer-forming subunit of the nicotinic acetylcholine receptor (nAChR) superfamily which encode ligand-gated ion channels that regulate fast action of acetylcholine at neuromuscular junctions and in the nervous system; ACR-23 is a member of the DEG-3-like group of nAChR subunits which appears to be unique to nematodes. |
| 25 |
deg-3 |
NM_073496 |
K03B8.9 |
1.5e-16 |
23.97 |
chrV 11,416,708 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
deg-3 - a member of the gene class DEGeneration of certain neurons |
| 26 |
acr-19 |
NM_060028 |
C31H5.3 |
3.3e-16 |
25 |
chrI 9,042,101 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
acr-19 encodes a predicted member of the alpha subunit family of nicotinic acetylcholine receptors. |
| 27 |
acr-18 |
NM_074467 |
F28F8.1 |
4.3e-16 |
24.23 |
chrV 15,555,549 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
acr-18 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR), predicted to be a ligand-gated ion channel regulating fast action of acetylcholine at neuromuscular junctions and in the nervous system; ACR-18 falls into the 'DEG-3' class of nAChR subunits, apparently unique to nematodes, which includes DEG-3, DES-2, ACR-5, ACR-17, ACR-20, and ACR-23. |
| 28 |
acr-10 |
NM_076291 |
R02E12.8 |
4.3e-16 |
24.69 |
chrX 4,015,009 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
acr-10 encodes an alpha-7-like homomer-forming subunit of the nicotinic acetylcholine receptor (nAChR) superfamily which encode ligand-gated ion channels that regulate fast action of acetylcholine at neuromuscular junctions and in the nervous system; ACR-10 is a member of the ACR-16-like group of nAChR subunits. |
| 29 |
acr-9 |
NM_077884 |
C40C9.2 |
5.6e-16 |
25.7 |
chrX 13,635,521 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
acr-9 encodes a predicted member of the alpha subunit family of nicotinic acetylcholine receptors. |
| 30 |
Y73F8A.30 |
NM_070464 |
Y73F8A.30 |
5.6e-16 |
23.81 |
chrIV 15,507,101 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
contains similarity to Pfam domain: PF00065 (Neurotransmitter-gated ion-channel), Score=202.3, E-value=1.5e-58, N=3 |
| 31 |
acr-5 |
NM_066036 |
K03F8.2 |
5.6e-16 |
24.31 |
chrIII 6,512,795 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'receptor activity' 'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
acr-5 encodes a predicted member of the alpha subunit family of nicotinic acetylcholine receptors that is expressed in the nervous system. |
| 32 |
acr-15 |
NM_072805 |
F25G6.4 |
1.6e-15 |
24.07 |
chrV 8,556,628 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
A homolog of an alpha type nicotinic acetylcholine receptor subunit involved in the mediation of fast synaptic transmission at neuromuscular junctions. |
| 33 |
acr-11 |
NM_059505 |
D2092.3 |
2.1e-15 |
25.31 |
chrI 6,631,353 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
A homolog of an alpha type nicotinic acetylcholine receptor subunit involved in the mediation of fast synaptic transmission at neuromuscular junctions. |
| 34 |
acr-16 |
NM_072806 |
F25G6.3a |
1.8e-14 |
24.19 |
chrV 8,565,266 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'receptor activity' 'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
acr-16 encodes an alpha-7-like homomer-forming subunit of the nicotinic acetylcholine receptor (nAChR) superfamily orthologous to human nicotinic cholinergic receptor alpha 7 (CHRNA7; OMIM:118511; possibly associated with schizophrenia and juvenile myoclonic epilepsy); ACR-16 functions as a ligand-gated ion channel that likely regulates fast action of acetylcholine at neuromuscular junctions and in the nervous system; ACR-16 is active as a homomeric receptor, and is expressed in distal and proximal intestinal cells. |
| 35 |
F21A3.7 |
NM_074460 |
F21A3.7 |
1.8e-14 |
25.21 |
chrV 15,517,846 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
Weak similarity to N-terminus of acetylcholine receptor proteins |
| 36 |
acr-3 |
NM_076728 |
K11G12.7 |
2e-13 |
22.22 |
chrX 6,701,720 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'receptor activity' 'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
acr-3 encodes a non-alpha subunit of the nicotinic acetylcholine receptor (nAChR) superfamily; ACR-3 functions as a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with UNC-38, an nAChR alpha subunit, the resulting hetero-oligomer can form levamisole-gated channels; ACR-3 is a member of the UNC-29-like group of nAChR subunits. |
| 37 |
R13A5.4 |
NM_066255 |
R13A5.4 |
2.6e-13 |
23.23 |
chrIII 7,563,267 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
ACHR |
| 38 |
lev-1 |
NM_070133 |
F09E8.7 |
7.6e-13 |
24.07 |
chrIV 13,176,685 |
n/a |
n/a |
lev-1 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR) which, when mutated, confers resistance to levamisole; LEV-1 is required for completely normal locomotion, and forms a cation channel when coexpressed with UNC-38 or UNC-63 and UNC-29; LEV-1 falls into the 'UNC-29' class of nAChR subunits, which includes UNC-29, ACR-2, and ACR-3. |
| 39 |
unc-29 |
NM_059998 |
T08G11.5 |
9.9e-13 |
22.59 |
chrI 8,907,647 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'receptor activity' 'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
unc-29 encodes an non-alpha subunit of the nicotinic acetylcholine receptor (nAChR) superfamily; UNC-29 is required for normal locomotion and egg-laying, and functions as a subunit of a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with LEV-1, a non-alpha nAChR subunit, and UNC-38 or UNC-63, alpha AChR subunits, the resulting multimer can form levamisole-gated channels; UNC-29 is expressed in body wall muscle. |
| 40 |
T21F2.1a |
NM_171812 |
T21F2.1a |
9.9e-13 |
23.83 |
chrX 16,702,212 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'membrane' 'neurotransmitter receptor activity' |
ligand-gated ionic channel |
| 41 |
eat-2 |
NM_064558 |
Y48B6A.4 |
1.7e-12 |
22.73 |
chrII 14,169,069 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'membrane' 'neurotransmitter receptor activity' |
eat-2 encodes a beta subunit of the nicotinic acetylcholine receptor (nAChR) superfamily which encode ligand-gated ion channels that regulate fast action of acetylcholine at neuromuscular junctions and in the nervous system; EAT-2 regulates the rate of pharyngeal pumping by by affecting MC pharyngeal neuron transmission, and is required for neurotransmission from the MC pharyngeal neuron to pharyngeal muscle, in which it is expressed, and also affects life span and defecation; eat-2 genetically interacts with eat-18, which encodes a predicted transcriptional activator also expressed in pharyngeal muscle. |
| 42 |
unc-63 |
NM_059132 |
Y110A7A.3 |
8.4e-12 |
21.48 |
chrI 5,145,400 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'receptor activity' 'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
unc-63 encodes an alpha subunit of the nicotinic acetylcholine receptor (nAChR) superfamily; UNC-63 is required for normal locomotion, and functions as a subunit of a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with UNC-29 and LEV-1, non-alpha nAChR subunits, the resulting multimer can form levamisole-gated channels; UNC-63 is expressed in body wall muscle and in a large number of neurons; UNC-63 is a member of the UNC-38-like group of nAChR subunits. |
| 43 |
unc-49 |
NM_066920 |
T21C12.1a |
1.4e-11 |
22.3 |
chrIII 10,526,590 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
unc-49 - a member of the gene class UNCoordinated |
| 44 |
T20B12.9 |
NM_066236 |
T20B12.9 |
1.9e-11 |
22.66 |
chrIII 7,393,439 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'receptor activity' 'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
contains similarity to Pfam domains PF02931 (Neurotransmitter-gated ion-channel ligand binding domain), PF02932 (Neurotransmitter-gated ion-channel transmembrane region) |
| 45 |
unc-38 |
NM_059071 |
F21F3.5 |
2.4e-11 |
22.26 |
chrI 4,899,296 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'receptor activity' 'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
unc-38 encodes an alpha subunit of the nicotinic acetylcholine receptor (nAChR) superfamily; UNC-38 is required for normal locomotion and egg-laying, and functions as a subunit of a ligand-gated ion channel that likely mediates fast actions of acetylcholine at neuromuscular junctions and in the nervous system; when coexpressed with UNC-29 and LEV-1, non-alpha nAChR subunits, the resulting multimer can form levamisole-gated channels. |
| 46 |
Y71D11A.5 |
NM_064937 |
Y71D11A.5 |
1.2e-10 |
23.48 |
chrIII 1,130,754 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
ion channel protein |
| 47 |
mod-1 |
NM_171495 |
K06C4.6a |
1.6e-10 |
20.31 |
chrV 8,914,550 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' 'extrachromosomal DNA' |
mod-1 - a member of the gene class Modulation Of locomotion Defective |
| 48 |
T19B10.10 |
NM_073457 |
T19B10.10 |
3.5e-10 |
22.22 |
chrV 11,257,756 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'rhodopsin-like receptor activity' 'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'G-protein coupled receptor protein signaling pathway' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
GABA receptor like |
| 49 |
T15B7.16 |
NM_072340 |
T15B7.16 |
4.6e-10 |
20.23 |
chrV 6,844,339 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
ligand-gated ionic channel protein |
| 50 |
acr-12 |
NM_077861 |
R01E6.4 |
4.6e-10 |
22.31 |
chrX 13,525,179 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'receptor activity' 'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
an ortholog of nicotinic acetylcholine receptor (nAChR). |
| 51 |
ggr-3 |
NM_062550 |
F09C12.1 |
1.3e-09 |
21.3 |
chrII 5,131,698 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'membrane' 'neurotransmitter receptor activity' |
ggr-3 - a member of the gene class GABA/Glycine Receptor family (see gbr) |
| 52 |
acr-14 |
NM_063315 |
T05C12.2 |
3e-09 |
23.79 |
chrII 8,175,982 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
acr-14 encodes a protein that contains neurotransmitter-gated ion-channel ligand-binding and transmembrane domains. |
| 53 |
gab-1 |
NM_067260 |
ZC482.1 |
5.1e-09 |
21.6 |
chrIII 12,775,681 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'membrane' 'neurotransmitter receptor activity' |
gab-1 - a member of the gene class GABa receptor subunit |
| 54 |
acr-13 |
NM_077531 |
C35C5.5 |
8.7e-09 |
22.1 |
chrX 11,552,761 |
n/a |
n/a |
acr-13 encodes an alpha subunit of nicotinic acetylcholine receptor (nAChR); ACR-13 falls into the 'ACR-8' class of nAChR subunits, which includes ACR-8 and ACR-12. |
| 55 |
Y46G5A.26 |
NM_064330 |
Y46G5A.26 |
8.7e-09 |
22.45 |
chrII 12,838,989 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'membrane' 'neurotransmitter receptor activity' |
contains similarity to Pfam domain: PF00065 (Neurotransmitter-gated ion-channel), Score=128.6, E-value=3.7e-37, N=2 |
| 56 |
F47A4.1b |
NM_171756 |
F47A4.1b |
1.1e-08 |
20.99 |
chrX 9,794,990 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'membrane' 'neurotransmitter receptor activity' |
ligand gated ion channel |
| 57 |
glc-3 |
NM_072040 |
ZC317.3 |
5.6e-08 |
24.51 |
chrV 5,451,240 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
The glc-3 gene encodes a fipronil and BIDN-sensitive, but picrotoxinin-insensitive, L-glutamate-gated chloride channel subunit. |
| 58 |
glc-4 |
NM_063088 |
C27H5.8 |
7.3e-08 |
21.95 |
chrII 7,173,523 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'membrane' 'neurotransmitter receptor activity' |
glc-4 - a member of the gene class Glutamate-gated ChLoride channel |
| 59 |
F11H8.2 |
NM_066131 |
F11H8.2 |
1.2e-07 |
22.34 |
chrIII 7,014,252 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
gamma-aminobutyric acid receptor |
| 60 |
glc-2 |
NM_059069 |
F25F8.2 |
1.6e-07 |
21.85 |
chrI 4,886,565 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
glc-2 - a member of the gene class Glutamate-gated ChLoride channel |
| 61 |
avr-15 |
NM_073948 |
R11G10.1a |
2.8e-07 |
21.74 |
chrV 13,507,880 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'ion channel activity' 'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'synaptic transmission' 'membrane' 'integral to membrane' 'neurotransmitter receptor activity' |
avr-15 encodes, via alternative splicing, two glutamate-gated chloride channel subunit homologs; these proteins mediate fast inhibitory glutamatergic neuromuscular transmission, as well as ivermectin sensitivity, and are required for normal pharyngeal function. |
| 62 |
T27E9.9 |
NM_067388 |
T27E9.9 |
6.2e-07 |
20.4 |
chrIII 13,482,077 |
'Neurotransmitter-gated ion-channel ligand binding domain' 'Neurotransmitter-gated ion-channel transmembrane region' |
'extracellular ligand-gated ion channel activity' 'transport' 'ion transport' 'membrane' 'neurotransmitter receptor activity' |
ligand-gated ion channel |