Research Publications (up
to 2000)
1.
Harris, D.C. and Gelb, M.H. (1981) "Binding of Xylenol Orange to
Transferrin. Demonstration of a Metal-Anion Linkage," Biochem. Biophys.
Acta 623, 1-9
2.
Gelb, M.H. and Harris, D.C. (1981) "Correlation of Proton Release and
Ultraviolet Difference spectra Associated with Metal Binding by
Transferrin," Arch. Biochem. Biophys. 200, 93-98.
3.
Gould, P.V., Gelb, M.H. and Sligar, S.G. (1981) "Interaction of
5-Bromocamphor with Cytochrome P-450cam," J. Biol. Chem. 256, 6686-6691.
4.
Gelb, M.H., Malkonen, P.J. and Sligar, S.G. (1982) P-450cam-Catalyzed
Epoxidation of 5,6-Dehydroscamphor," Biochem. Biophys. Res. Commun. 104,
853-858.
5.
Gelb, M.H., Heimbrook, D.C., Malkonen, P.J. and Sligar, S.G. (1982)
"Stereochemistry and Deuterium Isotope Effects in Camphor Hydroxylation by
the Cytochrome P-450cam Monoxygenase System," Biochemistry 21, 370-377.
6.
Gelb, M.H., Toscano, W.H., Jr. and Sligar, S.G. (1982) "Chemical
Mechanisms for Cytochrome P-450 Oxidation: Spectral and Catalytic Properties of
a Manganese-Substituted Protein," Proc. Nat. Acad. Sci. USA 79, 5758-5762.
7.
Sligar, S.G., Gelb, M.H. and Heimbrook, D.C. (1984) "Bioorganic Chemistry
and Cytochrome P-450-Dependent Catalysis," Xenobiotica 14, 63-86.
8.
Ringe, D., Seaton, B.A., Gelb, M.H., and Abeles, R.H. (1984) "The
Mechanism of Inactivation of Chymotrypsin by 5-Benzyl-6-chloro-2-pyrone,"
Biochemistry 24, 64-68.
9.
Gelb, M.H. and Abeles, R.H. (1984) "The Mechanism of Inactivation of
Chymotrypsin by 3-Benzyl-6-chloro-2-pyrone," Biochemistry 23, 6596-6604.
10.
Gelb, M.H. and Abeles, R.H. (1985) "Fluoro Ketone Inhibitors of Hydrolytic
Enzymes," Biochemistry 24, 1813-1817.
11.
Gelb, M.H. and Abeles, R.H. (1986) "Substituted Isatoic Anhydrides:
Selective Inactivations of Trypsin-Like Serine Proteases," J. Med. Chem.
29, 585-589.
12.
Ringe, D., Mottonen, J.M., Gelb, M.H. and Abeles, R.H. (1986) "X-ray
Diffraction Analysis of the Inactivation of Chymotrypsin by 3-Benzyl-
6-chloro-2-pyrone," Biochemistry 25, 5633-5638.
13.
Gelb, M.H. (1986) "Fluoro Ketone Phospholipid Analogues: New Inhibitors of
Phospholipase-A2," J. Am. Chem. Soc. 108, 3146-3147.
14.
Fearon, K., Spaltenstein, A., Hopkins, P.B., and Gelb, M.H. (1987)
"Fluoro-Ketone Containing Peptides as Inhibitors of Human Renin," J.
Med. Chem., 30, 1617-1621.
15.
Yuan, W., Berman, R., and Gelb, M.H. (1987) "Synthesis of Phospholipid
Analogues as Inhibitors of Phospholipase A2," J. Am. Chem. Soc., 109,
8071-8081.
16.
Lin, Yukang, Myhrman, R., Schrag, M.L., and Gelb, M.H. (1987) "Bacterial N
Succinyl-L-Diaminopimelic Acid Desuccinylase," J. Biol. Chem., 263,
1622-1627.
17.
Yuan, W. and Gelb, M.H. (1988) "Phosphonate-Containing Phospholipid
Analogues: Synthesis and Inhibition Studies with Phospholipase A2," J. Am.
Chem. Soc., 110, 2665-2666.
18.
Jauhiainen, M., Yuan, W., Dolphin, P.J., and Gelb, M.H. (1989) "Fluoro
Ketone Phospholipid Analogues as Inhibitors of Lecithin Cholesterol Acyl
Transferase," J. Biol. Chem. 264, 1963-1967.
19.
Yuan, W., Fearon, K., and Gelb, M.H. (1989) "Synthesis of
Sulfur-Containing Phospholipid Analogues as Mechanistic Probes of Phospholipase
A2 Catalysis," J. Org. Chem., 54, 906-910.
20.
Yuan, W., Fearon, K., and Gelb, M.H. (1989) "Rationally-Designed
Phospholipid Analogues as Mechanistic Probes of Phospholipase A2
Catalysis," J. Cellular Biochem., 39, 351-366.
21.
Jain, M.K., Yuan, W., and Gelb, M.H. (1989) "Competitive Inhibition of
Phospholipase A2 in Vesicles," Biochemistry, 28, 4135-4139.
22.
Farnsworth, C.C., Wolda, S.L., Gelb,M.H., and Glomset, J.A. (1989) "Human
Lamin B Contains a Farnesylated Cysteine Residue," J. Biol. Chem., 264,
20422-20429.
23.
Yuan, W., Quinn, D.M., Sigler, P.B., and Gelb, M.H. (1990) "Kinetic and
Inhibition Studies of Phospholipase A2 with Short-Chain Substrates and
Inhibitors," Biochemistry, 29, 6082-6094.
24.
Gelb, M.H., Lin, Y., Pickard, M.A., Song, Y., and Vederas, J.C. (1990)
"Synthesis of 3-Fluorodiaminopimelic Acid Isomers as Inhibitors of
Diaminopimelate Epimerase: Stereocontrolled Enzymatic Elimination of Hydrogen
Fluoride," J. Am. Chem. Soc., 112, 4932-4942.
25.
Farnsworth, C.C., Gelb, M.H., and Glomset, J.A. (1990) "Protein
Prenylation in Eukaryotic Cells: a New Type of Membrane Anchor," Trends
Biochem. Sci., 139-142.
26.
Farnsworth, C.C., Gelb, M.H., and Glomset, J.A. (1990) "Identification of
Geranylgeranyl-Modified Proteins in HeLa Cells," Science , 247, 320-322.
27.
Yamane, H.K., Farnsworth, C.C., Xie, H., Howald, W., Fung, B.K.-K., Clarke, S.,
Gelb, M.H., and Glomset, J.A. (1990) "Brain G-proteins Contain an
All-trans-Geranylgeranyl-Cysteine Methyl Ester on Their Carboxyl Termini,"
Proc. Nat. Acad. Sci. USA, 87, 5868-5872.
28.
White, S.P., Scott, D.L., Otwinowski, Z., Gelb, M.H. and Sigler, P.B. (1990)
"Crystal Structure of Cobra Venom Phospholipase A2 in a Complex with a
Transition State Analogue," Science, 250, 1560-1563.
29.
Scott, D.C., White, M.H., Gelb, M.H., and Sigler, P.B. (1990) "Crystal
Structure of Bee-Venom Phospholipase A2 in a Complex with a Transition State
Analogue," Science, 250, 1563-1566.
30.
Scott, D.L., White, S., Otwinowski, Z., Yuan, W., Gelb, M.H. and Sigler, P.B.
(1990) "Interfacial Catalysis: the Mechanism of Phospholipase A2,"
Science, 250, 1541-1546.
31.
Goodman, L.E., Judd, S.R., Farnsworth, C.C., Powers, S., Gelb, M.H., Glomset,
J.A., and Tamanoi, F. (1990) "Mutants of Saccharomyces Cerevisiae
Defective in the Farnesylation of ras Proteins," Proc. Nat. Acad. Sci USA,
87, 9665-9669.
32.
Kawata, M., Farnsworth, C.C., Yoshida, Y., Gelb, M.H., Glomset, J.A., and
Takai, Y. (1990) "Posttranslationally Processed Structure of Human
Platelet smg p21B. Evidence for Geranylgeranylation and Carboxyl Methylation of
the C-terminal Cysteine," Proc. Nat. Acad. Sci. USA, 87, 8960-8964.
33.
Glomset, J.A., Gelb, M.H., and Farnsworth, C.C. (1990) "Prenyl proteins in
eukaryotic cells: a new type of membrane anchor." Trends Biochem. Sci.,
15(4): 139-142.
34.
Jain, M.K. and Gelb, M.H. (1991) "Phospholipase A2-catalyzed hydrolysis of
vesicles: uses of interfacial catalysis in the scooting mode," Methods.
Enzymol, 197, 112-125.
35.
Ghomashchi, F., Yu, B.-Z., Berg, O., Jain, M.K., and Gelb, M.H. (1991)
"Interfacial Catalysis by Phospholipase A2: Substrate Specificity in
Vesicles," Biochemistry, 30, 7318-7329.
36.
Ghomashchi, F., O'Hare, T., Clary, D., and Gelb, M.H. (1991) "Interfacial
Catalysis by Phospholipase A2: Evaluation of the Interfacial Rate Constants by
Steady-State Isotope Effect Studies," Biochemistry, 30, 7298-7305.
37.
Ghomashchi, F., Jain, M.K., and Gelb, M.H. (1991) "Kinetic
Characterization of Phospholipase A2 Modified by Manoalogue,"
Biochemistry, 30, 9559-9569.
38.
Farnsworth, C.C., Casey, P., Howald, W., Glomset, J.A., and Gelb, M.H. (1991)
"Structural Analysis of Prenylated Proteins," Methods, 1. 231-240.
39.
Yamane, H.K., Farnsworth, C.C., Xie, H., Evans, T., Howald, W., Gelb, M.H.,
Glomset, J.A., Clarke, S., and Fung, B.K.-K. (1991) "Membrane-Binding
Domain of the Small G-protein G25K Contains an all-trans Geranylgeranyl
Cysteinyl Methyl Ester at its Carboxyl Terminus," Proc. Nat. Acad. Sci.
USA, 88, 286-290.
40.
Jain, M.K., Rogers, J., Berg, O., and Gelb, M.H. (1991) "Interfacial
Catalysis by Phospholipase A2: Activation by Substrate Replenishment,"
Biochemistry, 30, 7340-7348.
41.
Yokoyama, K., Goodwin, G., Ghomashchi, F., Glomset, J.A., and Gelb, M.H. (1991)
"A Protein Geranylgeranyl Transferase from Bovine Brain: Implications for
Protein Prenylation Specificity," Proc. Natl. Acad. Sci. USA, 88,
5302-5306.
42.
Finegold, A.A., Johnson, D.I., Farmsworth, C.C., Gelb, M.H., Judd, S.R.,
Glomset, J.A. and Tamanoi, F. (1991) "Protein Geranylgeranyltransferase of
Saccharomyces Cerevisiae is Specific for Cys-Xaa-Xaa-Leu Motif Proteins and
Requires the CDC43 Gene Product but not the DPR1 Gene Product," Proc. Natl.
Acad. Sci. USA, 88, 4448-4452.
43.
Glomset, J.A., Gelb, M.H., and Farnsworth, C.C. (1991) "The prenylation of
proteins," Curr. Opin. Lipid., 2, 118-124.
44.
Farnsworth, C.C., Kawata, M., Yoshida, Y., Takai, Y., Gelb, M.H., and Glomset,
J.A. (1991) "C-Terminus of the Small GTP-Binding Protein smg p25A Contains
Two Geranylgeranylated Cysteine Residues and a Methyl Ester," Proc. Natl.
Acad. Sci. USA, 88, 6196-6200.
45.
Gelb, M.H., Berg, O., and Jain, M.H. (1992) "Quantitative and structural
analysis of inhibitors of phospholipase A2," Curr. Opin. Struct. Biol., 1,
836-843.
46.
Scott, D.L., White, S.P., Browning, J.L., Rosa, J.J., Gelb, M.H., and Sigler,
P.B. (1991) "Structures of Free and Inhibited Human Secretory
Phospholipase A2 from Inflammatory Exudate," Science, 254, 1007-1010.
47.
Scott, D.L., Otwinowski, Z., Gelb, M.H., and Sigler, P.B. (1991) "Crystal
structure of bee-venom phospholipase A2: correction." Science, 252(5007):
764.
48.
Marshall, L.A., Bolognese, B., Yuan, W., and Gelb, M.H. (1992) "Phosphonate-Phospholipid
Analogues Inhibit Human Phosphalipase A2," Agents Actions, 34, 106-109.
49.
Ghomashchi, F., Schüttel, S., Jain, M.K., and Gelb, M.H. (1992) "Kinetic
Analysis of a High Molecular Weight Phospholipase A2 from Rat Kidney: Divalent
Metal-Dependent Trapping of Enzyme on Product-Containing Vesicle,"
Biochemistry 31, 3814-3824.
50.
James, M.N.G., Sielecki, A.R., Hayakawa, K., and Gelb, M.H. (1992)
"Crystallographic Analysis of Transition State Mimics Binding to
Penicillopepsin I: Difluorostatine and Difluorostatone Containing
Peptides," Biochemistry 31, 3872-3886.
51.
Jain, M.K., Yu, B.-Z., Rogers, J., Gelb, M.H., Tsai, M.-D., Hendrickson, E.K.,
and Hendrickson, H.S. (1992) "Interfacial Catalysis by Phospholipase A2:
The Rate-Limiting Step for Maximal Turnover," Biochemistry, 31, 7841-7847.
52.
Yokoyama, K., Goodwin, G.W., Ghomashchi, F., Glomset, J.A., and Gelb, M.H.
(1992) "Protein Prenytransferases," Trends Biochem. Soc., 20,
479-484.
53.
Glomset, J.A., Gelb, M.H., Farnsworth, C.C. (1992) "Geranylgeranylated
Proteins," Trends Biochem. Soc., 20, 489-494.
54.
Jain, M.K., Yu, B.-Z., Gelb, M.H., and Berg, O.G. (1992) "Assay of
Phospholipases A2 and Their Inhibitors by Kinetic Analysis in the Scooting
Mode," Mediators of Infammation, 1, 85-100.
55.
Dudler, T., Chen, W.-Q., Wang, S., Schneider, T., Annand, R.R., Dempcy, R.D.,
Crameri, R., Gmachl, M., Suter, M., and Gelb, M.H. (1992) "High-level
Expression in Escherichia coli and Rapid Purification of Enzymatically Active
Honey Bee Venom Phospholipase A2," Biochim. Biophys. Acta, 1165, 201-210.
56.
Gelb, M.H., Jain, M.K., and Berg, O. (1992) "Interfacial Enzymology of
Phospholipase A2," Biorg. Med. Chem. Lett., 2, 1335-1342.
57.
Jain, M.K., Ghomashchi, F., Yu, B.Z., Bayburt, T., Murphy, D., Houck, D.,
Brownell, J., Reid, J.C., Solowiej, J.E., Wong, S.-M., Mocek, U., Jarrell, R.,
Sasser, M., and Gelb, M.H. (1992) "Fatty Acid Amides: Scooting Mode-Based
Discovery of Tight-Binding Competitive Inhibitors of Secreted Phospholipase
A2," J. Med. Chem., 35, 3584-3586.
58.
Bayburt, T., Yu, B.-Z., Lin, H.-K., Browning, J., Jain, M.K., and Gelb, M.H.
(1993) "Human Nonpancreatic Secreted Phospholipase A2: Interfacial
Parameters, Substrate Specifities, and Competitive Inhibitors,"
Biochemistry, 32, 573-582.
59.
Yokoyama, K. and Gelb, M.H. (1993) "Purification of a Mammalian Protein
Geranylgeranyltransferase: Formation and Catalytic Properties of a
Enzyme-Geranylgeranyl pyrophosphate Complex," J. Biol. Chem., 268,
4055-4060.
60.
Lin, H.-K. and Gelb, M.H. (1993) "Competitive Inhibition of Interfacial
Catalysis by Phospholipase A2: Differential Interaction of Inhibitors With The
Vesicle Interface as a Controlling Factor of Inhibitor Potency," J. Am.
Chem. Soc., 115, 3932-3942.
61.
Street, I.P., Lin, H.-K., Laliberté, F., Ghomashchi, F., Wang, Z., Perrier, H.,
Tremblay, N.M., Huang, Z., Weech, P.-K., and Gelb, M.H. (1993) "Slow- and
Tight-Binding Inhibitors of the 85 kDa Human Phospholipase A2," Biochemistry,
32, 5935-5940.
62.
Hanel, A.M., Schüttel, S., and Gelb, M.H. (1993) "Processive Interfacial
Catalysis by Mammalian 85-kDa Phospholipase A2 Enzymes on Product-Containing
Vesicles: Application to the Determination of Substrate Preferences," Biochemistry,
32, 5949-5958.
63.
Jang, G.-F., Yokoyama, K., and Gelb, M.H. (1993) "A Prenylated
Protein-Specific Endoprotease in Rat Liver Microsomes That Produces a
Carboxyl-Terminal Tripeptide," Biochemistry, 32, 9500-9507.
64.
Bartoli, F., Lin, H-K., Ghomashchi, F., Gelb, M.H., Jain, M.K., and
Apitz-Castro, R. (1994) "Tight-Binding Inhibitors of the 85-kDa
Phospholipase A2 but not the 14-kDa Phospholipase A2 Inhibit the Release of
Free Arachidonate in Thrombin-Stimulated Human Platelets," J. Biol. Chem.,
22, 15625-15630.
65.
Gelb, M.H., Jain, M.K., and Berg, O.G. (1994) "Inhibition of Phospholipase
A2," FASEB J., 8, 916-924.
66.
Gronich, J., Konieczkowski, M., Gelb, M.H., Nemenoff, R.A., and Sedor, J.R.
(1994) "Interleukin 1a Causes Rapid Activation of Cytosolic Phospholipase
A2 by Phosphorylation in Rat Mesangial Cells," J. Clin. Invest., 93,
1224-1233.
67.
Jain, M.K., Krause, C.D., Buckley, J.T., Bayburt, T., and Gelb, M.H. (1994)
"Characterization of Interfacial Catalysis by Aeromonas hydrophila
Lipase/Acyltransferase in the Highly Processive Scooting Mode,"
Biochemistry, 33, 5011-5020.
68.
Schneider, T., Dudler, T., Gelb, M.H., and Suter, M. (1994) "Lysine
Residues in Bee Venom Phospholipase A2 Are Important for Binding to Human
Monoclonal or Polyclonal Antibodies of the IgG4 Isotope," Int. Arch.
Allergy Immunol., 104, 262-269.
69.
Dudler, T., Schneider, T., Annand, R.R., Gelb, M.H., and Suter, M. (1994)
"Antigenic Surface of the Bee Venom Allergen Phospholipase A2: Structural
and Functional Analysis of Human IgG4 Antibodies Reveals Potential Role in
Protection," J. Immunol., 152, 5514-5522.
70.
Farnsworth, C.C., Seabra, M.C., Ericsson, L.H., Gelb, M.H., and Glomset, J.A.
(1994) "Rab Geranylgeranyl Transferase Catalyzes the Geranylgeranylation
of Adjacent Cysteines in the Small GTPases, Rab1A, Rab3A, and Rab5A,"
Proc. Natl. Acad. Sci. USA, 91, 11963-11967.
71.
Jain, M.K., Gelb, M.H., Rogers, J., Berg, O. (1995) "Kinetic Basis for
Interfacial Catalysis by Phospholipase A2," Methods Enzymol., 249,
567-614.
72.
Liu, L., Jang, G-F., Farnsworth, C.C., Yokoyama, K., Glomset, J.A. and Gelb,
M.H. (1995) "Synthetic Prenylated Peptides: Tools for Studying the Prenyl
Protein-Specific Endoprotease and Other Aspects of Protein Prenylation,"
Methods Enzymol., 250, 189-206.
73.
Gelb, M.H., Jain, M.K., Hanel, A.M., Berg, O.G. (1995) "Interfacial
Enzymology of Glycerolipid Hydrolases: Lessons from Phospholipase A2,"
Ann. Rev. Biochem., 64, 653-688.
74.
McGeady, P., Kuroda, S., Shimizu, K., Takai, Y., and Gelb, M.H. (1995)
"The farnesyl group of H-Ras facilitates the activation of a soluble
upstream activator of mitogen-activated protein kinase," J. Biol. Chem.,
270, 26347-51.
75.
Gelb, M.H. (1995) "Modification of proteins by prenyl groups," Princ.
Med. Biol., 4, 323-333.
76.
Yokoyama, K., McGeady, P. and Gelb, M.H. (1995) "Mammalian Protein
Geranylgeranyl-transferase-I: Kinetic Mechanism and Substrate
Specificity," Biochemistry, 34, 1344-1354.
77.
Hanel, A.M. and Gelb, M.H. (1995) "Multiple Enzymatic Activities of the
Human Cytosolic 85-kDa Phospholipase A2: Hydrolytic Reactions and Acyl Transfer
to Glycerol," Biochemistry, 34, 7807-7818.
78.
Bayburt, T., Yu, B.-Z., Street, I., Ghomashchi, F., Laliberté, F., Perrier, H.,
Wang, Z., Jain, M.K., and Gelb, M.H. (1995) "Continuous, Vesicle-Based
Fluorimetric Assays of 14-kDa and 85-kDa Phospholipases A2," Analytical
Biochemistry, 232, 7-23.
79.
Ghomashchi, F., Zhang, X., Liu, L., and Gelb, M.H. (1995) "Binding of
Prenylated and Polybasic Peptides to Membranes: Affinities and Intervesicle
Exchange," Biochemistry, 34, 11910-11918.
80.
Glover, S., Bayburt, T., Jonas, M., Chi, E., and Gelb, M.H. (1995)
"Translocation of the 85-kDa Phospholipase A2 from Cytosol to the Nuclear
Envelope in Rat Basophilic Leukemia Cells Stimulated with Calcium Ionophore or
IgE/Antigen, " J. Biol. Chem., 270, 15359-15367.
81.
Gelb, M.H., Tamanoi, F., Yokoyama, K., Ghomashchi, F., Esson, K., and Gould,
M.N. (1995) "The inhibition of protein prenyltransferases by oxygenated
metabolites of limonene and perillyl alcohol," Cancer Letters, 91,
169-175.
82.
McIntosh, J.M., Ghomashchi, F., Gelb, M.H., Dooley, D.J., Stoehr, S.J.,
Giordani, A.B., Naisbitt, S.R., Olivera, B.M. (1995) "Conodipine-M, a
Novel Phospholipase A2 Isolated from the Venom of the Marine Snail Conus magus,"
J. Biol. Chem. 270, 3518-3526.
83.
Dudler, T., Machado, D.C., Kolbe, L., Annand, R., Rhodes, N., Gelb, M.H.,
Koelsch, E., Suter, M., and Helm, B. (1995) "A link between catalytic
activity, IgE-independent mast cell activation, and allergenicity of bee venom
phospholipase A2," J. Immunol., 155, 2605-13.
84.
Gelb, M.H., Reiss, Y., Ghomashchi, F., and Farnsworth, C.C. (1995)
"Exploring the Specificity of Prenyl Protein-Specific Methyltransferase
with Synthetic Prenylated Rab Peptides," Bioorganic and Medicinal
Chemistry Letters 5, 881-886.
85.
Gelb, M.H., Jain, M.K., Hanel, A.M., and Berg, O.G. (1995) "Interfacial
enzymology of glycero-lipid hydrolases: lessons from phospholipase A2."
Ann. Rev. Biochem., 64: 653-688.
86.
Annand, R.R., Kontoyianni, M., Penzotti, J.E., Dudler, T., Lybrand, T.P., and
Gelb, M.H. (1996) "The active site of bee venom phospholipase A2: The role
of Histidine-34, Aspartate-64, and Tyrosine-87," Biochemistry, 4591-4601.
87.
Dudler, T. and Gelb, M.H. (1996) "Palmitoylation of Ha-Ras Facilitates
Membrane Binding, Activation of Downstream Effectors, and Meiotic Maturation in
Xenopus Oocytes," J. Biol. Chem., 271, 11541-11547.
88.
de Carvalho, M.G.S., McCormack, A.L., Olson, E., Ghomashchi, F., Gelb, M.H.,
Yates, J.R., and Leslie, C.C. (1996) "Identification of Phosphorylation
Sites of Human 85-kDa Cytosolic Phospholipase A2 Expressed in Insect Cells and
Present in Human Monocytes," J. Biol. Chem., 271, 6987-6997.
89.
Liu, L., Dudler, T., and Gelb, M.H. (1996) "Purification of a Protein
Palmitoyltransferase that Acts on H-Ras Protein and on a C-Terminal N-Ras
Peptide," J. Biol. Chem., 271, 23269-23276.
90.
Yokoyama, K., Zimmerman, K., Scholten, J., and Gelb, M.H. (1997)
"Differential Prenyl Pyrophosphate Binding to Mammalian Protein
Geranylgeranyltransferase-I and Protein Farnesyltransferase and its Consequence
on the Specificity of Protein Prenylation," J. Biol. Chem., 272,
3944-3952.
91.
Bayburt, T., and Gelb, M.H. (1997) "Interfacial Catalysis by Human 85 kDa
Cytosolic Phospholipase A2 on Anionic Vesicles in the Scooting Mode,"
Biochemistry, 36, 3216-3231.
92.
McGeady, P., Porfiri, E., and Gelb, M.H. (1997) "The Farnesyl Group
Activates Ras Toward Guanine Nucleotide Exchange Catalyzed by the SOS Protein,"
Bioorganic & Medicinal Chemistry Letters, 7, 145-150.
93.
Yu, B.-Z., Ghomashchi, F., Cajal, Y., Annand, R.R., Berg, O.G., Gelb, M.H., and
Jain, M.K. (1997) "Use of an Imperfect Neutral Diluent and Outer Vesicle
Layer Scooting Mode Hydrolysis to Analyze the Interfacial Kinetics, Inhibition,
and Substrate Preferences of Bee Venom Phospholipase A2," Biochemistry,
36, 3870-3881.
94.
Nicolas, J.-P., Lin, Y., Lambeau, G., Ghomashchi, F., Lazdunski, M., and Gelb,
M.H. (1997) "Localization of Structural Elements of Bee Venom
Phospholipase A2 Involved in N-Type Receptor Binding and Neurotoxicity,"
J. Biol. Chem., 272, 7173-7181.
95.
Gelb, M.H. (1997) "Protein Prenylation, Et Cetera: Signal Transduction in
Two Dimensions," Science, 275, 1750-1751.
96.
Yokoyama, K., Lin, Y., Stuart, K.D., and Gelb, M.H. (1997) "Prenylation of
Proteins in Trypanosoma brucei," Molecular and Biochemical Parasitology,
87, 61-69.
97.
Raiteri, M., Arnaboldi, L., McGeady, P., Gelb, M.H., Verri, D., Tagliabue, C.,
Quarato, P., Ferraboschi, P., Santaniello, E., Paoletti, R., Furmagalli, R.,
and Corsini, A. (1997) "Pharmacological Control of the Mevalonate Pathway:
Effect on Arterial Smooth Muscle Cell Proliferation," J. Pharmacol. Exp.
Therap., 281, 1144-1153.
98.
Schneider, T., Dudler, T., Annand, R.R., Gelb, M.H., King, T.P. and Suter, M.
(1997) "Comparison of the Antibody Response to Bee Venom Phospholipase A2
Induced by Natural Exposure in Humans or by Immunization in Mice," J.
Molecular Recognition, 10, 93-100.
99.
Snitko, Y., Koduri, R., Han, S.K., Othman, R., Baker. S.F., Molini, B.J.,
Wilton, D.C., Gelb, M.H., and Cho, W.H. (1997) "Mapping the Interfacial
Binding Surface of Human Secretory Group IIa Phospholipase A2,"
Biochemistry, 36, 14325-14333.
100.
Dudler, T., and Gelb, M.H. (1997) "Replacement of the H-Ras Farnesyl Group
by Lipid Analogs: Implication for Downstream Processing and Effector Activation
in Xenopus laevis Oocytes," Biochemistry, 36, 12434-12441.
101.
Goldstein, A.S., Lukyanov, A., Carlson, P.A., Yager, P., and Gelb, M.H. (1997)
"Formation of high-axial-ratio-microstructures from natural and synthetic
sphingolipids," Chemistry and Physics of Lipids, 88, 21-36.
102.
Carlson, P., Gelb, M. H., and Yager, P. (1997) Zero-order interfacial enzymic
degradation of phopholipid tubules, " Biophys. J., 73, 230-238.
103.
Börsch-Haubold, A.G., Bartoli, F., Asselin, J., Dudler, T., Kramer, R.M.,
Apitz-Castro, R., Watson, S.P., and Gelb, M.H. (1998) "Identification of
the Phosphorylation Sites of Cytosolic Phospholipase A2 in Agonist-stimulated
Human Platelets and HeLa Cells," J. Biol. Chem., 273: 4449-4458.
104.
Lin, Y., Nielsen, R., Murray, D., Hubbell, W. L., Mailer, C., Robinson, B.H.,
and Gelb, M.H. (1998) "Docking Phospholipase A2 on Membranes Using
Electrostatic Potential-Modulated Spin Relaxation Magnetic Resonance,"
Science, 279: 1925-1929.
105.
Sekar, K., Kumar, A., Liu, X., Tsai, M.-D., Gelb, M.H., and Sundaralingam, M.
(1998) "Structure of the Complex of Bovine Pancreatic Phospholipase A2
with a Transition-State Analogue," Acta Crystallogr D Biol Crystallogr, 54
( Pt 3): 334-341.
106.
Hixon, M.S., Ball, A., and Gelb, M.H. (1998) "Calcium-Dependent and
Indepedent Interfacial Biology and Catalysis of Group IV Phospholipase
A2," Biochemistry, 37 (23): 8516 –8526.
107.
Aronov, A.M. and Gelb, M.H. (1998) "Phthalimide Resin Reagent for
Efficient Mitsunobu Amino-Dehydroxylation," Tet. Lett., 39 (28) , pp.
4947-4950.
108.
Yokoyama, K.; Trobridge, P.; Buckner, F.S.; Scholten, J.; Stuart, K.D.; Van
Voorhis, W.C. and Gelb, M.H. (1998) "The effects of protein
farnesyltransferase inhibitors on trypanosomatids: inhibition of protein
farnesylation and cell growth," Molec. Biochem. Parasitol., 94 (1): 87-97.
109.
Ghomashchi, F., Lin, Y., Hixon, M.S., Yu, B.-Z., Annand, R., Jain, M.K., and
Gelb, M.H. (1998) "Interfacial Recognition by Bee Venom Phospholipase A2:
Insights into Non-Electrostatic Molecular Determinants by Charge Reversal
Mutagenesis," Biochemistry, 37, 6697-6710.
110.
Bernstein, B.E., Williams, D.M., Bressi, J.C., Kuhn, P., Gelb, M.H., Blackburn,
G.M., and Hol, W.G.J. (1998) "A Bisubstrate Analog Induces Unexpected
Conformational Changes in Phosphoglycerate Kinase from Trypanosoma
brucei.," J. Mol. Biol., 279 (5):1137-1148.
111.
Jang, G.-F. and Gelb, M. H. (1998) "Substrate Specificity of Mammalian
Prenyl Protein-Specific Endoprotease Activity," Biochemistry, 37,
4473-4481.
112.
Gelb, M. H., Scholten, J. P., and Sebolt-Leopold, J. S. (1998) "Protein
Prenylation: From Discovery to Prospects for Cancer Treatment," Curr. Opinion
Chem. Biol., 2(1): 40-48.
113.
Lee, K., Lukynov, A., Gelb, M.H., and Yager, P. (1998) "Formation of High
Axial Ratio Microstructures From Peptides Modified with Glutamic Acid
Dialkylamides," Biochim. Biophys. Acta, 1371 (2), 168-184.
114.
Koduri, R., Wilton, D.C., Cho, W., and Gelb, M. H. (1998) "Action of Human
Group IIa Secreted Phospholipase A2 on Cell Membranes," J. Biol. Chem.,
273, 48, 32142-32153.
115.
Lin, Y., Ghomashchi, F., Nielsen, R., Snitko, Y., Yu, B.-Z., Han, S. K., Cho,
W., Wilton, D.C., Jain, M. K., Robinson, B. H., and Gelb, M. H. (1998)
"Binding of Bee Venom and Human Group IIa Phospholipases A2 to Membranes:
A Minor Role for Electrostatics," Biochem. Soc. Trans., 26, 341-345.
116.
Yokoyama, K., Trobridge, P., Buckner, F.S., Van Voorhis, W.C., Stuart, K.D.,
and Gelb, M.H. (1998) "Protein Farnesyltransferase from Trypanosoma
Brucei: a Heterodimer of 61- and 65-kDa Subunits as a New Target for
Antiparasite Therapeutics," J. Biol. Chem, 273, 41: 26497-26505.
117.
Aronov, A.M., Verlinde, C.L.M.J., Hol, W.G.J., Gelb, M.H. (1998)
"Selective Tight Binding Inhibitors of Trypanosomal
Glyceraldehyde-3-phosphate Dehydrogenase via Structure-Based Drug Design
," J. Med. Chem,41, 4790-4799.
118.
Aronov, A.M., Gelb, M. H. (1998) "Synthesis and Structure-Activity
Relationships of Adenosine Analogs as Inhibitors of Trypanosomal
Glyceraldehyde-3-Phosphate Dehydrogenase: Modifications at Positions 5' and
8," Bioorg. Med. Chem. Lett., 8, 3505-3510.
119.
Gerber, S. A., Scott, C. R., Turecek, F., Gelb, M. H. (1999) "Analysis of
Rates of Multiple Enzymes in Cell Lysates by Electrospray Ionization Mass
Spectrometry," J. Am. Chem. Soc. , 121(8); 1762-1762.
120.
Stecher, H., Gelb, M. H., Saari, J. C., Palczewski, K. (1999)
"Preferential release of 11-cis-retinol from retinal pigment epithelial
cells in the presence of cellular retinaldehyde-binding protein," J. Biol.
Chem., 274: 8577-8585
121.
Han, S. K., Kim, K. P., Koduri, R., Bittova, L., Munoz, N. M., Leff, A. R.,
Wilton, D. C., Gelb, M. H., and Cho, W. (1999) "Role of Trp31 in High
Membrane Binding and Proinflammatory Activity of Human Group V Phospholipase
A2," J. Biol. Chem., 274: 11881-11888.
122.
Aronov, A., Suresh, S., Buckner, F., Van Voorhis, W. C., Verlinde, C.,
Opperdoes, F., Hol, W., and Gelb. M. H. (1999) "Structure-based Design of
Sub-Micromolar, Biologically Active Inhibitors of Trypanosomatid
Glyceraldehyde-3-phosphate Dehydrogenase," Proc. Natl. Acad. Sci., 96:
4273-4278.
123.
Bryant, M. D., Flick, K. E., Koduri, R. S., Wilton, D. C., Stoddard, B. L., and
Gelb, M. H. (1999) 1,3-Dioxane-4,6-Dione-5-Carboxyamide-Based Inhibitors of
Human Group IIA Phospholipases A2: X-ray Structure of the Complex and
Interfacial Selection of Inhibitors from a Structural Library. Bioorg. &
Med. Chem. Lett., 9, 1097-1102.
124.
Valentin, E., Koduri, R. S., Scimeca, J.-C., Carle, G., Gelb, M. H., and
Lambeau, G. (1999) "Cloning and Recombinant Expression of a Novel
Mouse-secreted Phospholipase A2," J. Biol. Chem. 274, 19152-19160.
125.
Ball, A., Nielsen, R., Gelb, M., and Robinson, B. (1999) Interfacial Membrane
Docking of Cytosolic Phospholipase A2 C2 Domain Using Electrostatic
Potential-Modulated Spin Relaxation Magnetic Resonance. Proc. Natl. Acad. Sci.,
96, 6637-6642.
126.
Gelb, M. Cho, W., and Wilton, D. C. (1999) "Interfacial Binding of
Secreted Phospholipases A2: More Than Electrostatics and a Major Role for
Tryptophan."Curr. Opin. Struct. Biol., 9, 428-432.
127.
Zhao, XY, Yokoyama, K, Whitten, ME, Huang, J., Gelb, MH, and Palczewski, K.
(1999) "Novel form of rhodopsin kinase from chicken retina and pineal
gland." FEBS Letters, 454 (1-2), 115-121.
128.
Gygi, S.P., Rist, B., Gerber, S.A., Turecek, F., Gelb, M.H., and Aebersold, R.
(1999) "Quantitative analysis of complex protein mixtures using isotype-coded
affinity tags." Nature Biotechnology, Vol. 17, 994-999.
129.
Buschbeck, M., Ghomashchi, F., Gelb, M. H., Watson, S. P., Börsch-Haubold, A.
G. (1999) "Stress Stimuli Increase Calcium-Induced Arachidonic Acid
Release Through Phosphorylation of Cytosolic Phospholipase A2." Biochem.
J. 344, 359-366.
130.
Ghomashchi, F., Loo, R., Balsinde, J., Bartoli, F., Apitz-Castro, R., Clark, J.
D., Dennis, E. A., Gelb, M. H. (1999) "Trifluoromethyl ketones and
fluoromethyl phosphosphonates as inhibitors of group IV and VI phospholipases
A2: Structure-function studies with purified enzymes and intact cells,"
Biochim. Biophys. Acta, 1420:45-56.
131.
Jung-Hyun Min, Mahendra K. Jain, Cheryl Wilder, Leland Paul, Rafael
Apitz-Castro, Daniel C. Aspleaf, and Michael H. Gelb (1999)
"Membrane-bound plasma platelet activating factor acetylhydrolase acts on
substrate in the aqueous phase," Biochemistry, vol 38, pp 12935-42.
132.
Lee, K. C., Carlson, P. A., Goldstein, A. S., Yager, P., Gelb, M. H. (1999)
"Protection of a Decapeptide from Proteolytic Cleavage by Lipidation and
Self-Assembly into High-Axial-Ratio Microstructures: A Kinetic and Structural
Study," Langmuir, 15(17); 5500-5508.
133.
Börsch-Haubold, A.G., Ghomashchi, F.G., Pasquet, S., Goedert, M., Cohen, P.,
Gelb, M.H. and Watson, S.P. (1999) "Phosphorylation of cytosolic
phospholipase A2 in platelets is mediated by multiple stress-activated protein
kinase pathways," Eur. J. Biochem., Oct. 1; 265(1): 195-203.
134.
Corsini, A., Farnsworth, S.S, McGeady, P., Gelb, M.H., and Glomset, J.A. (1999)
"Incorporation of radiolabeled prenyl alcohols and their analogs into
mammalian cell proteins. A useful tool for studying protein prenylation,"
Methods. Mol. Biol., 116: 125-144.
135.
Dudler, T. and Gelb, M.H. (1999) "Probing the role of H-Ras lipidation for
signaling functions in Xenopus laevis oocytes,"
Methods.
Mol. Biol., 116: 161-176.
136.
Valentin, E., Ghomashchi, F., Gelb, M,H., Lazdunski, M., and Lambeau, G. (2000)
"On the diversity of secreted phospholipases A2: cloning, tissue
distribution, and functional expression of two novel mouse group II
enzymes," J. Biol. Chem., 274: 31195-31202.
137.
Bezzine, S., Koduri, R.S, Valentin, E., Murakami, M., Kudo, I., Ghomashchi, F.,
Sadilek, M., Lambeau, G., and Gelb, M.H. (2000) "Exogenously Added Human
Group X Secreted Phospholipase A2 but Not the Group IB, IIA, and V Enzymes
Efficiently Release Arachidonic Acid from Adherent Mammalian Cells," J.
Biol. Chem., 275: 3179-3191.
138.
Whitten, M., Yokoyama, K., Schieltz, D., Ghomashchi, F., Lam, D., Yates, J. R.,
Palczewski, K., and Gelb, M.H. (2000) "Structural Analysis of Protein
Prenyl Groups and Associated C-Terminal Modifications," Meth. Enzymol.,
316 (B): 436-451.
139.
Gelb, M.H. and Kudo, I. (2000) "Inhibition of Phospholipase A2: Analysis
and Compounds."
Proteins,
Nucleic Acids and Enzymes, Apr;45(6 Suppl):1065-1071.
140.
Goldstein, A.S. and Gelb, M.H. (2000) "An Alternate Preparation of
Thioester Resin Linkers for Solid-Phase Synthesis of Peptide C-terminal
Thioacids," Tet. Lett., 41(16): 2797-2800.
141.
Valentin, E., Ghomashchi, F., and Gelb, M.H. (2000) "Novel human secreted
phospholipase A2 with homology to the group III bee venom enzyme," J.
Biol. Chem., 275(11): 7492-7496.
142.
Mounier, C.M., Luchetta, P., Lecut, C., Koduri, R.S., Faure, G., Lambeau, G.,
Valentin, E., Singer, A., Ghomashchi, F., Beguin, S., Gelb, M.H., and Bon, C.
(2000) "Basic residues of human group IIA phospholipase A2 are important
for binding to factor Xa and prothrombinase inhibition: comparison with other
mammalian secreted phospholipases A2," Eur. J. Biochem., 267:4960-4969.
143.
Enomoto, A., Murakami, M., Valentin, E., Lambeau, G., Gelb, M.H., and Kudo, I.
(2000) "Redundant and segregated functions of granule-associated
heparin-binding group II subfamily of secretory phospholipases A2 in the
regulation of degranulation and prostaglandin D2 synthesis in mast cells,"
J.
Immunol., 165:4007-4014.
144.
Golisade, A., Bressi, J.C., Van Calenbergh, S., Gelb, M. H., and Link, A.
(2000) "Polymer-assisted solution-phase synthesis of
2'-amido-2'-deoxyadenosine derivatives targeted at the NAD+-binding sites of
parasite enzymes," J. Comb. Chem., 2(5):537-544.
145.
Hefner, Y. J., Börsch-Haubold, A. G., Murakami, M., Pasquet, S., Wilde, J.,
Schieltz, D., Ghomashchi, F., Yates, J. R., Armstrong, G., Paterson, A., Cohen,
P, Fukunaga, R., Hunter, T., Kudo, I., Watson, S. P., and Gelb, M. H. (2000)
"Serine-727 Phosphorylation and Activation of Cytosolic Phospholipase A2
by a MNK1-Related Protein Kinase," J. Biol. Chem., 275:37542-37551.
146.
Cook, T.A., Ghomashchi, F., Gelb, M.H., Florio, S.K., and Beavo, J.A. (2000)
"Binding of the Delta Subunit to Rod Phosphodiesterase Catalytic Subunits
Requires Methylated, Prenylated C-Termini of the Catalytic Subunits,"
Biochemistry, 39(44):13516-13523.
147.
Gelb, M.H., Min, J., and Jain, M.K. (2000) "Do membrane-bound enzymes
access their substrates from the membrane or aqueous phase: interfacial versus
non-interfacial enzymes," Biochim. Biophys. Acta. 1488(1-2):20-27.
148.
Valentin, E., Singer, A.G., Ghomashchi, F., Lazdunski, M., Gelb, M.H., and
Lambeau, G. (2000) "Cloning and recombinant expression of human group
IIF-secreted phospholipase A2," Biochem. Biophys. Res. Commun., 279(1):223-228.
149.
Bressi, J.C., Choe, J., Hough, M.T., Buckner, F.S., Van Voorhis, W.C.,
Verlinde, C.L., Hol, W.G., and Gelb, M.H. (2000) "Adenosine analogues as
inhibitors of trypanosoma brucei phosphoglycerate kinase: elucidation of a
novel binding mode for a 2-amino-N6-substituted adenosine," J. Med. Chem.,
43(22):4135-4150.
150.
Gelb, M.H., Valentin, E., Ghomashchi, F., Lazdunski, M., and Lambeau, G. (2000)
"Cloning and recombinant expression of structurally novel human secreted
phospholipase A2," J. Biol. Chem., 275(51):39823-39826.
151.
Buckner, F.S., Yokoyama, K., Nguyen, L., Grewal, A., Erdjument-Bromage, H.,
Tempst, P., Strickland, C.L., Xiao, L., Van Voorhis, W.C., and Gelb, M.H.
(2000) "Cloning, heterologous expression, and distinct substrate specificity
of protein farnesyltransferase from trypanosoma brucei," J. Biol. Chem.,
275(29):21870-21876.
152.
Schadow, A., Scholz-Pedretti, K., Lambeau, G., Gelb, M.H., Furstenberger, G.,
Pfeilschifter, J., and Kaszkin, M. (2001) "Characterization of group X
phospholipase A2 as the major enzyme secreted by human keratinocytes and its
regulation by the phorbol ester TPA," J. Investig. Dermatol.,
116(1):31-39.
153.
Cook, T.A., Ghomashchi, F., Gelb, M.H., Florio, S.K., and Beavo, J.A. (2000)
"The delta subunit of type 6 phosphodiesterase reduces light-induced cGMP
hydrolysis in rod outer segments," J. Biol. Chem., 276:5248-5255.
154.
Kennedy, K. J., Bressi, J. C., and Gelb, M. H. (2000) "A disubstituted
NAD+ analogue is a nanomolar inhibitor of trypanosomal glyceraldehyde-3-phosphate
dehydrogenase," Bioorg. Med. Chem. Lett., 11(2):95-98.
155.
Gelb M.H., Valentin E., Ghomashchi F., Lazdunski M., Lambeau G. (2000)
"Cloning and recombinant expression of a structurally novel human secreted
phospholipase A2," J. Biol. Chem., 275:39823-39826.
II. Books, Chapters in Books, Monographs
1. Sligar, S., Besman, M., Gelb, M., Heimbrook, D. and Pearson, D. (1980)
"Occurrence and role of an Acyl-Peroxide Intermediate in Oxygen-Dependent
P-450 Hydroxylations" in Biochemistry, Biophysics and Regulation of
Cytochrome P-450 (Gustafsson, J-A et
al., eds.) Elsevier/North Holland
Biomedical Press, New York, pp.
379-382.
2. Sligar, S.G., Gelb, M.H. and Heimbrook, D.C. (1982) "Bioorganic
Studies of the P-450cam Reaction Mechanism" in Microsomes, Drug
Oxidations and Drug Toxicity (Sato, R. and
Kato, R., eds.) Wiley Interscience, New York, pp. 155.
3. Gelb, M.H., Toscano, W.H., Jr. and Sligar, S.G. (1982) "Preparation
and Properties of Manganese-Substituted Cytochrome P-450cam in Cytochrome
P-450", in Biochemistry Biophysics and Environmental Implications. (Hietanen, E. et al., eds.) Elsevier Biomedical Press, New York, pp.
573-580.
4. Gelb, M. H. (1998) "Phospholipase A2," in The RBI Handbook, 3rd Edition (Whatling, K. E., ed.), RBI, Natick,
MA, pp 150-153.
5. James, M.N.G., Sielecki, A.R., Murphy, M.E.P., and Gelb, M.H. (1988)
"Molecular Design of Renin Inhibitors" Miami, Bio/Technology Winter Symposium.
6. Gelb, M.H., Farnsworth, C.C., and Glomset, J.A. (1991) "Structural
Characterization of Prenylated Proteins," in Lipidation of Proteins: A
Practical Approach (Turner, A.J., ed.), IRL
Press, Oxford.
7. Gelb, M.H. (1994) "Prenylated Proteins," in Fundamentals of
Medical Cell Biology, JAI Press, in press.
8. Gelb, M.H., Jain, M.K., and Berg, O.G. (1997) "Principles of Inhibition
of Phospholipase A2 and Other Interfacial Enzymes," in Phospholipase A2
Basic and Clinical Aspects in Inflammatory Diseases (Progress in Surgery,
vol. 24) (Uhl, W., Nevalainen, T.J., Büchler, M.W., eds.), Karger, Basel.
9. Gelb, M.H., Dudler, T., and Liu, L. (1997) "Palmitoylation of
Protein," in Comprehensive Natural Products Chemistry (Barton, D., Nakanishi, K., and Meth-Cohn, O.,
eds.), Pergamon, New York.
10. Gelb, M.H., Yokoyama, K., McGeady, P., and Jang, G.-F. (1997)
"Prenylation of Proteins," in Comprehensive Natural Products
Chemistry (Barton, D., Nakanishi, K., and
Meth-Cohn, O., eds.), Pergamon, New York.
11. Dudler, T. and Gelb, M.H. (1998) "The Xenopus Oocyte System for Studying the Function of
Prenylated Proteins," in Lipidation of Proteins Protocols (Gelb, M.H., ed.), Humana Press, Totowa, NJ.
12. Corsini, A., Farnsworth, C.C., McGeady, P., Gelb, M.H., and Glomset,
J.A. (1999) "Incorporation of Radiolabeled Prenyl Alcohols and Their
Analogs into Mammalian Cell Proteins," in Methods in Molecular Biology, vol. 116: Protein Lipidation Protocols (Gelb, M.H., ed.), Humana Press Inc., Totowa, NJ.
13. Yokoyama, K. and Gelb, M. H. (1999) Protein Geranylgeranyltransferase-I.
The Enzymes,. (F. Tamanoi, Ed.).
Academic Press, San Diego, in press.
14. Gelb, M.H., Buckner, F.S., Yokoyama, K., Ohkanda, J., Hamilton, A.D.,
Nguyen, L., Sebti, S.M., and Van Voorhis, W.C. (1999). "Protein
Prenylation in Trypanosomatids: A New Piggy-Back Medicinal Chemistry Target for
the Development of Agents Against Tropical Diseases," Proceedings of
the COST-99 Meeting on Drugs Against Parasitic Diseases, Montpellier, France, May, 1999.
15. Dudler, T. and Gelb, M.H. (1999) "Probing the role of H-Ras
lipidation for signaling function in Xenopus laevis oocytes," in Methods
in Molecular Biology, Vol. 116, Humana
Press, Towtowa, NJ.
16. Buckner, F.S. and Gelb, M.H. (1999) "Anti-Malarial Drugs: An
exciting lead compound gives impetus to the challenge of clinical drug
development," the SCOPE Commentary, National Science Foundation.
17. Verlinde, C.L.M.J., Hannaert, V., Blonski, C., Willson, M., Périé, J.J.,
Fothergill-Gilmore, L.A., Opperdoes, F.R., Gelb, M.H., Hol, W.G.J., Michels,
P.A.M. (2000) "Glycolysis as a target for the design of new
anti-trypanosome drugs" in Drug Resistance Res., in press.
18. Gelb, M.H., Buckner, F.S., Yokoyama, K., Ohkanda, J., Hamilton, A.D.,
Nguyen, L., Rossi-Bergmann, B., Stuart, K.D., Sebti, S.M., and Van Voorhis,
W.C. (2000) "Protein Prenylation in Trypaonsomatids in Farnesyltransferase
Inhibitors in Cancer Therapy," eds. S.M. Sebti and A. Hamilton. Human
Press, Totowa, NJ.
19. Lambeau, G., Valentin, E., Koduri, R., Fenard, D., Doglio, A., Gelb, M.,
and Lazdunski, M. (2001) "On the Functional Diversity of Secreted
Phospholipases A2: Cloning of Novel Mammalian and HIV-1 Antiviral
Properties," in Advances in Prostaglandin and Leukotriene Research, eds.
B. Samuelsson, R. Paoletti, G.C. Folco, E. Granström and S. Nicosia, Kluwer
Academic Publishers, Boston, MA.
20. Gelb, M.H., Hefner, Y., Börsch-Haubold, A.G., and Watson, S.P. (2001)
Regulation of Cytosolic Phospholipase A2 by Phosphorylation," in Advances
in Prostaglandin and Leukotriene Research, eds. B. Samuelsson, R. Paoletti,
G.C. Folco, E. Granström and S. Nicosia, Kluwer Academic Publishers, Boston,
MA.
III. Patents
1. Abeles, R.H. and Gelb, M.H. (1985) "Fluorinated/Chlorinated
Peptides," GB2171103A
2. Abeles, R.H. and Gelb, M.H. (1986, 1989, 1990) "Novel Peptides and Peptide
Derivatives, Their Preparation and Use the Pharmaceutical Compositions
Containing Them," GB171103B, CH0672792A, FR2577557A1, FR2577557B1
3. Abeles, R.H. and Gelb, M.H. (1991) "Flourine and chlorine statine or
statone containing peptides and method of use," US5066643
4. Abeles, R.H. and Gelb, M.H. "Peptide, ihre herstellung und sie
enthaltende pharmazeutische zubereitung," December 29, 1989. CH0672792A
5. Abeles, R.H. and Gelb, M.H. "Peptiodes et derives peptidiques, leur
preparation, leur utilisation en therapeutique et compositions pharmaceutiques
les contenant," May 11, 1990. FR2577557B1
6. Yager, P., Gelb, M.H., Lukyanov, A.H, Goldstein, A.S. and Disis, M. L.
(1997, 1998, 2000, 2001) "Therapeutic Delivery Using Compounds
Self-Assembled into High Axial Ratio Microstructures," US6180114,
US5851536, EP1146855A1, AU1273897A1, AU0022158A5, WO0037046A1, WO9718840A2,
WO9718840A3, CA2355696AA
7. Aebersold, R. H., Gelb, M. H., Gygi, S. P., Scott, C. R., Turecek, F.,
Gerber, S. A. and Riste, B. (2000, 2001, 2002, 2003) "Rapid quantitative
analysis of proteins or protein function in complex mixtures,"
EP1329513A1, AU0755334B2, EP1105517A4, EP1105517A1, AU5691399A1, WO0011208A1
8. Windsor, W.T., Weber, P.C., Wang, J.J-S., Strickland, C.L., Njoroge,
F.G., Guzi, T., Girijavallabhan, V.M., Ferreira, J.A., Desai, J.A., Cooper,
A.B., and Gelb, M.H. (2001) "Treatment of Malaria with Farnesyl Protein
Transferase Inhibitors," U.S. Patent Application Serial No. 60/263,277
9. Abeles, R.H. and Gelb, M.H. "Fluorine and chlorine statine or
statone containing peptides and method of use," November 19, 1997.
US5066643
10. Yager, P., Gelb, M.H., Lukyanov, A.N., Goldstein, A.S. and Disis, M.L.
"Therapeutic delivery using compounds self-assembled into high axial ratio
microstructures," December 22, 1998. US5851536
11. Yager, P., Gelb, M.H., Lukyanov, A.N., Goldstein, A.S. and Disis, M.L.
"Therapeutic delivery using compounds self-assembled into high axial ratio
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