2021

Bastounis EE, Serrano-Alcalde F, Radhakrishnan P, Engstrom P, Gomez-Benito MJ, Oswald MS, Yeh YT, Smith JG, Welch MD, Garcia-Aznar JM, Theriot JA. Mechanical competition triggered by innate immune signaling drives the collective extrusion of bacterially infected epithelial cells. Dev Cell. 2021;56(4):443-60 e11 PMCID:PMC7982222.

Hu CT, Diaz K, Yang LC, Sharma A, Greenberg HB, Smith JG. VP4 Is a Determinant of Alpha-Defensin Modulation of Rotaviral Infection. J Virol. 2022 Apr 13;96(7):e0205321. doi: 10.1128/jvi.02053-21. Epub 2022 Mar 14. PMID: 35285683; PMCID: PMC9006894.

2020

Diaz K, Hu CT, Sul Y, Bromme BA, Myers ND, Skorohodova KV, Gounder AP, Smith JG. Defensin-driven viral evolution. PLoS Pathog. 2020;16(11):e1009018. PubMed PMID: 33232373; PubMed Central PMCID:PMC7723274.

Holly MK, Han X, Zhao EJ, Crowley SM, Allaire JM, Knodler LA, Vallance BA, Smith JG. Salmonella enterica Infection of Murine and Human Enteroid-Derived Monolayers Elicits Differential Activation of Epithelium-Intrinsic Inflammasomes. Infect Immun. 2020 Jun 22;88(7). doi: 10.1128/IAI.00017-20. Print 2020 Jun 22. PubMed PMID: 32284374.

Vogt D, Zaver S, Ranjan A, DiMaio T, Gounder AP, Smith JG, Lagunoff M. STING is dispensable during KSHV infection of primary endothelial cells. Virology. 2020 Jan 15;540:150-159. doi: 10.1016/j.virol.2019.11.012. Epub 2019 Nov 25. PubMed PMID: 31928996; PubMed Central PMCID: PMC6961814.

2019

Smith, J. G. and G. R. Nemerow.  Complement Seals a Virus to Block Infection.  Cell Host Microbe. Apr 10;25(4):482-483. doi: 10.1016/j.chom.2019.03.010. PubMed PMID: 30974082.

Gulati NM, Miyagi M, Wiens ME, Smith JG, Stewart PL. α-Defensin HD5 Stabilizes Human Papillomavirus 16 Capsid/Core Interactions. Pathog Immun. 2019;4(2):196-234. doi: 10.20411/pai.v4i2.314. eCollection 2019. PubMed PMID: 31583330; PubMed Central PMCID: PMC6755940.

2018

Holly, M. K. and J. G. Smith.  Adenovirus infection of human enteroids reveals interferon sensitivity and preferential infection of goblet cells.  J Virol 92(9). PMCID:PMC5899204.

Seamons, A., P. M. Treuting, S. Meeker, C. Hsu, J. Paik, T. Brabb, S. S. Escobar, J. S. Alexander, A. Ericsson,  J. G. Smith, and L. Maggio-Price. Obstructive Lymphangitis Precedes Colitis in Murine Norovirus-Infected Stat1-Deficient Mice. Am J Pathol. 188(7):1536-54 PMCID:PMC6109697.

Holly, M. K. and J. G. Smith. Paneth Cells during Viral Infection and Pathogenesis. Viruses 10(5). PMCID:PMC5977218

Singh, A.K., Nguyen T.H., Vidovszky M.Z., Harrach B., Benko M., Kirwan A., Joshi L., Kilcoyne M., Berbis M.A., Canada F.J., Jimenez-Barbero J., Menendez M., Wilson S.S., Bromme B.A., Smith J.G., van Raaij M.J. Structure and n-acetylglucosamine binding of the distal domain of mouse adenovirus 2 fibre. J Gen Virol. 2018;99(11):1494-508 PMCID:PMC6537619.

2017

Holly, M. K., K. Diaz, and J. G. Smith.  Defensins in Viral Infection and Pathogenesis.  Annual Review of Virology 4(1):369-391. PMID:28715972.

Wilson, S. S., B. A. Bromme, M. K. Holly, M. E. Wiens, A. P. Gounder, Y. Sul, and J. G. Smith. Alpha-defensin-dependent enhancement of enteric viral infection. PLoS Pathog 13(6):e1006446. PMCID:PMC5489213.

Wiens, M. E. and J. G. Smith. alpha-Defensin HD5 Inhibits Human Papillomavirus 16 Infection via Capsid Stabilization and Redirection to the Lysosome. MBio 8:e02304-16. PMCID: PMC5263252.

2016

Wilson, S. S., M. E. Wiens, M. K. Holly, J. G. Smith. Defensins at the Mucosal Surface: Latest Insights into Defensin-Virus Interactions. J Virol 90:5216-5218. PMCID: PMC4934752.

Smith, J. G. Directed Evolution of Adenoviruses. Methods Mol Biol 1382:187-196. PMID:26611587.

Gounder, A. P., N. D. Myers, P. M. Treuting, B. A. Bromme, S. S. Wilson, M. E. Wiens, W. Lu, A. J. Ouellette, K. R. Spindler, W. C. Parks, and J. G. Smith. Defensins Potentiate a Neutralizing Antibody Response to Enteric Viral Infection. PLoS Pathog 12: e1005474. PMCID:PMC4774934.

2015

Wiens, M. E., and J. G. Smith. Alpha-defensin HD5 inhibits furin cleavage of human papillomavirus 16 L2 to block infection. J Virol 89:2866-2874 PMCID:PMC4325740.

Wilson, S. S., A. Tocchi, M. K. Holly, W. C. Parks, and J. G. Smith. A small intestinal organoid model of non-invasive enteric pathogen-epithelial cell interactions. Mucosal Immunol 8:352-361 PMCID:PMC4326599.

2014

Tenge, V. R., A. P. Gounder, M. E. Wiens, W. Lu, and J. G. Smith. Delineation of interfaces on human alpha-defensins critical for human adenovirus and human papillomavirus inhibition. PLoS Pathog 10(9):e1004360 PMCID:PMC4154873.

Wiens, M. E., S. S. Wilson, C. M. Lucero, and J. G. Smith. Defensins and viral infection: Dispelling common misconceptions. PLoS Pathog 10(7):e1004186 PMCID:PMC4102581.

2013

Wilson, S. S., M. E. Wiens, and J. G. Smith. Antiviral mechanisms of human defensins. J Mol Biol 425(24):4965-80 PMCID:PMC3842434.

Myers, N. D., K. V. Skorohodova, A. P. Gounder, and J. G. Smith. Directed evolution of mutator adenoviruses resistant to antibody neutralization. J Virol 87:6047-6050 PMCID:PMC3648140.

Flatt, J. W., R. Kim, J. G. Smith, G. R. Nemerow, and P. L. Stewart. An intrinsically disordered region of the adenovirus capsid is implicated in neutralization by human alpha defensin 5. PLoS One 8:e61571 PMCID:PMC3631211.

2012

Gounder, A. P., M. E. Wiens, S. S. Wilson, W. Lu, and J. G. Smith. Critical determinants of human alpha-defensin 5 activity against non-enveloped viruses. J Biol Chem 287:24554-24562 PMCID:PMC3397880.

2011

Moyer, C. L., C. M. Wiethoff, O. Maier, J. G. Smith, and G. R. Nemerow. Functional genetic and biophysical analyses of membrane disruption by human adenovirus. J Virol 85:2631-2641 PMCID:PMC3067937.

Smith, J. G., C. M. Wiethoff, P. L. Stewart, and G. R. Nemerow. 2010. Adenovirus. Curr Top Microbiol Immunol 343:195-224 PMCID:3093298.

Smith, J. G., M. Silvestry, S. Lindert, W. Lu, G. R. Nemerow, and P. L. Stewart. 2010. Insight into the mechanisms of adenovirus capsid disassembly from studies of defensin neutralization. PLoS Pathog 6:e1000959 PMCID:2891831.

Nguyen, E. K., G. R. Nemerow, and J. G. Smith. 2010. Direct evidence from single-cell analysis that human alpha-defensins block adenovirus uncoating to neutralize infection. J Virol 84:4041-4049 PMCID:2849482.

Silvestry, M., S. Lindert, J. G. Smith, O. Maier, C. M. Wiethoff, G. R. Nemerow, and P. L. Stewart. 2009. Cryo-electron microscopy structure of adenovirus type 2 temperature-sensitive mutant 1 reveals insight into the cell entry defect. J Virol 83:7375-7383 PMCID:2708647.

Smith, J. G., and G. R. Nemerow. 2008. Mechanism of adenovirus neutralization by human alpha-defensins. Cell host & microbe 3:11-19.

Smith, J. G., A. Cassany, L. Gerace, R. Ralston, and G. R. Nemerow. 2008. Neutralizing antibody blocks adenovirus infection by arresting microtubule-dependent cytoplasmic transport. J Virol 82:6492-6500 PMCID:2447115.

Smith, J. G., and J. M. Cunningham. 2007. Receptor-Induced Thiolate Couples Env Activation to Retrovirus Fusion and Infection. PLoS Pathog 3:e198 PMCID:2151085.

Smith, J. G., W. Mothes, S. C. Blacklow, and J. M. Cunningham. 2004. The mature avian leukosis virus subgroup A envelope glycoprotein is metastable, and refolding induced by the synergistic effects of receptor binding and low pH is coupled to infection. J Virol 78:1403-1410 PMCID:321377.