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For
a complete listing of Gelb lab publications see Pubmed
Publications 2023-May, 2024:
Schlotawa L, Tyka K, Kettwig M, Ahrens-Nicklas RC, Baud M, Berulava T,
Brunetti-Pierri N, Gagne A, Herbst ZM, Maguire JA, Monfregola J, Pena T,
Radhakrishnan K, Schröder S, Waxman EA, Ballabio A, Dierks T, Fischer A, French
DL, Gelb MH, Gärtner J.EMBO Mol Med. 2023 Mar
8;15(3):e14837. doi: 10.15252/emmm.202114837. Epub 2023 Feb
15.PMID: 36789546
Pilot study of newborn screening for six lysosomal
diseases in Brazil.
Kubaski F, Sousa I, Amorim T, Pereira D, Silva C, Chaves V,
Brusius-Facchin AC, Netto ABO, Soares J, Vairo F, Poletto E, Trometer J, Souza
A, Ranieri E, Polo G, Hong X, Herbst ZM, Burlina A, Gelb MH,
Giugliani R.Mol Genet Metab. 2023 Sep-Oct;140(1-2):107654. doi:
10.1016/j.ymgme.2023.107654. Epub 2023 Jul 13.PMID: 37507255
Vaz FM, Jamal Y, Barto R, Gelb MH, DeBarber AE, Wevers RA,
Nelen MR, Verrips A, Bootsma AH, Bouva MJ, Kleise N, van der Zee W, He T,
Salomons GS, Huidekoper HH.Clin Chim Acta. 2023 Jan 15;539:170-174. doi:
10.1016/j.cca.2022.12.011. Epub 2022 Dec 16.PMID: 36529270 Free PMC article.
Herbst ZM, Hong X, Urdaneta L, Klein T, Waggoner C, Liao HC, Kubaski F,
Giugliani R, Fuller M, Gelb MH.Mol Genet Metab. 2023
Sep-Oct;140(1-2):107632. doi: 10.1016/j.ymgme.2023.107632. Epub 2023 Jun
24.PMID: 37407323
Trinidad M, Hong X, Froelich S, Daiker J, Sacco J, Nguyen HP, Campagna
M, Suhr D, Suhr T, LeBowitz JH, Gelb MH, Clark WT.Genome Biol. 2023
Jul 21;24(1):172. doi: 10.1186/s13059-023-03001-z.PMID: 37480112 Free PMC article.
ScreenPlus: A comprehensive, multi-disorder newborn
screening program.
Kelly NR, Orsini JJ, Goldenberg AJ, Mulrooney NS, Boychuk NA, Clarke MJ,
Paleologos K, Martin MM, McNeight H, Caggana M, Bailey SM, Eiland LR, Ganesh J,
Kupchik G, Lumba R, Nafday S, Stroustrup A, Gelb MH, Wasserstein
MP.Mol Genet Metab Rep. 2023 Dec 14;38:101037. doi:
10.1016/j.ymgmr.2023.101037. eCollection 2024 Mar.PMID: 38173711 Free PMC article.
Herzeg A, Borges B, Lianoglou BR, Gonzalez-Velez J, Canepa E, Munar D,
Young SP, Bali D, Gelb MH, Chakraborty P, Kishnani PS, Harmatz P,
Cohen JL, MacKenzie TC.Prenat Diagn. 2023 Dec;43(13):1638-1649. doi: 10.1002/pd.6460. Epub 2023
Nov 13.PMID: 37955580 Review.
Saville JT, Herbst ZM, Gelb MH, Fuller M.Mol Genet Metab.
2023 Nov;140(3):107685. doi: 10.1016/j.ymgme.2023.107685. Epub 2023 Aug
14.PMID: 37604083 Review.
O'Donnell VB, Schebb NH, Milne GL, Murphy MP, Thomas CP, Steinhilber D,
Gelhaus SL, Kühn H, Gelb MH, Jakobsson PJ, Blair IA, Murphy RC,
Freeman BA, Brash AR, FitzGerald GA.Nat Commun. 2023 Nov 9;14(1):7172.
doi: 10.1038/s41467-023-41766-w.PMID: 37945602 Free PMC article. No abstract
available.
It's time to reconsider the newborn screening RUSP
prospective pilot study "N of 1" rule.
Gelb MH, Matern D, Ellinwood M, Gaviglio A.Mol Genet Metab. 2024
May;142(1):108352. doi: 10.1016/j.ymgme.2024.108352. Epub 2024 Feb
24.PMID: 38429125 No abstract available.
Herbst ZM, Hong X, Sadilek M, Fuller M, Gelb MH.Mol Genet Metab.
2023 Nov;140(3):107698. doi: 10.1016/j.ymgme.2023.107698. Epub 2023 Sep
7.PMID: 37820575 Review.
Wongkittichote P, Cho SH, Miller A, King K, Herbst ZM, Ren Z, Gelb
MH, Hong X.Clin Chem. 2024 Apr 10:hvae043. doi: 10.1093/clinchem/hvae043. Online
ahead of print.PMID: 38597162
Biochemical signatures of disease severity in multiple
sulfatase deficiency.
Adang LA, Mowafy S, Herbst ZM, Zhou Z, Schlotawa L, Radhakrishnan K,
Bentley B, Pham V, Yu E, Pillai NR, Orchard PJ, De Castro M, Vanderver A,
Pasquali M, Gelb MH, Ahrens-Nicklas RC.J Inherit Metab
Dis. 2024 Mar;47(2):374-386. doi: 10.1002/jimd.12688. Epub 2023 Nov
1.PMID: 37870986
Hong X, Pollard L, He M, Gelb MH, Wood TC.Mol Genet Metab
Rep. 2023 May 16;35:100978. doi: 10.1016/j.ymgmr.2023.100978. eCollection 2023
Jun.PMID: 37275682 Free PMC article.
A novel iPSC model reveals selective vulnerability of
neurons in multiple sulfatase deficiency.
Pham V, Sertori Finoti L, Cassidy MM, Maguire JA, Gagne AL, Waxman EA,
French DL, King K, Zhou Z, Gelb MH, Wongkittichote P, Hong X,
Schlotawa L, Davidson BL, Ahrens-Nicklas RC.Mol Genet Metab. 2024
Feb;141(2):108116. doi: 10.1016/j.ymgme.2023.108116. Epub 2023 Dec
21.PMID: 38161139
Bekri S, Bley A, Brown HA, Chanson C, Church HJ, Gelb MH,
Hong X, Janzen N, Kasper DC, Mechtler T, Morton G, Murko S, Oliva P, Tebani A,
Wu THY.Mol Genet Metab. 2024 May;142(1):108436. doi:
10.1016/j.ymgme.2024.108436. Epub 2024 Mar 22.PMID: 38552449
Liu Y, Gelb MH.Mol Genet Metab. 2024
Jan;141(1):108105. doi: 10.1016/j.ymgme.2023.108105. Epub 2023 Nov
30.PMID: 38128203
Posern C, Dreyer B, Maier SL, Eichler F, Gelb MH, Santer R,
Bley A, Murko S.Mol Genet Metab. 2024 May 3;142(2):108489. doi:
10.1016/j.ymgme.2024.108489. Online ahead of print.PMID: 38718669
Publications before 2023
Blackwell, K.; Gelb, M.H.; Grantham, A.;
Spencer, N.; Webb, C.; West, T. Family
Attitudes Regarding Newborn Screening for Krabbe Disease: Results from a Survey
of Leukodystrophy Registries. [published online ahead of print, 20 August 2020] Int. J. Neonatal Screen., 2020, 6. DOI: 10.3390/ijns6030066.
Su, P.; Khaledi,
H.; Waggoner, C.; Gelb, M.H. Detection of
GM1-Gangliosidosis in Newborn Dried Blood Spots by Enzyme and Biomarker Assays
Using Tandem Mass Spectrometry [published online ahead of print, 2020 Jun 7]. J Inherit Metab Dis. 2020;10.1002/jimd.12269.
doi:10.1002/jimd.12269
Weinstock, N.I.;
Shin, D.; Dhimal, N.; Hong, X.; Irons, E.E.; Silvestri, N.J.; Reed, C.B.;
Nguyen, D.; Sampson, O.; Cheng, Y-C.; Lau, J.T.Y.; Bongarzone, E.R.; Kofler,
J.; Escolar, M.L.; Gelb, M.H.; Wrabetz, L.; Feltri, M.L. “Macrophages Expressing GALC Improve
Peripheral Krabbe Disease by a Mechanism Independent of Cross-Correction.” Neuron, 2020, 107,
65-81. cover article editorial
Hong, X.; Sadilek,
M.; Gelb, M.H. A
highly multiplexed biochemical assay for analytes in dried blood spots:
application to newborn screening and diagnosis of lysosomal storage disorders
and other inborn errors of metabolism. Genet. Med., 2020, https://doi.org/10.1038/s41436-020-0790-9
Herbst, Z.;
Turgeon, C.T.; Biski, C.; Khaledi, H.; Shoemaker, N.B.; DeArmond, P.D.; Smith,
S.; Orsini, J.; Matern, D.; Gelb, M.H. Achieving
Congruence among Reference Laboratories for Absolute Abundance Measurement of
Analytes for Rare Diseases: Psychosine for Diagnosis and Prognosis of Krabbe
Disease. Int. J. Neonatal Screen. 2020, 6, 29; doi:10.3390/ijns6020029
Guenzel, A.J.; Turgeon, C.T.; Nickander, K.K.; White, A.L.; Peck, D.S.; Pino,
G.B.; Studinski, A.L.; Prasad, V.K.; Kurtzberg, J.; Escolar, M.L.; Lasio,
M.L.D.; Pellegrino, J.E.; Sakonju, A.; R.E.; Shallow, N.M.; Ream, M.A.; Orsini,
J.J.; Gelb, M.H.; Raymond, K.; Gavrilov, D.K.; Oglesbee, D.; Rinaldo, P.;
Tortorelli, S.; Matern, D. The
critical role of psychosine in screening, diagnosis, and monitoring of Krabbe
disease. Genet.
Med. 2020, https://doi.org/10.1038/s41436-020-0764-y.
Kumar, A.B.; Hong, X.; Yi, F.; Wood, T.; Gelb, M.H. Tandem mass spectrometry-based multiplex assays for
a-mannosidosis and fucosidosis. Mol. Genet. Metab. 2019, 127, 207-211
.
Chan, M-J; Liao, H-C; Gelb, M.H.; Chuang, C-H; Liu, M-Y; Chen, H-J; Kao, S-H;
Lin, H-Y; Huang, Y-H; Kumar, A.B.; Chennamaneni, N.K.; Nagendar, P.; Lin, S-P;
Chiang, C-C. Taiwan
National Newborn Screening Program by Tandem Mass Spectrometry for
Mucopolysaccharidoses Types I, II, and VI J Pediatr. 2019, 205, 176-182. doi:
10.1016/j.jpeds.2018.09.063. Epub 2018 Nov 6.
Hong, X.; Gelb, M.H. One-step synthesis of carbon-13-labeled
globotriaosylsphingosine (lyso-Gb3), an internal standard for biomarker
analysis of Fabry disease. Mol Genet Metab., 2018, 125, 292-294. doi: 10.1016/j.ymgme.2018.08.001. Epub 2018 Aug 10.
Khaledi, H.; Liu, Y.; Masi, S.; Gelb, M.H. Detection of Infantile Batten Disease by Tandem Mass
Spectrometry Assay of PPT1 Enzyme Activity in Dried Blood Spots. Anal Chem. 2018, 90,12168-12171.
doi: 10.1021/acs.analchem.8b03188. Epub 2018 Sep 24.
Gelb, M.H. Absolute Amounts of Analytes: When Gravimetric
Methods Are Insufficient. Clin Chem., 2018, 64,1430-1432. doi: 10.1373/clinchem.2018.290486. Epub 2018 Jul 27
Gelb, M. Newborn Screening for Lysosomal Storage Diseases:
Methodologies, Screen Positive Rates, Normalization of Datasets, Second-Tier
Tests, and Post-Analysis Tools. Int. J. Neonatal Screen. 2018, 4, 23.NIHMSID: NIHMS984633.
Yi, F.; Hong, X.; Kumar, A.B.; Zong, C.; Boons, G.J.; Scott, C.R.; Turecek, F.;
Robinson, B.H.; Gelb, M.H. Detection of mucopolysaccharidosis III-A (Sanfilippo
Syndrome-A) in dried blood spots (DBS) by tandem mass spectrometry. Mol Genet Metab. 2018, 125, 59-63. doi: 10.1016/j.ymgme.2018.05.005. Epub 2018 May 23.
Hong, X.; Kumar, A.B.;Scott, R.C.; Gelb, M.H. Multiplex
tandem mass spectrometry assay for newborn screening of X-linked
adrenoleukodystrophy, biotinidase deficiency, and galactosemia with flexibility
to assay other enzyme assays and biomarkers. Mol Genet Metab. 2018, 124, 101-108.
doi: 10.1016/j.ymgme.2018.03.012. Epub 2018 Mar 29.
Kwon, J.M.; Matern, D.; Kurtzberg, J.; Wrabetz, L.; Gelb, M.H.; Wenger DA,
Ficicioglu C, Waldman AT, Burton BK, Hopkins PV, Orsini JJ. Consensus
guidelines for newborn screening, diagnosis and treatment of infantile Krabbe
disease. Orphanet J Rare Dis. 2018 Feb 1;13(1):30.PMID: 29391017 [PubMed – in process]
Masi, S.; Chennamaneni, N.; Turecek, F.; Scott, C.R.; Gelb, M.H. Specific Substrate for the
Assay of Lysosomal Acid Lipase. Clin Chem. 2018 March .DOI:
10.1373/clinchem.2017.282251. PMID: 29339442.
Peake, Roy W.A.; Marsden, Deborah L.; Bodamer, Olaf A.; Gelb, Michael H.;
Millington, David S.; Wijburg, Frits. Newborn
Screening for Lysosomal Storage Disorders: Quo Vadis? Clinical Chemistry Nov 2016, 62,1430-1438;
DOI: 10.1373/clinchem.2016.258459.
Liao, H.C.; Spacil, Z.; Ghomashchi, F.; Escolar, M.L.; Kurtzberg, J.; Orsini,
J.J.; Turecek, F.; Scott, C.R.; Gelb, M.H. Lymphocyte
Galactocerebrosidase Activity by LC-MS/MS for Post-Newborn Screening Evaluation
of Krabbe Disease. Clin Chem. 2017 Jun 7. pii: clinchem.2016.264952. doi:
10.1373/clinchem.2016.264952. [Epub ahead of print].
Escolar, M.L.; Kiely, B.T.; Shawgo, E.; Hong, X.; Gelb, M.H.; Orsini, J.J.;
Matern, D.; Poe, M.D. Psychosine, a marker of Krabbe phenotype and treatment
effect. Mol Genet
Metab. 2017 May 22. pii: S1096-7192(17)30205-6.
doi: 10.1016/j.ymgme.2017.05.015. [Epub ahead of print] PMID: 28579020. Article.
Yang, L; Kumar, A.B.; Chennamaneni, N.K.; Hong, X.; Scott, C.R.; Gelb, M.H.;
Tureček. F. Multiplex
Tandem Mass Spectrometry Enzymatic Activity Assay for Newborn Screening of the
Mucopolysaccharidoes and Type 2 Neuronal Ceroid Lipofuscinosis. Clin. Chem. 2017, 63, 1118-1126. doi:10.1373/clinchem.2016.269167. Epub 2017 Apr
20. PMID: 28428354. Supplemental
materials.
Liao. H.C.; Chan, M.J.; Yan, C.F.; Chiang, C.C.; Niu, D.M.; Huang, C.K.; Gelb,
M.H. Mass Spectrometry but Not Fluorometry Distinguishes
Affected and Pseudodeficiency Patients in Newborn Screening
for Pompe Disease.Clin Chem. 2017 pii: clinchem.2016.269027. doi:10.1373/clinchem.2016.269027.
[Epub ahead of print] PMID: 28450385. [Epub ahead of print].
Lin, N.; Huang, J.; Violante, S.; Orsini, J.J.; Caggana, M.; Hughes, E.E.;
Stevens, C.; DiAntonio, L.; Chieh, L.H.; Hong, X.; Ghomashchi, F.; Babu, K.A.;
Zhou, H.; Kornreich, R.; Wasserstein, M.; Gelb, M.H.; Yu, C. Liquid
Chromatography-Tandem Mass Spectrometry Assay of Leukocyte Acid α-Glucosidase for Post-Newborn Screening Evaluation of Pompe Disease. Clin Chem. 2017 63:842-851. doi:10.1373/clinchem.2016.259036. Epub 2017 Feb
14. v. PMID: 28196920; PMCID: PMC5413112.
Elliott, S.; Buroker, N.; Cournoyer, J.J.; Potier, A.M.; Trometer, J.D.; Elbin,
C.; Schermer, M.J.; Kantola, J.; Boyce, A.; Tureček, F.; Gelb, M.H.; Scott, C.R. Pilot study of newborn screening for six lysosomal
storage diseasesusing Tandem Mass Spectrometry. Mol Genet Metab. 2016 118, 304-309. doi:
10.1016/j.ymgme.2016.05.015. Epub 2016. May 20. PMID: 27238910; PMCID:
PMC5318163.
Spacil, Z., Babu Kumar, A., Liao, HC., Auray-Blais, C., Stark, S., Suhr, TR.,
Scott, CR., Tureček, F.,
Gelb, MH.(2015) “Sulfatide Analysis by Mass Spectrometry for Screening of
Metachromatic Leukodystrophy in Dried Blood and Urine Samples,” Clin Chem. 2015
Nov 19. pii: clinchem.2015.245159. PMID: 26585924
Kumar AB, Spacil Z, Ghomashchi F, Masi S, Sumida T, Ito M, Tureček F, Scott CR, Gelb
MH.(2015)”Fluorimetric assays for N-acetylgalactosamine-6-sulfatase and
arylsulfatase B based on the natural substrates for confirmation of
mucopolysaccharidoses types IVA and VI” Clin Chim Acta. 2015 Aug 15. pii:
S0009-8981(15)00381-2. doi: 10.1016/j.cca.2015.08.010.
PMID:26282597
Kumar, A.B., Masi, S., Ghomashchi, F., Chennamaneni, N.K., Ito, M., Scott,
C.R., Tureček, F.,
Gelb, M.H., Spacil, Z. (2015) “Tandem Mass Spectrometry has a larger analytical
range than Fluorescence Assays of Lysosomal Enzymes: Application to newborn
screening and Diagnosis of Mucopolysaccharidoses Types II, IVA and VI.” Clin
Chem. 2015 Sep 14. pii: clinchem.2015.242560. DOI:10.1016/j.cca.2015.08.010
PMID:26369786
Ghomashchi, F., Barcenas, M., Tureček, F., Scott, C. R., Gelb, M. H., (2015) “Reliable assay of
acid sphingomyelinase deficiency with the mutation Q292K by tandem mass
spectrometry,” Clin Chem, 61:(5):771-778, DOI:10.2373/clinchem.2014.236448.
PMID: 25770139.
Gelb, M. H., Scott, C. R., Tureček, F. (2015) “Newborn screening for lysosomal storage
diseases,” Clin Chem, 61:335-346. PMID: 25477536, PMCID:
PMC4345406.
Barcenas, M., Xue, C., Marushchak-Vlaskin, T., Scott, C. R., Gelb, M. H., Tureček, F. (2014) “Tandem mass spectrometry
assays of palmitoyl protein thioesterase 1 and tripeptidyl peptidase activity
in dried blood spots for the detection of Neuronal Ceroid Lipofuscinoses in
newborns,” Anal. Chem., 86(15):7962-7968, DOI: 10.1021/ac501994b. PMID:
25019629.
Chennamaneni, N. K., Kumar, A. B., Barcenas, M., Specil, Z., Scott, C. R., Tureček, F., Gelb, M. H., (2014) “Improved
reagents for newborn screening of Mucopolysaccharidosis types I, II, and VI by
tandem mass spectrometry,” Anal. Chem., 86:4508-4514, DOI: 10.1021/ac5004135.
PMID: 24694010, PMCID: PMC4014144.
Fitterer, B., Hall, P., Antonishyn, N., Desikan, R., Gelb, M., Lehotay, D.
(2014) “Incidence and carrier frequency of Sandhoff disease in Saskatchewan
determined using a novel substrate with detection by tandem mass spectrometry
and molecular genetic analysis,” Mol. Genet. Metab., 111:382-289. doi:
10.1016/j.ymgme.2014.01.002. PMID: 24461908, PMCID: PMC4346577.
Barcenas, M., Suhr, T. R., Scott, C. R., Tureček, F., Gelb, M. H. (2014) “Quantification
of sulfatides in dried blood and urine spots from metachromatic leukodystrophy
patients by liquid chromatography/electrospray tandem mass spectrometry,”
Clinica Chimica Acta, 433:39-43, PMID: 24370383, PMCID: PMC4039571.
Scott, C. R., Elliot, S., Buroker, N., Thomas, L. I., Keutzer, J., Glass, M.,
Gelb, M. H., Tureček, F.
(2013) “Identification of infants at risk for developing Fabry, Pompe, or
Mucopolysaccharidosis-I from newborn blood spots by tandem mass spectrometry.”
Journal of Pediatrics, 163:498-503. doi: 10.1016/j.jpeds.2013.01.013 PMID:
23465405, PMCID: PMC3725184. .
Orsini, J. J., Martin, M. M., Showers, A. L., Bodamer, O. A., Zhang, X. K.,
Gelb, M. H., et al. (2012). “Lysosomal storage disorder 4+1 multiplex assay for
newborn screening using tandem mass spectrometry: Application to a small-scale
population study for five lysosomal storage disorders.” Clinica Chimica Acta,
413(15-16), 1270-1273. PMID: 22548856, PMCID: PMC3443687.
Spacil, Z., Tatipaka, H., Barcenas, M., Scott, C. R., Tureček, F., Gelb, M. H. (2012)
“High-throughput assay of 9 lysosomal enzymes for newborn screening.” Clinical
Chemistry., 59 (3), 1530-8561. PMID: 23315484.
Wolf, B. J., Ghomashchi, F., Kim, T., Abam, C. A., Sadilek, M., Jack, R.,
Thompson, J. N., Scott, C. R., Gleb, M. H., Tureček, F. (2012) “New substrates and enzyme
assays for the detection of mucopolysaccharidosis III (Sanfilippo Syndrome)
types A, B, C, and D by tandem mass spectrometry,” Bioconjug Chem., 23:557-564.
PMID: 22372747, PMCID: PMC: 3310265.
Spacil, Z., Hui, R., Gelb, M. H., & Tureček, F. (2011). “Protonation sites and
dissociation mechanisms of t-butylcarbamates in tandem mass spectrometric
assays for newborn screening.” Journal of Mass Spectrometry, 46(10), 1089-1098.
PMID: 22012676, PMCID: PMC3212097.
Spacil, Z., Elliott, S., Reeber, S. L., Gelb, M. H., Scott, C. R. and Tureček, F. (2011) “Comparative triplex tandem
mass spectrometry assays of lysosomal enzyme activities in dried blood spots
using fast liquid chromatography: Application to newborn screening of Pompe,
Fabry, and Hurler diseases” Anal. Chem., 83:4822-4828. PMID: 21548611, PMCID:
PMC 3115456
Wolfe, B. J., Blanchard, S., Sadilek, M., Scott, C. R., Tureček, F., Gelb, M. H. (2011) “Tandem mass
spectrometry for the direct assay of Lysosomal enzymes in dried blood spots:
Application to screening newborns for Mucopolysaccharidosis II (Hunter
Syndrome)” Anal. Chem., 83:1152-1156. PMID: 21192662, PMCID:
PMC3442111.
Khaliq, T., Sadilek, M., Scott, C. R., Tureček, F., Gelb, M. H. (2011) “Tandem mass
spectrometry for the direct assay of lysosomal enzymes in dried blood spots:
Application to screening newborns for Mucopolysaccharidosis IVA,” Clin. Chem.,
57(1):128-131. PMID: 21030685, PMCID: PMC3442110.
Duffey, T. A., Sadilek, M., Scott, C. R., Tureček, F., Gelb, M. H. (2010) “Tandem mass
spectrometry for the direct assay of lysosomal enzymes in dried blood spots:
Application to screening newborns for Mucopolysaccharidosis VI (Maroteaux-Lamy
Syndrome)”, Anal. Chem., 82:9587-9591. PMID: 20961069, PMCID:
PMC2980560.
Choiniere, J. R., Scott, C. R., Gelb, M. H., Tureček, F. (2010) “Direct assay of
delta-aminolevulinic acid dehydratase in heme biosynthesis for the detection of
porphyrias by tandem mass spectrometry,” Anal. Chem., 82:6730-6736. PMID:
20583792, PMCID: PMC2913591.
Duffey, T. A., Bellamy, G., Elliott, S., Fox, A. C., Glass, M., Tureček, F., Gelb, M. H., Scott, C. R. (2010)
“A tandem mass spectrometry triplex assay for the detection of Fabry, Pompe,
and Mucopolysaccharidosis-I (Hurler),” Clin Chem., 56(12):1854-1861. PMID:
20876176.
Zhang, X. K., Elbin, C. S., Tureček, F., Scott, R., Chuang, W. L., Keutzer, J. M., Gelb, M.
(2010) “Multiplex lysosomal enzyme activity assay on dried blood spots using
tandem mass spectrometry,” Methods Mol. Biol., 603:339-350. PMID: 20077085,
PMCID: PMC3442156.
Duffey, T. A., Khaliq, T., Scott, C. R., Tureček, F., Gelb, M. H. (2010) “Design and
synthesis of substrates for newborn screening of Maroteaux-Lamy and Morquio A
syndromes,” Bioorg. Med. Chem. Lett., 20(20):5994-5996. PMID: 20833037, MCID:
PMC2944228.
Blanchard, S., Tureček, F.,
Gelb, M. H. (2009) “Short synthetic sequence for 2-sulfation of
alpha-L-iduronate glycosides” Carbohydrate Research, 344:1032-1033. PMID:
19356745, PMCID: PMC2680446.
Blanchard, Sophie, Sadilek, Martin, Scott, C. Ronald, Tureček, Frantisek, and Gelb, Michael H. (2008)
“Tandem mass spectrometry for the direct assay of Lysosomal enzymes in dried
blood spots: Application to screening newborns for Mucopolysaccharidosis I,”
Clin. Chem., 54:2067-2070. PMID: 19042989, PMCID: PMC2891177.
Wang, Y., Scott, C. R., Gelb, M. H., Tureček, F. (2008) “Direct Assay of Enzymes in Heme Biosynthesis
for the Detection of Prophyrias by Tandem Mass Spectrometry,” Anal. Chem.,
80:2606-2611. PMID: 18294005, PMCID: PMC2565751.
Wang, Y., Gatti, P., Sadilek, M., Scott, C. R., Tureček, F., Gelb, M. H. (2008) “Direct Assay
of Enzymes in Heme Biosynthesis for the Detection of Porphyrias by Tandem Mass
Spectrometry. Uroporphyrinogen Decarboxylase and Coproporphyrinogen III
Oxidase,” Anal. Chem., 80:2599-2605. PMID: 18294003, PMCID:
PMC2515868.
Tureček, F., Scott,
C. R., Gelb, M. H. (2007) “Tandem mass spectrometry in the detection of inborn
errors of metabolism for newborn screening,” Methods Mol. Biol., 359:143-157.
PMID: 17484116
Lu, Y., Bottari, P., Aebersold, R., Tureček, F., Gelb, M. H. (2007) “Absolute quantification of
specific proteins in complex mixtures using visible isotope-coded affinity
tags,” Methods Mol. Biol., 359:159-176. PMID: 17484117.
Wang, D., Wood,T., Sadilek, M., Scott, C. R., Tureček, F. and M. H. Gelb (2007) “Tandem mass
spectrometry for the direct assay of enzymes in dried blood spots: Application
to newborn screening for Mucopolysaccharidosis II (Hunter Disease),” Clin.
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Gelb, M. H., Tureček, F.,
Scott, R. C., and Nestor, A. Chamoles. (2006) ” Direct multiplex assay of
enzymes in dried blood spots by tandem mass spectrometry for the newborn
screening of lysosomal storage disorders,” J Inherit Metab Dis
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Seebacher, J., Mallick, P., Zhang, N., Eddes J. S., Aebersold, R. and Gelb, M.
H. (2006)” Protein cross-linking analysis using mass spectrometry,
isotope-coded cross-linkers, and integrated computational data processing.”
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Scott, C. R. (2005) “Newborn screening for lysosomal storage disorders,”
Clinical Perspectives 12:11-15.
Wang, D., Eadala, B., Sadilek, M., Chamoles N. A., Tureček, F., Scott, C. R. and Gelb, M. H.
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Li, Y., Scott, C. R., Chamoles, N. A., Ghavami, A., Pinto, B. M., Tureček, F., Gelb, M. H. (2004) “Direct
multiplex assay of lysosomal enzymes in dried blood spots for newborn
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Lu, Y., Bottari, P., Tureček, F., Aebersold, R. and Gelb, M. H. (2004) “Absolute
quantification of specific proteins in complex mixtures using visible
isotope-coded affinity tags,” Anal. Chem., 76:4104-4111.
Li, Y., Brockman, K., Tureček, F., Scott, C. R., Gelb, M. H. (2004) “Tandem mass
spectrometry for the direct assay of enzymes in dried blood spots: Application
to newborn screening for Krabbe Disease,” Clin. Chem., 50: 638-640.
Bottari, P., Aebersold, R., Tureček, F., and Gelb, M. H. (2004) “Design and synthesis of
visible isotope-coded affinity tags for the absolute quantification of specific
proteins in complex mixtures,” Bioconj. Chem., 15:380-388.
Li, Y., Ogata, Y., Freeze, H. H., Scott, C. R., Tureček, F., and Gelb, M. H. (2003) “Affinity
capture and elution/electrospray ionization mass spectrometry assay of
phosphomannomutase and phosphomannose isomerase for the multiplex analysis of
congenital disorders of glycosylation types Ia and Ib,” Anal. Chem.,
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Ogata, Y., Scampavia, L., Ruzicka, J., Scott, C. R., Gelb, M. H., and Tureček, F. (2002) “Automated affinity
capture-release of biotin-containing conjugates using a lab-on-valve apparatus
coupled to UV/Visible and electrospray ionization mass spectrometry,” Anal.
Chem., 74:4702-4708.
Gerber, S. A., Tureček, F.,
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conjugates for profiling enzyme activity in the Sanfilippo Syndrome by affinity
chromatography/electrospray ionization mass spectrometry.” Bioconj. Chem.,
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Zhou, X., Tureček, F.,
Scott, C. R., and Gelb, M. H. “Quantification of cellular acid sphingomyelinase
and galactocerebroside B-galactosidase activities by electrospray ionization
mass spectrometry”. Clin. Chem., 2001, 47(5):874-881.
Gerber, S. A., Scott, C. R., Tureček, F., Gelb, M. H. “Direct profiling of multiple enzyme
activities in human cell lysates by affinity chromatography/electrospray
ionization mass spectrometry: Application to clinical enzymology”. Anal. Chem.,
2001, 73:1651-1657.
Gygi, S. P, Rist, B., Gerber, S. A., Tureček, F., Gelb, M. H, Aebersold R. “Quantitative analysis of
complex protein mixtures using isotope-coded affinity tags”. Nat Biotechnol.
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Alexander, Wells, Timothy N. C., and Van Voorhis, Wesley C. (2008) “Glycogen
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C., Worthey, E., Zucker, F., Hol, W. G. (2006) “Heterologous expression of
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light elements in determining precise binding modes of ligands to
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fibroblast-like synoviocyte arachidonic acid metabolism,” J. Biol. Chem.,
286:2492-2503. PMID: 21068383, PMCID: PMC3024744.
Reed KA, Tucker DE, Aloulou A, Adler D, Ghomashchi
F, Gelb MH, Leslie CC, Oates JA, Boutaud O. (2011) “Functional characterization
of mutations in inherited human cPLAâ‚‚ deficiency.” Biochemistry.
50(10):1731-8. PMID: 21247147, PMCID: PMC3051024.
Mouchlis, V.D., Magrioti, V., Barbayianni, E.,
Cermak, N., Oslund, R.C., Mavromoustakos, T.M., Gelb, M.H., Kokotos, G. (2011)
” Inhibition of secreted phospholipases A2 by 2-oxoamides based on alpha-amino
acids: Synthesis, in vitro evaluation and molecular docking calculations.”
Bioorg Med Chem. 19(2):735-43. PMID: 21216150, PMCID: PMC3050527.
Lai, Y., Oslund, R. C., Bollinger, J. G.,
Henderson, W. R. Jr., Santana, L. F., Altemeier, W. A., Gelb, M. H.,
Hallstrand, T. S. (2010) “Eosinophil cysteinyl leukotriene synthesis mediated
by exogenous secreted phospholipase A2 group X,” J. Biol. Chem., 285(53):41491-41500.
PMID: 20974857, PMCID: PMC3009875.
Boilard, E., Lai, Y., Larabee, K., Balestrieri,
B., Ghomashchi, F., Fujioka, D., Gobezie, R., Coblyn, J. S., Weinblatt, M. E.,
Massarotti, E. M., Thornhill, T. S., Divangahi, M., Remold, H., Lambeau, G.,
Gelb, M. H., Arm, J. P., Lee, D. M.(2010) “A novel anti-inflammatory role for
secretory phospholipase A2 in immune complex-mediated arthritis,” EMBO Mol.
Med., 2(5):172-187. PMID: 20432503, PMCID: PMC3058614.
Shridas, P., Bailey, W. M., Boyanovsky, B. B.,
Oslund, R. C., Gelb, M. H., Webb, N. R. (2010) “Group X secretory phospholipase
A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in
mouse adrenal glands,” J. Biol. Chem., 285(26):20031-20039. PMID: 20421306,
PMCID: PMC2888415.
Ghomashchi, F., Naika, G. S., Bollinger, J. G.,
Aloulou, A., Lehr, M., Leslie, C. C., Gelb, M. H. (2010) “Interfacial kinetic
and binding properties of mammalian group IVB phospholipase A2 (cPLA2{beta})
and comparison with the other cPLA2 isoforms,” J. Biol. Chem.,
285(46):36100-36111. PMID: 20705608, PMCID: PMC2975232.
Zack, M., Boyanovsky, B. B., Shridas, P., Bailey,
W., Forrest, K., Howatt, D. A., Gelb, M. H., de Beer, F. C., Daugherty, A.,
Webb, N. R. (2010) “Group X secretory phospholipase A(2) augments angiotensin
II-induced inflammatory responses and abdominal aortic aneurysm formation in
apoE-deficient mice,” Atherosclerosis, 214:58-64. PMID: 20833395, PMCID:
PMC3005558.
Bollinger, J. G., Thompson, W., Lai, Y., Oslund,
R. C., Hallstrand, T. S., Sadilek, M., Tureček, F., Gelb, M. H. (2010) “Improved
sensitivityi mass spectrometric detection of eicosanoids by charge reversal
derivatization,” Anal. Chem., 82:6790-6796. PMID: 20704368, PMCID: PMC2959116. supplement
Shridas, P., Bailey, W. M., Gizard, F., Oslund, R.
C., Gelb, M. H., Bruemmer, D., Webb, N. R. (2010) “Group X secretory
phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and
cholesterol efflux in macrophages,” Arterioscler Thromb Vasc Biol.,
30:2014-2021. PMID: 20844270, PMCID: PMC2958102.
Shridas, P., Bailey, W. M., Boyanovsky, B. B.,
Oslund, R. C., Gelb, M. H., Webb, N. R. (2010) “Group X secretory phospholipase
A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in
mouse adrenal glands,” J. Biol. Chem., 285:20031-20039. PMID: 20421306, PMCID:
PMC2888415.
Granata, F., Frattini, A., Loffredo, S., Staiano,
R. I., Petraroli, A., Ribatti, D., Oslund, R., Gelb, M. H., Lambeau, G.,
Marone, G., Triggiani, M. (2010) “Production of vascular endothelial growth
factors from human lung macrophages induced by group IIA and group X secreted
phospholipases A(2),” J. Immunol., 184:5232-5241. PMID: 20357262, PMCID:
PMC3073479.
Hallstrand, T. S., Wurfel, M. M., Lai, Y., Ni, Z,
Gelb, M. H., Altemeier, W. A., Beyer, R. P., Aitken, M. L., Henderson, W. R.
(2010) “Transglutaminase 2, a novel regulator of eicosanoid production in
asthma revealed by genome-wide expression profiling of distinct asthma
phenotypes,” PLoS One, 5(1):e8583. PMID: 20052409, PMCID: PMC2797392.
Surrel, F., Jemel, I., Boilard, E., Bollinger, J.
G., Payre, C., Mounier, C. M., Talvinen, K. A., Laine, V. J., Nevalainen, T.
J., Gelb, M. H., Lambeau, G. (2009) “Group X phospholipase A2 stimulates the
proliferation of colon cancer cells by producing various lipid mediators,” Mol.
Pharmacol., 76:778-790. PMID: 19602573, PMCID: PMC2769042.
Leslie, C. C., Gangelhoff, T. A., Gelb, M. H.
(2010) “Localization and function of cytosolic phospholipase A(2)alpha at the
Golgi,” Biochimie, 92:620-626. PMID: 20226226, PMCID: PMC2878860.
Olson, E. D., Nelson, J., Griffith, K., Nguyen,
T., Streeter, M., Wilson-Ashworth, H. A., Gelb, M. H., Judd, A. M., Bell, J. D.
(2010) “Kinetic evaluation of cell membrane hydrolysis during apoptosis by
human isoforms of secretory phospholipase A2,” J. Biol. Chem., 285:10993-11002.
PMID: 20139082, PMCID: PMC2856304.
Bollinger, J. G., Ii, H., Sadilek, M. and Gelb, M.
H., (2010) “Improved method for the quantification of lysophospholipids
including enol ether species by liquid chromatography-tandem mass
spectrometry,” J. Lipid Res., 51:440-447. PMID: 19717841, PMCID: PMC2803247.
Rosenson, R. S., Gelb, M. H. (2009) “Secretory
phospholipase A(2): A multifaceted family of proatherogenic enzymes,” Curr.
Cardiol. Rep., 11:445-451. PMID: 19863869.
Regan-Klapisz, E., Krouwer, V.,
Langelaar-Makkinje, M., Nallan, L., Gelb, M., Gerritsen, H., Verkleij, A. J.
and Post, J. A. (2009) “Golgi-associated cPLA2alpha regulates endothelial
cell-cell junction integrity by controlling the trafficking of transmembrane
junction proteins”, Molecular Biology of the Cell, 20:4225-4234. PMID:
19675210, PMCID: PMC2754936.
Surrel, F., Jemel, I., Boilard, E., Bollinger, J.
G., Payre, C., Mounier, C. M., Talvinen, K. A., Laine, V. J., Nevalainen, T.
J., Gelb, M. H., Lambeau, G. (2009) “Group X pospholipase A2 stimulates the
proliferation of colon cancer cells by producing various lipid mediators,” Mol.
Pharmacol., 76:778-790. PMID: 19602573, PMCID: PMC2769042.
Triggiani, M., Giannattasio, G., Calabrese, C.,
Loffredo, S., Granata, F., Fiorello, A., Santini, M., Gelb, M. H. (2009) “Lung
mast cells are a source of secreted phospholipases A2”, J. Allergy Clin
Immunol., 124:558-565. PMID 19541351, PMCID: PMC2788562.
Balestrieri, B., Maekawa, A., Xing, W., Gelb,
M.H., Katz, H.R., Arm, J.P. (2009) “Group V secretory phospholipase A2
modulates phagosome maturation and regulates the innate immune response against
Candida albicans”, J. Immunol., 182(8):4891-4898. PMID: 19342668, PMCID:
PMC2746418.
Giannattasio, G., Lai, Y., Granata, F., Mounier,
C.M., Nallan, L., Oslund, R., Leslie, C.C., Marone, G., Lambeau, G., Gelb,
M.H., Triggiani, M. (2009) “Expression of phospholipases A(2) in primary human
lung macrophages Role of cytosolic phospholipase A(2)-alpha in arachidonic acid
release and platelet activating factor synthesis”, Biochim Biophys Acta,
1791(2):92-102. PMID: 19130898, PMCID: PMC2676353.
Tucker, D.E., Ghosh, M., Ghomashchi, F., Loper,
R., Suram, S., St. John, B., Girotti, M., Bollinger, J.G., Gelb, M.H., Leslie,
C.C. (2009) “Role of phosphorylation and basic residues in the catalytic domain
of cytosolic phospholipase A2alpha in regulating interfacial kinetics and
binding and cellular function, J. Biol. Chem., J. Biol. Chem, 284:9596-9611.
PMID: 19176526, PMCID: PMC2666612.
Tucker, D.E., Gijon, M.A., Spencer, D.M., Qiu,
Z.H., Gelb, M.H., Leslie, C.C., (2008) “Regulation of cytosolic phospholipase
A2alpha by hsp90 and a p54 kinase in okadaic acid-stimulated macrophages”, J.
Leukoc Biol., 84(3):798-806.
Lambeau G., Gelb, M. H. (2008) “Biochmistry and
physiology of mammalian secreted phospholipases A2” Annu Rev Biochem,
77:495-520.
Patel, MI, Singh, J, Niknami, M, Kurek, C, Yao, M,
Lu, S, Maclean, F, King, NJ, Gelb, MH, Scott, KF, Russell, PJ, Boulas, J, Dong,
Q. (2008) “Cytosolic Phospholipase A2-alpha: A potential therapeutic target for
prostrate cancer”, Clin Cancer Res., 14:8070-8079.
Su, W, Yeku, O, Olepu, S, Genna, A, Park, J-S,
Ren, H, Du, G, Gelb, MH, Morris, AJ, and Frohman, MA (2008) “FIPI, a
Phospholipase D pharmacological inhibitor that alters cell spreading and
inhibits chemotaxis,” Molecular Pharmocology Fast Forward, published December
8, 2008, mol.108.053298.
Oslund, RC, Cermak, N, Verlinde, CLM, Gelb, MH,
(2008) “Simplified YM-26734 Inhibitors of secreted phospholipase A2 group IIA,”
Bioorganic and Medicinal Chemistry Letters, 18:5415-4319.
Wilensky, RL, Shi, Y, Mohler, ER, III, Hamamdzic,
D, Burgert, ME, Li, J, Postle, A, Fenning, RS, Bollinger, JG, Hoffman, BE,
Pelchovitz, DJ, Yang, J, Mirabile, RC, Webb, CL, Zhang, L, Zhang, P, Gelb, MH,
Walker, MC, Zalewski, A, and Macphee, CH, (2008) “Inhibition of
lipoprotein-associated phospholipase A2 reduces complex coronary
atherosclerotic plaque development,” Nature Medicine, 14 (10):1059-1066.
Oslund, RC, Cermak, N, Gelb, MH, (2008) “Highly
specific and broadly potent inhibitors of mammalian secreted phospholipases
A2,” J. Med. Chem., 51:4708-4714.
Tribler, L, Jensen, LT, Jørgensen, K, Brünner, N,
Gelb, MH, Nielsen, HJ and Jensen, SS, (2007) “Increased expression and activity
of group IIA and X secretory phospholipase A2 in Peritumoral versus central
colon carcinoma tissue,” Anticancer Research, 27:3179-3186.
Morgan, D, Cherny, VV, Finnegan A, Bollinger J,
Gelb MH, DeCoursey TE. (2007) “Sustained activation of proton cheannels and
NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not
CPLA2 alpha activity,” J. Physiol., 579(Pt 2):327-344.
Hallstrand, TS, Chi, EY, Singer, AG, Gelb, MH,
Henderson, Jr., WR (2007) “Secreted phospholipase A2 group X overexpression in
asthma and bronchial hyperresponsiveness,” Am. J. Respir Crit Care Med.,
176:1072-1078.
Wichmann O, Gelb MH, Schultz, C. (2007) “Probing
Phospholipase A2 with fluorescent phospholipid Substrates,” ChemBioChem,
8:1555-1569.
Ghomashchi, F., Bollinger, J.G. and Gelb, M. H.
(2007) “Facile preparation of leukotrienes C4, D4 and E4 containing carbon-13
and nitrogen-15 for quantification of cysteinyl leukotrienes by mass
spectrometry,” J. Radiolabel. Compds Radiopharm. 50:729
Ghosh, M., Loper, R., Ghomashchi, F., Tucker,
D.E., Bonventre, J.V., Gelb, M.H. and Christina C. Leslie. (2007) “Function,
Activity, and Membrane Targeting of Cytosolic Phospholipase A2-zeta in Mouse
Lung Fibroblasts,” J. Biol. Chem. 282:11676
Henderson, W.R., Chi, E.Y., Bollinger, J.G., Tien,
Y.T., Ye, X., Castelli, L. Rubtsov, Y.P., Singer, A.G., Chiang, G.K.,
Nevalainen, T., Rudensky, A.Y. and M. Gelb. (2007) “Importance of Group
X-secreted Phospholipase A2 in Allergen-Induced airway inflammation and
remodeling in a mouse asthma model,” J. Exp. Med. April 16 204:865-877
Rouault M, Calvez CL, Boilard E, Surrel F, Singer
A, Ghomashchi F, Bezzine S, Scarzello S, Bollinger J, Gelb MH, Lambeau G.
(2007) ” Recombinant production and properties of binding of the full set of
mouse secreted phospholipases a(2) to the mouse m-type receptor,” Biochemistry
46:1647-62.
Boilard, E., Rouault, M., Surrel, F., Le Calvez,
C. Bezzine, S., Singer, A., Gelb, M.H. and Gerard Lambeau. (2006) “Secreted
Phospholipase A2 Inhibitors Are Also Potent Blockers of Binding to the M-Type
Receptor,” Biochemistry 45:13202
Karabina, S.A., Brocheriou, I., Le Naour, G.,
Agrapart, M., Durand, H., Gelb, M.H., Lambeau, G. and Ewa Ninio.(2006)
“Atherogenic properties of LDL particles modified by human group X secreted
phospholipase A2 on human endothelial cell function,” The FASEB Journal 20:E2
[Published online Oct. 31]
Ghosh, M., Loper, R., Gelb, M.H. and Leslie,
C.C.(2006) “Identification of the Expressed Form of Human Cytosolic
Phospholipase A2β (cPLA2β),” J. Biol. Chem. 281:16615.
Gelb, M. H., Mounier, Carine M., Hefner, Ying,
Watson, Steve P., Platelet Phospholipases A2. In Platelets in thrombotic and non-thrombotic
disorders: pathophysiology, pharmacology, and therapeutics, Gresele, P. e. a., Ed. Cambridge
University Press: Cambridge, 2002; pp 221-237.
Ni,Z., Okeley, N. M., Smart, B.P., and Michael H.
Gelb (2006)” Intracellular Actions of Group IIA Secreted Phospholipase A2 and
Group IVA Cytosolic Phospholipase A2 Contribute to Arachidonic Acid Release and
Prostaglandin Production in Rat Gastric Mucosal Cells and Transfected Human
Embryonic Kidney Cells” J. Biol. Chem., 281: 16245-55 .
Eerola, L.I., Surrel, F., Nevalainen, T.J., Gelb,
M.H., Lambeau, G. and V. Jukka O. Laine (2006) “Analysis of expression of
secreted phospholipases A2 in mouse tissues at protein and mRNA levels,”
Biochimica et Biophysica Acta [Epub ahead of print] April 10
Rouault, M., Rash, L. D., Escoubas, P., Boilard,
E., Bollinger,J., Lomonte,B., Maurin, T., Guillaume,C., Canaan, S.,
Deregnaucourt, C., Schrevel,J., Doglio, A., Gutierrez, J. M., Lazdunski, M.,
Gelb, M. H., and G. Lambeau. (2006) “Neurotoxicity and Other Pharmacological
Activities of the Snake Venom Phospholipase A2 OS2: The N-Terminal Region Is
More Important Than Enzymatic Activity,” Biochemistry [Epub ahead of print]
Feb. 14
Smart, B.P., Oslund, R.C. and Walsh, L.A. (2006) ”
The First Potent Inhibitor of Mammalian Group X Secreted Phospholipase A2:
Elucidation of Sites for Enhanced Binding,” J. Med. Chem. Feb. 8 ; [Epub ahead
of print]
Huhtinen, H.T., Gronroos, J.O., Gronroos, J.M.
Uksila, J., Gelb, M.H., Nevalainen, T.J. and Laine, V.J. (2006) “Antibacterial
effects of human group IIA and group XIIA phospholipase A2 against Helicobacter
pylori in vitro,” APMIS 114:127-30
Siegel, J. B., Zanghellini, A., Lovick, H. M., Kiss, G.,
Lambert, A. R., St. Clair, J. L., Gallaher, J. L., Hilvert, D., Gelb, M. H.,
Stoddard, B. L., Houk, K. N., Michael, F.E., Baker, D. (2010) “Computational
design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder
reaction,” Science, 329:309-313. PMID: 20647463, PMCID: PMC3241958.
Chipuk, J .E., Gelb, M. H., Brodbelt, J. S. (2010)
“Rapid and selective screening for sulfhydryl analytes in plasma and urine
using surface-enhanced transmission mode desorption electrospray ionization
mass spectrometry,” Anal. Chem,82:4130-4139. PMID: 20402469, PMCID: PMC2872998.
Trinh, K., Andrews, L., Krause, J., Hanak, T.,
Lee, D., Gelb, M. and Pallanck, L. (2010) “Decaffeinated coffee and
nicotine-free tobacco provide neuroprotection in drosophila models of
Parkinson’s Disease through an NRF2-dependent mechanism,” J Neurosci,
30:5525-5532. PMID: 20410106, PMCID: PMC3842467.
Chipuk, J. E., Gelb, M. H., Brodbelt, J. S. (2010)
“Surface-enhanced transmission mode desorption electrospray ionization:
Increasing the specificity of ambient ionization mass spectrometric analyses,”
Anal. Chem. 82:16-18. PMID: 19902914, PMCID: PMC2800855.
Holt, A., Koehorst, R. B., Rutters-Meijneke, T.,
Gelb, M. H., Rijkers, D. T., Hemminga, M. A., Killian, J. A. (2009) “Tilt and
rotation angles of a transmembrane model peptide as studied by fluorescence
spectroscopy,” Biophys. J., 97:2258-2266. PMID: 19843458, PMCID: PMC2764067.
Gelb, M. H. and Holm, B. P. (2006) “A simple and
inexpensive device for removal of solvent from a large collection of sample
tubes,” J Comb Chem. 8:15-27. PMID: 16398548.
Kuksa, V., Bartl, F., Maeda, T., Jang, G.-F.,
Ritter, E., Heck, M., Van Hooser, J. P., Liang, Y., Filipek, S., Gelb, M. H.,
Hofmann, K. P., and Palczewski, K., “Biochemical and physiological properties
of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals”. J. Biol. Chem.,
2002, 277:42315-42324. PMID: 1217699, PMCID: PMC1363677.
Goldstein, A. S., Gelb, M. H., and Yager, P. “The
relationship between the structure of the headgroup of sphingolipids and their
ability to form complex high zxial ratio microstructures”. Chemistry and
Physics of Lipids, 2001, 109:1-14.
Goldstein, A. S., Gelb, M. H., and Yager, P.
“Continuous and highly variable rate controlled release of model drugs from
sphingolipid-based complex high axial ratio microstructures”. J. of Controlled
Release, 2001, 70:125-138.
Jang, G. F., Kuksa, V., Filipek, S., Bartl, F.,
Ritter, E., Gelb, M. H., Hofmann, K. P., and Palczewski, K., “Mechanism of
rhodopsin activation as examined with ring constrained retinal analogs and the
crystal structure of the ground state protein”. J. Biol. Chem., 2001, 276:
26148-26153.
Stecher, H., Gelb, M. H., Saari, J. C.,
Palczewski, K., “Preferential release of 11-cis-retinol from retinal pigment
epithelial cells in the presence of cellular retinaldehyde-binding protein”. J
Biol Chem. 274(13): 8577-85, 26 Mar 1999.