Chem 426 - Lecture schedule

Readings are from various web sites. Most journal articles can only be accessed from a University of Washington account.

Lecture schedule
Date	*Day*	Subject	Readings
March 31	M	Introduction - Validation	Anal. Chem. 1996;68:305A-309A
April 2	W	Statistics	Wikipedia - average Wikipedia - standard deviation Wikipedia - confidence interval Wikipedia - Regression analysis Wikipideia - detection limit
7	M	Absorbance & fluorescence	Invitrogen J. Chromatogr. 1989; 480:141-152 Nature Methods 2005; 2; 905-909
9	W	Fluorescence part II	Wikipedia Fluorscence Wikipedia Raman scatter
14	M	Electrophoresis of DNA	Wikipedia electrophoresis Nucleic acid review: Molecular Biology of the Cell
16	W	Hybridization arrays and methods	Science 1991; 251: 767-773 Nature 2005; 437: 1299-1320 Affymetrix Affymetrix overview Wikipedia stock options
21	M	Restriction digests & PCR	1978 Nobel press release 1980 Nobel lecture New England Biosystems: Overview & list Forensics The Innocence Project
23	W	Sanger DNA sequencing & bioinformatics	Nobel lecture 1980 Proc Natl Acad. Sci USA 1977; 73: 5463-5467 NCBI
28	M	Sequencing the human genome	Science 2001; 291: 1304-1351 Nature 2001; 409: 860-921 Angew. Chem. Int. Ed. 2000; 39: 4463-4468
30	W	Midterm I
May 5	M	Electrophoresis of proteins	Molecular Biology of the Cell Protein review: Molecular Biology of the Cell
7	W	Liquid chromatography	Wikipedia Library 4 Science
12	M	Mass spectrometry	Nobel Prize Presentation1958 Nobel Prize lecture 1989 Nobel Prize Presentation2002
14	W	Mass spectrometry & bioinformatics	ASMS ProteinProspector Nature Biotech 1999; 17: 676-682 Nature Biotech 1999; 17: 994-999
19	M	Post-translational modifications	Post-translational modifications Essentials of glycobiology 2004 Nobel Press release
21	W	Enzymes & enzyme chemistry	Wikipedia Chemical Society
26	M	Memorial Day - no class
28	W	Immunoassay	Molecular Biology of the cell
June 2	M	Flow cytometry	Science 1977; 198:149-157 Science 1990; 248: 73-76
4	W	Flow cytometry & fluorescence microscopy	Science 1977; 198:149-157 Wikipedia Science 1990; 248: 73-76
11	W	Midterm II 2:30-4:20 PM

Readings
Readings are taken from journals, books, and web sites. All are available on line, except the Journal of Chromatography paper discussed on April 2. Of course, URLs change. Please let me know if any links are broken.