Publications 1980-1989

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  1. H.G. Floss "Biosynthesis of Isochromanequinone Antibiotics", in "Antibiotics", Vol. IV, "Biosynthesis", J.W. Corcoran, Ed., Springer-Verlag, New York (1981), p. 215-235.

  2. H.G. Floss and C.-j. Chang "Biosynthesis of Some Unusual Macrolide Antibiotics", in "Antibiotics", Vol. IV, "Biosynthesis", J.W. Corcoran, Ed., Springer-Verlag, New York (1981), p. 193-214.

  3. H.G. Floss "Biosynthesis of Some Aromatic Antibiotics", in "Antibiotics", Vol. IV, "Biosynthesis", J.W. Corcoran, Ed., Springer-Verlag, New York (1981), p. 236-261.

  4. H.G. Floss "The Biosynthesis of Ergot Alkaloids (or The Story of the Unexpected)" in "Indole and Biogenetically Related Alkaloids", J.D. Phillipson, M.H. Zenk, Ed., Academic Press, London (1980), p. 249-270.

  5. C.E. Snipes, C.-j. Chang and H.G. Floss "Biosynthesis of the Antibiotic Granaticin: Assignment of the Carbon-13 Magnetic Resonance Spectrum", J. Nat. Prod. 42, 627 (1979).

  6. T.S.S. Chen, C.-j. Chang and H.G. Floss "Biosynthesis of the Boron-Containing Macrodiolide Antibiotic Aplasmomycin", J. Amer. Chem. Soc. 101, 5826 (1979).

  7. J.E. Robbers, L.-j. Cheng, J.A. Anderson and H.G. Floss "Synthesis of Ergot Alkaloids by Protoplasts of Claviceps Species", J. Nat. Prod. 42, 537 (1979).

  8. H.G. Floss "Critical Encounters", J. Pharm. Ed. 43, 347 (1979).

  9. H.G. Floss "Stereochemical Aspects of Natural Products Biosynthesis" in "The Biochemistry of Plants", Vol. 7, P.K. Stumpf and E.E. Conn, Eds., Academic Press, New York, New York (1981), p. 177-214.

  10. J.E. Robbers, H. Otsuka, H.G. Floss, E.V. Arnold and J. Clardy. "Clavicipitic Acid: Its Structure, Biosynthesis and Role in Ergot Alkaloid Formation", J. Org. Chem. 45, 1117 (1980).

  11. L.j. Cheng, J.E. Robbers and H.G. Floss "End-Product Regulation of Ergot Alkaloid Formation in Intact Cells and Protoplasts of Claviceps species, Strain SD 58", J. Nat. Prod. 43, 329 (1980).

  12. C.M. Belzecki, F. Quigley, H.G. Floss, N. Crespi-Perellino and A. Guicciardi "Mechanism of a- Hydroxy-a- Amino Acid Formation in the Biosynthesis of Peptide Ergot Alkaloids", J. Org. Chem. 45, 2215 (1980).

  13. R.W. Woodard, L. Mascaro, R. Hörhammer, S. Eisenstein and H.G. Floss "Stereochemistry of Indolmycin Biosynthesis. The Steric Course of C- and N-Methylation Reactions" J. Amer. Chem. Soc. 102, 6314 (1980).

  14. R.W. Woodard, M.D. Tsai, H.G. Floss, P.A. Crooks and J.K. Coward "Stereochemical Course of the Transmethylation Catalyzed by Catechol-O-Methyltransferase", J. Biol. Chem. 255, 9124 (1980).

  15. H. Otsuka, O.A. Mascaretti, L.H. Hurley and H.G. Floss "Stereochemical Aspects of Spectinomycin Biosynthesis", J. Amer. Chem. Soc. 102, 6817 (1980).

  16. M.W. Loewus, F.A. Loewus, G.U. Brillinger, H. Otsuka and H.G. Floss "Stereochemistry of the myo-Inositol 1-Phosphate Synthase Reaction", J. Biol. Chem. 255, 11710 (1980)

  17. O.A. Mascaretti, C.j. Chang, D. Hook, H. Otsuka, E.F. Kreutzer and H.G. Floss "Biosynthesis of the Macrolide Antibiotic Chlorothricin", Biochemistry 20, 919 (1981).

  18. H. Otsuka, F.R. Quigley, D. Gröger, J.A. Anderson and H.G. Floss "In Vivo and In Vitro Evidence for N-Methylation as the Second Pathway-Specific Step in Ergoline Biosynthesis", Planta Med. 40, 109 (1980).

  19. A.M. Crider, R. Lamey, H.G. Floss, J.M. Cassady and W.J. Bradner "Synthesis of Nitrosourea Derivatives of Pyridine and Piperidine as Potential Anti-Cancer Agents", J. Med. Chem. 23, 848 (1980).

  20. T.S.S. Chen, C.-j. Chang and H.G. Floss "Biosynthesis of the Boron-Containing Antibiotic Aplasmomycin. Nuclear Magnetic Resonance Analysis of Aplasmomycin and Desboroaplasmomycin", J. Antibiot. 33, 1316 (1980).

  21. R.W. Woodard, J. Weaver and H.G. Floss "Stereochemical Course of the Methylation of the Polygalacturonic Acid Carboxyl Groups of Pectin", Arch. Biochem. Biophys. 207, 51 (1981).

  22. F. Quigley and H.G. Floss "On the Mechanism of the Amino Acid Hydroxylation and the Formation of the Lysergyl Moiety in Ergotamine Biosynthesis", J. Org. Chem. 46, 464 (1981).

  23. J.C. Vederas and H.G. Floss "Stereochemistry of Pyridoxal Phosphate-Catalyzed Enzyme Reactions", Accts. Chem. Res. 13, 455 (1980).

  24. C.P. Gorst-Allman, B.A.M. Rudd, C.j. Chang and H.G. Floss "The Biosynthesis of Actinorhodin. Determination of the Point of Dimerization", J. Org. Chem. 46, 455 (1981).

  25. T.S.S. Chen, C.j. Chang and H.G. Floss "On the Biosynthesis of Boromycin", J. Org. Chem. 46, 2661 (1981).

  26. T.S.S. Chen, C.-j. Chang and H.G. Floss "Biosynthesis of the Boron-Containing Macrolide Antibiotic Aplasmomycin by Streptomces griseus", J. Amer. Chem. Soc. 103, 4565 (1981).

  27. C.j. Chang, H.G. Floss, D.J. Hook, J.A. Mabe, P.E. Manni, L.L. Martin, K. Schröder and T.-l. Shieh "The Biosynthesis of the Antibiotic Pyrrolnitrin by Pseudomonas aureofaciens", J. Antibiot. 34, 555 (1981).

  28. H.G. Floss "Preparation, Analysis and Biochemical Applications of Chiral Methyl Groups", Methods Enzymol. 87, 126 (1982).

  29. H.G. Floss, L. Mascaro, R.W. Woodard. "Stereochemistry of One-Carbon Transfer Reactions", Proc. Sino-American Symp. Chemistry of Natural Products, Wang Yu, Ed., Science Press, Beijing, China (1982), p. 110-114.

  30. H.G. Floss, C.j. Chang, T.S.S. Chen and C.P. Gorst-Allman "Biosynthesis of the Boron-Containing Macrolide Antibiotics Aplasmomycin and Boromycin", Proc. Sino-American Symp. Chemistry of Natural Products, Wang Yu, Ed., Science Press, Beijing, China (1982), 135-139.

  31. H.G. Floss, H. Otsuka and F. Quigley "Biosynthesis of the Ergot Alkaloids", Proc. Sino-American Symp. Chemistry of Natural Products, Wang Yu, Ed., Science Press, Beijing, China (1982), p. 180-184.

  32. S.B. Hassam and H.G. Floss "Biosynthesis of Ergot Alkaloids. Incorporation of (17R)-[17-3H]-And (17S)-[17-3H]-Chanoclavine-I into Elymoclavine by Claviceps", J. Nat. Prod. 44, 756 (1981).

  33. D.R. Houck and H. G. Floss "Preparation of Stereospecifically a- and ß-Tritiated Tryptamine and the Stereochemistry of Aromatic L-Amino Acid Decarboxylase", J. Nat. Prod. 44, 759 (1981).

  34. H.G. Floss and J.C. Vederas "Stereochemistry of Pyridoxal Phosphate-Catalyzed Reactions", Chaper IV in "New Comprehensive Biochemistry", Vol.3, "Stereochemistry", C. Tamm Ed., Elsevier/ North Holland Biomedical Press, Amsterdam (1982), p. 161-199

  35. H.G. Floss "Stereochemistry of One -Carbon Transfer Reactions", ACS Symposium Series, No. 185, "Asymmetric Reactions and Processes in Chemistry", E. Eliel and S. Otsuka, Eds., American Chemical Society (1982), p. 229-243

  36. J.E. Robbers, S. Srikrai, H.G. Floss and H.G. Schlossberger "Physiological Studies on Ergot. The Induction of Ergot Alkaloid Biosynthesis by the Tryptophan Bioisosteres, ß-1- and ß-2-Naphthylalanine", J. Nat. Prod. 45, 178 (1982).

  37. H.G. Floss and R.W. Woodard "Further Stereochemical Studies on Methyl Transfer Reactions", in "Biochemistry of S-Adenosylmethionine and Related Compounds", E. Usdin, R.T. Borchardt and C.R. Creveling, Ed., MacMillan Press, Inc., London (1982), pp. 539-544.

  38. C.-C. Chang, A. Laghai, M.H. O'Leary and H.G. Floss "Some Stereochemical Features of Aspartate-ß-Decarboxylase", J. Biol. Chem. 257, 3564 (1982).

  39. A. Bacher, Q. LeVan, M. Bühler, P.J. Keller, V. Eimicke and H.G. Floss "Biosynthesis of Riboflavin. Incorporation of D-[1-13C]Ribose", J. Amer. Chem. Soc. 104, 3754 (1982).

  40. E.W. Miles, D.R. Houck and H.G. Floss "Stereochemistry of Sodium Borohydride Reduction of Tryptophan Synthase of Escherichia coli and Its Amino Acid Schiff's Bases", J. Biol. Chem. 257, 14203 (1982).

  41. B. Krone, A. Zeeck and H.G. Floss "Biosynthetic Relationships in the Naphthocyclinone Series of Isochromane Quinone Antibiotics", J. Org. Chem. 47, 472 (1982).

  42. J.A. Clemens, E.C. Kornfeld, L.A. Phebus, C.J. Shaar, E.B. Smalstig, J.M. Cassady, D.E. Nichols, H.G. Floss and E. Kelly "Dopaminergic Agents Related to Ergolines", in "Chemical Regulation of Biological Mechanisms", S. Turner, Ed., Spec. Publ. No. 42, Royal Society of Chemistry, London (1982), pp. 167-180.

  43. A. Bacher, Q. LeVan, M. Bühler, P.J. Keller and H.G. Floss "Biosynthesis of Riboflavin. Origin of the Xylene Ring" in "Chemistry and Biology of Pteridines", J.A. Blair, Ed., DeGruyter, Berlin (1983), p. 699-703.

  44. H.G. Floss, M.-D. Tsai and R.W. Woodard "Stereochemistry of Biological Reactions at Pro-prochiral Centers", Topics in Stereochem. 15, 253 (1984).

  45. P.J. Keller, Q. LeVan, A. Bacher and H. G. Floss "Biosynthesis of Riboflavin. 13C-NMR Techniques for the Analysis of Multiply 13C-Labeled Riboflavins", Tetrahedron 39, 3471 (1983).

  46. S.-J. Shen, H.G. Floss, H. Kumagai, H. Yamada, N. Esaki, K. Soda, S.A. Wasserman and C. Walsh "Mechanism of Pyridoxal Phosphate-dependent Enzymatic Amino-acid Racemization", J.C.S. Chem. Comm. 1983, 82.

  47. S.-U. Kim, Y.-J. Cho, H.G. Floss, and J.A. Anderson. "Conversion of Elymoclavine to Paspalic Acid By A Particulate Fraction From An Ergotamine-Producing Strain of Claviceps sp." Planta Med. 48, 145 (1983).

  48. P.J. Keller, Q. LeVan, A. Bacher, J.F. Kozlowski and H.G. Floss "Biosynthesis of Riboflavin. Analysis of Biosynthetically 13C-Labeled Riboflavin by Double Quantum and 2D-NMR", J. Amer. Chem. Soc. 105, 2505 (1983).

  49. H.G. Floss, Q. LeVan, P.J. Keller and A. Bacher "Biosynthesis of Riboflavin. An Unusual Rearrangement in the Formation of 6,7-Dimethyl-8-ribityllumazine", J. Amer. Chem. Soc. 105, 2493 (1983).

  50. K. Kobayashi, P.K. Jadhav, T.M. Zydowsky and H.G. Floss "A Simple and Efficient Synthesis of Chiral Acetic Acid of High Optical Purity", J. Org. Chem. 48, 3510 (1983).

  51. A. Bacher, Q. LeVan, P.J. Keller and H.G. Floss "Biosynthesis of Riboflavin. Incorporation of 13C-Labeled Precursors into the Xylene Ring", J. Biol. Chem. 258, 13431 (1983).

  52. P. Nielsen, G. Neuberger, H.G. Floss and A. Bacher "Biosynthesis of Riboflavin. Enzymatic Formation of the Xylene Moiety from [14C]Ribulose 5-Phosphate", Biochem. Biophys. Res. Comm. 118, 814 (1984).

  53. Y. Asano, R.W. Woodard, D.R. Houck and H.G. Floss "Stereochemical Course of the Transmethylation Catalyzed by Histamine N-Methyltransferase", Arch. Biochem. Biophys. 231, 253 (1984).

  54. K. Kobayashi, K. Kakinuma and H.G. Floss "Synthesis of Chiral Acetic Acid by Chirality Transfer From D-Glucose", J. Org. Chem., 49, 1290 (1984).

  55. J.J. Lee, Y. Asano, T.-L. Shieh, F. Spreafico, K. Lee and H.G. Floss "Steric Course of the 5-Enolpyruvylshikimate-3-phosphate Synthetase and Anthranilate Synthetase Reactions", J. Amer. Chem. Soc. 106, 3367 (1984).

  56. H.G. Floss, P.J. Keller, Q. Le Van, P. Nielsen, G. Neuberger and A. Bacher "Biosynthesis of Riboflavin", in "Natural Products Chemistry", Atta-ur-Rahman, Ed., Springer, Berlin (1986), pp. 108-120.

  57. B. Badet, K. Lee, H.G. Floss and C. Walsh "Stereochemical Studies of Processing of D- and L-isomers of Suicide Substrates by an Amino Acid Racemase from Pseudomonas striata", J.C.S. Chem. Comm. 1984, 838.

  58. M.M. Palcic and H.G. Floss "Conformation and Stereochemistry of Free and Bound Pyridoxal Phosphate and Its Derivatives", in "Pyridoxal Phosphate: Chemical, Biochemical and Medical Aspects", Part A (Vol. 1A), D. Dolphin, Ed., John Wiley and Sons, New York, N. Y. (1984), pp. 25-68.

  59. Y. Takeda, V. Mak, C.-C. Chang, C.-j. Chang and H.G. Floss "Biosynthesis of Ketomycin", J. Antibiot. 37, 868 (1984).

  60. M.O. Fatope, T.M. Zydowsky and H.G. Floss "Oxidative Degradation of O6-Methylguanine with Oxone", J. Chem. Res. (S), 308-309 (1984).

  61. A. Bacher, P. Nielsen, G. Neuberger and H.G. Floss "Biosynthesis of Riboflavin. Enzymatic Formation of 6,7-Dimethyl-8-ribityllumazine", in "Flavins and Flavoproteins", R.C. Bray, P.C. Engel, S.G. Mayhew, Eds., W. DeGruyter, Berlin (1984), p. 799-802.

  62. P.J. Keller, H. G. Floss, Q. Le Van, G. Neuberger, P. Nielsen and A. Bacher "Transfer of Hydrogen Atoms from Pentose Phosphate to the Xylene Ring of Riboflavin", in "Flavins and Flavoproteins", R.C. Bray, P.C. Engel, S.G. Mayhew, Eds., W. DeGruyter, Berlin (1984), p. 795-798.

  63. S.-W. Lee, B.A.M. Rudd, X.-G. He, C.-j. Chang and H.G. Floss "Identification of a Red Pigment from Streptomyces coelicolor A3(2) as a Mixture of Prodigiosin Derivatives", J. Antibiot. 38, 128 (1985).

  64. M.M. Palcic, M. Antoun, K. Tanizawa, K. Soda and H.G. Floss "Stereochemistry of the Kynureninase Reaction", J. Biol. Chem. 260, 5248 (1985).

  65. A. Nakagawa, T.-S. Wu, P.J. Keller, J.P. Lee, S. Omura and H.G. Floss "Biosynthesis of Asukamycin. Formation of the 2-Aminocyclopentenol-3-one Moiety", J.C.S. Chem. Comm. 1985, 519.

  66. Y. Asano, J.J. Lee, T.L. Shieh, F. Spreafico, C. Kowal and H.G. Floss "Steric Course of the Reactions Catalyzed by 5-Enolpyruvylshikimate 3-Phosphate Synthase, Chorismate Mutase and Anthranilate Synthase", J. Amer. Chem. Soc. 107, 4314 (1985).

  67. D.A. Hopwood, F. Malpartida, H.M. Kieser, H. Ikeda, J. Duncan, I. Fujii, B.A.M. Rudd, H.G. Floss and S. Omura "Production of 'hybrid' antibiotics by genetic engineering", Nature 314, 642 (1985).

  68. Q. Le Van, P.J. Keller, D.H. Bown, H.G. Floss and A. Bacher "Biosynthesis of Riboflavin in Bacillus subtilis: Origin of the Four-Carbon Moiety", J. Bacteriol. 162, 1280 (1985).

  69. J.J. Lee, T.S.S. Chen, C.-j. Chang, C. Fenselau and H.G. Floss "Isolation of Two Minor Components of the Boromycin Fermentation: N-Acetylboromycin and N-Formylboromycin", J. Antibiot. 38, 1444 (1985).

  70. H.G. Floss, S.P. Cole, X.-G. He, B.A.M. Rudd, J. Duncan, I. Fujii, C.-j. Chang and P.J. Keller "Biosynthesis of Polyketide Antibiotics", in "Regulation of Secondary Metabolite Formation", H. Kleinkauf, Ed., Proc. 16th Workshop Conference Hoechst, Cologne, May 1985, p. 283-304.

  71. A. Bacher, Q. Le Van, P.J. Keller and H.G. Floss "Biosynthesis of Riboflavin. Incorporation of Multiply 13C-Labeled Precursors Into the Xylene Ring", J. Amer. Chem. Soc. 107, 6380 (1985).

  72. H.G. Floss "The Shikimate Pathway - An Overview", Recent Adv. Phytochem. 20, 13 (1986).

  73. H.G. Floss "Games With Chiral Methyl Groups", in "Mechanisms of Enzymatic Reactions: Stereochemistry", P.A. Frey, Ed., Elsevier, New York (1986), pp. 71-88.

  74. Q. Le Van, B. Schwarzkopf, A. Bacher, P.J. Keller, S. Lee and H.G. Floss "Biosynthesis of 7,8-Didemethyl-8-hydroxy-5-deazariboflavin, the Chromophoric Moiety of Coenzyme F420", J. Amer. Chem. Soc. 107, 830 (1985).

  75. P. Nielsen, G. Neuberger, I. Fujii, D.H. Bown, P.J. Keller, H.G. Floss and A. Bacher. "Biosynthesis of Riboflavin. Enzymatic Formation of 6,7-Dimethyl-8-ribityllumazine From Pentose Phosphates", J. Biol. Chem. 261, 3661 (1986).

  76. X.-G. He, C.-C. Chang, C.-j. Chang, J.C. Vederas, A.G. McInnes, J.A. Walter and H.G. Floss "Further Studies on the Biosynthesis of Granaticin", Z. Naturforschg. 41C, 215 (1986).

  77. J.M. Beale, J.P. Lee, A. Nakagawa, S. Omura and H.G. Floss "Biosynthesis of the Antibiotic Reductiomycin", J. Amer. Chem. Soc. 108, 331 (1986).

  78. P.J. Keller, H.G. Floss, Q. LeVan, B. Schwarzkopf and A. Bacher "Biosynthesis of Methanopterin in Methanobacterium thermoautotrophicum", J. Amer. Chem. Soc. 108, 344 (1986).

  79. T.C. Somers, J.D. White, J.J. Lee, P.J. Keller, C.-j. Chang and H.G. Floss "A NMR Analysis of Boromycin Sodium Complex and Sodium Desvalinoboromycinate", J. Org. Chem. 51, 464 (1986).

  80. S. Huang, J.M. Beale, P.J. Keller and H.G. Floss "Synthesis of R- and S-[1-13C1, 2-2H1]Malonate and Its Stereochemical Analysis by NMR Spectroscopy", J. Amer. Chem. Soc. 108, 1100 (1986).

  81. D.H. Bown, P.J. Keller, H.G. Floss and A. Bacher "Solution Structures of 6,7-Didemethyl-8-Substituted Lumazines. 13C-NMR Evidence for Intramolecular Ether Formation", J. Org. Chem. 51, 2461 (1986).

  82. T.M. Zydowsky, L.F. Courtney, V. Frasca, K. Kobayashi, H. Shimizu, L.-D. Yuen, R.G. Matthews, S.J. Benkovic and H.G. Floss "Stereochemical Analysis of the Methyl Transfer Catalyzed by Cobalamin-Dependent Methionine Synthase From E. coli B"", J. Amer. Chem. Soc. 108, 3152 (1986).

  83. D.R. Houck, K. Kobayashi, J.M. Williamson and H.G. Floss "Stereochemistry of Methylation in Thienamycin Biosynthesis: Example of a Methyl Transfer from Methionine with Retention of Configuration", J. Amer. Chem. Soc. 108, 5365 (1986).

  84. J.J. Lee, J.P. Lee, P.J. Keller, C.E. Cottrell, C.-j. Chang, H. Zähner and H.G. Floss "Further Studies on the Biosynthesis of Chlorothricin", J. Antibiot. 39, 1123 (1986).

  85. H.G. Floss "The Impact of Molecular Biology and Genetic Engineering on Natural Products Research", in "Essays on Science", H.M. Said, Ed., Hamdard Found. Press, Karachi, pp. 117-129 (1986).

  86. D.R. Houck, L.-C. Chen, P.J. Keller, J.M. Beale and H.G. Floss "Biosynthesis of the Modified Peptide Antibiotic Nosiheptide in Streptomyces actuosus", J. Amer. Chem. Soc. 109, 1250 (1987).

  87. S.P. Cole, B.A.M. Rudd, D.A. Hopwood, C.-j. Chang and H.G. Floss "Biosynthesis of the Antibiotic Actinorhodin. Analysis of Blocked Mutants of Streptomyces coelicolor", J. Antibiot. 40, 340 (1987).

  88. H.G. Floss "Hybrid Antibiotics - The Contribution of New Gene Combinations", Trends in Biotechnol. 5, 112 (1987).

  89. M.B. Purvis, D.G.I. Kingston, N. Fujii and H.G. Floss "Stereochemistry of Incorporation of Serine Into the Oxazole Ring of Virginiamycin M1", J.C.S. Chem. Comm. 1987, 302.

  90. H.G. Floss, P.J. Keller and J.M. Beale "Studies on the Biosynthesis of Antibiotics", J. Nat. Prod. 49, 957 (1986).

  91. T.-S. Wu, J. Duncan, S.-W. Tsao, C.-j. Chang, P.J. Keller and H.G. Floss "Biosynthesis of the Ansamycin Antibiotic Ansatrienin (Mycotrienin) by Streptomyces collinus", J. Nat. Prod. 50, 108 (1987).

  92. M.M. Palcic, S.-j. Shen, E. Schleicher, H. Kumagai, S. Sawada, H. Yamada and H.G. Floss "Stereochemistry and Mechanism of Reactions Catalyzed by Tyrosine Phenol-Lyase From Escherichia intermedia", Z. Naturforschg. 42C, 307 (1987).

  93. H. Otsuka and H.G. Floss "Steric Course of the Rhodium-Catalyzed Decarbonylation of Chiral 4-Methyl-[1-3H,2-2H1]Pentanal", Z. Naturforschg. 42C, 449 (1987).

  94. J.M. Beale, C.E. Cottrell, P.J. Keller and H.G. Floss "Triple Quantum 'INADEQUATE': Development for Biosynthetic Studies", J. Magn. Res. 72, 574 (1987).

  95. H. Lebertz, H. Simon, L.F. Courtney, S.J. Benkovic, L.D. Zydowsky, K. Lee and H.G. Floss "Stereochemistry of Acetic Acid Formation From 5-Methyltetrahydrofolate by Clostridium thermoaceticum", J. Amer. Chem. Soc. 109, 3173 (1987).

  96. S.A. Raybuck, N.R. Bastian, L.D. Zydowsky, K. Kobayashi, H.G. Floss, W.H. Orme-Johnson and C.T. Walsh "Nickel-Containing CO Dehydrogenase Catalyzes Reversible Decarbonylation of Acetyl-CoA With Retention of Stereochemistry at the Methyl Group", J. Amer. Chem. Soc. 109, 3171 (1987).

  97. U. Degwert, R. v. Hülst, H. Pape, R.E. Herrold, J.M. Beale, P.J. Keller, J.P. Lee and H.G. Floss "Studies on the Biosynthesis of the a-Glucosidase Inhibitor Acarbose: Valienamine, a m-C7N Unit Not Derived from the Shikimate Pathway", J. Antibiot. 40, 855 (1987).

  98. J.J. Lee, P.M. Dewick, C.P. Gorst-Allman, F. Spreafico, C. Kowal, C.-j. Chang, A.G. McInnes, J.A. Walter, P.J. Keller and H.G. Floss "Further Studies on the Biosynthesis of the Boron-Containing Antibiotic Aplasmomycin", J. Amer. Chem. Soc. 109, 5426 (1987).

  99. E.J. O'Connor, M. Kobayashi, H.G. Floss and J.A. Gladysz "A Versatile New Synthesis of Organic Compounds with Chiral Methyl Groups: Stereochemistry of Protolytic Rhenium-Carbon Bond Cleavage in Chiral Complexes ((nu)5-C5H5)(Re)(NO)(PPh3)(R)", J. Amer. Chem. Soc. 109, 4837 (1987).

  100. B. Schwarzkopf, Q. LeVan, W. Eisenreich, P.J. Keller, H.G. Floss and A. Bacher "Biosynthesis of Pteridines and Deazaflavins in Methanogenic Bacteria", in "Unconjugated Pterins and Related Biogenic Amines", H.-Ch. Curtius, N. Blau, R.A. Levine, Ed., de Gruyter, Berlin, 1987, pp. 117-123.

  101. M. Kobayashi and H.G. Floss "Biosynthesis of Ergot Alkaloids: Origin of the Oxygen Atoms in Chanoclavine-I and Elymoclavine", J. Org. Chem. 52, 4350 (1987).

  102. M. Kobayashi, T. Frenzel, J.P. Lee, M.H. Zenk and H.G. Floss "Stereochemical Fate of O-Methyl Groups in the Biosynthesis of Protoberberine Alkaloids", J. Amer. Chem. Soc. 109, 6184 (1987).

  103. A. Bacher, R. Volk, P.F. Keller, H.G. Floss, Q. Le Van, W. Eisenreich and B. Schwarzkopf "Biosynthesis of Flavins and Deazaflavins", in "Flavins and Flavoproteins 1987", D.E. Edmondson, D.B. McCormick, Eds., de Gruyter, Berlin, 1987, pp. 431-440.

  104. A.P. Kozikowski, M. Okita, M. Kobayashi and H.G. Floss "Probing Ergot Alkaloid Biosynthesis: Synthesis and Feeding of a Proposed Intermediate Along the Biosynthetic Pathway - A New Amidomalonate for Tryptophan Elaboration", J. Org. Chem. 53, 863 (1988).

  105. L.D. Zydowsky, T.M. Zydowsky, E.S. Haas, J.W. Brown, J.N. Reeve and H.G. Floss "Stereochemical Course of Methyl Transfer From Methanol to Methyl Coenzyme M in Cell-Free Extracts of Methanosarcina barkeri", J. Amer. Chem. Soc. 109, 7922 (1987).

  106. R. Casati, J.M. Beale and H.G. Floss "Biosynthesis of Ansatrienin. Nonincorporation of Shikimic Acid Into the mC7N Unit and Stereochemistry of the Conversion to the Cyclohexanecarboxylic Acid Moiety", J. Amer. Chem. Soc. 109, 8102 (1987).

  107. A.P. Kozikowski, J.-P. Wu, M. Shibuya and H.G. Floss "Probing Ergot Alkaloid Biosynthesis: Identification of Advanced Intermediates Along the Biosynthetic Pathway", J. Amer. Chem. Soc. 110, 1970 (1988).

  108. J. Rohr, A. Zeeck and H.G. Floss "Urdamycins, New Angucycline Antibiotics from Streptomyces fradiae. III. Structures of Urdamycins C and D", J. Antibiot. 41, 126 (1988).

  109. D.R. Houck, L.-C. Chen, P.J. Keller, J.M. Beale and H.G. Floss "Studies on the Biosynthesis of the Modified Peptide Antibiotic Nosiheptide in Streptomyces actuosus", J. Amer. Chem. Soc. 110, 5800 (1988).

  110. J.M. Beale, R.E. Herrold, H.G. Floss, R. Thiericke, A. Zeeck, A. Nakagawa and S. Omura "Studies on the Biosynthesis of the metaC7N Unit in the Antibiotics Manumycin and Asukamycin", J. Amer. Chem. Soc. 110, 4435 (1988).

  111. P.J. Keller, Q. LeVan, S.-U. Kim, D.H. Bown, H.-C. Chen, A. Kohnle, A. Bacher and H.G. Floss "Biosynthesis of Riboflavin: Mechanism of Formation of the Ribitylamino Linkage", Biochemistry 27, 1117 (1988).

  112. J.M. Beale, H.G. Floss, T. Lehmann and M. Luckner "Digitoxigenin-3b-O-[b-D-fucopyranosyl-4'-b-D-glucopyranoside], the Main Cardenolide of Somatic Embryos of Digitalis lanata", Phytochemistry 27, 3143 (1988).

  113. H.G. Floss "Biosynthesis of the Antibiotics Nosiheptide and Thiostrepton", in "Biology of Actinomycetes 88", Y. Okami, T. Beppu, H. Ogawara, Ed., Japan Scientific Societies Press, Tokyo, 1988, p. 401-405.

  114. H.G. Floss, R. Casati, H. Cho and J.M. Beale "Studies on the Biosynthesis of Antibiotics", Pure & Applied Chem. 61, 485 (1989).

  115. H.G. Floss and J.M. Beale "Studies on the Biosynthesis of Antibiotics", Angew. Chem. 101, 147 (1989); Angew. Chem. Int. Ed. Engl. 28, 146 (1989).

  116. D.C. Dosch, W.R. Strohl and H.G. Floss "Molecular Cloning of the Nosiheptide Resistance Gene From Streptomyces actuosus ATCC 25421", Biochem. Biophys. Res. Comm. 156, 517 (1988).

  117. T. Frenzel, J.M. Beale, M. Kobayashi, M.H. Zenk and H.G. Floss "Stereochemistry of Enzymatic Formation of the Berberine Bridge in Protoberberine Alkaloids", J. Amer. Chem. Soc. 110, 7878 (1988).

  118. W.R. Strohl, P.L. Bartel, N.C. Connors, C.-b. Zhu, D.C. Dosch, J.M. Beale, Jr., H.G. Floss, K. Stutzman-Engwall, S. Otten and C.R. Hutchinson "Biosynthesis of Natural and Hybrid Polyketides by Anthracycline Producing Streptomyces", in "Genetics and Molecular Biology of Industrial Microorganisms", C.L. Hershberger, S.W. Queener, G. Hegeman, Eds., Amer. Soc. Microbiol., Washington, D.C., 1989, pp. 68-84.

  119. R. Thiericke, A. Zeeck, J.A. Robinson, J.M. Beale and H.G. Floss "The Biosynthesis of Manumycin. Origin of the Oxygen and Nitrogen Atoms", J. Chem. Soc., Chem. Comm. 1989, 402.

  120. L. Heide, H.G. Floss and M. Tabata "Mode of Incorporation of Shikimic Acid into p-Hydroxybenzoic Acid in Lithospermum erythrorhizon Cell Cultures", Phytochemistry 28, 2643 (1989).

  121. E.-R. Woo, I. Fujii, Y. Ebizuka, U. Sankawa, A. Kawaguchi, S. Huang, J.M. Beale, M. Shibuya, U. Mocek and H.G. Floss "Non-Stereospecific Proton Removal in the Enzymatic Formation of Orsellinic Acid from Chiral Malonate", J. Amer. Chem. Soc., 111, 5498 (1989).

  122. J. Rohr, J.M. Beale and H.G. Floss "Urdamycins, New Angucycline Antibiotics from Streptomyces fradiae. IV. Biosynthetic Studies of Urdamycins A ~ D", J. Antibiot. 42, 1151 (1989).

  123. P. Zhou, D. O'Hagan, U. Mocek, Z. Zeng, L.-D. Yuen, T. Frenzel, C.J. Unkefer, J.M. Beale and H.G. Floss "Biosynthesis of the Antibiotic Thiostrepton. Methylation of Tryptophan in the Formation of the Quinaldic Acid Moiety by Transfer of the Methionine Methyl Group with Net Retention of Configuration", J. Amer. Chem. Soc. 111, 7274 (1989).

  124. M. Shibuya, H.-M. Chou, M. Fountoulakis, S. Hassam, S.-U. Kim, K. Kobayashi, H. Otsuka, E. Rogalska, J.M. Cassady and H.G. Floss "Stereochemistry of the Isoprenylation of Tryptophan Catalyzed by 4-(g,g-Dimethylallyl)tryptophan Synthase from Claviceps, the First Pathway-Specific Enzyme in Ergot Alkaloid Biosynthesis", J. Amer. Chem. Soc. 112, 297 (1990).

  125. U. Mocek, L.-C. Chen, P.J. Keller, D.R. Houck, J.M. Beale and H.G. Floss "1H- And 13C-NMR Assignments of the Thiopeptide Antibiotic Nosiheptide", J. Antibiot. 42, 1643 (1989).

  126. U. Mocek, J.M. Beale and H.G. Floss "Reexamination of the 1H- and 13C-NMR Spectral Assignments of Thiostrepton", J. Antibiot. 42, 1649 (1989).