The SAS System 1 17:04 Tuesday, March 4, 2003 The Mixed Procedure Model Information Data Set WORK.CFKIDS Dependent Variable fev1 Covariance Structure Compound Symmetry Subject Effect id Estimation Method ML Residual Variance Method Profile Fixed Effects SE Method Model-Based Degrees of Freedom Method Between-Within The SAS System 2 17:04 Tuesday, March 4, 2003 The Mixed Procedure Class Level Information Class Levels Values id 200 100073 100111 100185 100329 100352 100636 100736 100815 100895 100897 101035 101174 101232 101309 101394 101456 101518 101701 101718 101799 101806 101891 102053 102316 102407 102512 102529 102551 102593 102685 102791 102804 102869 102979 102985 103209 103262 103283 103393 103399 103411 103564 103595 103624 103633 103728 103806 103850 104101 104367 104442 104806 104818 104864 104883 104916 105002 105070 105187 105197 105241 105319 105466 105474 105560 105707 105712 105796 105803 105837 105915 106080 106106 106148 106197 106204 106236 106345 106373 106389 106537 106672 106699 106702 106709 106720 106739 106938 106998 107004 107122 107243 107483 107508 107553 107625 107638 107755 107862 108225 108237 108331 108579 108642 108692 108841 108958 109245 109442 109469 109473 109506 109589 109669 109790 109825 109847 109996 110027 110054 110177 110330 110427 110615 110814 110970 110977 111139 111292 111309 111495 111508 111564 111709 111789 111876 112017 112074 112093 112095 113680 113829 114118 114392 114494 114542 114674 114706 114913 115191 115206 115224 115271 115334 115345 115395 115453 115487 115596 115720 115727 115785 115800 116004 116204 116260 116318 116320 116347 116448 116493 116764 117021 117023 117116 117126 117243 117249 117254 117413 117521 117561 117590 117609 117721 117740 117881 117997 118049 118059 118111 118213 118227 118352 118576 118645 118742 118746 118860 119028 The SAS System 3 17:04 Tuesday, March 4, 2003 The Mixed Procedure Dimensions Covariance Parameters 2 Columns in X 9 Columns in Z 0 Subjects 200 Max Obs Per Subject 9 Observations Used 1513 Observations Not Used 0 Total Observations 1513 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 14060.74494218 1 2 12510.03437077 0.00000479 2 1 12510.01061655 0.00000000 Convergence criteria met. Covariance Parameter Estimates Cov Parm Subject Estimate CS id 497.26 Residual 148.33 Fit Statistics -2 Log Likelihood 12510.0 AIC (smaller is better) 12532.0 AICC (smaller is better) 12532.2 BIC (smaller is better) 12568.3 Null Model Likelihood Ratio Test DF Chi-Square Pr > ChiSq 1 1550.73 <.0001 Solution for Fixed Effects Standard Effect Estimate Error DF t Value Pr > |t| Intercept 103.81 6.6235 195 15.67 <.0001 age0 -1.8553 0.3300 195 -5.62 <.0001 ageL -0.5882 0.3925 1309 -1.50 0.1342 The SAS System 4 17:04 Tuesday, March 4, 2003 The Mixed Procedure Solution for Fixed Effects Standard Effect Estimate Error DF t Value Pr > |t| female -1.1620 3.3569 195 -0.35 0.7296 f508_1 -4.2821 5.5437 195 -0.77 0.4408 f508_2 -6.7427 5.5748 195 -1.21 0.2279 ageL*female -0.8257 0.2491 1309 -3.32 0.0009 ageL*f508_1 -0.4873 0.4218 1309 -1.16 0.2482 ageL*f508_2 -0.6568 0.4207 1309 -1.56 0.1187 Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F age0 1 195 31.60 <.0001 ageL 1 1309 2.25 0.1342 female 1 195 0.12 0.7296 f508_1 1 195 0.60 0.4408 f508_2 1 195 1.46 0.2279 ageL*female 1 1309 10.99 0.0009 ageL*f508_1 1 1309 1.33 0.2482 ageL*f508_2 1 1309 2.44 0.1187 The SAS System 5 17:04 Tuesday, March 4, 2003 The Mixed Procedure Model Information Data Set WORK.CFKIDS Dependent Variable fev1 Covariance Structure Unstructured Subject Effect id Estimation Method ML Residual Variance Method Profile Fixed Effects SE Method Model-Based Degrees of Freedom Method Containment The SAS System 6 17:04 Tuesday, March 4, 2003 The Mixed Procedure Class Level Information Class Levels Values id 200 100073 100111 100185 100329 100352 100636 100736 100815 100895 100897 101035 101174 101232 101309 101394 101456 101518 101701 101718 101799 101806 101891 102053 102316 102407 102512 102529 102551 102593 102685 102791 102804 102869 102979 102985 103209 103262 103283 103393 103399 103411 103564 103595 103624 103633 103728 103806 103850 104101 104367 104442 104806 104818 104864 104883 104916 105002 105070 105187 105197 105241 105319 105466 105474 105560 105707 105712 105796 105803 105837 105915 106080 106106 106148 106197 106204 106236 106345 106373 106389 106537 106672 106699 106702 106709 106720 106739 106938 106998 107004 107122 107243 107483 107508 107553 107625 107638 107755 107862 108225 108237 108331 108579 108642 108692 108841 108958 109245 109442 109469 109473 109506 109589 109669 109790 109825 109847 109996 110027 110054 110177 110330 110427 110615 110814 110970 110977 111139 111292 111309 111495 111508 111564 111709 111789 111876 112017 112074 112093 112095 113680 113829 114118 114392 114494 114542 114674 114706 114913 115191 115206 115224 115271 115334 115345 115395 115453 115487 115596 115720 115727 115785 115800 116004 116204 116260 116318 116320 116347 116448 116493 116764 117021 117023 117116 117126 117243 117249 117254 117413 117521 117561 117590 117609 117721 117740 117881 117997 118049 118059 118111 118213 118227 118352 118576 118645 118742 118746 118860 119028 The SAS System 7 17:04 Tuesday, March 4, 2003 The Mixed Procedure Dimensions Covariance Parameters 2 Columns in X 9 Columns in Z Per Subject 1 Subjects 200 Max Obs Per Subject 9 Observations Used 1513 Observations Not Used 0 Total Observations 1513 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 14060.74494218 1 2 12510.03437077 0.00000479 2 1 12510.01061655 0.00000000 Convergence criteria met. Estimated G Matrix Row Effect id Col1 1 Intercept 100073 497.26 Covariance Parameter Estimates Cov Parm Subject Estimate UN(1,1) id 497.26 Residual 148.33 Fit Statistics -2 Log Likelihood 12510.0 AIC (smaller is better) 12532.0 AICC (smaller is better) 12532.2 BIC (smaller is better) 12568.3 Null Model Likelihood Ratio Test DF Chi-Square Pr > ChiSq 1 1550.73 <.0001 The SAS System 8 17:04 Tuesday, March 4, 2003 The Mixed Procedure Solution for Fixed Effects Standard Effect Estimate Error DF t Value Pr > |t| Intercept 103.81 6.6235 195 15.67 <.0001 age0 -1.8553 0.3300 1309 -5.62 <.0001 ageL -0.5882 0.3925 1309 -1.50 0.1342 female -1.1620 3.3569 1309 -0.35 0.7293 f508_1 -4.2821 5.5437 1309 -0.77 0.4400 f508_2 -6.7427 5.5748 1309 -1.21 0.2267 ageL*female -0.8257 0.2491 1309 -3.32 0.0009 ageL*f508_1 -0.4873 0.4218 1309 -1.16 0.2482 ageL*f508_2 -0.6568 0.4207 1309 -1.56 0.1187 Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F age0 1 1309 31.60 <.0001 ageL 1 1309 2.25 0.1342 female 1 1309 0.12 0.7293 f508_1 1 1309 0.60 0.4400 f508_2 1 1309 1.46 0.2267 ageL*female 1 1309 10.99 0.0009 ageL*f508_1 1 1309 1.33 0.2482 ageL*f508_2 1 1309 2.44 0.1187 The SAS System 9 17:04 Tuesday, March 4, 2003 The Mixed Procedure Model Information Data Set WORK.CFKIDS Dependent Variable fev1 Covariance Structure Unstructured Subject Effect id Estimation Method ML Residual Variance Method Profile Fixed Effects SE Method Model-Based Degrees of Freedom Method Containment The SAS System 10 17:04 Tuesday, March 4, 2003 The Mixed Procedure Class Level Information Class Levels Values id 200 100073 100111 100185 100329 100352 100636 100736 100815 100895 100897 101035 101174 101232 101309 101394 101456 101518 101701 101718 101799 101806 101891 102053 102316 102407 102512 102529 102551 102593 102685 102791 102804 102869 102979 102985 103209 103262 103283 103393 103399 103411 103564 103595 103624 103633 103728 103806 103850 104101 104367 104442 104806 104818 104864 104883 104916 105002 105070 105187 105197 105241 105319 105466 105474 105560 105707 105712 105796 105803 105837 105915 106080 106106 106148 106197 106204 106236 106345 106373 106389 106537 106672 106699 106702 106709 106720 106739 106938 106998 107004 107122 107243 107483 107508 107553 107625 107638 107755 107862 108225 108237 108331 108579 108642 108692 108841 108958 109245 109442 109469 109473 109506 109589 109669 109790 109825 109847 109996 110027 110054 110177 110330 110427 110615 110814 110970 110977 111139 111292 111309 111495 111508 111564 111709 111789 111876 112017 112074 112093 112095 113680 113829 114118 114392 114494 114542 114674 114706 114913 115191 115206 115224 115271 115334 115345 115395 115453 115487 115596 115720 115727 115785 115800 116004 116204 116260 116318 116320 116347 116448 116493 116764 117021 117023 117116 117126 117243 117249 117254 117413 117521 117561 117590 117609 117721 117740 117881 117997 118049 118059 118111 118213 118227 118352 118576 118645 118742 118746 118860 119028 The SAS System 11 17:04 Tuesday, March 4, 2003 The Mixed Procedure Dimensions Covariance Parameters 4 Columns in X 9 Columns in Z Per Subject 2 Subjects 200 Max Obs Per Subject 9 Observations Used 1513 Observations Not Used 0 Total Observations 1513 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 14060.74494218 1 2 12404.97297030 0.00011928 2 1 12404.34905705 0.00000254 3 1 12404.33665183 0.00000000 Convergence criteria met. Estimated G Matrix Row Effect id Col1 Col2 1 Intercept 100073 498.65 -7.2819 2 ageL 100073 -7.2819 4.3558 Covariance Parameter Estimates Cov Parm Subject Estimate UN(1,1) id 498.65 UN(2,1) id -7.2819 UN(2,2) id 4.3558 Residual 118.06 Fit Statistics -2 Log Likelihood 12404.3 AIC (smaller is better) 12430.3 AICC (smaller is better) 12430.6 BIC (smaller is better) 12473.2 The SAS System 12 17:04 Tuesday, March 4, 2003 The Mixed Procedure Null Model Likelihood Ratio Test DF Chi-Square Pr > ChiSq 3 1656.41 <.0001 Solution for Fixed Effects Standard Effect Estimate Error DF t Value Pr > |t| Intercept 104.52 6.5619 195 15.93 <.0001 age0 -1.9104 0.3269 1113 -5.84 <.0001 ageL -0.6019 0.5838 196 -1.03 0.3038 female -1.2969 3.3284 1113 -0.39 0.6969 f508_1 -4.2382 5.4951 1113 -0.77 0.4407 f508_2 -6.6550 5.5256 1113 -1.20 0.2287 ageL*female -0.7637 0.3770 1113 -2.03 0.0430 ageL*f508_1 -0.5003 0.6288 1113 -0.80 0.4264 ageL*f508_2 -0.7450 0.6275 1113 -1.19 0.2354 Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F age0 1 1113 34.15 <.0001 ageL 1 196 1.06 0.3038 female 1 1113 0.15 0.6969 f508_1 1 1113 0.59 0.4407 f508_2 1 1113 1.45 0.2287 ageL*female 1 1113 4.10 0.0430 ageL*f508_1 1 1113 0.63 0.4264 ageL*f508_2 1 1113 1.41 0.2354 The SAS System 13 17:04 Tuesday, March 4, 2003 The Mixed Procedure Model Information Data Set WORK.CFKIDS Dependent Variable fev1 Covariance Structures Unstructured, Spatial Power Subject Effects id, id Estimation Method ML Residual Variance Method Profile Fixed Effects SE Method Model-Based Degrees of Freedom Method Containment The SAS System 14 17:04 Tuesday, March 4, 2003 The Mixed Procedure Class Level Information Class Levels Values id 200 100073 100111 100185 100329 100352 100636 100736 100815 100895 100897 101035 101174 101232 101309 101394 101456 101518 101701 101718 101799 101806 101891 102053 102316 102407 102512 102529 102551 102593 102685 102791 102804 102869 102979 102985 103209 103262 103283 103393 103399 103411 103564 103595 103624 103633 103728 103806 103850 104101 104367 104442 104806 104818 104864 104883 104916 105002 105070 105187 105197 105241 105319 105466 105474 105560 105707 105712 105796 105803 105837 105915 106080 106106 106148 106197 106204 106236 106345 106373 106389 106537 106672 106699 106702 106709 106720 106739 106938 106998 107004 107122 107243 107483 107508 107553 107625 107638 107755 107862 108225 108237 108331 108579 108642 108692 108841 108958 109245 109442 109469 109473 109506 109589 109669 109790 109825 109847 109996 110027 110054 110177 110330 110427 110615 110814 110970 110977 111139 111292 111309 111495 111508 111564 111709 111789 111876 112017 112074 112093 112095 113680 113829 114118 114392 114494 114542 114674 114706 114913 115191 115206 115224 115271 115334 115345 115395 115453 115487 115596 115720 115727 115785 115800 116004 116204 116260 116318 116320 116347 116448 116493 116764 117021 117023 117116 117126 117243 117249 117254 117413 117521 117561 117590 117609 117721 117740 117881 117997 118049 118059 118111 118213 118227 118352 118576 118645 118742 118746 118860 119028 The SAS System 15 17:04 Tuesday, March 4, 2003 The Mixed Procedure Dimensions Covariance Parameters 3 Columns in X 9 Columns in Z Per Subject 1 Subjects 200 Max Obs Per Subject 9 Observations Used 1513 Observations Not Used 0 Total Observations 1513 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 14060.74494218 1 2 12626.88483020 160.08535227 2 2 12446.80953904 0.01051442 3 1 12391.88312758 0.00079687 4 2 12389.46260819 0.00013189 5 1 12388.77154784 0.00000309 6 1 12388.75645624 0.00000000 Convergence criteria met. Estimated G Matrix Row Effect id Col1 1 Intercept 100073 470.87 Covariance Parameter Estimates Cov Parm Subject Estimate UN(1,1) id 470.87 SP(POW) id 0.3348 Residual 171.35 Fit Statistics -2 Log Likelihood 12388.8 AIC (smaller is better) 12412.8 AICC (smaller is better) 12413.0 BIC (smaller is better) 12452.3 The SAS System 16 17:04 Tuesday, March 4, 2003 The Mixed Procedure Null Model Likelihood Ratio Test DF Chi-Square Pr > ChiSq 2 1671.99 <.0001 Solution for Fixed Effects Standard Effect Estimate Error DF t Value Pr > |t| Intercept 104.19 6.6792 195 15.60 <.0001 age0 -1.8560 0.3281 1309 -5.66 <.0001 ageL -0.5882 0.4982 1309 -1.18 0.2379 female -1.2584 3.4197 1309 -0.37 0.7129 f508_1 -4.7020 5.6449 1309 -0.83 0.4050 f508_2 -6.7594 5.6735 1309 -1.19 0.2337 ageL*female -0.8559 0.3206 1309 -2.67 0.0077 ageL*f508_1 -0.4242 0.5377 1309 -0.79 0.4303 ageL*f508_2 -0.7042 0.5360 1309 -1.31 0.1892 Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F age0 1 1309 32.01 <.0001 ageL 1 1309 1.39 0.2379 female 1 1309 0.14 0.7129 f508_1 1 1309 0.69 0.4050 f508_2 1 1309 1.42 0.2337 ageL*female 1 1309 7.13 0.0077 ageL*f508_1 1 1309 0.62 0.4303 ageL*f508_2 1 1309 1.73 0.1892 The SAS System 17 17:04 Tuesday, March 4, 2003 The Mixed Procedure Model Information Data Set WORK.CFKIDS Dependent Variable fev1 Covariance Structures Unstructured, Spatial Power Subject Effects id, id Estimation Method ML Residual Variance Method Profile Fixed Effects SE Method Model-Based Degrees of Freedom Method Containment The SAS System 18 17:04 Tuesday, March 4, 2003 The Mixed Procedure Class Level Information Class Levels Values id 200 100073 100111 100185 100329 100352 100636 100736 100815 100895 100897 101035 101174 101232 101309 101394 101456 101518 101701 101718 101799 101806 101891 102053 102316 102407 102512 102529 102551 102593 102685 102791 102804 102869 102979 102985 103209 103262 103283 103393 103399 103411 103564 103595 103624 103633 103728 103806 103850 104101 104367 104442 104806 104818 104864 104883 104916 105002 105070 105187 105197 105241 105319 105466 105474 105560 105707 105712 105796 105803 105837 105915 106080 106106 106148 106197 106204 106236 106345 106373 106389 106537 106672 106699 106702 106709 106720 106739 106938 106998 107004 107122 107243 107483 107508 107553 107625 107638 107755 107862 108225 108237 108331 108579 108642 108692 108841 108958 109245 109442 109469 109473 109506 109589 109669 109790 109825 109847 109996 110027 110054 110177 110330 110427 110615 110814 110970 110977 111139 111292 111309 111495 111508 111564 111709 111789 111876 112017 112074 112093 112095 113680 113829 114118 114392 114494 114542 114674 114706 114913 115191 115206 115224 115271 115334 115345 115395 115453 115487 115596 115720 115727 115785 115800 116004 116204 116260 116318 116320 116347 116448 116493 116764 117021 117023 117116 117126 117243 117249 117254 117413 117521 117561 117590 117609 117721 117740 117881 117997 118049 118059 118111 118213 118227 118352 118576 118645 118742 118746 118860 119028 The SAS System 19 17:04 Tuesday, March 4, 2003 The Mixed Procedure Dimensions Covariance Parameters 4 Columns in X 9 Columns in Z Per Subject 1 Subjects 200 Max Obs Per Subject 9 Observations Used 1513 Observations Not Used 0 Total Observations 1513 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 14060.74494218 1 2 12560.96666205 88.11165506 2 2 12411.72177997 8.83775406 3 2 12388.50129704 0.03610399 4 1 12388.35026009 0.00000085 5 1 12388.11690996 0.00000032 6 1 12387.96473922 0.00000119 7 1 12387.92834767 0.00000065 8 2 12387.14890649 0.00204426 9 2 12385.73314179 0.01456219 10 2 12384.03067403 0.00634040 11 2 12381.41947371 0.01616892 12 2 12376.86557554 0.07126901 13 2 12370.73243563 0.01937379 14 2 12367.39944654 0.00154826 15 2 12360.04012641 0.00019716 16 2 12359.04870481 0.00002393 17 2 12358.92717363 0.00000125 18 1 12358.92093752 0.00000001 Convergence criteria met. Estimated G Matrix Row Effect id Col1 1 Intercept 100073 387.98 Covariance Parameter Estimates Cov Parm Subject Estimate UN(1,1) id 387.98 Variance id 179.56 SP(POW) id 0.8229 Residual 72.5084 The SAS System 20 17:04 Tuesday, March 4, 2003 The Mixed Procedure Fit Statistics -2 Log Likelihood 12358.9 AIC (smaller is better) 12384.9 AICC (smaller is better) 12385.2 BIC (smaller is better) 12427.8 Null Model Likelihood Ratio Test DF Chi-Square Pr > ChiSq 3 1701.82 <.0001 Solution for Fixed Effects Standard Effect Estimate Error DF t Value Pr > |t| Intercept 104.75 6.7411 195 15.54 <.0001 age0 -1.8739 0.3272 1309 -5.73 <.0001 ageL -0.7095 0.5757 1309 -1.23 0.2180 female -1.2088 3.4769 1309 -0.35 0.7281 f508_1 -5.0121 5.7374 1309 -0.87 0.3825 f508_2 -7.0993 5.7659 1309 -1.23 0.2184 ageL*female -0.8259 0.3716 1309 -2.22 0.0264 ageL*f508_1 -0.3159 0.6211 1309 -0.51 0.6111 ageL*f508_2 -0.5817 0.6195 1309 -0.94 0.3479 Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F age0 1 1309 32.81 <.0001 ageL 1 1309 1.52 0.2180 female 1 1309 0.12 0.7281 f508_1 1 1309 0.76 0.3825 f508_2 1 1309 1.52 0.2184 ageL*female 1 1309 4.94 0.0264 ageL*f508_1 1 1309 0.26 0.6111 ageL*f508_2 1 1309 0.88 0.3479 The SAS System 21 17:04 Tuesday, March 4, 2003 The Mixed Procedure Model Information Data Set WORK.CFKIDS Dependent Variable fev1 Covariance Structures Unstructured, Spatial Power Subject Effects id, id Estimation Method ML Residual Variance Method Profile Fixed Effects SE Method Model-Based Degrees of Freedom Method Containment The SAS System 22 17:04 Tuesday, March 4, 2003 The Mixed Procedure Class Level Information Class Levels Values id 200 100073 100111 100185 100329 100352 100636 100736 100815 100895 100897 101035 101174 101232 101309 101394 101456 101518 101701 101718 101799 101806 101891 102053 102316 102407 102512 102529 102551 102593 102685 102791 102804 102869 102979 102985 103209 103262 103283 103393 103399 103411 103564 103595 103624 103633 103728 103806 103850 104101 104367 104442 104806 104818 104864 104883 104916 105002 105070 105187 105197 105241 105319 105466 105474 105560 105707 105712 105796 105803 105837 105915 106080 106106 106148 106197 106204 106236 106345 106373 106389 106537 106672 106699 106702 106709 106720 106739 106938 106998 107004 107122 107243 107483 107508 107553 107625 107638 107755 107862 108225 108237 108331 108579 108642 108692 108841 108958 109245 109442 109469 109473 109506 109589 109669 109790 109825 109847 109996 110027 110054 110177 110330 110427 110615 110814 110970 110977 111139 111292 111309 111495 111508 111564 111709 111789 111876 112017 112074 112093 112095 113680 113829 114118 114392 114494 114542 114674 114706 114913 115191 115206 115224 115271 115334 115345 115395 115453 115487 115596 115720 115727 115785 115800 116004 116204 116260 116318 116320 116347 116448 116493 116764 117021 117023 117116 117126 117243 117249 117254 117413 117521 117561 117590 117609 117721 117740 117881 117997 118049 118059 118111 118213 118227 118352 118576 118645 118742 118746 118860 119028 The SAS System 23 17:04 Tuesday, March 4, 2003 The Mixed Procedure Dimensions Covariance Parameters 5 Columns in X 9 Columns in Z Per Subject 2 Subjects 200 Max Obs Per Subject 9 Observations Used 1513 Observations Not Used 0 Total Observations 1513 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 14060.74494218 1 4 12789.43790862 467.03136828 2 1 12637.88576095 . 3 1 12620.29124861 188.06103786 4 1 12516.36549031 161.10976159 5 1 12386.54982061 0.00427062 6 2 12366.46639565 0.00052084 7 1 12363.65381505 0.00002829 8 1 12363.51300708 0.00000011 9 1 12363.51248278 0.00000000 Convergence criteria met. Estimated G Matrix Row Effect id Col1 Col2 1 Intercept 100073 471.67 -3.3885 2 ageL 100073 -3.3885 3.2290 Covariance Parameter Estimates Cov Parm Subject Estimate UN(1,1) id 471.67 UN(2,1) id -3.3885 UN(2,2) id 3.2290 SP(POW) id 0.1883 Residual 135.58 Fit Statistics -2 Log Likelihood 12363.5 AIC (smaller is better) 12391.5 AICC (smaller is better) 12391.8 The SAS System 24 17:04 Tuesday, March 4, 2003 The Mixed Procedure Fit Statistics BIC (smaller is better) 12437.7 Null Model Likelihood Ratio Test DF Chi-Square Pr > ChiSq 4 1697.23 <.0001 Solution for Fixed Effects Standard Effect Estimate Error DF t Value Pr > |t| Intercept 104.79 6.5409 195 16.02 <.0001 age0 -1.9139 0.3257 1113 -5.88 <.0001 ageL -0.5819 0.5826 196 -1.00 0.3191 female -1.2844 3.3203 1113 -0.39 0.6989 f508_1 -4.4954 5.4811 1113 -0.82 0.4123 f508_2 -6.6850 5.5105 1113 -1.21 0.2253 ageL*female -0.8137 0.3760 1113 -2.16 0.0307 ageL*f508_1 -0.4729 0.6279 1113 -0.75 0.4515 ageL*f508_2 -0.7740 0.6264 1113 -1.24 0.2169 Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F age0 1 1113 34.52 <.0001 ageL 1 196 1.00 0.3191 female 1 1113 0.15 0.6989 f508_1 1 1113 0.67 0.4123 f508_2 1 1113 1.47 0.2253 ageL*female 1 1113 4.68 0.0307 ageL*f508_1 1 1113 0.57 0.4515 ageL*f508_2 1 1113 1.53 0.2169 The SAS System 25 17:04 Tuesday, March 4, 2003 The Mixed Procedure Model Information Data Set WORK.CFKIDS Dependent Variable fev1 Covariance Structures Unstructured, Spatial Power Subject Effects id, id Estimation Method ML Residual Variance Method Profile Fixed Effects SE Method Model-Based Degrees of Freedom Method Containment The SAS System 26 17:04 Tuesday, March 4, 2003 The Mixed Procedure Class Level Information Class Levels Values id 200 100073 100111 100185 100329 100352 100636 100736 100815 100895 100897 101035 101174 101232 101309 101394 101456 101518 101701 101718 101799 101806 101891 102053 102316 102407 102512 102529 102551 102593 102685 102791 102804 102869 102979 102985 103209 103262 103283 103393 103399 103411 103564 103595 103624 103633 103728 103806 103850 104101 104367 104442 104806 104818 104864 104883 104916 105002 105070 105187 105197 105241 105319 105466 105474 105560 105707 105712 105796 105803 105837 105915 106080 106106 106148 106197 106204 106236 106345 106373 106389 106537 106672 106699 106702 106709 106720 106739 106938 106998 107004 107122 107243 107483 107508 107553 107625 107638 107755 107862 108225 108237 108331 108579 108642 108692 108841 108958 109245 109442 109469 109473 109506 109589 109669 109790 109825 109847 109996 110027 110054 110177 110330 110427 110615 110814 110970 110977 111139 111292 111309 111495 111508 111564 111709 111789 111876 112017 112074 112093 112095 113680 113829 114118 114392 114494 114542 114674 114706 114913 115191 115206 115224 115271 115334 115345 115395 115453 115487 115596 115720 115727 115785 115800 116004 116204 116260 116318 116320 116347 116448 116493 116764 117021 117023 117116 117126 117243 117249 117254 117413 117521 117561 117590 117609 117721 117740 117881 117997 118049 118059 118111 118213 118227 118352 118576 118645 118742 118746 118860 119028 The SAS System 27 17:04 Tuesday, March 4, 2003 The Mixed Procedure Dimensions Covariance Parameters 6 Columns in X 9 Columns in Z Per Subject 2 Subjects 200 Max Obs Per Subject 9 Observations Used 1513 Observations Not Used 0 Total Observations 1513 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 14060.74494218 1 2 12675.52636517 170.88378255 2 2 12461.75312696 32.61418200 3 2 12368.20429663 0.96499338 4 2 12363.73297428 0.00432434 5 1 12363.26129495 0.00001865 6 1 12363.19374083 0.00000013 7 1 12363.18070539 0.00000011 8 2 12362.87023929 0.00092367 9 2 12362.31370211 0.00589083 10 2 12361.71741691 0.00220002 11 2 12361.09426343 0.00166602 12 2 12359.68192312 0.04111517 13 2 12358.21699776 0.00027773 14 2 12357.48166336 0.00036839 15 2 12355.67110717 0.00044560 16 4 12355.30778560 0.00003712 17 2 12355.11200291 0.00001087 18 2 12355.05205461 0.00000201 19 2 12355.04082357 0.00000037 20 1 12355.03879914 0.00000003 21 1 12355.03863403 0.00000000 Convergence criteria met. Estimated G Matrix Row Effect id Col1 Col2 1 Intercept 100073 398.62 4.1603 2 ageL 100073 4.1603 1.1320 The SAS System 28 17:04 Tuesday, March 4, 2003 The Mixed Procedure Covariance Parameter Estimates Cov Parm Subject Estimate UN(1,1) id 398.62 UN(2,1) id 4.1603 UN(2,2) id 1.1320 Variance id 122.28 SP(POW) id 0.7052 Residual 67.6618 Fit Statistics -2 Log Likelihood 12355.0 AIC (smaller is better) 12385.0 AICC (smaller is better) 12385.4 BIC (smaller is better) 12434.5 Null Model Likelihood Ratio Test DF Chi-Square Pr > ChiSq 5 1705.71 <.0001 Solution for Fixed Effects Standard Effect Estimate Error DF t Value Pr > |t| Intercept 105.37 6.5101 195 16.18 <.0001 age0 -1.9349 0.3241 1113 -5.97 <.0001 ageL -0.6654 0.5789 196 -1.15 0.2518 female -1.1502 3.3059 1113 -0.35 0.7280 f508_1 -4.8657 5.4549 1113 -0.89 0.3726 f508_2 -7.0908 5.4848 1113 -1.29 0.1963 ageL*female -0.8353 0.3737 1113 -2.24 0.0256 ageL*f508_1 -0.3637 0.6244 1113 -0.58 0.5604 ageL*f508_2 -0.6486 0.6229 1113 -1.04 0.2979 Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F age0 1 1113 35.64 <.0001 ageL 1 196 1.32 0.2518 female 1 1113 0.12 0.7280 f508_1 1 1113 0.80 0.3726 f508_2 1 1113 1.67 0.1963 ageL*female 1 1113 5.00 0.0256 ageL*f508_1 1 1113 0.34 0.5604 The SAS System 29 17:04 Tuesday, March 4, 2003 The Mixed Procedure Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F ageL*f508_2 1 1113 1.08 0.2979