The viability and function of neurons rely on proper control of metabolic energy. Our primary aim now is to understand how metabolic energy is produced and distributed in photoreceptors. We are investigating the molecular mechansisms by which these neurons respond to the changing temporal and spatial energy demands of darkness and light.
- A G-protein (transducin) plays a central role in phototransduction.
- A phosphodiesterase that mediates phototransduction is regulated by an inhibitor subunit and transducin.
- Rods and cones use different proteins for phototransduction.
- Membrane guanylyl cyclases and calcium-sensitive regulatory proteins control cyclic GMP synthesis for phototransduction.
- Rhodopsin is phosphorylated differentially at specific sites in vivo.
- Zebrafish is a powerful genetic tool for vision research.
The Best Hurley/Brockerhoff Lab Meeting Ever took place on May 3, 2013 at our new lab location. Some of the participants, are shown below. Huge thanks go to Jason Chen for organizing this (and thanks to Max Sokolov for the photo).