The SAS System 1 12:13 Tuesday, May 10, 2005 The Mixed Procedure Model Information Data Set WORK.PANSS Dependent Variable score Covariance Structure Compound Symmetry Subject Effect id Estimation Method ML Residual Variance Method Profile Fixed Effects SE Method Model-Based Degrees of Freedom Method Between-Within Class Level Information Class Levels Values id 255 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 166 167 168 169 170 171 172 173 174 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 group 3 1 2 3 Dimensions Covariance Parameters 2 Columns in X 9 The SAS System 2 12:13 Tuesday, May 10, 2005 The Mixed Procedure Dimensions Columns in Z 0 Subjects 255 Max Obs Per Subject 5 Observations Used 952 Observations Not Used 0 Total Observations 952 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 8160.39101964 1 2 7739.51241626 0.00000380 2 1 7739.50089208 0.00000000 Convergence criteria met. Covariance Parameter Estimates Cov Parm Subject Estimate CS id 195.26 Residual 119.95 Fit Statistics -2 Log Likelihood 7739.5 AIC (smaller is better) 7757.5 AICC (smaller is better) 7757.7 BIC (smaller is better) 7789.4 Null Model Likelihood Ratio Test DF Chi-Square Pr > ChiSq 1 420.89 <.0001 Solution for Fixed Effects Standard Effect group Estimate Error DF t Value Pr > |t| Intercept 28.9187 5.1076 251 5.66 <.0001 y0 0.6598 0.05131 251 12.86 <.0001 time 0.2701 0.3088 694 0.87 0.3819 group 1 -1.3281 2.6746 251 -0.50 0.6199 group 2 -10.9959 2.6573 251 -4.14 <.0001 The SAS System 3 12:13 Tuesday, May 10, 2005 The Mixed Procedure Solution for Fixed Effects Standard Effect group Estimate Error DF t Value Pr > |t| group 3 0 . . . . time*group 1 -1.1913 0.4141 694 -2.88 0.0041 time*group 2 -1.4494 0.3936 694 -3.68 0.0002 time*group 3 0 . . . . Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F y0 1 251 165.39 <.0001 time 1 694 14.48 0.0002 group 2 251 10.32 <.0001 time*group 2 694 7.18 0.0008 Estimates Standard Label Estimate Error DF t Value Pr > |t| Group 2 versus Group 1 at 8 weeks -11.7325 2.9001 694 -4.05 <.0001 Group 3 versus Group 1 at 8 weeks 10.8582 3.1492 694 3.45 0.0006 Estimates Label Alpha Lower Upper Group 2 versus Group 1 at 8 weeks 0.05 -17.4265 -6.0385 Group 3 versus Group 1 at 8 weeks 0.05 4.6752 17.0413 The SAS System 4 12:13 Tuesday, May 10, 2005 The Mixed Procedure Model Information Data Set WORK.PANSS Dependent Variable score Covariance Structure Unstructured Subject Effect id Estimation Method ML Residual Variance Method Profile Fixed Effects SE Method Model-Based Degrees of Freedom Method Containment Class Level Information Class Levels Values id 255 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 166 167 168 169 170 171 172 173 174 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 group 3 1 2 3 Dimensions Covariance Parameters 4 Columns in X 9 The SAS System 5 12:13 Tuesday, May 10, 2005 The Mixed Procedure Dimensions Columns in Z Per Subject 2 Subjects 255 Max Obs Per Subject 5 Observations Used 952 Observations Not Used 0 Total Observations 952 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 8160.39101964 1 2 7642.52753404 0.00060125 2 1 7640.49910141 0.00004243 3 1 7640.36785811 0.00000027 4 1 7640.36704473 0.00000000 Convergence criteria met. Estimated G Matrix Row Effect id Col1 Col2 1 Intercept 1 167.31 -1.6175 2 time 1 -1.6175 5.7473 Covariance Parameter Estimates Cov Parm Subject Estimate UN(1,1) id 167.31 UN(2,1) id -1.6175 UN(2,2) id 5.7473 Residual 83.0945 Fit Statistics -2 Log Likelihood 7640.4 AIC (smaller is better) 7662.4 AICC (smaller is better) 7662.6 BIC (smaller is better) 7701.3 The SAS System 6 12:13 Tuesday, May 10, 2005 The Mixed Procedure Null Model Likelihood Ratio Test DF Chi-Square Pr > ChiSq 3 520.02 <.0001 Solution for Fixed Effects Standard Effect group Estimate Error DF t Value Pr > |t| Intercept 24.3705 4.8491 251 5.03 <.0001 y0 0.6941 0.04905 469 14.15 <.0001 time 1.1213 0.4362 225 2.57 0.0108 group 1 -0.8403 2.4341 469 -0.35 0.7301 group 2 -10.1537 2.4133 469 -4.21 <.0001 group 3 0 . . . . time*group 1 -1.5230 0.5904 469 -2.58 0.0102 time*group 2 -2.0521 0.5630 469 -3.64 0.0003 time*group 3 0 . . . . Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F y0 1 469 200.24 <.0001 time 1 225 0.09 0.7596 group 2 469 11.08 <.0001 time*group 2 469 6.82 0.0012 Estimates Standard Label Estimate Error DF t Value Pr > |t| Group 2 versus Group 1 at 8 weeks -13.5464 4.1152 469 -3.29 0.0011 Group 3 versus Group 1 at 8 weeks 13.0244 4.4442 469 2.93 0.0035 Estimates Label Alpha Lower Upper Group 2 versus Group 1 at 8 weeks 0.05 -21.6329 -5.4600 Group 3 versus Group 1 at 8 weeks 0.05 4.2915 21.7573 The SAS System 7 12:13 Tuesday, May 10, 2005 The Mixed Procedure Model Information Data Set WORK.PANSS Dependent Variable score Covariance Structures Variance Components, Spatial Power Subject Effects id, id Estimation Method ML Residual Variance Method Profile Fixed Effects SE Method Model-Based Degrees of Freedom Method Containment Class Level Information Class Levels Values id 255 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 166 167 168 169 170 171 172 173 174 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 group 3 1 2 3 The SAS System 8 12:13 Tuesday, May 10, 2005 The Mixed Procedure Dimensions Covariance Parameters 3 Columns in X 9 Columns in Z Per Subject 1 Subjects 255 Max Obs Per Subject 5 Observations Used 952 Observations Not Used 0 Total Observations 952 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 8160.39101964 1 2 7751.18706115 0.24638882 2 1 7738.39749681 1.36425388 3 1 7693.84601586 0.00396543 4 2 7686.46939474 0.00039332 5 1 7685.46649477 0.00002178 6 1 7685.40046421 0.00000004 7 1 7685.40033811 0.00000000 Convergence criteria met. Estimated G Matrix Row Effect id Col1 1 Intercept 1 145.02 Covariance Parameter Estimates Cov Parm Subject Estimate Intercept id 145.02 SP(POW) id 0.6226 Residual 176.74 Fit Statistics -2 Log Likelihood 7685.4 AIC (smaller is better) 7705.4 AICC (smaller is better) 7705.6 BIC (smaller is better) 7740.8 The SAS System 9 12:13 Tuesday, May 10, 2005 The Mixed Procedure Solution for Fixed Effects Standard Effect group Estimate Error DF t Value Pr > |t| Intercept 29.4418 5.2469 251 5.61 <.0001 y0 0.6575 0.05194 694 12.66 <.0001 time 0.2225 0.3952 694 0.56 0.5737 group 1 -1.3304 2.9520 694 -0.45 0.6524 group 2 -10.6361 2.9385 694 -3.62 0.0003 group 3 0 . . . . time*group 1 -1.1468 0.5339 694 -2.15 0.0321 time*group 2 -1.4716 0.5107 694 -2.88 0.0041 time*group 3 0 . . . . Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F y0 1 694 160.21 <.0001 time 1 694 9.75 0.0019 group 2 694 7.85 0.0004 time*group 2 694 4.34 0.0134 Estimates Standard Label Estimate Error DF t Value Pr > |t| Group 2 versus Group 1 at 8 weeks -11.9047 3.1703 694 -3.76 0.0002 Group 3 versus Group 1 at 8 weeks 10.5045 3.4965 694 3.00 0.0028 Estimates Label Alpha Lower Upper Group 2 versus Group 1 at 8 weeks 0.05 -18.1291 -5.6802 Group 3 versus Group 1 at 8 weeks 0.05 3.6396 17.3694 The SAS System 10 12:13 Tuesday, May 10, 2005 The Mixed Procedure Model Information Data Set WORK.PANSS Dependent Variable score Covariance Structures Variance Components, Spatial Power Subject Effects id, id Estimation Method ML Residual Variance Method Profile Fixed Effects SE Method Model-Based Degrees of Freedom Method Containment Class Level Information Class Levels Values id 255 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 166 167 168 169 170 171 172 173 174 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 group 3 1 2 3 The SAS System 11 12:13 Tuesday, May 10, 2005 The Mixed Procedure Dimensions Covariance Parameters 4 Columns in X 9 Columns in Z Per Subject 1 Subjects 255 Max Obs Per Subject 5 Observations Used 952 Observations Not Used 0 Total Observations 952 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 8160.39101964 1 2 7779.58772404 129.45881880 2 1 7715.04468635 17.77055439 3 1 7694.13944203 1.37315751 4 1 7690.51231670 0.02869827 5 1 7687.21556739 0.00027601 6 2 7685.03446599 0.00874167 7 2 7684.75653797 0.02392759 8 2 7684.24808090 0.00796539 9 2 7683.70908353 0.02932095 10 2 7682.22115776 0.00000848 11 2 7681.29855814 0.01114507 12 2 7679.17944941 0.06597822 13 2 7676.98161826 0.02001294 14 2 7672.51568891 0.44332552 15 3 7666.09243797 0.00044928 16 1 7664.73664641 0.00001252 17 1 7664.69839675 0.00000004 18 1 7664.69828447 0.00000000 Convergence criteria met. Estimated G Matrix Row Effect id Col1 1 Intercept 1 Covariance Parameter Estimates Cov Parm Subject Estimate Intercept id 0 Variance id 267.70 SP(POW) id 0.9104 Residual 51.7404 The SAS System 12 12:13 Tuesday, May 10, 2005 The Mixed Procedure Fit Statistics -2 Log Likelihood 7664.7 AIC (smaller is better) 7684.7 AICC (smaller is better) 7684.9 BIC (smaller is better) 7720.1 Solution for Fixed Effects Standard Effect group Estimate Error DF t Value Pr > |t| Intercept 28.9333 5.2466 251 5.51 <.0001 y0 0.6599 0.05197 694 12.70 <.0001 time 0.3427 0.3956 694 0.87 0.3867 group 1 -1.1790 2.9441 694 -0.40 0.6890 group 2 -10.4999 2.9329 694 -3.58 0.0004 group 3 0 . . . . time*group 1 -1.1793 0.5355 694 -2.20 0.0280 time*group 2 -1.5196 0.5127 694 -2.96 0.0031 time*group 3 0 . . . . Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F y0 1 694 161.18 <.0001 time 1 694 7.09 0.0079 group 2 694 7.75 0.0005 time*group 2 694 4.59 0.0105 Estimates Standard Label Estimate Error DF t Value Pr > |t| Group 2 versus Group 1 at 8 weeks -12.0428 3.1993 694 -3.76 0.0002 Group 3 versus Group 1 at 8 weeks 10.6136 3.5226 694 3.01 0.0027 Estimates Label Alpha Lower Upper Group 2 versus Group 1 at 8 weeks 0.05 -18.3243 -5.7612 Group 3 versus Group 1 at 8 weeks 0.05 3.6974 17.5298 The SAS System 13 12:13 Tuesday, May 10, 2005 The Mixed Procedure Model Information Data Set WORK.PANSS Dependent Variable score Covariance Structures Unstructured, Spatial Power Subject Effects id, id Estimation Method ML Residual Variance Method Profile Fixed Effects SE Method Model-Based Degrees of Freedom Method Containment Class Level Information Class Levels Values id 255 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 166 167 168 169 170 171 172 173 174 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 group 3 1 2 3 The SAS System 14 12:13 Tuesday, May 10, 2005 The Mixed Procedure Dimensions Covariance Parameters 5 Columns in X 9 Columns in Z Per Subject 2 Subjects 255 Max Obs Per Subject 5 Observations Used 952 Observations Not Used 0 Total Observations 952 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 8160.39101964 1 2 7645.09165127 7.15902694 2 1 7642.45880502 0.09430525 3 1 7641.23348068 0.01061814 4 1 7639.69465655 0.03380318 5 1 7636.77699524 0.00052578 6 1 7635.08400856 0.00001543 7 1 7635.03748442 0.00000002 8 1 7635.03741571 0.00000000 Convergence criteria met. Estimated G Matrix Row Effect id Col1 Col2 1 Intercept 1 190.39 -6.5748 2 time 1 -6.5748 6.6598 Covariance Parameter Estimates Cov Parm Subject Estimate UN(1,1) id 190.39 UN(2,1) id -6.5748 UN(2,2) id 6.6598 SP(POW) id -0.3472 Residual 77.9731 Fit Statistics -2 Log Likelihood 7635.0 AIC (smaller is better) 7659.0 AICC (smaller is better) 7659.4 BIC (smaller is better) 7701.5 The SAS System 15 12:13 Tuesday, May 10, 2005 The Mixed Procedure Null Model Likelihood Ratio Test DF Chi-Square Pr > ChiSq 4 525.35 <.0001 Solution for Fixed Effects Standard Effect group Estimate Error DF t Value Pr > |t| Intercept 24.3605 4.8279 251 5.05 <.0001 y0 0.6926 0.04880 469 14.19 <.0001 time 1.1893 0.4427 225 2.69 0.0078 group 1 -0.6866 2.4412 469 -0.28 0.7786 group 2 -10.0173 2.4200 469 -4.14 <.0001 group 3 0 . . . . time*group 1 -1.5566 0.6001 469 -2.59 0.0098 time*group 2 -2.0644 0.5728 469 -3.60 0.0003 time*group 3 0 . . . . Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F y0 1 469 201.45 <.0001 time 1 225 0.01 0.9397 group 2 469 10.86 <.0001 time*group 2 469 6.71 0.0013 Estimates Standard Label Estimate Error DF t Value Pr > |t| Group 2 versus Group 1 at 8 weeks -13.3932 4.1408 469 -3.23 0.0013 Group 3 versus Group 1 at 8 weeks 13.1392 4.4740 469 2.94 0.0035 Estimates Label Alpha Lower Upper Group 2 versus Group 1 at 8 weeks 0.05 -21.5300 -5.2564 Group 3 versus Group 1 at 8 weeks 0.05 4.3476 21.9307 The SAS System 16 12:13 Tuesday, May 10, 2005 The Mixed Procedure Model Information Data Set WORK.PANSS Dependent Variable score Covariance Structures Unstructured, Spatial Power Subject Effects id, id Estimation Method ML Residual Variance Method Profile Fixed Effects SE Method Model-Based Degrees of Freedom Method Containment Class Level Information Class Levels Values id 255 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 166 167 168 169 170 171 172 173 174 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 group 3 1 2 3 The SAS System 17 12:13 Tuesday, May 10, 2005 The Mixed Procedure Dimensions Covariance Parameters 6 Columns in X 9 Columns in Z Per Subject 2 Subjects 255 Max Obs Per Subject 5 Observations Used 952 Observations Not Used 0 Total Observations 952 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 8160.39101964 1 2 7801.22839084 204.33082289 2 1 7707.71375389 33.97812190 3 1 7664.22577796 4.40412814 4 1 7645.54137586 0.34127138 5 1 7642.94243795 0.01027431 6 2 7638.64567035 0.00280791 7 3 7635.30877256 0.00007953 8 4 7634.95810278 0.00005689 9 2 7634.86738599 0.00000136 10 2 7634.68719756 0.00029336 11 2 7634.56048530 0.00001811 12 2 7634.11524807 0.00158005 13 2 7633.72962301 0.00019977 14 2 7632.63820757 0.00853786 15 2 7630.81731913 0.02135073 16 2 7628.79252504 0.00108570 17 2 7627.27354293 0.00024416 18 2 7626.76263635 0.00002592 19 1 7626.68258074 0.00000017 20 1 7626.68206778 0.00000000 Convergence criteria met. Estimated G Matrix Row Effect id Col1 Col2 1 Intercept 1 183.17 -5.0225 2 time 1 -5.0225 6.0222 The SAS System 18 12:13 Tuesday, May 10, 2005 The Mixed Procedure Covariance Parameter Estimates Cov Parm Subject Estimate UN(1,1) id 183.17 UN(2,1) id -5.0225 UN(2,2) id 6.0222 Variance id 24.2824 SP(POW) id -0.8003 Residual 58.7310 Fit Statistics -2 Log Likelihood 7626.7 AIC (smaller is better) 7652.7 AICC (smaller is better) 7653.1 BIC (smaller is better) 7698.7 Null Model Likelihood Ratio Test DF Chi-Square Pr > ChiSq 5 533.71 <.0001 Solution for Fixed Effects Standard Effect group Estimate Error DF t Value Pr > |t| Intercept 24.3704 4.8385 251 5.04 <.0001 y0 0.6922 0.04889 469 14.16 <.0001 time 1.2080 0.4401 225 2.74 0.0065 group 1 -0.7440 2.4493 469 -0.30 0.7615 group 2 -10.0853 2.4273 469 -4.15 <.0001 group 3 0 . . . . time*group 1 -1.5298 0.5961 469 -2.57 0.0106 time*group 2 -2.0187 0.5683 469 -3.55 0.0004 time*group 3 0 . . . . Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F y0 1 469 200.40 <.0001 time 1 225 0.01 0.9138 group 2 469 10.90 <.0001 time*group 2 469 6.52 0.0016 The SAS System 19 12:13 Tuesday, May 10, 2005 The Mixed Procedure Estimates Standard Label Estimate Error DF t Value Pr > |t| Group 2 versus Group 1 at 8 weeks -13.2525 4.1004 469 -3.23 0.0013 Group 3 versus Group 1 at 8 weeks 12.9823 4.4367 469 2.93 0.0036 Estimates Label Alpha Lower Upper Group 2 versus Group 1 at 8 weeks 0.05 -21.3099 -5.1952 Group 3 versus Group 1 at 8 weeks 0.05 4.2641 21.7005 The SAS System 20 12:13 Tuesday, May 10, 2005 The Mixed Procedure Model Information Data Set WORK.PANSS Dependent Variable score Covariance Structures Unstructured, Spatial Exponential Subject Effects id, id Estimation Method ML Residual Variance Method Profile Fixed Effects SE Method Model-Based Degrees of Freedom Method Containment Class Level Information Class Levels Values id 255 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 166 167 168 169 170 171 172 173 174 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 group 3 1 2 3 The SAS System 21 12:13 Tuesday, May 10, 2005 The Mixed Procedure Dimensions Covariance Parameters 6 Columns in X 9 Columns in Z Per Subject 2 Subjects 255 Max Obs Per Subject 5 Observations Used 952 Observations Not Used 0 Total Observations 952 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 8160.39101964 1 4 7643.85578006 0.00007966 2 2 7641.82280038 0.00000911 3 2 7640.39017111 0.00000073 4 1 7640.36704613 0.00000000 Convergence criteria met but final hessian is not positive definite. Estimated G Matrix Row Effect id Col1 Col2 1 Intercept 1 167.31 -1.6171 2 time 1 -1.6171 5.7463 Covariance Parameter Estimates Cov Parm Subject Estimate UN(1,1) id 167.31 UN(2,1) id -1.6171 UN(2,2) id 5.7463 Variance id 82.0983 SP(EXP) id 0 Residual 0.9990 Fit Statistics -2 Log Likelihood 7640.4 AIC (smaller is better) 7664.4 AICC (smaller is better) 7664.7 BIC (smaller is better) 7706.9 The SAS System 22 12:13 Tuesday, May 10, 2005 The Mixed Procedure Null Model Likelihood Ratio Test DF Chi-Square Pr > ChiSq 4 520.02 <.0001 Solution for Fixed Effects Standard Effect group Estimate Error DF t Value Pr > |t| Intercept 24.3708 4.8491 251 5.03 <.0001 y0 0.6941 0.04905 469 14.15 <.0001 time 1.1212 0.4362 225 2.57 0.0108 group 1 -0.8404 2.4341 469 -0.35 0.7301 group 2 -10.1538 2.4133 469 -4.21 <.0001 group 3 0 . . . . time*group 1 -1.5230 0.5904 469 -2.58 0.0102 time*group 2 -2.0521 0.5630 469 -3.64 0.0003 time*group 3 0 . . . . Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F y0 1 469 200.24 <.0001 time 1 225 0.09 0.7593 group 2 469 11.08 <.0001 time*group 2 469 6.82 0.0012 Estimates Standard Label Estimate Error DF t Value Pr > |t| Group 2 versus Group 1 at 8 weeks -13.5462 4.1150 469 -3.29 0.0011 Group 3 versus Group 1 at 8 weeks 13.0242 4.4440 469 2.93 0.0035 Estimates Label Alpha Lower Upper Group 2 versus Group 1 at 8 weeks 0.05 -21.6323 -5.4601 Group 3 versus Group 1 at 8 weeks 0.05 4.2916 21.7567 The SAS System 23 12:13 Tuesday, May 10, 2005 The Mixed Procedure Model Information Data Set WORK.PANSS Dependent Variable score Covariance Structure Unstructured Subject Effect id Estimation Method ML Residual Variance Method None Fixed Effects SE Method Model-Based Degrees of Freedom Method Between-Within Class Level Information Class Levels Values id 255 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 166 167 168 169 170 171 172 173 174 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 group 3 1 2 3 Dimensions Covariance Parameters 15 Columns in X 9 The SAS System 24 12:13 Tuesday, May 10, 2005 The Mixed Procedure Dimensions Columns in Z 0 Subjects 255 Max Obs Per Subject 5 Observations Used 952 Observations Not Used 0 Total Observations 952 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 8160.39101964 1 4 7580.51479042 0.00106579 2 1 7577.10370546 0.00004019 3 1 7576.98298555 0.00000010 4 1 7576.98269273 0.00000000 Convergence criteria met. Covariance Parameter Estimates Cov Parm Subject Estimate UN(1,1) id 207.89 UN(2,1) id 170.91 UN(2,2) id 322.95 UN(3,1) id 161.11 UN(3,2) id 269.67 UN(3,3) id 401.12 UN(4,1) id 162.24 UN(4,2) id 245.05 UN(4,3) id 325.40 UN(4,4) id 431.02 UN(5,1) id 141.39 UN(5,2) id 206.01 UN(5,3) id 302.31 UN(5,4) id 398.20 UN(5,5) id 464.64 Fit Statistics -2 Log Likelihood 7577.0 AIC (smaller is better) 7621.0 AICC (smaller is better) 7622.1 BIC (smaller is better) 7698.9 The SAS System 25 12:13 Tuesday, May 10, 2005 The Mixed Procedure Null Model Likelihood Ratio Test DF Chi-Square Pr > ChiSq 14 583.41 <.0001 Solution for Fixed Effects Standard Effect group Estimate Error DF t Value Pr > |t| Intercept 24.8636 4.6507 251 5.35 <.0001 y0 0.6951 0.04691 251 14.82 <.0001 time 0.8541 0.4292 251 1.99 0.0477 group 1 -0.4756 2.3574 251 -0.20 0.8403 group 2 -9.0752 2.3486 251 -3.86 0.0001 group 3 0 . . . . time*group 1 -1.3137 0.5788 251 -2.27 0.0241 time*group 2 -1.7409 0.5515 251 -3.16 0.0018 time*group 3 0 . . . . Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F y0 1 251 219.59 <.0001 time 1 251 0.53 0.4664 group 2 251 9.53 0.0001 time*group 2 251 5.13 0.0065 Estimates Standard Label Estimate Error DF t Value Pr > |t| Group 2 versus Group 1 at 8 weeks -12.0167 3.8843 251 -3.09 0.0022 Group 3 versus Group 1 at 8 weeks 10.9853 4.2639 251 2.58 0.0106 Estimates Label Alpha Lower Upper Group 2 versus Group 1 at 8 weeks 0.05 -19.6666 -4.3668 Group 3 versus Group 1 at 8 weeks 0.05 2.5877 19.3830 The SAS System 26 12:13 Tuesday, May 10, 2005 The Mixed Procedure Model Information Data Set WORK.PANSS Dependent Variable score Covariance Structure Unstructured Subject Effect id Estimation Method ML Residual Variance Method Profile Fixed Effects SE Method Model-Based Degrees of Freedom Method Containment Class Level Information Class Levels Values id 255 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 166 167 168 169 170 171 172 173 174 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 group 3 1 2 3 Dimensions Covariance Parameters 4 Columns in X 9 The SAS System 27 12:13 Tuesday, May 10, 2005 The Mixed Procedure Dimensions Columns in Z Per Subject 2 Subjects 255 Max Obs Per Subject 5 Observations Used 952 Observations Not Used 0 Total Observations 952 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 8160.39101964 1 2 7642.52753404 0.00060125 2 1 7640.49910141 0.00004243 3 1 7640.36785811 0.00000027 4 1 7640.36704473 0.00000000 Convergence criteria met. Covariance Parameter Estimates Cov Parm Subject Estimate UN(1,1) id 509.26 UN(2,1) id 44.3610 UN(2,2) id 5.7473 Residual 83.0945 Fit Statistics -2 Log Likelihood 7640.4 AIC (smaller is better) 7662.4 AICC (smaller is better) 7662.6 BIC (smaller is better) 7701.3 Null Model Likelihood Ratio Test DF Chi-Square Pr > ChiSq 3 520.02 <.0001 The SAS System 28 12:13 Tuesday, May 10, 2005 The Mixed Procedure Solution for Fixed Effects Standard Effect group Estimate Error DF t Value Pr > |t| Intercept 33.3409 5.5649 251 5.99 <.0001 y0 0.6941 0.04905 469 14.15 <.0001 time8 1.1213 0.4362 225 2.57 0.0108 group 1 -13.0244 4.4442 469 -2.93 0.0035 group 2 -26.5708 4.2876 469 -6.20 <.0001 group 3 0 . . . . time8*group 1 -1.5230 0.5904 469 -2.58 0.0102 time8*group 2 -2.0521 0.5630 469 -3.64 0.0003 time8*group 3 0 . . . . Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F y0 1 469 200.24 <.0001 time8 1 225 0.09 0.7596 group 2 469 19.40 <.0001 time8*group 2 469 6.82 0.0012 Estimates Standard Label Estimate Error DF t Value Pr > |t| Group 2 versus Group 1 at 8 weeks -13.5464 4.1152 469 -3.29 0.0011 Group 3 versus Group 1 at 8 weeks 13.0244 4.4442 469 2.93 0.0035 Estimates Label Alpha Lower Upper Group 2 versus Group 1 at 8 weeks 0.05 -21.6329 -5.4600 Group 3 versus Group 1 at 8 weeks 0.05 4.2915 21.7573 The SAS System 29 12:13 Tuesday, May 10, 2005 The Mixed Procedure Model Information Data Set WORK.PANSS Dependent Variable score Covariance Structure Unstructured Subject Effect id Estimation Method ML Residual Variance Method None Fixed Effects SE Method Model-Based Degrees of Freedom Method Between-Within Class Level Information Class Levels Values id 255 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 166 167 168 169 170 171 172 173 174 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 group 3 1 2 3 Dimensions Covariance Parameters 15 Columns in X 9 The SAS System 30 12:13 Tuesday, May 10, 2005 The Mixed Procedure Dimensions Columns in Z 0 Subjects 255 Max Obs Per Subject 5 Observations Used 952 Observations Not Used 0 Total Observations 952 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 8160.39101964 1 4 7580.51479042 0.00106579 2 1 7577.10370546 0.00004019 3 1 7576.98298555 0.00000010 4 1 7576.98269273 0.00000000 Convergence criteria met. Covariance Parameter Estimates Cov Parm Subject Estimate UN(1,1) id 207.89 UN(2,1) id 170.91 UN(2,2) id 322.95 UN(3,1) id 161.11 UN(3,2) id 269.67 UN(3,3) id 401.12 UN(4,1) id 162.24 UN(4,2) id 245.05 UN(4,3) id 325.40 UN(4,4) id 431.02 UN(5,1) id 141.39 UN(5,2) id 206.01 UN(5,3) id 302.31 UN(5,4) id 398.20 UN(5,5) id 464.64 Fit Statistics -2 Log Likelihood 7577.0 AIC (smaller is better) 7621.0 AICC (smaller is better) 7622.1 BIC (smaller is better) 7698.9 The SAS System 31 12:13 Tuesday, May 10, 2005 The Mixed Procedure Null Model Likelihood Ratio Test DF Chi-Square Pr > ChiSq 14 583.41 <.0001 Solution for Fixed Effects Standard Effect group Estimate Error DF t Value Pr > |t| Intercept 31.6967 5.3318 251 5.94 <.0001 y0 0.6951 0.04691 251 14.82 <.0001 time8 0.8541 0.4292 251 1.99 0.0477 group 1 -10.9853 4.2639 251 -2.58 0.0106 group 2 -23.0020 4.0900 251 -5.62 <.0001 group 3 0 . . . . time8*group 1 -1.3137 0.5788 251 -2.27 0.0241 time8*group 2 -1.7409 0.5515 251 -3.16 0.0018 time8*group 3 0 . . . . Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F y0 1 251 219.59 <.0001 time8 1 251 0.53 0.4664 group 2 251 16.10 <.0001 time8*group 2 251 5.13 0.0065 Estimates Standard Label Estimate Error DF t Value Pr > |t| Group 2 versus Group 1 at 8 weeks -12.0167 3.8843 251 -3.09 0.0022 Group 3 versus Group 1 at 8 weeks 10.9853 4.2639 251 2.58 0.0106 Estimates Label Alpha Lower Upper Group 2 versus Group 1 at 8 weeks 0.05 -19.6666 -4.3668 Group 3 versus Group 1 at 8 weeks 0.05 2.5877 19.3830 The SAS System 32 12:13 Tuesday, May 10, 2005 The Mixed Procedure Model Information Data Set WORK.PANSS Dependent Variable score Covariance Structure Unstructured Subject Effect id Estimation Method ML Residual Variance Method None Fixed Effects SE Method Model-Based Degrees of Freedom Method Between-Within Class Level Information Class Levels Values id 255 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 166 167 168 169 170 171 172 173 174 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 group 3 1 2 3 Dimensions Covariance Parameters 15 Columns in X 10 The SAS System 33 12:13 Tuesday, May 10, 2005 The Mixed Procedure Dimensions Columns in Z 0 Subjects 255 Max Obs Per Subject 5 Observations Used 952 Observations Not Used 0 Total Observations 952 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 8154.17236610 1 4 7580.45001293 0.00120057 2 1 7576.58602195 0.00004972 3 1 7576.43625661 0.00000015 4 1 7576.43582561 0.00000000 Convergence criteria met. Covariance Parameter Estimates Cov Parm Subject Estimate UN(1,1) id 207.91 UN(2,1) id 170.68 UN(2,2) id 322.70 UN(3,1) id 160.66 UN(3,2) id 268.69 UN(3,3) id 399.28 UN(4,1) id 161.46 UN(4,2) id 243.31 UN(4,3) id 322.38 UN(4,4) id 426.33 UN(5,1) id 140.17 UN(5,2) id 203.98 UN(5,3) id 299.24 UN(5,4) id 392.88 UN(5,5) id 459.43 Fit Statistics -2 Log Likelihood 7576.4 AIC (smaller is better) 7622.4 AICC (smaller is better) 7623.6 BIC (smaller is better) 7703.9 The SAS System 34 12:13 Tuesday, May 10, 2005 The Mixed Procedure Null Model Likelihood Ratio Test DF Chi-Square Pr > ChiSq 14 577.74 <.0001 Solution for Fixed Effects Standard Effect group Estimate Error DF t Value Pr > |t| Intercept 36.8952 8.7272 251 4.23 <.0001 y0 0.6371 0.08998 251 7.08 <.0001 time8 1.6775 1.1816 251 1.42 0.1570 y0*time8 -0.00916 0.01220 251 -0.75 0.4533 group 1 -11.1613 4.2494 251 -2.63 0.0092 group 2 -22.7527 4.0881 251 -5.57 <.0001 group 3 0 . . . . time8*group 1 -1.3389 0.5775 251 -2.32 0.0212 time8*group 2 -1.7032 0.5524 251 -3.08 0.0023 time8*group 3 0 . . . . Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F y0 1 251 50.13 <.0001 time8 1 251 0.34 0.5587 y0*time8 1 251 0.56 0.4533 group 2 251 15.67 <.0001 time8*group 2 251 4.99 0.0075 Estimates Standard Label Estimate Error DF t Value Pr > |t| Group 2 versus Group 1 at 8 weeks -11.5914 3.9088 251 -2.97 0.0033 Group 3 versus Group 1 at 8 weeks 11.1613 4.2494 251 2.63 0.0092 Estimates Label Alpha Lower Upper Group 2 versus Group 1 at 8 weeks 0.05 -19.2896 -3.8932 Group 3 versus Group 1 at 8 weeks 0.05 2.7922 19.5304 The SAS System 35 12:13 Tuesday, May 10, 2005 The Mixed Procedure Model Information Data Set WORK.PANSS Dependent Variable score Covariance Structure Unstructured Subject Effect id Estimation Method ML Residual Variance Method None Fixed Effects SE Method Model-Based Degrees of Freedom Method Between-Within Class Level Information Class Levels Values id 255 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 166 167 168 169 170 171 172 173 174 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 group 3 1 2 3 time8 5 -7 -6 -4 -2 0 The SAS System 36 12:13 Tuesday, May 10, 2005 The Mixed Procedure Dimensions Covariance Parameters 15 Columns in X 25 Columns in Z 0 Subjects 255 Max Obs Per Subject 5 Observations Used 952 Observations Not Used 0 Total Observations 952 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 8155.08948270 1 4 7561.40112267 0.00116636 2 1 7557.67740944 0.00004583 3 1 7557.54014528 0.00000012 4 1 7557.53981009 0.00000000 Convergence criteria met. Covariance Parameter Estimates Cov Parm Subject Estimate UN(1,1) id 207.80 UN(2,1) id 170.07 UN(2,2) id 315.40 UN(3,1) id 160.26 UN(3,2) id 263.48 UN(3,3) id 395.95 UN(4,1) id 166.78 UN(4,2) id 246.17 UN(4,3) id 329.16 UN(4,4) id 437.59 UN(5,1) id 144.38 UN(5,2) id 210.13 UN(5,3) id 309.34 UN(5,4) id 407.55 UN(5,5) id 470.77 Fit Statistics -2 Log Likelihood 7557.5 AIC (smaller is better) 7619.5 AICC (smaller is better) 7621.7 BIC (smaller is better) 7729.3 The SAS System 37 12:13 Tuesday, May 10, 2005 The Mixed Procedure Null Model Likelihood Ratio Test DF Chi-Square Pr > ChiSq 14 597.55 <.0001 Solution for Fixed Effects Standard Effect group time8 Estimate Error DF t Value Pr > |t| Intercept 31.6497 5.3430 251 5.92 <.0001 y0 0.6969 0.04684 251 14.88 <.0001 time8 -7 -5.8027 3.0205 251 -1.92 0.0559 time8 -6 -5.5491 2.9702 251 -1.87 0.0629 time8 -4 -3.7696 2.6153 251 -1.44 0.1507 time8 -2 1.7242 1.7635 251 0.98 0.3292 time8 0 0 . . . . group 1 -10.8254 4.2977 251 -2.52 0.0124 group 2 -23.3801 4.1199 251 -5.67 <.0001 group 3 0 . . . . group*time8 1 -7 8.8483 4.0693 251 2.17 0.0306 group*time8 1 -6 6.8138 4.0056 251 1.70 0.0902 group*time8 1 -4 4.1439 3.5066 251 1.18 0.2384 group*time8 1 -2 -2.3976 2.3082 251 -1.04 0.2999 group*time8 1 0 0 . . . . group*time8 2 -7 12.6901 3.8798 251 3.27 0.0012 group*time8 2 -6 7.5258 3.8036 251 1.98 0.0490 group*time8 2 -4 5.0902 3.3137 251 1.54 0.1258 group*time8 2 -2 -2.7170 2.1852 251 -1.24 0.2149 group*time8 2 0 0 . . . . group*time8 3 -7 0 . . . . group*time8 3 -6 0 . . . . group*time8 3 -4 0 . . . . group*time8 3 -2 0 . . . . group*time8 3 0 0 . . . . Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F y0 1 251 221.32 <.0001 time8 4 251 1.51 0.2001 group 2 251 25.25 <.0001 group*time8 8 251 3.09 0.0024 The SAS System 38 12:13 Tuesday, May 10, 2005 The Mixed Procedure Estimates Standard Label Estimate Error DF t Value Pr > |t| Group 2 versus Group 1 at 8 weeks -11.5186 2.6357 251 -4.37 <.0001 Group 3 versus Group 1 at 8 weeks 7.3437 2.7431 251 2.68 0.0079 Estimates Label Alpha Lower Upper Group 2 versus Group 1 at 8 weeks 0.05 -16.7095 -6.3277 Group 3 versus Group 1 at 8 weeks 0.05 1.9412 12.7462 The SAS System 39 12:13 Tuesday, May 10, 2005 The Mixed Procedure Model Information Data Set WORK.PANSS Dependent Variable score Covariance Structure Unstructured Subject Effect id Estimation Method ML Residual Variance Method None Fixed Effects SE Method Model-Based Degrees of Freedom Method Between-Within Class Level Information Class Levels Values id 255 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 166 167 168 169 170 171 172 173 174 433 434 435 436 437 438 439 440 441 442 443 444 445 446 447 448 449 450 451 452 453 454 455 456 457 458 459 460 461 462 463 464 465 466 467 468 469 470 471 472 473 474 475 476 477 478 479 480 481 482 483 484 485 486 487 488 489 490 491 492 493 494 495 496 497 498 499 500 501 502 503 504 505 506 507 508 509 510 511 512 513 514 515 516 517 group 3 1 2 3 time8 5 -7 -6 -4 -2 0 The SAS System 40 12:13 Tuesday, May 10, 2005 The Mixed Procedure Dimensions Covariance Parameters 15 Columns in X 30 Columns in Z 0 Subjects 255 Max Obs Per Subject 5 Observations Used 952 Observations Not Used 0 Total Observations 952 Iteration History Iteration Evaluations -2 Log Like Criterion 0 1 8148.92396870 1 4 7558.47954106 0.00117082 2 1 7554.74061355 0.00004540 3 1 7554.60470454 0.00000011 4 1 7554.60437094 0.00000000 Convergence criteria met. Covariance Parameter Estimates Cov Parm Subject Estimate UN(1,1) id 207.80 UN(2,1) id 170.44 UN(2,2) id 316.09 UN(3,1) id 160.00 UN(3,2) id 263.03 UN(3,3) id 394.15 UN(4,1) id 164.81 UN(4,2) id 242.83 UN(4,3) id 323.83 UN(4,4) id 427.96 UN(5,1) id 143.35 UN(5,2) id 208.03 UN(5,3) id 305.93 UN(5,4) id 402.15 UN(5,5) id 468.76 Fit Statistics -2 Log Likelihood 7554.6 AIC (smaller is better) 7624.6 AICC (smaller is better) 7627.4 BIC (smaller is better) 7748.5 The SAS System 41 12:13 Tuesday, May 10, 2005 The Mixed Procedure Null Model Likelihood Ratio Test DF Chi-Square Pr > ChiSq 14 594.32 <.0001 Solution for Fixed Effects Standard Effect group time8 Estimate Error DF t Value Pr > |t| Intercept 36.9077 8.8119 251 4.19 <.0001 y0 0.6395 0.09084 251 7.04 <.0001 time8 -7 -10.7400 8.3168 251 -1.29 0.1978 time8 -6 -11.8391 8.1845 251 -1.45 0.1493 time8 -4 -6.5534 7.1049 251 -0.92 0.3572 time8 -2 4.8737 4.5303 251 1.08 0.2830 time8 0 0 . . . . y0*time8 -7 0.05390 0.08584 251 0.63 0.5306 y0*time8 -6 0.06878 0.08451 251 0.81 0.4165 y0*time8 -4 0.02981 0.07332 251 0.41 0.6846 y0*time8 -2 -0.03686 0.04681 251 -0.79 0.4317 y0*time8 0 0 . . . . group 1 -11.0910 4.3027 251 -2.58 0.0105 group 2 -23.1551 4.1344 251 -5.60 <.0001 group 3 0 . . . . group*time8 1 -7 9.1169 4.0801 251 2.23 0.0263 group*time8 1 -6 7.0729 4.0265 251 1.76 0.0802 group*time8 1 -4 4.3712 3.5317 251 1.24 0.2170 group*time8 1 -2 -2.4100 2.3026 251 -1.05 0.2963 group*time8 1 0 0 . . . . group*time8 2 -7 12.4723 3.9030 251 3.20 0.0016 group*time8 2 -6 7.2561 3.8370 251 1.89 0.0598 group*time8 2 -4 5.0236 3.3483 251 1.50 0.1348 group*time8 2 -2 -2.4216 2.1905 251 -1.11 0.2700 group*time8 2 0 0 . . . . group*time8 3 -7 0 . . . . group*time8 3 -6 0 . . . . group*time8 3 -4 0 . . . . group*time8 3 -2 0 . . . . group*time8 3 0 0 . . . . Type 3 Tests of Fixed Effects Num Den Effect DF DF F Value Pr > F y0 1 251 126.62 <.0001 time8 4 251 0.87 0.4853 y0*time8 4 251 0.76 0.5536 group 2 251 24.78 <.0001 group*time8 8 251 3.03 0.0029 The SAS System 42 12:13 Tuesday, May 10, 2005 The Mixed Procedure Estimates Standard Label Estimate Error DF t Value Pr > |t| Group 2 versus Group 1 at 8 weeks -11.2282 2.6360 251 -4.26 <.0001 Group 3 versus Group 1 at 8 weeks 7.4608 2.7336 251 2.73 0.0068 Estimates Label Alpha Lower Upper Group 2 versus Group 1 at 8 weeks 0.05 -16.4197 -6.0366 Group 3 versus Group 1 at 8 weeks 0.05 2.0772 12.8444