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For a complete listing of Gelb lab publications see Pubmed 

 

 

Publications 2023-May, 2024:

 

Drug screening identifies tazarotene and bexarotene as therapeutic agents in multiple sulfatase deficiency.

Schlotawa L, Tyka K, Kettwig M, Ahrens-Nicklas RC, Baud M, Berulava T, Brunetti-Pierri N, Gagne A, Herbst ZM, Maguire JA, Monfregola J, Pena T, Radhakrishnan K, Schröder S, Waxman EA, Ballabio A, Dierks T, Fischer A, French DL, Gelb MH, Gärtner J.EMBO Mol Med. 2023 Mar 8;15(3):e14837. doi: 10.15252/emmm.202114837. Epub 2023 Feb 15.PMID: 36789546 

 

Pilot study of newborn screening for six lysosomal diseases in Brazil.

Kubaski F, Sousa I, Amorim T, Pereira D, Silva C, Chaves V, Brusius-Facchin AC, Netto ABO, Soares J, Vairo F, Poletto E, Trometer J, Souza A, Ranieri E, Polo G, Hong X, Herbst ZM, Burlina A, Gelb MH, Giugliani R.Mol Genet Metab. 2023 Sep-Oct;140(1-2):107654. doi: 10.1016/j.ymgme.2023.107654. Epub 2023 Jul 13.PMID: 37507255

 

Newborn screening for Cerebrotendinous Xanthomatosis: A retrospective biomarker study using both flow-injection and UPLC-MS/MS analysis in 20,000 newborns.

Vaz FM, Jamal Y, Barto R, Gelb MH, DeBarber AE, Wevers RA, Nelen MR, Verrips A, Bootsma AH, Bouva MJ, Kleise N, van der Zee W, He T, Salomons GS, Huidekoper HH.Clin Chim Acta. 2023 Jan 15;539:170-174. doi: 10.1016/j.cca.2022.12.011. Epub 2022 Dec 16.PMID: 36529270 Free PMC article.

 

Endogenous, non-reducing end glycosaminoglycan biomarkers are superior to internal disaccharide glycosaminoglycan biomarkers for newborn screening of mucopolysaccharidoses and GM1 gangliosidosis.

Herbst ZM, Hong X, Urdaneta L, Klein T, Waggoner C, Liao HC, Kubaski F, Giugliani R, Fuller M, Gelb MH.Mol Genet Metab. 2023 Sep-Oct;140(1-2):107632. doi: 10.1016/j.ymgme.2023.107632. Epub 2023 Jun 24.PMID: 37407323

 

Predicting disease severity in metachromatic leukodystrophy using protein activity and a patient phenotype matrix.

Trinidad M, Hong X, Froelich S, Daiker J, Sacco J, Nguyen HP, Campagna M, Suhr D, Suhr T, LeBowitz JH, Gelb MH, Clark WT.Genome Biol. 2023 Jul 21;24(1):172. doi: 10.1186/s13059-023-03001-z.PMID: 37480112 Free PMC article.

 

ScreenPlus: A comprehensive, multi-disorder newborn screening program.

Kelly NR, Orsini JJ, Goldenberg AJ, Mulrooney NS, Boychuk NA, Clarke MJ, Paleologos K, Martin MM, McNeight H, Caggana M, Bailey SM, Eiland LR, Ganesh J, Kupchik G, Lumba R, Nafday S, Stroustrup A, Gelb MH, Wasserstein MP.Mol Genet Metab Rep. 2023 Dec 14;38:101037. doi: 10.1016/j.ymgmr.2023.101037. eCollection 2024 Mar.PMID: 38173711 Free PMC article.

 

Intrauterine enzyme replacement therapies for lysosomal storage disorders: Current developments and promising future prospects.

Herzeg A, Borges B, Lianoglou BR, Gonzalez-Velez J, Canepa E, Munar D, Young SP, Bali D, Gelb MH, Chakraborty P, Kishnani PS, Harmatz P, Cohen JL, MacKenzie TC.Prenat Diagn. 2023 Dec;43(13):1638-1649. doi: 10.1002/pd.6460. Epub 2023 Nov 13.PMID: 37955580 Review.

 

Endogenous, non-reducing end glycosaminoglycan biomarkers for the mucopolysaccharidoses: Accurate diagnosis and elimination of false positive newborn screening results.

Saville JT, Herbst ZM, Gelb MH, Fuller M.Mol Genet Metab. 2023 Nov;140(3):107685. doi: 10.1016/j.ymgme.2023.107685. Epub 2023 Aug 14.PMID: 37604083 Review.

 

Failure to apply standard limit-of-detection or limit-of-quantitation criteria to specialized pro-resolving mediator analysis incorrectly characterizes their presence in biological samples.

O'Donnell VB, Schebb NH, Milne GL, Murphy MP, Thomas CP, Steinhilber D, Gelhaus SL, Kühn H, Gelb MH, Jakobsson PJ, Blair IA, Murphy RC, Freeman BA, Brash AR, FitzGerald GA.Nat Commun. 2023 Nov 9;14(1):7172. doi: 10.1038/s41467-023-41766-w.PMID: 37945602 Free PMC article. No abstract available.

 

It's time to reconsider the newborn screening RUSP prospective pilot study "N of 1" rule.

Gelb MH, Matern D, Ellinwood M, Gaviglio A.Mol Genet Metab. 2024 May;142(1):108352. doi: 10.1016/j.ymgme.2024.108352. Epub 2024 Feb 24.PMID: 38429125 No abstract available.

 

Newborn screening for the full set of mucopolysaccharidoses in dried blood spots based on first-tier enzymatic assay followed by second-tier analysis of glycosaminoglycans.

Herbst ZM, Hong X, Sadilek M, Fuller M, Gelb MH.Mol Genet Metab. 2023 Nov;140(3):107698. doi: 10.1016/j.ymgme.2023.107698. Epub 2023 Sep 7.PMID: 37820575 Review.

 

Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Analysis of Urinary Oligosaccharides and Glycoamino Acids for the Diagnosis of Mucopolysaccharidosis and Glycoproteinosis.

Wongkittichote P, Cho SH, Miller A, King K, Herbst ZM, Ren Z, Gelb MH, Hong X.Clin Chem. 2024 Apr 10:hvae043. doi: 10.1093/clinchem/hvae043. Online ahead of print.PMID: 38597162

 

Biochemical signatures of disease severity in multiple sulfatase deficiency.

Adang LA, Mowafy S, Herbst ZM, Zhou Z, Schlotawa L, Radhakrishnan K, Bentley B, Pham V, Yu E, Pillai NR, Orchard PJ, De Castro M, Vanderver A, Pasquali M, Gelb MH, Ahrens-Nicklas RC.J Inherit Metab Dis. 2024 Mar;47(2):374-386. doi: 10.1002/jimd.12688. Epub 2023 Nov 1.PMID: 37870986

 

Multiplex tandem mass spectrometry enzymatic activity assay for the screening and diagnosis of Mucolipidosis type II and III.

Hong X, Pollard L, He M, Gelb MH, Wood TC.Mol Genet Metab Rep. 2023 May 16;35:100978. doi: 10.1016/j.ymgmr.2023.100978. eCollection 2023 Jun.PMID: 37275682 Free PMC article.

 

A novel iPSC model reveals selective vulnerability of neurons in multiple sulfatase deficiency.

Pham V, Sertori Finoti L, Cassidy MM, Maguire JA, Gagne AL, Waxman EA, French DL, King K, Zhou Z, Gelb MH, Wongkittichote P, Hong X, Schlotawa L, Davidson BL, Ahrens-Nicklas RC.Mol Genet Metab. 2024 Feb;141(2):108116. doi: 10.1016/j.ymgme.2023.108116. Epub 2023 Dec 21.PMID: 38161139

 

Higher precision, first tier newborn screening for metachromatic leukodystrophy using 16:1-OH-sulfatide.

Bekri S, Bley A, Brown HA, Chanson C, Church HJ, Gelb MH, Hong X, Janzen N, Kasper DC, Mechtler T, Morton G, Murko S, Oliva P, Tebani A, Wu THY.Mol Genet Metab. 2024 May;142(1):108436. doi: 10.1016/j.ymgme.2024.108436. Epub 2024 Mar 22.PMID: 38552449

 

Tandem mass spectrometric assay of N-acetylglucosamine-6-sulfatase for multiplex analysis of mucopolysaccharidosis-IIID in dried blood spots.

Liu Y, Gelb MH.Mol Genet Metab. 2024 Jan;141(1):108105. doi: 10.1016/j.ymgme.2023.108105. Epub 2023 Nov 30.PMID: 38128203

 

Quantification of N-acetyl-l-aspartate in dried blood spots: A simple and fast LC-MS/MS neonatal screening method for the diagnosis of Canavan disease.

Posern C, Dreyer B, Maier SL, Eichler F, Gelb MH, Santer R, Bley A, Murko S.Mol Genet Metab. 2024 May 3;142(2):108489. doi: 10.1016/j.ymgme.2024.108489. Online ahead of print.PMID: 38718669

 

 

 

Publications before 2023

 

A close-up of a dna model Description automatically generated

 

Blackwell, K.; Gelb, M.H.; Grantham, A.; Spencer, N.; Webb, C.; West, T.  Family Attitudes Regarding Newborn Screening for Krabbe Disease: Results from a Survey of Leukodystrophy Registries. [published online ahead of print, 20 August 2020] Int. J. Neonatal Screen., 2020, 6. DOI: 10.3390/ijns6030066.

 

Su, P.; Khaledi, H.; Waggoner, C.; Gelb, M.H. Detection of GM1-Gangliosidosis in Newborn Dried Blood Spots by Enzyme and Biomarker Assays Using Tandem Mass Spectrometry [published online ahead of print, 2020 Jun 7]. J Inherit Metab Dis. 2020;10.1002/jimd.12269. doi:10.1002/jimd.12269  

 

Weinstock, N.I.; Shin, D.; Dhimal, N.; Hong, X.; Irons, E.E.; Silvestri, N.J.; Reed, C.B.; Nguyen, D.; Sampson, O.; Cheng, Y-C.; Lau, J.T.Y.; Bongarzone, E.R.; Kofler, J.; Escolar, M.L.; Gelb, M.H.; Wrabetz, L.; Feltri, M.L. “Macrophages Expressing GALC Improve Peripheral Krabbe Disease by a Mechanism Independent of Cross-Correction.” Neuron, 2020, 107, 65-81.  cover  article  editorial

 

Hong, X.; Sadilek, M.; Gelb, M.H. A highly multiplexed biochemical assay for analytes in dried blood spots: application to newborn screening and diagnosis of lysosomal storage disorders and other inborn errors of metabolism. Genet. Med., 2020, https://doi.org/10.1038/s41436-020-0790-9 

 

Herbst, Z.; Turgeon, C.T.; Biski, C.; Khaledi, H.; Shoemaker, N.B.; DeArmond, P.D.; Smith, S.; Orsini, J.; Matern, D.; Gelb, M.H. Achieving Congruence among Reference Laboratories for Absolute Abundance Measurement of Analytes for Rare Diseases: Psychosine for Diagnosis and Prognosis of Krabbe Disease. Int. J. Neonatal Screen. 2020, 6, 29; doi:10.3390/ijns6020029

Guenzel, A.J.; Turgeon, C.T.; Nickander, K.K.; White, A.L.; Peck, D.S.; Pino, G.B.; Studinski, A.L.; Prasad, V.K.; Kurtzberg, J.; Escolar, M.L.; Lasio, M.L.D.; Pellegrino, J.E.; Sakonju, A.; R.E.; Shallow, N.M.; Ream, M.A.; Orsini, J.J.; Gelb, M.H.; Raymond, K.; Gavrilov, D.K.; Oglesbee, D.; Rinaldo, P.; Tortorelli, S.; Matern, D. The critical role of psychosine in screening, diagnosis, and monitoring of Krabbe disease. Genet. Med. 2020, https://doi.org/10.1038/s41436-020-0764-y.

Kumar, A.B.; Hong, X.; Yi, F.; Wood, T.; Gelb, M.H. Tandem mass spectrometry-based multiplex assays for a-mannosidosis and fucosidosis. Mol. Genet. Metab. 2019, 127, 207-211

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Chan, M-J; Liao, H-C; Gelb, M.H.; Chuang, C-H; Liu, M-Y; Chen, H-J; Kao, S-H; Lin, H-Y; Huang, Y-H; Kumar, A.B.; Chennamaneni, N.K.; Nagendar, P.; Lin, S-P; Chiang, C-C. Taiwan National Newborn Screening Program by Tandem Mass Spectrometry for Mucopolysaccharidoses Types I, II, and VI J Pediatr. 2019, 205, 176-182. doi: 10.1016/j.jpeds.2018.09.063. Epub 2018 Nov 6.


Hong, X.; Gelb, M.H. One-step synthesis of carbon-13-labeled globotriaosylsphingosine (lyso-Gb3), an internal standard for biomarker analysis of Fabry disease. Mol Genet Metab., 2018, 125, 292-294. doi: 10.1016/j.ymgme.2018.08.001. Epub 2018 Aug 10.


Khaledi, H.; Liu, Y.; Masi, S.; Gelb, M.H. Detection of Infantile Batten Disease by Tandem Mass Spectrometry Assay of PPT1 Enzyme Activity in Dried Blood Spots. Anal Chem. 2018, 90,12168-12171. doi: 10.1021/acs.analchem.8b03188. Epub 2018 Sep 24.


Gelb, M.H. Absolute Amounts of Analytes: When Gravimetric Methods Are Insufficient. Clin Chem., 2018, 64,1430-1432. doi: 10.1373/clinchem.2018.290486. Epub 2018 Jul 27

Gelb, M. Newborn Screening for Lysosomal Storage Diseases: Methodologies, Screen Positive Rates, Normalization of Datasets, Second-Tier Tests, and Post-Analysis Tools. Int. J. Neonatal Screen. 2018, 4, 23.NIHMSID: NIHMS984633.

Yi, F.; Hong, X.; Kumar, A.B.; Zong, C.; Boons, G.J.; Scott, C.R.; Turecek, F.; Robinson, B.H.; Gelb, M.H. Detection of mucopolysaccharidosis III-A (Sanfilippo Syndrome-A) in dried blood spots (DBS) by tandem mass spectrometry. Mol Genet Metab. 2018, 125, 59-63. doi: 10.1016/j.ymgme.2018.05.005. Epub 2018 May 23.



Hong, X.; Kumar, A.B.;Scott, R.C.; Gelb, M.H. Multiplex tandem mass spectrometry assay for newborn screening of X-linked adrenoleukodystrophy, biotinidase deficiency, and galactosemia with flexibility to assay other enzyme assays and biomarkers. Mol Genet Metab. 2018, 124, 101-108. doi: 10.1016/j.ymgme.2018.03.012. Epub 2018 Mar 29.



Kwon, J.M.; Matern, D.; Kurtzberg, J.; Wrabetz, L.; Gelb, M.H.; Wenger DA, Ficicioglu C, Waldman AT, Burton BK, Hopkins PV, Orsini JJ. Consensus guidelines for newborn screening, diagnosis and treatment of infantile Krabbe disease. Orphanet J Rare Dis. 2018 Feb 1;13(1):30.PMID: 29391017 [PubMed – in process]

Masi, S.; Chennamaneni, N.; Turecek, F.; Scott, C.R.; Gelb, M.H. Specific Substrate for the Assay of Lysosomal Acid Lipase. Clin Chem. 2018 March .DOI: 10.1373/clinchem.2017.282251. PMID: 29339442.

Peake, Roy W.A.; Marsden, Deborah L.; Bodamer, Olaf A.; Gelb, Michael H.; Millington, David S.; Wijburg, Frits. Newborn Screening for Lysosomal Storage Disorders: Quo Vadis? Clinical Chemistry Nov 2016, 62,1430-1438; DOI: 10.1373/clinchem.2016.258459.

Liao, H.C.; Spacil, Z.; Ghomashchi, F.; Escolar, M.L.; Kurtzberg, J.; Orsini, J.J.; Turecek, F.; Scott, C.R.; Gelb, M.H. Lymphocyte Galactocerebrosidase Activity by LC-MS/MS for Post-Newborn Screening Evaluation of Krabbe Disease. Clin Chem. 2017 Jun 7. pii: clinchem.2016.264952. doi: 10.1373/clinchem.2016.264952. [Epub ahead of print].

Escolar, M.L.; Kiely, B.T.; Shawgo, E.; Hong, X.; Gelb, M.H.; Orsini, J.J.; Matern, D.; Poe, M.D. Psychosine, a marker of Krabbe phenotype and treatment effect. Mol Genet Metab. 2017 May 22. pii: S1096-7192(17)30205-6. doi: 10.1016/j.ymgme.2017.05.015. [Epub ahead of print] PMID: 28579020. Article.

Yang, L; Kumar, A.B.; Chennamaneni, N.K.; Hong, X.; Scott, C.R.; Gelb, M.H.; Tureček. F. Multiplex Tandem Mass Spectrometry Enzymatic Activity Assay for Newborn Screening of the Mucopolysaccharidoes and Type 2 Neuronal Ceroid Lipofuscinosis. Clin. Chem. 2017, 63, 1118-1126. doi:10.1373/clinchem.2016.269167. Epub 2017 Apr 20. PMID: 28428354. Supplemental materials.

Liao. H.C.; Chan, M.J.; Yan, C.F.; Chiang, C.C.; Niu, D.M.; Huang, C.K.; Gelb, M.H. Mass Spectrometry but Not Fluorometry Distinguishes Affected and Pseudodeficiency Patients in Newborn Screening for Pompe Disease.Clin Chem. 2017 pii: clinchem.2016.269027. doi:10.1373/clinchem.2016.269027. [Epub ahead of print] PMID: 28450385. [Epub ahead of print].

Lin, N.; Huang, J.; Violante, S.; Orsini, J.J.; Caggana, M.; Hughes, E.E.; Stevens, C.; DiAntonio, L.; Chieh, L.H.; Hong, X.; Ghomashchi, F.; Babu, K.A.; Zhou, H.; Kornreich, R.; Wasserstein, M.; Gelb, M.H.; Yu, C. Liquid Chromatography-Tandem Mass Spectrometry Assay of Leukocyte Acid α-Glucosidase for Post-Newborn Screening Evaluation of Pompe Disease. Clin Chem. 2017 63:842-851. doi:10.1373/clinchem.2016.259036. Epub 2017 Feb 14. v. PMID: 28196920; PMCID: PMC5413112.



Elliott, S.; Buroker, N.; Cournoyer, J.J.; Potier, A.M.; Trometer, J.D.; Elbin, C.; Schermer, M.J.; Kantola, J.; Boyce, A.; Tureček, F.; Gelb, M.H.; Scott, C.R. Pilot study of newborn screening for six lysosomal storage diseasesusing Tandem Mass Spectrometry. Mol Genet Metab. 2016 118, 304-309. doi: 10.1016/j.ymgme.2016.05.015. Epub 2016. May 20. PMID: 27238910; PMCID: PMC5318163.

 

Spacil, Z., Babu Kumar, A., Liao, HC., Auray-Blais, C., Stark, S., Suhr, TR., Scott, CR., Tureček, F., Gelb, MH.(2015) “Sulfatide Analysis by Mass Spectrometry for Screening of Metachromatic Leukodystrophy in Dried Blood and Urine Samples,” Clin Chem. 2015 Nov 19. pii: clinchem.2015.245159. PMID: 26585924  

Kumar AB, Spacil Z, Ghomashchi F, Masi S, Sumida T, Ito M, Tureček F, Scott CR, Gelb MH.(2015)”Fluorimetric assays for N-acetylgalactosamine-6-sulfatase and arylsulfatase B based on the natural substrates for confirmation of mucopolysaccharidoses types IVA and VI” Clin Chim Acta. 2015 Aug 15. pii: S0009-8981(15)00381-2. doi: 10.1016/j.cca.2015.08.010. PMID:26282597  

 

Kumar, A.B., Masi, S., Ghomashchi, F., Chennamaneni, N.K., Ito, M., Scott, C.R., Tureček, F., Gelb, M.H., Spacil, Z. (2015) “Tandem Mass Spectrometry has a larger analytical range than Fluorescence Assays of Lysosomal Enzymes: Application to newborn screening and Diagnosis of Mucopolysaccharidoses Types II, IVA and VI.” Clin Chem. 2015 Sep 14. pii: clinchem.2015.242560. DOI:10.1016/j.cca.2015.08.010 PMID:26369786  

 

Ghomashchi, F., Barcenas, M., Tureček, F., Scott, C. R., Gelb, M. H., (2015) “Reliable assay of acid sphingomyelinase deficiency with the mutation Q292K by tandem mass spectrometry,” Clin Chem, 61:(5):771-778, DOI:10.2373/clinchem.2014.236448. PMID: 25770139. 

Gelb, M. H., Scott, C. R., Tureček, F. (2015) “Newborn screening for lysosomal storage diseases,” Clin Chem, 61:335-346. PMID: 25477536, PMCID: PMC4345406.  

 

Barcenas, M., Xue, C., Marushchak-Vlaskin, T., Scott, C. R., Gelb, M. H., Tureček, F. (2014) “Tandem mass spectrometry assays of palmitoyl protein thioesterase 1 and tripeptidyl peptidase activity in dried blood spots for the detection of Neuronal Ceroid Lipofuscinoses in newborns,” Anal. Chem., 86(15):7962-7968, DOI: 10.1021/ac501994b. PMID: 25019629.  

Chennamaneni, N. K., Kumar, A. B., Barcenas, M., Specil, Z., Scott, C. R., Tureček, F., Gelb, M. H., (2014) “Improved reagents for newborn screening of Mucopolysaccharidosis types I, II, and VI by tandem mass spectrometry,” Anal. Chem., 86:4508-4514, DOI: 10.1021/ac5004135. PMID: 24694010, PMCID: PMC4014144.  

Fitterer, B., Hall, P., Antonishyn, N., Desikan, R., Gelb, M., Lehotay, D. (2014) “Incidence and carrier frequency of Sandhoff disease in Saskatchewan determined using a novel substrate with detection by tandem mass spectrometry and molecular genetic analysis,” Mol. Genet. Metab., 111:382-289. doi: 10.1016/j.ymgme.2014.01.002. PMID: 24461908, PMCID: PMC4346577. 



Barcenas, M., Suhr, T. R., Scott, C. R., Tureček, F., Gelb, M. H. (2014) “Quantification of sulfatides in dried blood and urine spots from metachromatic leukodystrophy patients by liquid chromatography/electrospray tandem mass spectrometry,” Clinica Chimica Acta, 433:39-43, PMID: 24370383, PMCID: PMC4039571. 

 
Scott, C. R., Elliot, S., Buroker, N., Thomas, L. I., Keutzer, J., Glass, M., Gelb, M. H., Tureček, F. (2013) “Identification of infants at risk for developing Fabry, Pompe, or Mucopolysaccharidosis-I from newborn blood spots by tandem mass spectrometry.” Journal of Pediatrics, 163:498-503. doi: 10.1016/j.jpeds.2013.01.013 PMID: 23465405, PMCID: PMC3725184. . 

Orsini, J. J., Martin, M. M., Showers, A. L., Bodamer, O. A., Zhang, X. K., Gelb, M. H., et al. (2012). “Lysosomal storage disorder 4+1 multiplex assay for newborn screening using tandem mass spectrometry: Application to a small-scale population study for five lysosomal storage disorders.” Clinica Chimica Acta, 413(15-16), 1270-1273. PMID: 22548856, PMCID: PMC3443687. 

Spacil, Z., Tatipaka, H., Barcenas, M., Scott, C. R., Tureček, F., Gelb, M. H. (2012) “High-throughput assay of 9 lysosomal enzymes for newborn screening.” Clinical Chemistry., 59 (3), 1530-8561. PMID: 23315484.  

 

Wolf, B. J., Ghomashchi, F., Kim, T., Abam, C. A., Sadilek, M., Jack, R., Thompson, J. N., Scott, C. R., Gleb, M. H., Tureček, F. (2012) “New substrates and enzyme assays for the detection of mucopolysaccharidosis III (Sanfilippo Syndrome) types A, B, C, and D by tandem mass spectrometry,” Bioconjug Chem., 23:557-564. PMID: 22372747, PMCID: PMC: 3310265. 

Spacil, Z., Hui, R., Gelb, M. H., & Tureček, F. (2011). “Protonation sites and dissociation mechanisms of t-butylcarbamates in tandem mass spectrometric assays for newborn screening.” Journal of Mass Spectrometry, 46(10), 1089-1098. PMID: 22012676, PMCID: PMC3212097. 



Spacil, Z., Elliott, S., Reeber, S. L., Gelb, M. H., Scott, C. R. and Tureček, F. (2011) “Comparative triplex tandem mass spectrometry assays of lysosomal enzyme activities in dried blood spots using fast liquid chromatography: Application to newborn screening of Pompe, Fabry, and Hurler diseases” Anal. Chem., 83:4822-4828. PMID: 21548611, PMCID: PMC 3115456  

Wolfe, B. J., Blanchard, S., Sadilek, M., Scott, C. R., Tureček, F., Gelb, M. H. (2011) “Tandem mass spectrometry for the direct assay of Lysosomal enzymes in dried blood spots: Application to screening newborns for Mucopolysaccharidosis II (Hunter Syndrome)” Anal. Chem., 83:1152-1156. PMID: 21192662, PMCID: PMC3442111.  

Khaliq, T., Sadilek, M., Scott, C. R., Tureček, F., Gelb, M. H. (2011) “Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: Application to screening newborns for Mucopolysaccharidosis IVA,” Clin. Chem., 57(1):128-131. PMID: 21030685, PMCID: PMC3442110. 

 

Duffey, T. A., Sadilek, M., Scott, C. R., Tureček, F., Gelb, M. H. (2010) “Tandem mass spectrometry for the direct assay of lysosomal enzymes in dried blood spots: Application to screening newborns for Mucopolysaccharidosis VI (Maroteaux-Lamy Syndrome)”, Anal. Chem., 82:9587-9591. PMID: 20961069, PMCID: PMC2980560.  

Choiniere, J. R., Scott, C. R., Gelb, M. H., Tureček, F. (2010) “Direct assay of delta-aminolevulinic acid dehydratase in heme biosynthesis for the detection of porphyrias by tandem mass spectrometry,” Anal. Chem., 82:6730-6736. PMID: 20583792, PMCID: PMC2913591.  



Duffey, T. A., Bellamy, G., Elliott, S., Fox, A. C., Glass, M., Tureček, F., Gelb, M. H., Scott, C. R. (2010) “A tandem mass spectrometry triplex assay for the detection of Fabry, Pompe, and Mucopolysaccharidosis-I (Hurler),” Clin Chem., 56(12):1854-1861. PMID: 20876176.  



Zhang, X. K., Elbin, C. S., Tureček, F., Scott, R., Chuang, W. L., Keutzer, J. M., Gelb, M. (2010) “Multiplex lysosomal enzyme activity assay on dried blood spots using tandem mass spectrometry,” Methods Mol. Biol., 603:339-350. PMID: 20077085, PMCID: PMC3442156. 



Duffey, T. A., Khaliq, T., Scott, C. R., Tureček, F., Gelb, M. H. (2010) “Design and synthesis of substrates for newborn screening of Maroteaux-Lamy and Morquio A syndromes,” Bioorg. Med. Chem. Lett., 20(20):5994-5996. PMID: 20833037, MCID: PMC2944228.

  

Blanchard, S., Tureček, F., Gelb, M. H. (2009) “Short synthetic sequence for 2-sulfation of alpha-L-iduronate glycosides” Carbohydrate Research, 344:1032-1033. PMID: 19356745, PMCID: PMC2680446.  



Blanchard, Sophie, Sadilek, Martin, Scott, C. Ronald, Tureček, Frantisek, and Gelb, Michael H. (2008) “Tandem mass spectrometry for the direct assay of Lysosomal enzymes in dried blood spots: Application to screening newborns for Mucopolysaccharidosis I,” Clin. Chem., 54:2067-2070. PMID: 19042989, PMCID: PMC2891177.

 

Wang, Y., Scott, C. R., Gelb, M. H., Tureček, F. (2008) “Direct Assay of Enzymes in Heme Biosynthesis for the Detection of Prophyrias by Tandem Mass Spectrometry,” Anal. Chem., 80:2606-2611. PMID: 18294005, PMCID: PMC2565751.  

Wang, Y., Gatti, P., Sadilek, M., Scott, C. R., Tureček, F., Gelb, M. H. (2008) “Direct Assay of Enzymes in Heme Biosynthesis for the Detection of Porphyrias by Tandem Mass Spectrometry. Uroporphyrinogen Decarboxylase and Coproporphyrinogen III Oxidase,” Anal. Chem., 80:2599-2605. PMID: 18294003, PMCID: PMC2515868.  

Tureček, F., Scott, C. R., Gelb, M. H. (2007) “Tandem mass spectrometry in the detection of inborn errors of metabolism for newborn screening,” Methods Mol. Biol., 359:143-157. PMID: 17484116 

Lu, Y., Bottari, P., Aebersold, R., Tureček, F., Gelb, M. H. (2007) “Absolute quantification of specific proteins in complex mixtures using visible isotope-coded affinity tags,” Methods Mol. Biol., 359:159-176. PMID: 17484117. 

Wang, D., Wood,T., Sadilek, M., Scott, C. R., Tureček, F. and M. H. Gelb (2007) “Tandem mass spectrometry for the direct assay of enzymes in dried blood spots: Application to newborn screening for Mucopolysaccharidosis II (Hunter Disease),” Clin. Chem. 53:137-140. PMID: 17082248, PMCID: PMC2497000.  

Gelb, M. H., Tureček, F., Scott, R. C., and Nestor, A. Chamoles. (2006) ” Direct multiplex assay of enzymes in dried blood spots by tandem mass spectrometry for the newborn screening of lysosomal storage disorders,” J Inherit Metab Dis 29:397–404. 

Seebacher, J., Mallick, P., Zhang, N., Eddes J. S., Aebersold, R. and Gelb, M. H. (2006)” Protein cross-linking analysis using mass spectrometry, isotope-coded cross-linkers, and integrated computational data processing.” Journal of Proteome Research, 5(9):2270-82.

 

Scott, C. R. (2005) “Newborn screening for lysosomal storage disorders,” Clinical Perspectives 12:11-15. 

Wang, D., Eadala, B., Sadilek, M., Chamoles N. A., Tureček, F., Scott, C. R. and Gelb, M. H. (2005) “Tandem mass spectrometric analysis of dried blood spots for screening of Mucopolysaccharidosis I in newborns,” Clin. Chem. 51:898-900. 

Li, Y., Scott, C. R., Chamoles, N. A., Ghavami, A., Pinto, B. M., Tureček, F., Gelb, M. H. (2004) “Direct multiplex assay of lysosomal enzymes in dried blood spots for newborn screening,” Clin. Chem., 50:1785-96.  



Lu, Y., Bottari, P., Tureček, F., Aebersold, R. and Gelb, M. H. (2004) “Absolute quantification of specific proteins in complex mixtures using visible isotope-coded affinity tags,” Anal. Chem., 76:4104-4111. 

 

Li, Y., Brockman, K., Tureček, F., Scott, C. R., Gelb, M. H. (2004) “Tandem mass spectrometry for the direct assay of enzymes in dried blood spots: Application to newborn screening for Krabbe Disease,” Clin. Chem., 50: 638-640.

 

Bottari, P., Aebersold, R., Tureček, F., and Gelb, M. H. (2004) “Design and synthesis of visible isotope-coded affinity tags for the absolute quantification of specific proteins in complex mixtures,” Bioconj. Chem., 15:380-388. 

Li, Y., Ogata, Y., Freeze, H. H., Scott, C. R., Tureček, F., and Gelb, M. H. (2003) “Affinity capture and elution/electrospray ionization mass spectrometry assay of phosphomannomutase and phosphomannose isomerase for the multiplex analysis of congenital disorders of glycosylation types Ia and Ib,” Anal. Chem., 75:42-48.  

Ogata, Y., Scampavia, L., Ruzicka, J., Scott, C. R., Gelb, M. H., and Tureček, F. (2002) “Automated affinity capture-release of biotin-containing conjugates using a lab-on-valve apparatus coupled to UV/Visible and electrospray ionization mass spectrometry,” Anal. Chem., 74:4702-4708. 



Gerber, S. A., Tureček, F., and Gelb, M. H. (2001) “Design and synthesis of substrate and internal standard conjugates for profiling enzyme activity in the Sanfilippo Syndrome by affinity chromatography/electrospray ionization mass spectrometry.” Bioconj. Chem., 12(4): 603-315. 



Zhou, X., Tureček, F., Scott, C. R., and Gelb, M. H. “Quantification of cellular acid sphingomyelinase and galactocerebroside B-galactosidase activities by electrospray ionization mass spectrometry”. Clin. Chem., 2001, 47(5):874-881.

Gerber, S. A., Scott, C. R., Tureček, F., Gelb, M. H. “Direct profiling of multiple enzyme activities in human cell lysates by affinity chromatography/electrospray ionization mass spectrometry: Application to clinical enzymology”. Anal. Chem., 2001, 73:1651-1657. 

Gygi, S. P, Rist, B., Gerber, S. A., Tureček, F., Gelb, M. H, Aebersold R. “Quantitative analysis of complex protein mixtures using isotope-coded affinity tags”. Nat Biotechnol. 1999 Oct;17(10):994-9


Gerber, S. A., Scott, C. R., Tureček, F., Gelb, M. H. (1999) “Analysis of rates of muliple enzymes in cell lysates by electrospray ionization mass spesctrometery,” J. Am. Chem. Soc. 121:1102-1103; 121:176.  

 

 

A close-up of red blood cells Description automatically generated

 

Buckner, F.; Buchysnskyy, A.; Najendar, P.; Patrick, D.A.; Gillespie, J.R.; Herbst, Z.; Tidwell, R.R.; Gelb, M.H.  "Phenotypic Drug Discovery for Human African Trypanosomiasis: A Powerful Approach." Trop. Med. Infect. Dis., 2020, 5, 23. DOI:10.3390/tropicalmed5010023

Patrick, D.A.; Gillespie, J.R.; McQueen, J.; Hulverson, M.A.; Ranade, R.M.; Creason, S.A.; Herbst, Z.M.; Gelb, M.H.; Buckner, F.S.; Tidwell, R.R. Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis. J Med Chem. 2017, 60, 957-971. doi: 10.1021/acs.jmedchem.6b01163. 

Tatipaka, H. B., Gillespie, J. R., Chatterjee, A. K., Norcross, N. R., Halverson, M. A., Ranade, R. M., Nagendar, P., Creason, S. A., McQueen, J., Duster, N. A., Nagle, A., Supek, F., Molteni, V. Wenzler, T., Brun, R., Glynne, R., Buckner, F. S., and Gelb, M. H. (2014) Substituted 2-Phenylimidazopyridines: A new class of drug leads for human African Trypanosomiasis, J. Med. Chem., 57(3):828-835, PMID: 24354316, PMCID: PMC3962778. 

Buckner F. S., Fau – Bahia, M. T., Bahia Mt Fau – Suryadevara, P. K., Suryadevara Pk Fau – White, K. L., White Kl Fau – Shackleford, D. M., Shackleford Dm Fau – Chennamaneni, N. K., Chennamaneni Nk Fau – Hulverson, M. A., et al. (2012). Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib. Antimicrob Agents Chemother. 56(9):4914-21. PMID: 22777048, PMCID: PMC3421879. 

Pacrez-Moreno, G., Sealey-Cardona, M., Rodrigues-Poveda, C., Gelb, M. H., Ruiz-Pacrez, L. M., Castillo-Acosta, V., et al. (2012). Endogenous sterol biosynthesis is important for mitochondrial function and cell morphology in procyclic forms of Trypanosoma brucei. International Journal for Parasitology, 42(11), 975-989. PMID: 22964455. 

Crowther, G. J., Napuli, A. J., Gilligan, J. H., Gagaring, K., Borboa, R., Francek, C., Chen, Z., Dagostino, E. F., Stockmyer, J. B., Wang, Y., Rodenbough, P. P., Castaneda, L. J., Leibly, D. J., Bhandari, J., Gelb, M. H., Brinker, A., Engels, I. H., Taylor, J., Chatterjee, A. K., Fantauzzi, P., Glynne, R. J., Van Voorhis, W. C., Kuhen, K. L. (2011) Identification of inhibitors of putative malaria drug targets among novel antimalarial compounds. Mol. Biochem. Parasitol., 175:21-29. PMID: 20813141, PMCID: PMC3108854. 

Whitty, A., Gelb, M. H. (2010) Critical challenges and emerging paradigms in drug discovery, Curr. Opin. Chem. Biol., 14(4):437-439. PMID: 20621548, PMCID: PMC3060036. 

Kraus, J. M., Tatipaka, H. B., McGuffin, S. A., Chennamaneni, N. K., Karimi, M., Arif, J., Verlinde, L. M. J., Buckner, F. S., Gelb, M. H. (2010) Second generation analogues of the cancer drug clinical candidate Tipifarnib for anti-Chagas disease drug discovery. J. Med. Chem., 53:3887-3898. PMID: 20429511, PMCID: PMC2877169. 

 Crowther, G. J., He, P., Rodenbough, P. P., Thomas, A. P., Kovzun, K. V., Leibly, D. J., Bhandari, J., Castaneda, L. J., Hol, W. G. J., Gelb, M. H., Napuli, A. J., Van Voorhis, W. C. (2010) Use of thermal melt curves to assess the quality of enzyme preparations, Analytical Biochemistry, 399:268-275. PMID: 20018159, PMCID: PMC3270315. 

 Chennamaneni, N. K., Arif, J., Buckner, F. S. and Gelb, M. H. (2009) Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents, Bioorganic and Medicinal Chemistry Letters, 19:6582-6584. PMID: 19875282, PMCID: PMC2783978. 

 Suryadevara, P. K., Olepu, S., Lockman, J. W., Ohkanda, J., Karimi, M. Verlinde, C. L. M. J., Kraus, J. M., Schoepe, J., Van Voorhis, W. C., Hamilton, A. D., Buckner, F. S., and Gelb, M. H., (2009) Structurally simple inhibitors of lanosterol 14alpha-demethylase are efficacious in a rodent model of acute Chagas disease, J. Med. Chem. 52:3703-3715. PMID: 19463001, PMCID: PMC2771698. 

Kraus, J. M., Verlinde, C. L. M. J., Karimi, Mandana, Lepesheva, G. I., Gelb, M. H., and Buckner, F. S. (2009) Rational modification of a candidate cancer drug for use against chagas disease. J. Med Chem. 52:1639-1647. PMID: 19239254, PMCID: PMC2715367. 

 Torres-Santos, E. C., Sampaio-Santos, M. I., Buckner, F. S., Yokoyama, K., Gelb, M., Urbina, J. A., and Rossi-Bergmann, B. (2009) Altered sterol profile induced in Leishmania amazonensis by a natural dihydroxymethoxylated chalcone, Journal of Antimicrobial Chemotherapy, 63:469-472. PMID: 19176591, PMCID: PMC2640159. 

 Fan, E., Baker, D., Fields, S., Gelb, M. H., Buckner, F. S., Van Voorhis, W. C., Phizicky, E., Dumont, M., Mehlin, C., Grayhack, E., Sullivan, M., Verlinde, C., Detitta, G., Meldrum D. R., Merritt, E. A., Earnest, T., Soltis, M., Zucker, F., Myler, P. J., Schoenfeld, L., Kim, D., Worthey, L., Lacount, D., Vignali, M., Li, J., Mondal, S., Massey, A., Carroll, B., Gulde, S., Luft, J., Desoto, L., Holl, M., Caruthers, J., Bosch, J., Robien, M., Arakaki, T., Holmes, M., Le, Trong I., Hol, W. G. (2008) “Structural genomics of pathogenic protozoa: an overview” Methods Mol Biol., 426:497-513. PMID: 18542886. 

 Ojo, Kayode K., Gillespie, J. Robert, Reichers, Aaron J., Napuli, Alberto J., Verlinde, Christophe L. M. J., Buckner, Frederick S., Gelb, Michael H., Domostoj, Mathias M., Wells, Susan J., Scheer, Alexander, Wells, Timothy N. C., and Van Voorhis, Wesley C. (2008) “Glycogen synthase kinase 3 is a potential drug target for African trypanosomiasis therapy,” Antimicrobial Agents and Chemotherapy 52:3710-3717. PMID: 18644955, PMCID: PMC2565902. 

Mehlin, C., Boni, E., Buckner, F. S., Engel, L., Feist, T., Gelb, M. H., Haji, L., Kim, D., Liu, C., Mueller, N., Myler, P. J., Reddy, J. T., Sampson, J. N., Subramanian, E., Van Voorhis, W. C., Worthey, E., Zucker, F., Hol, W. G. (2006) “Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes,” Mol Biochem Parasitol. 148:144-160. PMID: 16644028. 

 Eastman, R. T., Buckner, F. S., Yokoyana, K., Gelb, M. H. and Van Voorhis, W. C. (2006) “Thematic review series: lipid posttranslational modifications. Fighting parasitic disease by blocking protein farnesylation,” J. Lipid Res. 47: 233-40 

 Gelb, M. H., Van Voorhis, W. C., Buckner, F. S., Yokoyama, K., Eastman, R., Carpenter, E. P., Panethymitaki, C., Brown, K. A., and Smith, D. F. (2003) “Protein farnesyl and N-myristoyl transferases: piggy-back medicinal chemistry targets for the development of antitrypanosomatid and antimalarial therapeutics,” Molec. Biochem. Parasitol., 126:155-163. 

 Choe, J., Suresh, S., Wisedchaisri, G., Kennedy, K. J., Gelb, M. H. and Hol, W. G. J. (2002) “Anomalous differences of light elements in determining precise binding modes of ligands to glycerol-3-phosphate dehydrogenase,” Chem. Biol., 9:1189-1197. 

 Gelb, M. H. and Hol, W. J. G. (2002) “Drugs to combat tropical protozoan parasites,” Science, 297:343-344. 

 Suresh, S., Bressi, J. C., Kennedy, K. J., Verlinde, C. L. M. J., Gelb, M. H., and Hol, W. G. J. (2001) “Conformational Changes in Leishmania mexicana Glyceraldehyde-3-phosphate Dehydrogenase Induced by Designed Inhibitors,” J. Mol. Biol., 309:423-435. 

 Bressi, J. C., Verlinde, C. L. M .J., Aronov, A. M., Shaw, M. L., Shin, S. S., Nguyen, L. N., Suresh, S., Buckner, F. S., Van Voorhis, W. C., Kuntz, I. D., Hol, W. G. J., and Gelb, M. H. (2001) “Adenosine Analogues as Selective Inhibitors of Glyceraldehyde-3-phosphate Dehydrogenase of Trypanosomatidae via Structure-Based Drug Design,” J. Med. Chem, 44(13):2080-2093. 

 Verlinde, C. L. M. J., Hannaert, V., Blonski, C., Willson, M., Perie, J. J., Fothergill-Gilmore, L. A., Opperdoes, F. R., Gelb, M. H., Hol, W. G. J., and Michels, P. A. M. (2001) “Glycolysis as a target for the design of new anti-trypanosome drugs,” Drug Res. Updates, 4:1-14. 

 Kennedy, K. J., Bressi, J. C., and Gelb, M. H. A Disubstituted NAD+ Analogue is a Nanomolar Inhibitor of Trypanosomal Glyceraldehyde-3-phosphate Dehydrogenase, Bioorg. Med. Chem. Lett., 11(2):95-98. 

Bressi, J. C., Choe, J., Hough, M. T., Buckner, F. S., Van Voorhis, W. C., Verlinde, C. L. M. J., Hol, W. G. J., Gelb, M. H. (2000) “Adenosine analogues as inhibitors of Trypanosoma brucei phosphoglycerate kinase: Elucidation of a novel binding mode for a 2-amino-N6-substituted adenosine,” J. Med. Chem., 43:4135-4150. 

Golisade, A., Bressi, J. C., Van Calenbergh, S., Gelb, M. H., Link, A. Polymer-Assisted Solution-Phase Synthesis of 2′-Amido-2′-deoxyadenosine Derivatives Targeted at the NAD(+)-Binding Sites of Parasite Enzymes. J Comb Chem. 2000 Sep 12;2(5):537-544. 

 Aronov, A. M.; Suresh, S., Buckner, F. S., Van Voorhis, W. C., Verlinde, C. L., Opperdoes, F. R., Hol, W. G., Gelb, M. H. Structure-based design of submicromolar, biologically active inhibitors of trypanosomatid glyceraldehyde-3-phosphate dehydrogenase. Proc Natl Acad Sci U S A. 96(8): 4273-8, 13 Apr 1999. 

 Aronov, A. M., Verlinde, C. L., Hol, W. G., Gelb, M. H. Selective tight binding inhibitors of trypanosomal glyceraldehyde-3-phosphate dehydrogenase via structure-based drug design. J Med Chem. 41(24): 4790-9, Nov 1998. 

 

 

 

 

A diagram of a cell structure Description automatically generated

 

Yun B, Lee H, Powell R, Reisdorph N, Ewing H, Gelb MH, Hsu KL, Cravatt BF, Leslie CC. Regulation of calcium release from the endoplasmic reticulum by the serine hydrolase ABHD2. Biochem Biophys Res Commun. 2017,. pii: S0006-291X(17)31327-X. doi: 10.1016/j.bbrc.2017.06.195. [Epub ahead of print] PMID: 28684316.

Yamamoto, K., Mik,i Y., Sato, M., Taketomi, Y., Nishito, Y., Taya, C., Muramatsu, K., Ikeda, K., Nakanishi, H., Taguchi R., Kambe N., Kabashima K., Lambeau G., Gelb MH., Murakami M. (2015) The role of group IIF-secreted phospholipase A2 in epidermal homeostasis and hyperplasia. J Exp Med. pii: jem.20141904. PMID: 26438362  

Duchez, A. C., Boudreau, L. H., Bollinger, J., Belleannee, C., Cloutier, N., Laffont, B., Mendoza-Villarroel, R. E., Levesque, T., Rollet-Labelle, E., Rousseau, M., Allaeys, I., Tremblay, J. J., Poubelle, P. E., Lambeau, G., Pouliot, M., Provost, P., Soulet, D., Gelb, M. H., Boilard, E. (2015) Platelet microparticless are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA, Proc. Natl Acad. Sci USA.2015 Jun 23. pii:201507905. [Epub ahead of print]. PMID: 26106157. 

Rousseau, M., Naika, G. S., Perron, J., Jacques, F., Gelb, M. H., Boilard, E. (2015) Study of the role of cytosolic phospholipase A2 alpha in eicosanoid generation and thymocyte maturation in the thymus, PLoS One, May 13;10(5):e0126204. doi: 10.1371/journal.pone.0126204.eCollection 2015. PMID: 25969996, PMCID: 4430275. 

Rousseau, M., Belleannee, C., Duchez, A.-C., Cloutier, N., Levesque, T., Jacques, F., Perron, J., Nigrovic, P. A., Dieude, M., Hebert, M.-J., Gelb, M. H., Boilard, E. (2015) Detection and quantification of microparticles from different cellular lineages using flow cytometry. Evaluation of the impact of secreted phospholipase A2 on microparticle assessment. POLS ONE, DOI: 10.1371/journal.pone.0116812. PMID: 25587983, PMCID: PMC 4294685. 

Boudreau, L. H., Duchez, A.-C., Cloutier, N., Soulet, D., Martin, N., Bollinger, J., Pare, A., Rousseau, M., Naika, G. S., Levesque, T., Laflamme, C., Marcoux, G., Lambeau, G., Farndale, R. W., Pouliot, M., Hamzeh-Cognasse, H., Cognasse, F., Garraud, O., Nigrovic, P. A., Guderley, H., Lacroix, S., Thibault, L., Semple, J. W., Gelb, M. H., and Bollard, E. (2014) Platelets release mitochondria serving as substrate for bactericidal group IIA-secreted phospholipase A2 to promote inflammation, Blood, 124(14):2173-2183. PMID: 25082876, PMCID: PMC4260364. 

Sato, H., Taketomi, Y., Ushida, A., Isogai, Y., Kojima, T., Hirabayashi, T., Miki, Y., Yamamoto, K., Nishito, Y., Kobayashi, T., Ikeda, K., Taguchi, R., Hara, S., Ida, S., Miyamoto, Y., Watanabe, M., Baba, H., Miyata, K., Oike, Y., Gelb, M. H., Murakami, M., (2014) The adipocyte-inducible secreted phospholipases PLA2G5 and PLA2G2E play distinct roles in obesity, Cell Met., 20:1-14. PMID: 24910243, PMCID: PMC4079757. 

Kelvin, A. A., Degousee, N., Banner, D., Stefanski, E., Leon, A. J., Angoulvant, D., Paquette, S. G., Huang, S. S. H., Danesh, A., Robbins, C. S., Noyan, H., Husain, M., Lambeau, G., Gelb, M., Kelvin, D. J., Rubin, B. B. (2014) “Lack of group X secreted phospholipase A2 increases survival following pandemic H1N1 influenza infection,” Virology, 454-455, 78-92. PMID: 24725934, PMCID: PMC4106042 . 

Yun, B., Lee, H., Ghosh, M., Cravatt, B. F., Hsu, K. L., Bonventre, J. V., Ewing, H., Gelb, M. H., Leslie, C. C. (2013) Serine hydrolase Inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation, J. Biol Chem., 289:1491-1504, PMID: 24297180, PMCID: PMC3894331. 

Bollinger, J. G., Naika, G. S., Sadilek, M., Gelb, M. H. (2013) LC/ESI-MS/MS detection of FAs by charge reversal derivatization with more than four orders of magnitude improvement in sensitivity, J. Lipid Res., 54:3523-3530. PMID: 23945566, PMCID: PMC3826698. 

Miki, Y., Yamamoto, K., Taketomi, Y., Sato, H., Shimo, K., Kobayashi, T., Ishikawa, Y., Ishii, T., Nakanishi, H., Ikeda, K., Taguchi, R., Kabashima, K., Arita, M., Arai, H., Lambeau, G., Bollinger, J. M., Hara, S., Gelb, M. H., Murakami, M. (2013) Lymphoid tissue phospholipase A2 group IID resolves contact hypersensitivity by driving antiinflammatory lipid mediators, J. Exp Med., May 20, 2013, 1217-1234. PMID: 23690440, PMCID: PMC3674707. 

Taketomi, Y., Ueno, N., Kojima, T., Sato, H., Murase, R., Yamamoto, K., Tanaka, S., Sakanaka, M. Nakamura, M., Nishito, Y., Kawana, M., Kambe, N., Ikeda, K., Taguchi, R., Nakamizo, S., Kabashima, K., Gelb, M. H., Arita, M., Yokomizo, T., Nakamura, M., Watanabe, K., Hirai, H., Nakamura, M., Okayama, Y., Ra, C., Aritake, K., Urade, Y., Morimoto, K., Sugimoto, Y., Shimizu, T., Narumiya, S., Hara, S., Murakami, M. Mast cell maturation is driven via a group III phospholipase A2-prostaglandin D2-DP1 receptor paracrine axis. Nature Immunology, 14, 554-563, doi:10.1038/ni.2586 PMID: 23624557, PMCID: PMC4065307.  

Lee, L.K., Bryant, K.J., Bouveret, R., Lei, P.W.,Duff, A.P., Harrop, S.J., Huang, E.P., Harvey, R.P., Gelb, M.H., Gray, P.P., Curmi, P.M., Cunningham, A.M., Church, W.B., Scott, K.F. (2013) Selective inhibition of human group IIA secreted phospholipase A2 (hGIIA) signaling reveals arachidonic acid metabolism is associated with colocalization of hGIIA to vimentin in rheumatoid synoviocytes. Journal of Biological Chemistry. PMID: 23482564, PMCID: PMC3663547. 

Hallstrand, T. S., Lai, Y., Ni, Z., Oslund, R. C., Henderson, W. R., Gelb, M. H., et al. (2012). Relationship between levels of secreted phospholipase A2 groups IIA and X in the airways and asthma severity. Clinical & Experimental Allergy, 41(6), 801-810. PMID: 21255140, PMCID: PMC3093436. 

Sandoval, G., Aloulou, A., Ali, Y., Bezzine, S., Gargouri, Y., & Gelb, M. (2012). Phospholipases: An Overview. In Lipases and Phospholipases (Vol. 861, pp. 63-85): Humana Press. 

Henderson, H.R., Ye, X., Lai, Y., Bollinger, J.G., Tien, Y.T., Chi, E.Y., Gelb, M.H. (2012) Key role of group V secreted phospholipase A2 in Th2 cytokine and dendritic cell-driven airway hyperresponsiveness and remodeling, PLoS ONE, 8:1-16. PMID: 23451035, PMCID: PMC3581544. 

Oslund, R.C., Gelb, M.H. (2012) Biochemical Characterization of Selective Inhibitors of Human Group IIA Secreted Phospholipase A2 and Hyaluronic Acid-Linked Inhibitor Conjugates, Biochemistry, 51: 8617−8626. PMID: 20320658, PMCID: PMC3549043. 

Thompson, W., Oslund, R.C., Bollinger, J., Ewing, H., and Gelb, M.H. (2012) “High-Throughput Assay of Secreted Phospholipases A2 Inhibitors.” Chapter 10 in Lipases and Phospholipases: Methods and Protocols, Methods” in Molecular Biology, Vol. 861, (Ed. Georgina Sandoval), pp. 149-158. 

Henderson WR Jr, Oslund RC, Bollinger JG, Ye X, Tien YT, Xue J, Gelb MH. (2011) “Blockade of human group X secreted phospholipase A2 (GX-sPLA2)-induced airway inflammation and hyperresponsiveness in a mouse asthma model by a selective GX-sPLA2 inhibitor.” J Biol Chem. 2011 286(32):28049-55. PMID: 21652694 PMCID:3151050 

Hallstrand, T.S., Lai, Y., Henderson, Jr., W.R., Altemeier, W.A., Gelb, M.H. (2011) “Epithelial regulation of eicosanoid production in asthma,” Pulmonary Pharmacology & Therapeutics, 25:432-437. PMID: 23323271, PMCID: PMC3627426. 

Yang, J.-S., Valente, C., Polishchuk, R. S., Turacchio, G., Layre, E., Branch Moody, D., et al. (2011). “COPI acts in both vesicular and tubular transport.” Nat Cell Biol, 13(8), 996-1003. PMID: 21725317, PMCID: PMC3179785. 

Jemel, I., Ii, H., Oslund, R.C., Payre, C., Dabert-Gay, A.-S., Douguet, D., Chargui, K., Scarzello, S., Gelb, M. H., and Lambeau, G. (2011) “Group X secreted phospholipase A2 proenzyme is matured by a furin-like proprotein convertase and releases arachidonic acid inside of human HEK293 cells,” J. Biol. Chem., 286:36509-36521. PMID: 21878635, PMCID: PMC3196088.  

Bryant, K.J., Bidgood, M.J., Lei, P.W., Taberner, M., Salom, C., Kumar, V., Lee, L., Church, W. B., Courtenay, B., Smart, B. P., Gelb, M. H., Cahill, M.A., Graham, G. G., McNeil, M. P., Scott, K. F. (2011) “A bifunctional role for group IIA secreted phospholipase A2 in human rheumatoid fibroblast-like synoviocyte arachidonic acid metabolism,” J. Biol. Chem., 286:2492-2503. PMID: 21068383, PMCID: PMC3024744. 

Reed KA, Tucker DE, Aloulou A, Adler D, Ghomashchi F, Gelb MH, Leslie CC, Oates JA, Boutaud O. (2011) “Functional characterization of mutations in inherited human cPLAâ‚‚ deficiency.” Biochemistry. 50(10):1731-8. PMID: 21247147, PMCID: PMC3051024. 

Mouchlis, V.D., Magrioti, V., Barbayianni, E., Cermak, N., Oslund, R.C., Mavromoustakos, T.M., Gelb, M.H., Kokotos, G. (2011) ” Inhibition of secreted phospholipases A2 by 2-oxoamides based on alpha-amino acids: Synthesis, in vitro evaluation and molecular docking calculations.” Bioorg Med Chem. 19(2):735-43. PMID: 21216150, PMCID: PMC3050527. 

Lai, Y., Oslund, R. C., Bollinger, J. G., Henderson, W. R. Jr., Santana, L. F., Altemeier, W. A., Gelb, M. H., Hallstrand, T. S. (2010) “Eosinophil cysteinyl leukotriene synthesis mediated by exogenous secreted phospholipase A2 group X,” J. Biol. Chem., 285(53):41491-41500. PMID: 20974857, PMCID: PMC3009875.  

Boilard, E., Lai, Y., Larabee, K., Balestrieri, B., Ghomashchi, F., Fujioka, D., Gobezie, R., Coblyn, J. S., Weinblatt, M. E., Massarotti, E. M., Thornhill, T. S., Divangahi, M., Remold, H., Lambeau, G., Gelb, M. H., Arm, J. P., Lee, D. M.(2010) “A novel anti-inflammatory role for secretory phospholipase A2 in immune complex-mediated arthritis,” EMBO Mol. Med., 2(5):172-187. PMID: 20432503, PMCID: PMC3058614. 

Shridas, P., Bailey, W. M., Boyanovsky, B. B., Oslund, R. C., Gelb, M. H., Webb, N. R. (2010) “Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glands,” J. Biol. Chem., 285(26):20031-20039. PMID: 20421306, PMCID: PMC2888415. 

Ghomashchi, F., Naika, G. S., Bollinger, J. G., Aloulou, A., Lehr, M., Leslie, C. C., Gelb, M. H. (2010) “Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2{beta}) and comparison with the other cPLA2 isoforms,” J. Biol. Chem., 285(46):36100-36111. PMID: 20705608, PMCID: PMC2975232.  

Zack, M., Boyanovsky, B. B., Shridas, P., Bailey, W., Forrest, K., Howatt, D. A., Gelb, M. H., de Beer, F. C., Daugherty, A., Webb, N. R. (2010) “Group X secretory phospholipase A(2) augments angiotensin II-induced inflammatory responses and abdominal aortic aneurysm formation in apoE-deficient mice,” Atherosclerosis, 214:58-64. PMID: 20833395, PMCID: PMC3005558. 

Bollinger, J. G., Thompson, W., Lai, Y., Oslund, R. C., Hallstrand, T. S., Sadilek, M., Tureček, F., Gelb, M. H. (2010) “Improved sensitivityi mass spectrometric detection of eicosanoids by charge reversal derivatization,” Anal. Chem., 82:6790-6796. PMID: 20704368, PMCID: PMC2959116.  supplement

Shridas, P., Bailey, W. M., Gizard, F., Oslund, R. C., Gelb, M. H., Bruemmer, D., Webb, N. R. (2010) “Group X secretory phospholipase A2 negatively regulates ABCA1 and ABCG1 expression and cholesterol efflux in macrophages,” Arterioscler Thromb Vasc Biol., 30:2014-2021. PMID: 20844270, PMCID: PMC2958102.  

Shridas, P., Bailey, W. M., Boyanovsky, B. B., Oslund, R. C., Gelb, M. H., Webb, N. R. (2010) “Group X secretory phospholipase A2 regulates the expression of steroidogenic acute regulatory protein (StAR) in mouse adrenal glands,” J. Biol. Chem., 285:20031-20039. PMID: 20421306, PMCID: PMC2888415. 

Granata, F., Frattini, A., Loffredo, S., Staiano, R. I., Petraroli, A., Ribatti, D., Oslund, R., Gelb, M. H., Lambeau, G., Marone, G., Triggiani, M. (2010) “Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A(2),” J. Immunol., 184:5232-5241. PMID: 20357262, PMCID: PMC3073479. 

Hallstrand, T. S., Wurfel, M. M., Lai, Y., Ni, Z, Gelb, M. H., Altemeier, W. A., Beyer, R. P., Aitken, M. L., Henderson, W. R. (2010) “Transglutaminase 2, a novel regulator of eicosanoid production in asthma revealed by genome-wide expression profiling of distinct asthma phenotypes,” PLoS One, 5(1):e8583. PMID: 20052409, PMCID: PMC2797392. 

Surrel, F., Jemel, I., Boilard, E., Bollinger, J. G., Payre, C., Mounier, C. M., Talvinen, K. A., Laine, V. J., Nevalainen, T. J., Gelb, M. H., Lambeau, G. (2009) “Group X phospholipase A2 stimulates the proliferation of colon cancer cells by producing various lipid mediators,” Mol. Pharmacol., 76:778-790. PMID: 19602573, PMCID: PMC2769042. 

Leslie, C. C., Gangelhoff, T. A., Gelb, M. H. (2010) “Localization and function of cytosolic phospholipase A(2)alpha at the Golgi,” Biochimie, 92:620-626. PMID: 20226226, PMCID: PMC2878860. 

Olson, E. D., Nelson, J., Griffith, K., Nguyen, T., Streeter, M., Wilson-Ashworth, H. A., Gelb, M. H., Judd, A. M., Bell, J. D. (2010) “Kinetic evaluation of cell membrane hydrolysis during apoptosis by human isoforms of secretory phospholipase A2,” J. Biol. Chem., 285:10993-11002. PMID: 20139082, PMCID: PMC2856304.  

Bollinger, J. G., Ii, H., Sadilek, M. and Gelb, M. H., (2010) “Improved method for the quantification of lysophospholipids including enol ether species by liquid chromatography-tandem mass spectrometry,” J. Lipid Res., 51:440-447. PMID: 19717841, PMCID: PMC2803247.  

Rosenson, R. S., Gelb, M. H. (2009) “Secretory phospholipase A(2): A multifaceted family of proatherogenic enzymes,” Curr. Cardiol. Rep., 11:445-451. PMID: 19863869. 

Regan-Klapisz, E., Krouwer, V., Langelaar-Makkinje, M., Nallan, L., Gelb, M., Gerritsen, H., Verkleij, A. J. and Post, J. A. (2009) “Golgi-associated cPLA2alpha regulates endothelial cell-cell junction integrity by controlling the trafficking of transmembrane junction proteins”, Molecular Biology of the Cell, 20:4225-4234. PMID: 19675210, PMCID: PMC2754936. 

Surrel, F., Jemel, I., Boilard, E., Bollinger, J. G., Payre, C., Mounier, C. M., Talvinen, K. A., Laine, V. J., Nevalainen, T. J., Gelb, M. H., Lambeau, G. (2009) “Group X pospholipase A2 stimulates the proliferation of colon cancer cells by producing various lipid mediators,” Mol. Pharmacol., 76:778-790. PMID: 19602573, PMCID: PMC2769042. 

Triggiani, M., Giannattasio, G., Calabrese, C., Loffredo, S., Granata, F., Fiorello, A., Santini, M., Gelb, M. H. (2009) “Lung mast cells are a source of secreted phospholipases A2”, J. Allergy Clin Immunol., 124:558-565. PMID 19541351, PMCID: PMC2788562. 

Balestrieri, B., Maekawa, A., Xing, W., Gelb, M.H., Katz, H.R., Arm, J.P. (2009) “Group V secretory phospholipase A2 modulates phagosome maturation and regulates the innate immune response against Candida albicans”, J. Immunol., 182(8):4891-4898. PMID: 19342668, PMCID: PMC2746418. 

Giannattasio, G., Lai, Y., Granata, F., Mounier, C.M., Nallan, L., Oslund, R., Leslie, C.C., Marone, G., Lambeau, G., Gelb, M.H., Triggiani, M. (2009) “Expression of phospholipases A(2) in primary human lung macrophages Role of cytosolic phospholipase A(2)-alpha in arachidonic acid release and platelet activating factor synthesis”, Biochim Biophys Acta, 1791(2):92-102. PMID: 19130898, PMCID: PMC2676353. 

Tucker, D.E., Ghosh, M., Ghomashchi, F., Loper, R., Suram, S., St. John, B., Girotti, M., Bollinger, J.G., Gelb, M.H., Leslie, C.C. (2009) “Role of phosphorylation and basic residues in the catalytic domain of cytosolic phospholipase A2alpha in regulating interfacial kinetics and binding and cellular function, J. Biol. Chem., J. Biol. Chem, 284:9596-9611. PMID: 19176526, PMCID: PMC2666612. 

 

 
Tucker, D.E., Gijon, M.A., Spencer, D.M., Qiu, Z.H., Gelb, M.H., Leslie, C.C., (2008) “Regulation of cytosolic phospholipase A2alpha by hsp90 and a p54 kinase in okadaic acid-stimulated macrophages”, J. Leukoc Biol., 84(3):798-806. 

Lambeau G., Gelb, M. H. (2008) “Biochmistry and physiology of mammalian secreted phospholipases A2” Annu Rev Biochem, 77:495-520. 

Patel, MI, Singh, J, Niknami, M, Kurek, C, Yao, M, Lu, S, Maclean, F, King, NJ, Gelb, MH, Scott, KF, Russell, PJ, Boulas, J, Dong, Q. (2008) “Cytosolic Phospholipase A2-alpha: A potential therapeutic target for prostrate cancer”, Clin Cancer Res., 14:8070-8079. 

Su, W, Yeku, O, Olepu, S, Genna, A, Park, J-S, Ren, H, Du, G, Gelb, MH, Morris, AJ, and Frohman, MA (2008) “FIPI, a Phospholipase D pharmacological inhibitor that alters cell spreading and inhibits chemotaxis,” Molecular Pharmocology Fast Forward, published December 8, 2008, mol.108.053298. 

Oslund, RC, Cermak, N, Verlinde, CLM, Gelb, MH, (2008) “Simplified YM-26734 Inhibitors of secreted phospholipase A2 group IIA,” Bioorganic and Medicinal Chemistry Letters, 18:5415-4319.  

Wilensky, RL, Shi, Y, Mohler, ER, III, Hamamdzic, D, Burgert, ME, Li, J, Postle, A, Fenning, RS, Bollinger, JG, Hoffman, BE, Pelchovitz, DJ, Yang, J, Mirabile, RC, Webb, CL, Zhang, L, Zhang, P, Gelb, MH, Walker, MC, Zalewski, A, and Macphee, CH, (2008) “Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development,” Nature Medicine, 14 (10):1059-1066.  

Oslund, RC, Cermak, N, Gelb, MH, (2008) “Highly specific and broadly potent inhibitors of mammalian secreted phospholipases A2,” J. Med. Chem., 51:4708-4714.  

Tribler, L, Jensen, LT, Jørgensen, K, Brünner, N, Gelb, MH, Nielsen, HJ and Jensen, SS, (2007) “Increased expression and activity of group IIA and X secretory phospholipase A2 in Peritumoral versus central colon carcinoma tissue,” Anticancer Research, 27:3179-3186. 

Morgan, D, Cherny, VV, Finnegan A, Bollinger J, Gelb MH, DeCoursey TE. (2007) “Sustained activation of proton cheannels and NADPH oxidase in human eosinophils and murine granulocytes requires PKC but not CPLA2 alpha activity,” J. Physiol., 579(Pt 2):327-344. 

Hallstrand, TS, Chi, EY, Singer, AG, Gelb, MH, Henderson, Jr., WR (2007) “Secreted phospholipase A2 group X overexpression in asthma and bronchial hyperresponsiveness,” Am. J. Respir Crit Care Med., 176:1072-1078. 

Wichmann O, Gelb MH, Schultz, C. (2007) “Probing Phospholipase A2 with fluorescent phospholipid Substrates,” ChemBioChem, 8:1555-1569. 

Ghomashchi, F., Bollinger, J.G. and Gelb, M. H. (2007) “Facile preparation of leukotrienes C4, D4 and E4 containing carbon-13 and nitrogen-15 for quantification of cysteinyl leukotrienes by mass spectrometry,” J. Radiolabel. Compds Radiopharm. 50:729 

Ghosh, M., Loper, R., Ghomashchi, F., Tucker, D.E., Bonventre, J.V., Gelb, M.H. and Christina C. Leslie. (2007) “Function, Activity, and Membrane Targeting of Cytosolic Phospholipase A2-zeta in Mouse Lung Fibroblasts,” J. Biol. Chem. 282:11676 

Henderson, W.R., Chi, E.Y., Bollinger, J.G., Tien, Y.T., Ye, X., Castelli, L. Rubtsov, Y.P., Singer, A.G., Chiang, G.K., Nevalainen, T., Rudensky, A.Y. and M. Gelb. (2007) “Importance of Group X-secreted Phospholipase A2 in Allergen-Induced airway inflammation and remodeling in a mouse asthma model,” J. Exp. Med. April 16 204:865-877 

Rouault M, Calvez CL, Boilard E, Surrel F, Singer A, Ghomashchi F, Bezzine S, Scarzello S, Bollinger J, Gelb MH, Lambeau G. (2007) ” Recombinant production and properties of binding of the full set of mouse secreted phospholipases a(2) to the mouse m-type receptor,” Biochemistry 46:1647-62. 

Boilard, E., Rouault, M., Surrel, F., Le Calvez, C. Bezzine, S., Singer, A., Gelb, M.H. and Gerard Lambeau. (2006) “Secreted Phospholipase A2 Inhibitors Are Also Potent Blockers of Binding to the M-Type Receptor,” Biochemistry 45:13202 

Karabina, S.A., Brocheriou, I., Le Naour, G., Agrapart, M., Durand, H., Gelb, M.H., Lambeau, G. and Ewa Ninio.(2006) “Atherogenic properties of LDL particles modified by human group X secreted phospholipase A2 on human endothelial cell function,” The FASEB Journal 20:E2 [Published online Oct. 31] 

Ghosh, M., Loper, R., Gelb, M.H. and Leslie, C.C.(2006) “Identification of the Expressed Form of Human Cytosolic Phospholipase A2β (cPLA2β),” J. Biol. Chem. 281:16615. 

Gelb, M. H., Mounier, Carine M., Hefner, Ying, Watson, Steve P., Platelet Phospholipases A2. In Platelets in thrombotic and non-thrombotic disorders: pathophysiology, pharmacology, and therapeutics, Gresele, P. e. a., Ed. Cambridge University Press: Cambridge, 2002; pp 221-237.

Ni,Z., Okeley, N. M., Smart, B.P., and Michael H. Gelb (2006)” Intracellular Actions of Group IIA Secreted Phospholipase A2 and Group IVA Cytosolic Phospholipase A2 Contribute to Arachidonic Acid Release and Prostaglandin Production in Rat Gastric Mucosal Cells and Transfected Human Embryonic Kidney Cells” J. Biol. Chem., 281: 16245-55 . 

Eerola, L.I., Surrel, F., Nevalainen, T.J., Gelb, M.H., Lambeau, G. and V. Jukka O. Laine (2006) “Analysis of expression of secreted phospholipases A2 in mouse tissues at protein and mRNA levels,” Biochimica et Biophysica Acta [Epub ahead of print] April 10 

Rouault, M., Rash, L. D., Escoubas, P., Boilard, E., Bollinger,J., Lomonte,B., Maurin, T., Guillaume,C., Canaan, S., Deregnaucourt, C., Schrevel,J., Doglio, A., Gutierrez, J. M., Lazdunski, M., Gelb, M. H., and G. Lambeau. (2006) “Neurotoxicity and Other Pharmacological Activities of the Snake Venom Phospholipase A2 OS2: The N-Terminal Region Is More Important Than Enzymatic Activity,” Biochemistry [Epub ahead of print] Feb. 14 

Smart, B.P., Oslund, R.C. and Walsh, L.A. (2006) ” The First Potent Inhibitor of Mammalian Group X Secreted Phospholipase A2: Elucidation of Sites for Enhanced Binding,” J. Med. Chem. Feb. 8 ; [Epub ahead of print]  

Huhtinen, H.T., Gronroos, J.O., Gronroos, J.M. Uksila, J., Gelb, M.H., Nevalainen, T.J. and Laine, V.J. (2006) “Antibacterial effects of human group IIA and group XIIA phospholipase A2 against Helicobacter pylori in vitro,” APMIS 114:127-30 

Vandal, O.H., Gelb, M.H., Ehrt, S. and Nathan, C.F. (2006) “Cytosolic Phospholipase A2 enzymes are not required by mouse bone marrow-derived macrophages for the control of Mycobacterium tuberculosis in Vitro ,” Infect. Immun. Mar. 74:1751-6. 

Nevalainen, T.J., Eerola, L.I., Rintala, E., Laine, V.J., Lambeau, G. and Gelb, M.H. (2005) ” Time-resolved fluoroimmunoassays of the complete set of secreted phospholipases A2 in human serum,” Biochim Biophys Acta. 1733:210-213 

Forsell, P.K., Olsson, A.O., Andersson, E., Nallan, L. and Gelb, M.H. (2005) “Polychlorinated biphenyls induce arachidonic acid release in human platelets in a tamoxifen sensitive manner via activation of group IVA cytosolic phospholipase A(2)-alpha,” Biochem Pharmacol. Nov. 12 ; [Epub ahead of print] 

Petan, T., Krizaj, I., Gelb, MH. and Pungercar, J. (2005) “Ammodytoxins, potent presynaptic neurotoxins, are also highly efficient phospholipase A(2) enzymes,” Biochemistry, 44:12535-12545 

Tucker, D.E., Stewart, A., Nallan, L., Bendale, P., Ghomashchi, F., Gelb, MH. and Leslie, CC. (2005) “Group IVC cytosolic phospholipase A2{gamma} is farnesylated and palmitoylated in mammalian cells,” J. Lipid Res., 46:2122-33. 

Kita, Y., Takahashi, T., Uozumi, N., Nallan, L.,Gelb, M.H. and Shimizu, T. (2005) “Pathway-oriented profiling of lipid mediators in macrophages,” Biochem. Biophys. Res. Commun., 330:898-906. 

Nielsen, R.D., Che, K., Gelb, M.H. and Robinson, B.H. (2005) “A Ruler for Determining the Position of Proteins in Membranes,” J. Am. Chem. Soc., 127:6430-42. 

Babon, A., Almunia, C., Boccaccio, C., Beaumelle, B., Gelb, M.H., Menez, A., Maillere, B., Abastado, J.P., Salcedo, M. and Gillet, D., (2005) “Cross-presentation of a CMV pp65 epitope by human dendritic cells using bee venom PLA(2) as a membrane-binding vector,” FEBS Lett., 579:1658-64. 

Yuan, C., Tu, S., Gelb, M.H. and Tsai, M-D. (2005) “Unusual Four-Bond Secondary H/D Isotope Effect Supports a Short-Strong Hydrogen Bond between Phospholipase A2 and a Transition State Analogue Inhibitor,” Biochemistry, 44:4748-54. 

Granata, F., Petraroli, A., Boilard, E., Bezzine, S., Bollinger, J., Del Vecchio, L., Gelb, M.H., Lambeau, G., Marone, G., and Triggiani M. (2005) “Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the m-type receptor,” J. Immunol., 174: 464-74. 

Masuda, S., Murakami, M., Matsumoto, S., Eguchi, N., Urade, Y., Lambeau, G., Gelb, M.H., Ishikawa, Y., Ishii, T. and Kudo, I. (2004) “Localization of various secretory phospholipase A(2) enzymes in male reproductive organs,” Biochim Biophys Acta., 1686:61-76. 

Ivanovski, G., Petan, T., Krizaj, I., Gelb, M.H., Gubensek, F. and Pungercar, J. (2004) “Basic amino acid residues in the beta-structure region contribute, but not critically, to presynaptic neurotoxicity of ammodytoxin A,” Biochim Biophys Acta., 1702:217-25. 

Buhot, C., Chenal, A., Sanson, A., Pouvelle-Moratille, S., Gelb, M.H., Menez, A., Gillet, D. and Maillere, B. (2004) “Alteration of the tertiary structure of the major bee venom allergen Api m 1 by multiple mutations is concomitant with low IgE reactivity,” Protein Sci. 13:2970-8. 

Smart, B.P., Pan, Y.H., Weeks, A.K., Bollinger, J.G., Bahnson, B.J. and Gelb, M.H. (2004) “Inhibition of the complete set of mammalian secreted phospholipases A(2) by indole analogues a structure-guided study,” Bioorg Med Chem., 12:1737-49. 

Landreville, S., Coulombe, S., Carrier, P., Gelb, M.H., Guérin, S.L., and Salesse, C. (2004) Expression of Phospholipases A2 and C in Human Corneal Epitheliel Cells,” IOVS, 45:3997-4003. 

Bollinger, J.G., Diraviyam, K., Ghomashchi, F., Murray, D., and Gelb, M.H. (2004) “Interfacial Binding of Bee Venom Secreted Phospholipase A2 to Membranes Occurs Predominantly by a Nonelectrostatic Mechanism,” Biochemistry, 43:13293-13304. 

Rubin, B.B., Downey, G.P., Koh, A., Degousee, N., Ghomashchi, F., Nallan, L., Stefanski, E., Smart, B.P., Lindsay, T.F., Cherepanov, V., Vachon, E., Kelvin, D., Sadilek, M., Brown, G.E., Yaffe, M.B., Plumb, J., Grinstein, S., Glogauer, M., and Gelb, M.H. (2004) “Cytosolic phospholipase A2 alpha is necessary for platelet activating factor biosynthesis, efficient neutrophil mediated bacterial killing and the innate immune response to pulmonary infection,” J. Biol. Chem., 280:7519-29. 

Haas, U., Podda, M., Behne, M., Gurrieri, S., Alonso, A., Fürstenberger, G., Pfeilschifter, J., Lambeau, G., Gelb, M.H., and Kaszkin, M. (2004) “Characterization and Differentiation-dependent Regulation of Secreted Phospholipases A2 in Human Keratinocytes and in Healthy and Psoriatic Human Skin,” J. Invest. Dermatol., 124:204-211. 

Sved, P., Scott, K.F., McLeod, D., King, N.J., Singh, J., Tsatralis, T., Nikolov, B., Boulas, J., Nallan, L., Gelb, M.H., Sajinovic, M., Graham, G.G., Russell, P.J., and Dong, Q. (2004) “Oncogenic action of secreted phospholipase A2 in prostate cancer,” Cancer Res., 64: 6934-40. 

Nielsen, R.D., Canaan, S., Gladden, J.A., Gelb, M.H., Mailer, C., and Robinson, B.H. (2004) “Comparing continuous wave progressive saturation EPR and time domain saturation recovery EPR over the entire motional range of nitroxide spin labels,” J Magn Reson., 169:129-63. 

Leslie, C.C., Gelb, M.H. (2004) “Assaying phospholipase A2 activity,” Methods Mol Biol., 284:229-42. 

Mounier, C.M., Ghomashchi, F., Lindsay, M.R., James, S., Singer, A.G., Parton, R.G., and Gelb, M.H. (2004) “Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A2 occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A2-a,” J. Biol. Chem. 279:25024-25038. 

Okeley, N.M, Gelb, M.H. (2004) “Membrane Transport, Structure, Function, and Biogenesis: A designed probe for acidic phospholipids reveals the enriched anionic character of the cytosolic face of the mammalian plasma membrane,” J. Biol. Chem, 279:21833-21840. 

Stephane Canaan, S., Zoltan Zadori, Z., Ghomashchi,F., Bollinger, J., Sadilek, M., Marie Eve Moreau, M.E., Tijssen, P., and Gelb, M.H. (2004) “Interfacial enzymology of parvovirus phospholipases A2,” J. Biol. Chem, 279:14502-14508. 

Triggiani, M., Giannattasio, G., Balestrieri, B., Granata, F., Gelb, M.H., de Paulis, A., and Marone, G. (2004) “Differential modulation of mediator release from human basophils and mast cells by mizolastine,” Clin. Exp. Allergy, 34:241-9. 

Rounault, M., Bollinger, J.G., Lazdunski, M., Gelb, M.H., Lambeau, G. (2003) “Novel Mammalian Group XII Secreted Phospholipase A2 Lacking Enzymatic Activity,” Biochemistry, 42:11494-11503. 

Beck, S., Lambeau, G., Scholz-Pedretti, K., Gelb, M.H., Janssen, M.J.W., Edwards, S.H., Wilton, D.C., Pfeilschifter, J., and Kaszkin, M. (2003) “Potentiation of TNF a-induced sPLA2-IIA expression in mesangial cells by an autocrine loop involving secreted phospholipase A2 and PPAR a activation,” J. Biol. Chem., 278:29799-29812. 

Gurrieri, S., Fürstenberger, G., Schadow, A., Haas, U., Singer, A.G., Ghomashchi, F., Pfeilschifter, J., Lambeau, G., Gelb, M.H., and Kaszkin, M. (2003) “Differentiation-dependent regulation of secreted phospholipases A2 in murine epidermis,” J. Invest. Dermatol., 121:156-164. 

Poi, M.J., Tomaszewski, J.W., Yuan, C., Dunlap, C.A., Andersen, N.H., Gelb, M.H., and Tsai, M.-D. (2003) “A low-barrier hydrogen bond between histidine of secreted phospholipase A2 and a transition state analog inhibitor,” J. Mol. Biol., 329:997-1009. 

Beers, S.A., Buckland, A.G., Giles, N., Gelb, M.H. and Wilton, D.C. (2003) “Effect of tryptophan insertions on the properties of the human group IIA phospholipase A2: mutagenesis produces an enzyme with characteristics similar to those of the human group V phospholipase A2,” Biochem., 42(24):7326-7338. 

Murakami, M., Masuda, S., Shimbara, S., Bezzine, S., Lazdunski, M., Lambeau, G., Gelb, M.H., Matsukura, S., Kokubu, F., Adachi, M. and Kudo, I. (2003) “Cellular Arachidonate-Releasing Function of Novel Classes of Secretory Phospholipase A2s (Group III and XII),” J. Biol. Chem., 278:10657-10667. 

Singer, A.G., Ghomashchi, F., Le Calvez, C., Bollinger, J., Bezzine, S., Rouault, M., Sadilek, M., Lazdunski, M., Lambeau, G., and Gelb, M.H. (2002) “Interfacial Kinetic and Binding Properties of the Complete set of Human and Mouse Groups I, II, V, X, and XII Secreted Phospholipases A2,” J. Biol. Chem., 277:48535-48549. 

Bezzine, S., Bollinger, J.G., Singer, A.G., Veatch, S.L., Keller, S.L., and Gelb, M.H. (2002) “On the Binding Preference of Human Groups IIA and X Phospholipases A2 for Membranes with Anionic Phospholipids,” J. Biol. Chem., 277:48523-48534. 

Koprivnjak, T., Peschel, A., Gelb, M.H., Liang, N.S., and Weiss, J.O. (2002) “Role of charge properties of bacterial envelope in bactericidal action of human Group IIA phospholipase A2 against Staphylococcus andreas,” J. Biol. Chem., 277:47636-47644. 

Murakami, M., Yoshihara, K., Shimbara, S., Lambeau, G., Gelb, M.H., Singer, A.G., Sawada, M., Inagaki, N., Nagai, H., Ishihara, M., Ishikawa, Y., Ishii, T., and Kudo, I. (2002) “Cellular Arachidonate-releasing Function and Inflammation-associated Expression of Group IIF Secretory Phospholipase A2,” J. Biol. Chem., 277(21):19145-19155. 

Pan, Y.H., Yu, B.-Z., Singer, A.G., Ghomashchi, F., Lambeau, G., Gelb, M.H., Jain, M.J., and Bahnson, B.J. (2002) “Crystal structure of human group-X secreted phospholipase A2; electrostatically neutral interfacial binding surface targets zwitterionic membranes,” J. Biol. Chem., 277:29086-29093. 

Canaan, S., Nielsen, R., Ghomashchi, F., Robinson, B.H., and Gelb, M.H. (2002) “Unusal Mode of Binding of human group-IIA secreted phospholipase A2 to anionic interfaces as studied by continuous wave and time domain electron paramagnetic resonance spectroscopy,” J. Biol. Chem, 277:30984-30990. 

Murakami, M., Yoshihara, K., Shimbara, S., Lambeau, G., Singer, A., Gelb, M.H., Sawada, M., Inagaki, N., Nagai, H., and Kudo, I. (2002) “Arachidonate release and eicosanoid generation by group IIE phospholipase A2,” Biochem. Biophys. Res. Comm., 292(3):689-696. 

Degousee, N., Ghomashchi, F., Stefanski, E., Singer, A., Smart, B.P., Borregaard, N., Reithmeier, R., Lindsay, T.F., Lichtenberger, C., Reinisch, W., Lambeau, G., Arm, J., Tischfield, J.T., Gelb, M.H., and Rubin, B.B. (2001) “Groups IV, V and X Phospholipases A2 in Human Neutrophils,” J. Biol. Chem., 277(7):5061-5073. 

Beers, S.A., Buckland, A.G., Koduri, R.S., Cho, W., Gelb, M.H., and Wilton, D.C. (2002) “The antibacterial properties of secreted phospholipases A2: a major physiological role for the group IIA enzyme that depends on the very high pI of the enzyme to allow penetration of the bacterial cell wall,” J. Biol. Chem., 277(3):1788-1793. 

Koduri, R.S., Grönroos, J.O., Laine, V.J.O., Calvez, C.L., Lambeau, G., Nevalainen, T.J., and Gelb, M.H. (2002) “Bactericidal Properties of Human and Murine Groups I, II, V, X, and XII Secreted Phospholipases A2,” J. Biol. Chem., 277:5849-5857. 

Berg, O.G., Gelb, M.H., Tsai, M.-D., and Jain, M.K. (2001) “Interfacial Enzymology: The Secreted Phospholipase A2-Paradigm,” Chem. Rev., 101:2613-2653. 

Muthalif, M.M., Hefner, Y., Canaan, S., Harper, J., Zhou, H., Parmentier, J.-H., Aebersold, R., Gelb, M.H., and Malik, K.U. (2001) “Functional Interacton of Calcium/Calmodulin-Dependent Protein Kinase II and Cytosolic Phospholipase A2.” J. Biol. Chem., 276: 39653-39660. 

Ghomaschi, F., Stewart, A., Hefner, Y., Ramanadham, S., Turk, J., Leslie, C.C., and Gelb, M.H. (2001) “A pyrrolidine-based specific inhibitor of cytosolic phospholipase A2[alpha] blocks arachidonic acid release in a variety of mammalian cells.” Biochimica et Biophysica Acta. 78118:1-7. 

Min, J.H., Wilder, C., Aoki, J., Arai, H., Inoue, K., Paul, L., and Gelb, M.H. (2001) “Platelet-Activating Factor Acetylhydrolases: Broad Substrate Specificity and Lipoprotein Binding Does Not Modulate the Catalytic Properties of the Plasma Enzyme.” Biochemistry. 40(15):4539-4549. 

Schadow, A., Scholz-Pedretti, K., Lambeau, G., Gelb, M.H., Furstenberger, G., Pfeilschifter, J., and Kaszkin, M. (2001) “Characterization of group X phospholipase A2 as the major enzyme secreted by human keratinocytes and its regulation by the phorbol ester TPA,” J. Investig. Dermatol., 116(1):31-39. 

Valentin E, Singer AG, Ghomashchi F, Lazdunski M, Gelb MH, Lambeau G. Cloning and Recombinant Expression of Human Group IIF-Secreted Phospholipase A(2). Biochem Biophys Res Commun. 279:223-228. 

Mounier CM, Luchetta P, Lecut C, Koduri RS, Faure G, Lambeau G, Valentin E, Singer A, Ghomashchi F, Beguin S, Gelb MH, Bon C. Related Articles, Links Basic residues of human group IIA phospholipase A2 are important for binding to factor Xa and prothrombinase inhibition comparison with other mammalian secreted phospholipases A2. Eur J Biochem. 2000 Aug;267(16):4960-4969. 

M. Murakami, R. S. Koduri, A. Enomoto, S. Shimbara, M. Seki, K. Yoshihara, A. Singer, E. Valentin, F. Ghomashchi, G. Lambeau, M.H. Gelb, and I. Kudo (2000) Distinct Arachidonate-Releasing Functions of Mammalian Secreted Phospholipase A2s in Human Embryonic Kidney 293 and Rat Mastocytoma RBL-2H3 Cells through Heparin Sulfate Shuttling and External Plasma Membrane Mechanisms, J. Biol. Chem., 276(13):10083-10096. 

Ying Hefner, Angelika G. Borsch-Haubold, Makomoto Murakami, Jonathan I. Wilde, Sophie Pasquet, David Schieltz, Farideh Ghomashchi, John R. Yates, III,Christopher G. Armstrong, Andrew Paterson, Philip Cohen, Rikiro Fukunaga, Tony Hunter, Ichiro Kudo, Steve P. Watson, and Michael H. Gelb. Serine-727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases J. Biol. Chem., 275:37543-37551 

Enomoto A., Murakami, M., Valentin, E., Lambeau, G. Gelb, M. H. and Kudo, I; Redundant and Segregated Functions of Granule-Associated Heparin-Binding Group II Subfamily of Secretory Phospholipases A2 in the Regulation of Degranulation and Prostaglandin D2 Synthesis in Mast Cells: J. Immunol. 4007-4014 (2000). 

Gelb MH, Min J, Jain MK. (2000) Do membrane-bound enzymes access their substrates from the membrane or aqueous phase: interfacial versus non-interfacial enzymes. Biochim Biophys Acta. 2000 Oct 31; 1488(1-2):20-27. 

Linda S. Jung, Jennifer S. Shumaker-Parry, Charles T. Campbell,* Sinclair S. Yee, and Michael H. Gelb* ; Quantification of Tight Binding to Surface-Immobilized Phospholipid Vesicles Using Surface Plasmon Resonance: Binding Constant of Phospholipase A2, Journal of the American Chemical Society; 2000; 122(17); 4177-4184. 

Gelb MH, Valentin E, Ghomashchi F, Lazdunski M, Lambeau G. Cloning and recombinant expression of a structurally novel human secreted phospholipase A2. J Biol Chem. 2000; 275(51); 39823-39826. 

Bezzine S, Koduri RS, Valentin E, Murakami M, Kudo I, Ghomashchi F, Sadilek M, Lambeau G, Gelb MH. Exogenously added human group X secreted phospholipase A(2) but not the group IB, IIA, and V enzymes efficiently release arachidonic acid from adherent mammalian cells. Journal of Biological Chemistry. 275(5): 3179-91, Feb 2000 

Valentin E, Ghomashchi F, Gelb MH, Lazdunski M, Lambeau G. Novel secreted phospholipase A(2) with homology to the group III bee venom enzyme. Journal of Biological Chemistry. 275, 7492-7496, 2000 

Valentin E, Ghomashchi F, Gelb MH, Lazdunski M, Lambeau G. On the diversity of secreted phospholipases A(2). Cloning,tissue distribution, and functional expression of two novel mouse group II enzymes. Journal of Biological Chemistry. 274(44):31195-202, Oct 1999 

F. Ghomashchi, R. Loo, J. Balsinde, F. Bartoli, E. A. Dennis, and M. H. Gelb (1999) Trifluoromethyl ketones and methyl fluorophosphonates as inhibitors of group IV and VI Phospholipases A2: structure-function studies with vesicle, micelle and membrane assays. Biochim. Biophys. Acta 1420, 45-56. 

Min JH, Jain MK, Wilder C, Paul L, Apitz-Castro R, Aspleaf DC, Gelb MH. Membrane-bound plasma platelet activating factor acetylhydrolase acts on substrate in the aqueous phase. Biochemistry. 38(39): 12935-42, Sep 1999. 

Buschbeck M, Ghomashchi F, Gelb MH, Watson SP, Borsch-Haubold AG. Stress stimuli increase calcium-induced arachidonic acid release through phosphorylation of cytosolic phospholipase A2. Biochemical Journal. 344 Pt 2: 359-66, Dec 1999. 

Valentin E, Koduri RS, Scimeca JC, Carle G, Gelb MH, Lazdunski M, Lambeau G. Cloning and recombinant expression of a novel mouse-secreted phospholipase A2. J Biol Chem. 1999 Jul 2;274(27):19152-60. 

Gelb, MH, Cho, W, and Wilton, DC. (1999) “Interfacial binding of secreted phospholipases A2: more than electrostatics and a major role for tryptophan,” Curr. Opinion in Struct. Biol., 9(4):428-432. 

Han SK, Kim KP, Koduri R, Bittova L, Munoz NM, Leff AR, Wilton DC, Gelb MH, Cho W. Roles of Trp31 in high membrane binding and proinflammatory activity of human group V phospholipase A2. J Biol Chem 274(17): 11881-8, Apr 1999. 

Ball A; Nielsen R; Gelb MH; Robinson BH. Interfacial membrane docking of cytosolic phospholipase A2 C2 domain using electrostatic potential-modulated spin relaxation magnetic resonance.. Proc Natl Acad Sci U S A. 96(12): 6637-42, 8 Jun 1999. 

Hixon MS, Ball A, Gelb MH. Calcium-dependent and -independent interfacial binding and catalysis of cytosolic group IV phospholipase A2. Biochemistry. 1998 Jun 9;37(23):8516-26. 

Ghomashchi F;Lin Y;Hixon M S;Yu B Z;Annand R;Jain M K;Gelb M H. Interfacial recognition by bee venom phospholipase A2: insights into nonelectrostatic molecular determinants by charge reversal mutagenesis.. Biochemistry. 37(19): 6697-710, 12 May 1998. 

Lin Y; Nielsen R;Murray D;Hubbell W L;Mailer C;Robinson B H;Gelb M H. Docking phospholipase A2 on membranes using electrostatic potential-modulated spin relaxation magnetic resonance. Science. 279(5358): 1925-9, 20 Mar 1998

Koduri RS, Baker SF, Snitko Y, Han SK, Cho W, Wilton DC, Gelb MH. Action of human group IIa secreted phospholipase A2 on cell membranes. Vesicle but not heparinoid binding determines rate of fatty acid release by exogenously added enzyme. J Biol Chem. 273(48): 32142-53, Nov 1998. 

Borsch-Haubold AG, Bartoli F, Asselin J, Dudler T, Kramer RM, Apitz-Castro R, Watson SP, Gelb MH. Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells. J Biol Chem. 1998 Feb 20;273(8):4449-58. 

Nicolas JP, Lin Y, Lambeau G, Ghomashchi F, Lazdunski M, Gelb MH. Localization of structural elements of bee venom phospholipase A2 involved in N-type receptor binding and neurotoxicity. J Biol Chem. 1997 Mar 14;272(11):7173-81. 

Snitko Y, Koduri RS, Han SK, Othman R, Baker SF, Molini BJ, Wilton DC, Gelb MH, Cho W. Mapping the interfacial binding surface of human secretory group IIa phospholipase A2. Biochemistry. 1997 Nov 25;36(47):14325-33. 

Yu B Z;Ghomashchi F;Cajal Y;Annand R R;Berg O G;Gelb M H;Jain M K. Use of an imperfect neutral diluent and outer vesicle layer scooting mode hydrolysis to analyze the interfacial kinetics, inhibition, and substrate preferences of bee venom phospholipase A2. Biochemistry. 36(13): 3870-81, 1 Apr 1997. 

Annand RR, Kontoyianni M, Penzotti JE, Dudler T, Lybrand TP, Gelb MH. Active site of bee venom phospholipase A2: the role of histidine-34, aspartate-64 and tyrosine-87. Biochemistry. 1996 Apr 9;35(14):4591-601. 

de Carvalho MG, McCormack AL, Olson E, Ghomashchi F, Gelb MH, Yates JR 3rd, Leslie CC. Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes. J Biol Chem. 1996 Mar 22;271(12):6987-97. 

Bayburt T;Gelb M H. Interfacial catalysis by human 85 kDa cytosolic phospholipase A2 on anionic vesicles in the scooting mode. Biochemistry. 36(11): 3216-31, 18 Mar 1997. 

 

 

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Siegel, J. B., Zanghellini, A., Lovick, H. M., Kiss, G., Lambert, A. R., St. Clair, J. L., Gallaher, J. L., Hilvert, D., Gelb, M. H., Stoddard, B. L., Houk, K. N., Michael, F.E., Baker, D. (2010) “Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction,” Science, 329:309-313. PMID: 20647463, PMCID: PMC3241958. 

Chipuk, J .E., Gelb, M. H., Brodbelt, J. S. (2010) “Rapid and selective screening for sulfhydryl analytes in plasma and urine using surface-enhanced transmission mode desorption electrospray ionization mass spectrometry,” Anal. Chem,82:4130-4139. PMID: 20402469, PMCID: PMC2872998. 

Trinh, K., Andrews, L., Krause, J., Hanak, T., Lee, D., Gelb, M. and Pallanck, L. (2010) “Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in drosophila models of Parkinson’s Disease through an NRF2-dependent mechanism,” J Neurosci, 30:5525-5532. PMID: 20410106, PMCID: PMC3842467. 

Chipuk, J. E., Gelb, M. H., Brodbelt, J. S. (2010) “Surface-enhanced transmission mode desorption electrospray ionization: Increasing the specificity of ambient ionization mass spectrometric analyses,” Anal. Chem. 82:16-18. PMID: 19902914, PMCID: PMC2800855. 

Holt, A., Koehorst, R. B., Rutters-Meijneke, T., Gelb, M. H., Rijkers, D. T., Hemminga, M. A., Killian, J. A. (2009) “Tilt and rotation angles of a transmembrane model peptide as studied by fluorescence spectroscopy,” Biophys. J., 97:2258-2266. PMID: 19843458, PMCID: PMC2764067. 

Gelb, M. H. and Holm, B. P. (2006) “A simple and inexpensive device for removal of solvent from a large collection of sample tubes,” J Comb Chem. 8:15-27. PMID: 16398548. 

Kuksa, V., Bartl, F., Maeda, T., Jang, G.-F., Ritter, E., Heck, M., Van Hooser, J. P., Liang, Y., Filipek, S., Gelb, M. H., Hofmann, K. P., and Palczewski, K., “Biochemical and physiological properties of rhodopsin regenerated with 11-cis-6-ring- and 7-ring-retinals”. J. Biol. Chem., 2002, 277:42315-42324. PMID: 1217699, PMCID: PMC1363677. 

Goldstein, A. S., Gelb, M. H., and Yager, P. “The relationship between the structure of the headgroup of sphingolipids and their ability to form complex high zxial ratio microstructures”. Chemistry and Physics of Lipids, 2001, 109:1-14.

Goldstein, A. S., Gelb, M. H., and Yager, P. “Continuous and highly variable rate controlled release of model drugs from sphingolipid-based complex high axial ratio microstructures”. J. of Controlled Release, 2001, 70:125-138. 

Jang, G. F., Kuksa, V., Filipek, S., Bartl, F., Ritter, E., Gelb, M. H., Hofmann, K. P., and Palczewski, K., “Mechanism of rhodopsin activation as examined with ring constrained retinal analogs and the crystal structure of the ground state protein”. J. Biol. Chem., 2001, 276: 26148-26153. 

Stecher, H., Gelb, M. H., Saari, J. C., Palczewski, K., “Preferential release of 11-cis-retinol from retinal pigment epithelial cells in the presence of cellular retinaldehyde-binding protein”. J Biol Chem. 274(13): 8577-85, 26 Mar 1999.