University of Washington
Department of Global Health

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 Lingappa Lab

 1616 Eastlake Ave E

 Suite 305

 Seattle, WA

 98102

 

 

 

 

 

 

 

 

 

 

 

 

 

Latest publications (open access):

 

 

Intracellular Destinies: Degradation, Targeting, Assembly, and Endocytosis of HIV Gag.
Kevin C. Klein, Jonathan C. Reed, Jaisri R. Lingappa
AIDS Rev. 2007 Jul-Sep;9(3):150-61
[Download]

 

 

Host ABCE1 is at Plasma Membrane HIV Assembly Sites and Its Dissociation from Gag is Linked to Subsequent Events of Virus Production.
Julia E. Dooher, Bobbie L. Schneider, Jonathan C. Reed, Jaisri R. Lingappa
Traffic. 2007 Mar; 8(3):195-211
[Download]

 

 

Overview:

The Lingappa lab studies the biochemistry and cell biology of viral-host interactions. Current areas of interest include 1) understanding viral-host interactions critical for HIV-1 capsid assembly; 2) determining how T cells regulate activity of Apobec 3G, an antiviral cellular protein; and 3) using cell-free systems to understand assembly of a variety of different viruses including primate lentiviruses, hepatitis C virus, and alphaviruses. For more information on current projects, see our research page.