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Latest publications: HIV Gag-Leucine zipper chimeras form ABCE1-containing intermediates and RNAse-resistant immature capsids similar to those formed by wild-type HIV-1 Gag. APOBEC3 proteins expressed in mammary epithelial cells are packaged into retroviruses and can restrict transmission of milk-borne virions. Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms. Beth K.Thielen, John P. McNevin, M. Juliana McElrath, Brook Vander Stoep Hunt, Kevin C. Klein, and Jaisri R. Lingappa. Journal of Biological Chemistry 285(36): 27753-27766, 2010.[Download] Assembly of immature HIV-1 capsids using a cell-free system. Jaisri R. Lingappa and Beth K. Thielen. Methods in Molecular Biology 489: 185-95, 2009. PMCID2678559 [Download]
Overview: The Lingappa lab studies the biochemistry and cell biology of viral-host interactions. Current areas of interest include 1) understanding viral-host interactions critical for HIV-1 capsid assembly; 2) investigating restrictions to HIV infection in primary cells; 3) using cell-free systems to understand assembly of a variety of different viruses including primate lentiviruses, hepatitis C virus, and alphaviruses; and 4) identifying targets of novel antiviral drugs. For more information on current projects, see our research page.
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