UW Publications


Tenge, V. R., A. P. Gounder, M. E. Wiens, W. Lu, and J. G. Smith. 2014. Delineation of interfaces on human alpha-defensins critical for human adenovirus and human papillomavirus inhibition. PLoS Pathog.10(9):e1004360 PMCID:4154873.

Wiens, M. E., S. S. Wilson, C. M. Lucero, and J. G. Smith. 2014. Defensins and viral infection: Dispelling common misconceptions. PLoS Pathog.10(7):e1004186 PMCID:4102581.

Wilson, S. S., A. Tocchi, M. K. Holly, W. C. Parks, and J. G. Smith. 2014. A small intestinal organoid model of non-invasive enteric pathogen-epithelial cell interactions. Mucosal Immunol, in press. PMCID:Journal - In Process.

Wilson, S. S., M. E. Wiens, and J. G. Smith. 2013. Antiviral mechanisms of human defensins. J Mol Biol 425(24):4965-80 PMCID:3842434.

Myers, N. D., K. V. Skorohodova, A. P. Gounder, and J. G. Smith. 2013. Directed evolution of mutator adenoviruses resistant to antibody neutralization. J Virol 87:6047-6050.

Flatt, J. W., R. Kim, J. G. Smith, G. R. Nemerow, and P. L. Stewart. 2013. An intrinsically disordered region of the adenovirus capsid is implicated in neutralization by human alpha defensin 5. PLoS One 8:e61571.

Gounder, A. P., M. E. Wiens, S. S. Wilson, W. Lu, and J. G. Smith. 2012. Critical determinants of human alpha-defensin 5 activity against non-enveloped viruses. J Biol Chem 287:24554-24562

Moyer, C. L., C. M. Wiethoff, O. Maier, J. G. Smith, and G. R. Nemerow. 2011. Functional genetic and biophysical analyses of membrane disruption by human adenovirus. J Virol 85:2631-2641.

Smith, J. G., C. M. Wiethoff, P. L. Stewart, and G. R. Nemerow. 2010. Adenovirus. Curr Top Microbiol Immunol 343:195-224.

Smith, J. G., M. Silvestry, S. Lindert, W. Lu, G. R. Nemerow, and P. L. Stewart. 2010. Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization. PLoS Pathog 6:e1000959.

Nguyen, E. K., G. R. Nemerow, and J. G. Smith. 2010. Direct evidence from single-cell analysis that human alpha-defensins block adenovirus uncoating to neutralize infection. J Virol 84:4041-4049.

Silvestry, M., S. Lindert, J. G. Smith, O. Maier, C. M. Wiethoff, G. R. Nemerow, and P. L. Stewart. 2009. Cryo-electron microscopy structure of adenovirus type 2 temperature-sensitive mutant 1 reveals insight into the cell entry defect. J Virol 83:7375-7383.

Smith, J. G., and G. R. Nemerow. 2008. Mechanism of adenovirus neutralization by human alpha-defensins. Cell host & microbe 3:11-19.

Smith, J. G., A. Cassany, L. Gerace, R. Ralston, and G. R. Nemerow. 2008. Neutralizing antibody blocks adenovirus infection by arresting microtubule-dependent cytoplasmic transport. J Virol 82:6492-6500.

Smith, J. G., and J. M. Cunningham. 2007. Receptor-Induced Thiolate Couples Env Activation to Retrovirus Fusion and Infection. PLoS Pathogens 3:e198.

Smith, J. G., W. Mothes, S. C. Blacklow, and J. M. Cunningham. 2004. The mature avian leukosis virus subgroup A envelope glycoprotein is metastable, and refolding induced by the synergistic effects of receptor binding and low pH is coupled to infection. J Virol 78:1403-1410.

Smith, J. G., and S. L. Eck. 1999. Molecular characterization of an adenoviral vector resulting from both homologous and nonhomologous recombination. Cancer Gene Ther 6:475-481.

Smith, J. G., and S. L. Eck. 1998. Immune Response to Viral Vectors, p. 147-157. In E. A. Chiocca and X. O. Breakefield (ed.), Gene Therapy for Neurological Disorders and Brain Tumors. Humana Press, Totowa, NJ.

Boxhorn, H. K., J. G. Smith, Y. J. Chang, D. Guerry, W. M. Lee, U. Rodeck, L. A. Turka, and S. L. Eck. 1998. Adenoviral transduction of melanoma cells with B7-1: antitumor immunity and immunosuppressive factors. Cancer Immunol Immunother 46:283-292.

Smith, J. G., S. E. Raper, E. B. Wheeldon, D. Hackney, K. Judy, J. M. Wilson, and S. L. Eck. 1997. Intracranial administration of adenovirus expressing HSV-TK in combination with ganciclovir produces a dose-dependent, self-limiting inflammatory response. Hum Gene Ther 8:943-954.

Alavi, J. B., J. G. Smith, and S. L. Eck. 1997. Adenoviral gene therapy of central nervous system tumors, p. 219-235. In E. Wickstrom (ed.), Clinical Trials of Genetic Therapy with Antisense DNA and DNA Vectors. Marcel Dekker, Inc., New York, NY.

Past Publications