UW Publications



Holly, M. K. and J. G. Smith.  Adenovirus infection of human enteroids reveals interferon sensitivity and preferential infection of goblet cells.  J Virol Epub. Feb 21.  PMID:29467318.


Holly, M. K., K. Diaz, and J. G. Smith.  Defensins in Viral Infection and Pathogenesis.  Annual Review of Virology 4(1):369-391. PMID:28715972.

Wilson, S. S., B. A. Bromme, M. K. Holly, M. E. Wiens, A. P. Gounder, Y. Sul, and J. G. Smith. Alpha-defensin-dependent enhancement of enteric viral infection. PLoS Pathog 13(6):e1006446. PMCID:5489213.

Wiens ME, Smith JG. alpha-Defensin HD5 Inhibits Human Papillomavirus 16 Infection via Capsid Stabilization and Redirection to the Lysosome. MBio 8:e02304-16. PMCID: 5263252.


Wilson SS, Wiens ME, Holly MK, Smith JG. Defensins at the Mucosal Surface: Latest Insights into Defensin-Virus Interactions. J Virol 90:5216-5218. PMCID: 4934752.

Smith JG. Directed Evolution of Adenoviruses. Methods Mol Biol 1382:187-196. PMID:26611587.

Gounder, A. P., N. D. Myers, P. M. Treuting, B. A. Bromme, S. S. Wilson, M. E. Wiens, W. Lu, A. J. Ouellette, K. R. Spindler, W. C. Parks, and J. G. Smith. Defensins Potentiate a Neutralizing Antibody Response to Enteric Viral Infection. PLoS Pathog 12: e1005474. PMCID:4774934.


Wiens, M. E., and J. G. Smith. Alpha-defensin HD5 inhibits furin cleavage of human papillomavirus 16 L2 to block infection. J Virol 89:2866-2874 PMCID:4325740.

Wilson, S. S., A. Tocchi, M. K. Holly, W. C. Parks, and J. G. Smith. A small intestinal organoid model of non-invasive enteric pathogen-epithelial cell interactions. Mucosal Immunol 8:352-361 PMCID:4326599.


Tenge, V. R., A. P. Gounder, M. E. Wiens, W. Lu, and J. G. Smith. Delineation of interfaces on human alpha-defensins critical for human adenovirus and human papillomavirus inhibition. PLoS Pathog 10(9):e1004360 PMCID:4154873.

Wiens, M. E., S. S. Wilson, C. M. Lucero, and J. G. Smith. Defensins and viral infection: Dispelling common misconceptions. PLoS Pathog 10(7):e1004186 PMCID:4102581.


Wilson, S. S., M. E. Wiens, and J. G. Smith. Antiviral mechanisms of human defensins. J Mol Biol 425(24):4965-80 PMCID:3842434.

Myers, N. D., K. V. Skorohodova, A. P. Gounder, and J. G. Smith. Directed evolution of mutator adenoviruses resistant to antibody neutralization. J Virol 87:6047-6050 PMCID:3648140.

Flatt, J. W., R. Kim, J. G. Smith, G. R. Nemerow, and P. L. Stewart. An intrinsically disordered region of the adenovirus capsid is implicated in neutralization by human alpha defensin 5. PLoS One 8:e61571 PMCID:3631211.


Gounder, A. P., M. E. Wiens, S. S. Wilson, W. Lu, and J. G. Smith. Critical determinants of human alpha-defensin 5 activity against non-enveloped viruses. J Biol Chem 287:24554-24562 PMCID:3397880.


Moyer, C. L., C. M. Wiethoff, O. Maier, J. G. Smith, and G. R. Nemerow. Functional genetic and biophysical analyses of membrane disruption by human adenovirus. J Virol 85:2631-2641 PMCID:3067937.

Smith, J. G., C. M. Wiethoff, P. L. Stewart, and G. R. Nemerow. 2010. Adenovirus. Curr Top Microbiol Immunol 343:195-224 PMCID:3093298.

Smith, J. G., M. Silvestry, S. Lindert, W. Lu, G. R. Nemerow, and P. L. Stewart. 2010. Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization. PLoS Pathog 6:e1000959 PMCID:2891831.

Nguyen, E. K., G. R. Nemerow, and J. G. Smith. 2010. Direct evidence from single-cell analysis that human alpha-defensins block adenovirus uncoating to neutralize infection. J Virol 84:4041-4049 PMCID:2849482.

Silvestry, M., S. Lindert, J. G. Smith, O. Maier, C. M. Wiethoff, G. R. Nemerow, and P. L. Stewart. 2009. Cryo-electron microscopy structure of adenovirus type 2 temperature-sensitive mutant 1 reveals insight into the cell entry defect. J Virol 83:7375-7383 PMCID:2708647.

Smith, J. G., and G. R. Nemerow. 2008. Mechanism of adenovirus neutralization by human alpha-defensins. Cell host & microbe 3:11-19.

Smith, J. G., A. Cassany, L. Gerace, R. Ralston, and G. R. Nemerow. 2008. Neutralizing antibody blocks adenovirus infection by arresting microtubule-dependent cytoplasmic transport. J Virol 82:6492-6500 PMCID:2447115.

Smith, J. G., and J. M. Cunningham. 2007. Receptor-Induced Thiolate Couples Env Activation to Retrovirus Fusion and Infection. PLoS Pathog 3:e198 PMCID:2151085.

Smith, J. G., W. Mothes, S. C. Blacklow, and J. M. Cunningham. 2004. The mature avian leukosis virus subgroup A envelope glycoprotein is metastable, and refolding induced by the synergistic effects of receptor binding and low pH is coupled to infection. J Virol 78:1403-1410 PMCID:321377.

Smith, J. G., and S. L. Eck. 1999. Molecular characterization of an adenoviral vector resulting from both homologous and nonhomologous recombination. Cancer Gene Ther 6:475-481.

Smith, J. G., and S. L. Eck. 1998. Immune Response to Viral Vectors, p. 147-157. In E. A. Chiocca and X. O. Breakefield (ed.), Gene Therapy for Neurological Disorders and Brain Tumors. Humana Press, Totowa, NJ.

Boxhorn, H. K., J. G. Smith, Y. J. Chang, D. Guerry, W. M. Lee, U. Rodeck, L. A. Turka, and S. L. Eck. 1998. Adenoviral transduction of melanoma cells with B7-1: antitumor immunity and immunosuppressive factors. Cancer Immunol Immunother 46:283-292.

Smith, J. G., S. E. Raper, E. B. Wheeldon, D. Hackney, K. Judy, J. M. Wilson, and S. L. Eck. 1997. Intracranial administration of adenovirus expressing HSV-TK in combination with ganciclovir produces a dose-dependent, self-limiting inflammatory response. Hum Gene Ther 8:943-954.

Alavi, J. B., J. G. Smith, and S. L. Eck. 1997. Adenoviral gene therapy of central nervous system tumors, p. 219-235. In E. Wickstrom (ed.), Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors. Marcel Dekker, Inc., New York, NY.

Past Publications