Publications 1990-Present

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  1. H.G. Floss, T. Frenzel, D.R. Houck, L.-D. Yuen, P. Zhou, L.D. Zydowsky and J.M. Beale "Stereochemistry of One-Carbon Metabolism in Aerobes and Anaerobes", in "Molecular Mechanisms in Bioorganic Processes", C. Bleasdale, B.T. Golding, Ed., Royal Soc. Chem., Cambridge, UK, 1990, pp. 26-48.

  2. P.J. Oths, R.M. Mayer and H.G. Floss "Stereochemistry and Mechanism of the GDP-mannose 4,6-Dehydratase Reaction", Carbohydr. Res. 198, 91 (1990).

  3. H.G. Floss, J.M. Beale, D.C. Dosch, T. Frenzel, D.R. Houck, J.J. Lee, Y. Li, T. Kamigauchi, U. Mocek, D. O'Hagan, R. Tsuchiya, R. Woodman, L.-D. Yuen, Z. Zeng, P. Zhou and W.R. Strohl "Biosynthesis of Natural Products - Nosiheptide and Thiostrepton", in "Recent Advances in Biochemistry", S.M. Byun, S.Y. Lee, C.H. Yang, eds., Biochem. Soc. of the Republ. of Korea, Seoul, 1991, pp. 465-474.

  4. F.A.L. Anet, D. O'Leary, J.M. Beale and H.G. Floss "Stereogenic (Chiral) Methyl Groups: Determination of Configuration by Direct Tritium Nuclear Magnetic Resonance Spectroscopy", J. Amer. Chem. Soc. 111, 8935 (1989).

  5. R. Thiericke, A. Zeeck, A. Nakagawa, S. Omura, R.E. Herrold, S.T.S. Wu, J.M. Beale and H.G. Floss "The Biosynthesis of the Manumycin Group Antibiotics", J. Amer. Chem. Soc. 112, 3979 (1990).

  6. T. Frenzel, P. Zhou and H.G. Floss "Formation of 2-Methyltryptophan in the Biosynthesis of Thiostrepton. Isolation of S-Adenosylmethionine: Tryptophan 2-Methyltransferase", Arch. Biochem. Biophys. 278, 35 (1990).

  7. Y. Li, D.C. Dosch, W.R. Strohl and H.G. Floss "Nucleotide Sequence and Transcriptional Analysis of the Nosiheptide Resistance Gene from Streptomyces actuosus", Gene 91, 9 (1990).

  8. M.A. Vanoni, S. Lee, H.G. Floss and R.G. Matthews "The Stereochemistry of Reduction of Methylenetetrahydrofolate to Methyltetrahydrofolate Catalyzed by Pig Liver Methylenetetrahydrofolate Reductase" J. Amer. Chem. Soc. 112, 3987 (1990).

  9. H.-l. Zhang, X.-g. He, A. Adefarati, J. Gallucci, S.P. Cole, J.M. Beale, P.J. Keller, C.-j. Chang and H.G. Floss "Mutactin, a Novel Polyketide from Streptomyces coelicolor. Structure and Biosynthetic Relationship to Actinorhodin", J. Org. Chem. 55, 1682 (1990).

  10. P.L. Bartel, C.-B. Zhu, J.S. Lampel, D.C. Dosch, N.C. Connors, W.R. Strohl, J.M. Beale and H.G. Floss "Biosynthesis of Anthraquinones by Interspecies Cloning of Actinorhodin Biosynthesis Genes in Streptomycetes: Clarification of Actinorhodin Gene Function", J. Bacteriol. 172, 4816, 1990.

  11. D.K. Ho, J.C. Wu, D.V. Santi and H.G. Floss "Stereochemical Studies of the C-Methylation of Deoxycytidine Catalyzed by HhaI Methylase and the N-Methylation of Deoxyadenosine Catalyzed by EcoRI Methylase", Arch. Biochem. Biophys. 284, 264 (1991).

  12. Y. Li, D.C. Dosch, R.H. Woodman, H.G. Floss and W.R. Strohl "Transcriptional organization and regulation of the nosiheptide resistance gene in Streptomyces actuosus", J. Ind. Microbiol. 8, 1 (1991).

  13. D. Gröger, L. Gröger, D. D'Amico, M.-X. He and H.G. Floss "Steric Course of the N-Methylation in the Biosynthesis of Ergot Alkaloids by Claviceps purpurea", J. Basic Microbiol. 31, 121 (1991).

  14. K. Reynolds, J. Martin, S.-j. Shen, N. Esaki, K. Soda and H.G. Floss "Mechanistic Studies of Two Amino Acid Racemases of Broad Substrate Specificity from Pseudomonas striata and Aeromonas caviae", J. Basic Microbiol. 31, 177 (1991).

  15. P. Zhou, Y. Jiang, Z. Bao, Y. Cui and H.G. Floss "A Study on Mutagenesis of Streptomyces actuosus Which Produce Nosiheptide", Acta Acad. Med. (Shanghai) 18, 133 (1991).

  16. Y. Ahn, J.A. Krzycki and H.G. Floss "Steric Course of the Reduction of Ethyl-Coenzyme M to Ethane Catalyzed by Methyl Coenzyme M Reductase from Methanosarcina barkeri", J. Amer. Chem. Soc. 113, 4700 (1991).

  17. C.A. Steginsky, J.M. Beale, H.G. Floss and R.M. Mayer "The Structural Determination of Alginic Acid and the Effects of Calcium Binding as Determined by High-Field NMR", Carbohydr. Res. 225, 11 (1992).

  18. H.G. Floss and W.R. Strohl "Genetic Engineering of Hybrid Antibiotics - A Progress Report", Tetrahedron 47, 6045 (1991).

  19. H.G. Floss, H. Cho, K.A. Reynolds, E. Kennedy, B.S. Moore, J.M. Beale, U. Mocek and K. Poralla "Diversions of the Shikimate Pathway - The Biosynthesis of Cyclohexanecarboxylic Acid", in "Secondary Metabolite Biosynthesis and Metabolism", R.J. Petroski and S.P. McCormick, Eds., Environmental Science Research, Volume 44, Plenum Press, New York, N.Y., pp. 77-88 (1992).

  20. J.Boyce-Korkis and H.G. Floss "Biosynthesis of Ergot Alkaloids: Some New Results on an Old Problem", Priklad. Biokhim. Mikrobiol. (USSR) 28, 844 (1992).

  21. K.A. Reynolds and H.G. Floss "Stereochemical Aspects of Natural Product Biosyntheses", in "Studies in Natural Products Chemistry", Vol. II, "Stereoselective Synthesis (Part G), Atta-ur-Rahman, Ed.,. Elsevier, Amsterdam 1992, pp. 181-228.

  22. M.A. Vanoni, S. Lee, H. Floss and R.G. Matthews "Stereochemistry of reduction of methylenetetrahydrofolate to methyltetrahydrofolate catalyzed by mammalian methylenetetrahydrofolate reductase", in "Flavins and Flavoproteins", Curti, B., Ronchi, S., and Zanetti, G., Eds., DeGruyter, Berlin, 1991, pp. 815-818.

  23. K.A. Reynolds, P. Wang, K.M. Fox and H.G. Floss "Biosynthesis of Ansatrienin by Streptomyces collinus: Cell-free Transformations of Cyclohexene- and Cyclohexedienecarboxylic Acids", J. Antibiot. 45, 441 (1992).

  24. M.W. Thompson, W.R. Strohl and H.G. Floss "Purification and Characterization of TDP-D-Glucose 4,6-dehydratase from Anthracycline-producing Streptomycetes", J. Gen. Microbiol. 138, 779 (1992).

  25. J.T. Kealey, S. Lee,. H.G. Floss and D.V. Santi "Stereochemistry of methyl transfer catalyzed by tRNA (m5U54)methyltransferase - evidence for a single displacement mechanism", Nucleic Acids Res. 19, 6465 (1991).

  26. H. Cho, L. Heide and H.G. Floss "Synthesis of D-(-)-[1,7-13C2]Shikimic Acid", J. Labelled Comp. Radiopharm. 31, 589 (1992).

  27. P. Zhou, U. Mocek, B. Siesel and H.G. Floss "Biosynthesis of pyrrolnitrin. Incorporation of 13C,15N double-labelled D- and L-tryptophan", J. Basic Microbiol. 32, 209 (1992).

  28. W.R. Strohl and H.G. Floss "Thiostrepton and Related Antibiotics", in "Genetics and Biochemistry of Antibiotic Production", L.C. Vining and C. Stuttard, Eds., Butterworth/Heinemann, Stoneham, MA, 1995, pp. 223-238.

  29. C.-G. Kim, A. Kirschning, P. Bergon, Y. Ahn, J.J. Wang, M. Shibuya and H.G. Floss "Formation of 3-Amino-5-hydroxybenzoic Acid, the Precursor of mC7N Units in Ansamycin Antibiotics, by a New Variant of the Shikimate Pathway", J. Amer. Chem. Soc. 114, 4941 (1992).

  30. K.A. Reynolds, P. Wang, K.M. Fox, M.K. Speedie, Y. Lam and H.G. Floss "Purification and Characterization of a Novel Enoyl Coenzyme A Reductase from Streptomyces collinus", J. Bacteriol. 174, 3850 (1992).

  31. H.G. Floss "Sulfur as a Carrier of Methyl Groups in One-Carbon Metabolism - Stereochemical Studies" Phosphorus, Sulfur, and Silicon, 74, 59 (1993).

  32. N. Priestley, H.G. Floss, W. Froland, J.D. Lipscomb, P.G. Williams and H. Morimoto "Cryptic Stereospecificity of Methane Monooxygenase", J. Amer. Chem. Soc. 114, 7561 (1992).

  33. Y. Ahn, Q. Ye, H. Cho, C.T. Walsh and H.G. Floss "Stereochemistry of Carbon-Phosphorus Cleavage in Ethylphosphonate Catalyzed by C-P Lyase from E. coli", J. Amer. Chem. Soc. 114, 7863 (1992).

  34. H.G. Floss and S. Lee "Chiral Methyl Groups - Small is Beautiful", Accts. Chem. Res. 26, 116 (1993).

  35. P.E. Fleming, U. Mocek and H.G. Floss "Biosynthesis of Taxoids. Mode of Formation of the Taxol Side Chain", J. Amer. Chem. Soc. 115, 805 (1993).

  36. U. Mocek, J.M. Beale, T. Frenzel, D.R. Houck, D. O'Hagan, R. Tsuchiya, L.-D. Yuen, Z.-P. Zeng, P. Zhou and H.G. Floss "Amino acid modification in the biosynthesis of thiopeptide antibiotics", in "Frontiers and new horizons in amino acid research", K. Takai, Ed., Elsevier, 1992, pp. 77-89.

  37. A.P. Kozikowski, C. Chen, J.-P. Wu, M. Shibuya, C.-G. Kim and H.G. Floss "Probing Ergot Alkaloid Biosynthesis: Intermediates in the Formation of Ring C", J. Amer. Chem. Soc. 115, 2482 (1993).

  38. B.S. Moore, H. Cho, R. Casati, E. Kennedy, K.A. Reynolds, U. Mocek, J.M. Beale and H.G. Floss "Biosynthetic Studies on Ansatrienin A. Formation of the Cyclohexanecarboxylic Acid Moiety", J. Amer. Chem. Soc. 115, 5254 (1993).

  39. B.S. Moore, K. Poralla and H.G. Floss "Biosynthesis of the Cyclohexanecarboxylic Acid Starter Unit of w-Cyclohexyl Fatty Acids in Alicyclobacillus acidocaldarius", J. Amer. Chem. Soc. 115, 5267 (1993).

  40. U. Mocek, A.R. Knaggs, R. Tsuchiya, T. Nguyen, J.M. Beale and H.G. Floss "Biosynthesis of the Modified Peptide Antibiotic Nosiheptide in Streptomyces actuosus", J. Amer. Chem. Soc. 115, 7557 (1993).

  41. T.M. Smith, N.D. Priestley, A.R. Knaggs, T. Nguyen and H.G. Floss "3,4-Dimethylindole-2-carboxylate and 4-(1-Hydroxyethyl)-2-quinolinecarboxylate Activating Enzymes from the Nosiheptide and Thiostrepton Producers, Streptomyces actuosus and Streptomyces laurentii", J.Chem.Soc Chem. Commun. 1993,1612.

  42. U. Mocek, Z. Zeng, D. O'Hagan, P. Zhou, L.D.G. Fan, J.M. Beale and H.G. Floss "Biosynthesis of the Modified Peptide Antibiotic Thiostrepton in Streptomyces azureus and Streptomyces laurentii", J. Amer. Chem. Soc. 115, 7992 (1993).

  43. J.P. Lee, S.-W. Tsao, X.-G. He, C.-j. Chang and H.G. Floss "Biosynthesis of Naphthomycin A in Streptomyces collinus", Can. J. Chem. 72, 182 (1994).

  44. C.W. Van't Land, U. Mocek and H.G. Floss "Biosynthesis of the Phenazine Antibiotics, the Saphenamycins and Esmeraldins, in Streptomyces antibioticus", J. Org. Chem. 58, 6576 (1993).

  45. H. Cho, J.M. Beale, C. Graff, U. Mocek, A. Nakagawa, S. Omura and H.G. Floss "Studies on the Biosynthesis of the Antibiotic Reductiomycin in Streptomyces xanthochromogenus", J. Amer. Chem. Soc. 115, 12296 (1993).

  46. A. Kirschning, P. Bergon, J.J. Wang, S.A. Breazeale and H.G. Floss "Synthesis of 3,4-Dideoxy-4-amino-D-arabino-heptulosonic Acid 7-Phosphate, the Biosynthetic Precursor of C7N Units in Ansamycin Antibiotics", Carbohydr. Res. 256, 245 (1994).

  47. K.-H. Han, P. Fleming, K. Walker, M. Loper, W.S. Chilton, U. Mocek, M.P. Gordon and H.G. Floss "Genetic Transformation of Taxus as an Alternative System for Taxol Production", Plant Sci. 95, 187 (1994).

  48. H. Cho, I. Sattler, J.M. Beale, A. Zeeck and H.G. Floss "Some Aspects of the Stereochemistry and Biosynthesis of Asukamycin", J. Org. Chem. 58, 7925 (1993).

  49. B.S. Moore and H.G. Floss "Biosynthetic Studies on the Origin of the Cyclohexanecarboxylic Acid Moiety of Ansatrienin A and w-Cyclohexyl Fatty Acids", J. Nat. Prod. 57, 382 (1994).

  50. H. Bockholt, G. Udvarnoki, J. Rohr, U. Mocek, J. M. Beale and H. G. Floss "Biosynthetic Studies on the Xanthone Antibiotics Lysolipins X and I", J. Org. Chem. 59, 2064 (1994).

  51. P. E. Fleming, A. R. Knaggs, X.-G. He, U. Mocek and H. G. Floss "Biosynthesis of Taxoids. Mode of Attachment of the Taxol Side Chain", J. Amer. Chem. Soc. 116, 4137 (1994).

  52. U. Hanefeld, H. G. Floss and H. Laatsch "Biosynthesis of the Marine Antibiotic Pentabromopseudilin. 1. The Benzene Ring", J. Org. Chem. 59, 3604 (1994).

  53. X.-g. He, U. Mocek, H. G. Floss, A. Cáceres, L. Girón, H. Buckley, G. Cooney and B. W. Wilson "An Antifungal Compound from Solanum nigrescens" J. Ethnopharmacol. 43, 173 (1994).

  54. A. Bechthold and H. G. Floss "Overexpression of the thiostrepton resistance gene from Streptomyces azureus in Escherichia coli and characterization of recognition sites of the 23S rRNA A1067 2'-methyltransferase in the guanosine triphosphate center of 23S ribosomal RNA" Eur. J. Biochem. 224, 431 (1994).

  55. B. S. Axelsson, S. Lee, H. G. Floss, A. Saeed, P. A. Spencer and D. W. Young "Stereochemistry of Conversion of the Suicide Substrates D-b-Chloroalanine and D- and L-Serine-O-sulfates to Pyruvate by D-Amino Acid Aminotransferase and by L-Aspartate Aminotransferase" J. Chem. Soc. Perkin I 1994, 2137.

  56. H. G. Floss and U. Mocek "Biosynthesis of Taxol", in "Taxol: Science and Applications", M. Suffness, Ed., CRC Press, Boca Raton, FL, 1995, pp. 191-208.

  57. P. E. Fleming, H. G. Floss, M. Haertel, A. R. Knaggs, A. Lansing, U. Mocek and K. D. Walker "Biosynthetic Studies on Taxol" Pure & Appl. Chem. 66, 2045 (1994).

  58. U. Mocek and H. G. Floss "Biosynthesis and Metabolic Pathways by 13C and 15N NMR", in "Encyclopedia of Nuclear Magnetic Resonance", D. M. Grant and R. K. Harris, eds., John Wiley and Sons, Chichester, 1995, Vol. II, pp. 959-962.

  59. H. G. Floss "Isotopic Chirality" in "Stable Isotope Applications in Biomolecular Structure and Mechanisms", J. Trewhella, T. A. Cross, C. J. Unkefer, Ed., Los Alamos, New Mexico, 1995, pp. 73-86.

  60. H. G. Floss, C.-G. Kim, B. S. Moore "New Variants of the Shikimate Pathway" in "The Biosynthesis of Antibiotics and Other Microbial Metabolites", W. Kuhn, H. P. Fiedler, Eds., Attempto Verlag, Tuebingen, 1995, pp. 91-97.

  61. H. G. Floss "Biosynthesis and Production of Taxol", Proc. BIO JAPAN '94 OSAKA, 1994, pp. 70-77.

  62. J.A. Bjorklund, T. Frenzel, M. Rueffer, M. Kobayashi, U. Mocek, C. Fox, J.M. Beale, S. Gröger, M.H. Zenk, H.G. Floss "Cryptic Stereochemistry of Berberine Alkaloid Biosynthesis", J. Am. Chem. Soc., 117, 1533-1545 (1995).

  63. J. Micklefield, K.J. Harris, S. Gröger, U. Mocek, H. Hilbi, P. Dimroth, H.G. Floss "The Stereochemical Course of Malonate Decarboxylation in Malonomonas rubra", J. Am. Chem. Soc. 117, 1153 (1995).

  64. B.S. Moore, H.G. Floss, K. Poralla "Three New w-Cycloheptyl Fatty Acids from Alicyclobacillus cycloheptanicus and Their Biosynthetic Interrelationships", J. Nat. Prod.. 58, 590 (1995).

  65. N.C.J. E. Chesters, D. O'Hagan, R.J. Robins, A. Kastelle, H.G. Floss "The Biosynthesis of Tropic Acid: The Stereochemical Course of the Mutase involved in Hyoscyamine Biosynthesis in Datura stramonium", J. Chem. Soc., Chem. Commun. 1995, 129-130.

  66. A Bechthold, J. K. Sohng, T. M. Smith, X. Chu, H. G. Floss "Identification of Streptomyces violaceoruber Tü22 Genes Involved in the Biosynthesis of Granaticin", Mol. Gen. Genet. 248, 610-620 (1995).

  67. T. M. Smith, Y.-F. Jiang, P. Shipley, H. G. Floss "The Thiostrepton Resistance Gene in Streptomyces laurentii is Located Within a Cluster of Ribosomal Protein Operons", Gene 164, 137-142 (1995).

  68. H. G. Floss, C.-G. Kim "Formation of the mC7N Unit in Rifamycin and Related Antibiotics", Proc. Ann. Meeting Korean Soc. Appl. Microbiol., Seoul, April 1995.

  69. B. Sauerbrei, J Niggemann, S. Gröger, S. Lee, H. G. Floss "Synthesis of [6''-3H]-, [6''-2H]- and [2-2H]-D-maltotriose", Carbohydr. Res. 280, 223-235 (1996).

  70. T. M. Smith, Y.-F. Jiang, H. G. Floss 'Thiopeptide Antibiotics" in "Biotechnology of Antibiotics", W. R. Strohl, Ed., 2nd Ed., Marcel-Dekker, New York, 1997, pp 393-413.

  71. I. K. Stamos, E.A. Kelly, H.G. Floss, J.M. Cassady "Synthesis and Analysis of Compounds Having the Skeleton of Ergot Alkaloids with the Nitrogen Atom in the D-Ring Transposed", J. Heterocyclic Chem. 32, 1303 (1995).

  72. N. C. J. E. Chesters, K. Walker, D. O'Hagan, H. G. Floss "The Biosynthesis of Tropic Acid: A Reevaluation of the Stereochemical Course of the Conversion of Phenyllactate to Tropate in Datura stramonium", J. Am. Chem. Soc. 118, 925-926 (1996).

  73. B. Wilkinson, M. Zhu, N. D. Priestley, H.-H. T. Nguyen, H. Morimoto, P. G. Williams, S. I. Chan, H. G. Floss "A Concerted Mechanism for Ethane Hydroxylation by the Particulate Methane Monooxygenase from Methylococcus capsulatus(Bath)", J. Am. Chem. Soc. 118, 921-922 (1996).

  74. X. Lin, M. Hezari, A. E. Koepp, H. G. Floss, R. Croteau "Mechanism of Taxadiene Synthase, a Diterpene Cyclase that Catalyzes the First Step of Taxol Biosynthesis in Pacific Yew", Biochemistry 35, 2968-2977 (1996).

  75. N. D. Priestley, T. M. Smith, P. R. Shipley, H. G. Floss "Studies on the Biosynthesis of Thiostrepton: 4-(1-Hydroxyethyl)-Quinoline-2-Carboxylate as a Free Intermediate on the Pathway to the Quinaldic Acid Moiety", Bioorganic & Medicinal Chemistry 4, 1135-1147 (1996).

  76. C.-G. Kim, A. Kirschning, P. Bergon, P. Zhou, E. Su, B. Sauerbrei, S. Ning, Y. Ahn, M. Breuer, E. Leistner, H. G. Floss "Biosynthesis of 3-Amino-5-hydroxybenzoic Acid, the Precursor of mC7N Units in Ansamycin Antibiotics" J. Amer. Chem. Soc. 118, 7486-7491 (1996).

  77. D. Gröger, H. G. Floss "Biochemistry of Ergot Alkaloids - Achievements and Challenges" in "The Alkaloids", G. A. Cordell, Ed., Academic Press, San Diego, 1998, Vol. 50, pp.171-218.

  78. H. G. Floss "Biosynthesis of Antibiotics", Proceedings from the 1966 Genetics and Molecular Biology of Industrial Microorganisms Conference, R. Baltz, G. Hegeman and P. Skatrud, Eds., Developments in Industrial Microbiology Series Vol. 34, pp. 101-107, 1997.

  79. S. Handa, H. G. Floss "Biosynthesis of w-cyclohexyl fatty acids in Alicyclobacillus acidocaldarius: the stereochemistry of the initial 1,4-conjugate elimination", J. Chem. Soc., Chem. Comm. 1997, 153-154.

  80. A. M. Valentine, B. Wilkinson, K. E. Liu, S. Komar-Panicucci, N. D. Priestley, P. G. Williams, H. Morimoto, H. G. Floss, S. J. Lippard "Tritiated Chiral Alkanes as Substrates for Soluble Methane Monooxygenase from Methylococcus capsulatus (Bath): Probes for the Mechanism of Hydroxylation", J. Am. Chem. Soc. 119, 1818-1827 (1997).

  81. B. S. Moore, K. Walker, I. Tornus, S. Handa, K. Poralla, H. G. Floss "Biosynthetic Studies of w-Cycloheptyl Fatty Acids in Alicyclobacillus cycloheptanicus. Formation of Cycloheptanecarboxylic Acid from Phenylacetic Acid", J. Org. Chem. 62, 2173-2185 (1997).

  82. H. G. Floss "Natural Products Derived from Unusual Variants of the Shikimate Pathway", Nat. Prod. Repts. 14, 433-452 (1997).

  83. Y. Hu, C. R. Melville, S. J. Gould, H. G. Floss "3-Amino-4-hydroxybenzoic Acid is the Precursor of the C7N Unit in Asukamycin and Manumycin", J. Am. Chem. Soc. 119, 4301-4302 (1997).

  84. K. A. Reynolds, K. K. Wallace, S. Handa, H. A. I. McArthur, H. G. Floss "Biosynthesis of the Shikimate-Derived Starter Unit of the Immunosuppressant Ascomycin: Stereochemistry of the 1,4-Conjugate Elimination" J. Antibiot. 50, 701-703 (1997).

  85. T. E. Spratt, T. M. Zydowsky, H. G. Floss "Stereochemistry of the In Vitro and In Vivo Methylation of DNA by (R)- and (S)-N-[2H1, 3H]Methyl-N-Nitrosourea and (R)- and (S)-N-[2H1, 3H]Methyl-N-Methylamine", Chem. Res. Toxicol. 10, 1412-1419 (1997).

  86. P. R. August, T.-W. Yu, H. G. Floss " Molecular Biological Aspects of Antibiotic Biosynthesis", in "Drug Discovery from Nature", S. Grabley, R. Thierecke, Eds., Springer Verlag, Heidelberg, 1999, pp. 215-232.

  87. C.-G. Kim, T.-W. Yu, C. B. Fryhle, S. H.anda, H. G. Floss "3-Amino-5-hydroxybenzoic Acid (AHBA) Synthase, the Terminal Enzyme in the Formation of the Precursor of mC7N Units in Rifamycin and Related Antibiotics", J. Biol. Chem. 273, 6030-6040 (1998).

  88. S. Lee, H. G. Floss, B. A. Gilbert, R. R. Rando "Steric course of the methyl transfer from AdoMet to S-farnesyl-3-thiopropionate by G protein methyltransferase", J. Org. Chem. 63, 898-899 (1998).

  89. D. Hunziker, T.-W. Yu,C. R. Hutchinson, H. G. Floss, C. Khosla "Primer Unit Specificity in Rifamycin Biosynthesis Principally Resides in the Later Stages of the Biosynthetic Pathway", J. Am. Chem. Soc. 120, 1092-1093 (1998).

  90. Kyung-Hwan Han, Milton P. Gordon, Heinz G. Floss "Genetic transformation of Taxus to improve production of Taxol", in "Transgenic Trees", "Biotechnology in Agriculture and Forestry, Vol. 44", Y. P. S. Bajaj, Ed., Springer-Verlag, Heidelberg, 1999.

  91. P. R. August, L. Tang, Y. J. Yoon, S. Ning, R. Müller, T.-W. Yu, M. Taylor, D. Hoffmann, C.-G. Kim, X. Zhang, C. R. Hutchinson, H. G. Floss "Biosynthesis of the Ansamycin Antibiotic Rifamycin. Deductions from the Molecular Analysis of the rif Biosynthetic Gene Cluster of Amycolatopsis mediterranei S699", Chemistry & Biology, 5, 69-79 (1998).

  92. K. D. Walker, H. G. Floss "Detection of a Phenylalanine Aminomutase in Cell-free Extracts of Taxus brevifolia and Preliminary Characterization of Its Reaction", J. Am. Chem. Soc. 120, 5333-5334 (1998).

  93. S. Lee, A. Kirschning, M. Müller, C. Way, H. G. Floss "Enzymatic synthesis of [7-14C,7-3H]- and [1-13C]-sedoheptulose 7-phosphate and [1-13C]-ido-heptulose 7-phosphate", J. Molec. Catal. B: Enzymat. 6, 369-377 (1999).

  94. T.-W. Yu, Y. Shen, R. McDaniel, H. G. Floss, C. Khosla, D. A. Hopwood, B. S. Moore "Combinatorial Biosynthesis of Novel Polyketides from Streptomyces Spore Pigment Polyketide Synthases" J. Am. Chem. Soc. 120, 7749-7759 (1998).

  95. Y. Takeda, T. Masuda, T. Matsumoto, Y. Takechi, T. Shingu, H.G. Floss "Nuclear Magnetic Resonance and Biosynthetic Studies of Neoantimycin and Structure Elucidation of Isoneoantimycin, a Minor Metabolite Related to Neoantimycin" J. Nat. Prod. 61, 978-981 (1998).

  96. K. Ichinose, D. J. Bedford, D. Tornus, A. Bechthold, M. J. Bibb, W. P. Revill, H. G. Floss, D. A. Hopwood "The granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tü22: sequence analysis and expression in a heterologous host", Chemistry & Biology 5, 647-659 (1998).

  97. M. Müller, R. Müller, T.-W. Yu, H. G. Floss "Synthesis of (-)-3-Amino-3-deoxy-quinic Acid", J. Org. Chem. 63, 9753-9755 (1998).

  98. B. S. Moore, H. G. Floss "Biosynthesis of Cyclic Fatty Acids Containing Cyclopropyl-, Cyclopentyl-, Cyclohexyl-, and Cycloheptyl-rings" in "Comprehensive Natural Products Chemistry", D. Barton, K. Nakanishi, Eds., Vol. 1 "Polyketides and Other Secondary Metabolites Including Fatty Acids and Their Derivatives", U. Sankawa, Vol. Ed., Elsevier, Amsterdam, 1999, pp. 61-82.

  99. G. Draeger, S.-H. Park, H. G. Floss "Mechanism of the 2-Deoxygenation Step in the Biosynthesis of the Deoxyhexose Moieties of the Antibiotics Granaticin and Oleandomycin", J. Am. Chem. Soc. 121, 2611-2612 (1999).

  100. S. Chen, D. v. Bamberg, V. Hale, M. Breuer, B. Hardt, R. Müller, H. G. Floss, K. A. Reynolds, E. Leistner "Biosynthesis of Ansatrienin (Mycotrienin) and Naphthomycin: Identification and Analysis of Two Separate Biosynthetic Gene Clusters in Streptomyces collinus Tü 1892" Eur. J. Biochem. 261, 98-107 (1999).

  101. A. Stratmann, T. Mahmud, S.-S. Lee, J. Distler, H. G. Floss, W. Piepersberg "The AcbC Protein from Actinoplanes sp. Is a C7-Cyclitol Synthase Related to 3-Dehydroquinate Synthases and Is Involved in the Biosynthesis of the a-Glucosidase Inhibitor Acarbose", J. Biol. Chem. 274, 10889-10896 (1999).

  102. Y. Shen, P. Yoon, T.-W. Yu, H. G. Floss, David Hopwood, B. S. Moore "Ectopic Expression of the Minimal whiE Polyketide Synthase Generates a Library of Aromatic Polyketides of Diverse Sizes and Shapes", Proc. Nat. Acad. Sci. USA 96, 3622-3627 (1999).

  103. M. McDonald, B. Wilkinson, C. W. Van't Land, U. Mocek, S. Lee, H. G. Floss "Biosynthesis of Phenazine Antibiotics in Streptomyces antibioticus: Stereochemistry of Methyl Transfer from Carbon-2 of Acetate", J. Am. Chem. Soc., 121, 5619-5624 (1999).

  104. J. C. Eads, M. Beeby, G. Scapin, T.-W. Yu, H. G. Floss "The Crystal Structure of 3-Amino-5-hydroxybenzoic Acid (AHBA) Synthase", Biochemistry, 38, 9840-9849 (1999).

  105. T. Mahmud, I. Tornus, E. Egelkrout, E. Wolf, C. Uy, H. G. Floss, S. Lee "Biosynthetic Studies on the a-Glucosidase Inhibitor Acarbose in Actinoplanes sp.: 2-Epi-5-epi-valiolone Is the Direct Precursor of the Valienamine Moiety" J. Am. Chem. Soc., 121, 6973-6983 (1999).

  106. T.-W. Yu, Y. Shen, Y. Doi-Katayama, L. Tang, C. Park, B. S. Moore, C. R. Hutchinson, H. G. Floss "Direct evidence that the rifamycin polyketide synthase assembles polyketide chains processively", Proc. Nat. Acad. Sci. USA, 96, 9051-9056 (1999).

  107. S. Handa, J. H. Koo, Y. S. Kim, H. G. Floss "Stereochemical Course of Biotin-Independent Malonate Decarboxylase Catalysis" Arch. Biochem. Biophys., 370, 93-96 (1999).

  108. H. G. Floss " Antibiotic Biosynthesis: From Natural to Unnatural Compounds", J. Ind. Microbiol., in press.

  109. H. G. Floss, T.-W. Yu "Lessons from the rifamycin biosynthetic gene cluster", Curr. Opinions Chem. Biol., 1999, 3, 592-597.

  110. C. Dehnhardt, M. McDonald, S. Lee, H.G. Floss, J. Mulzer "Highly Stereoselective Synthesis of a Chiral Methyl Group by a Facially Controlled Sigmatropic [1,5]-Hydrogen Shift", J. Am. Chem. Soc., 121, 10848-10849 (1999).

  111. Y. Doi-Katayama, Y. J. Yoon, C.-Y. Choi, T.-W. Yu, H.G. Floss, C.R. Hutchinson "Thioesterases and The Premature Termination of Polyketide Chain Elongation in Rifamycin B Biosynthesis by Amycolatopsis mediterranei S699", J. Antibiotics, in press.