AMIA Informatics 2008 Year in Review
A compendium of notable publications and events in the field of biomedical informatics, November 2007 - October 2008
by
Daniel Masys, M.D.
Professor and Chair
Dept. of Biomedical Informatics
Vanderbilt University School of Medicine
Presented here are the citations and events from the Year in Review session at the AMIA Symposium, Tuesday November 11, 2008 at 8:30, International Ballroom East in the Washington Hilton Hotel. 


Candidate new literature in Clinical Informatics
Topic Areas
Computerized Clinical Decision Support

For Providers
  1. Stevens J, Kelleher KJ, Gardner W, Chisolm D, McGeehan J, Pajer K, Buchanan L. Trial of computerized screening for adolescent behavioral concerns. Pediatrics. 2008 Jun;121(6):1099-105.
  2. Poller L, Keown M, Ibrahim S, Lowe G, et al.  An international multicenter randomized study of computer-assisted oral anticoagulant dosage vs. medical staff dosage. J Thromb Haemost. 2008 Jun;6(6):935-43.
  3. Matheny ME, Sequist TD, Seger AC, Fiskio JM, Sperling M, Bugbee D, Bates DW, Gandhi TK. A randomized trial of electronic clinical reminders to improve medication laboratory monitoring. J Am Med Inform Assoc. 2008 Jul-Aug;15(4):424-9. Epub 2008 Apr 24.
  4. Tamblyn R, Huang A, Taylor L, et al. A randomized trial of the effectiveness of on-demand versus computer-triggered drug decision support in primary care. J Am Med Inform Assoc. 2008 Jul-Aug;15(4):430-8. Epub 2008 Apr 24.
  5. Hicks LS, Sequist TD, Ayanian JZ, Shaykevich S, Fairchild DG, Orav EJ, Bates DW. Impact of computerized decision support on blood pressure management and control: a randomized controlled trial. J Gen Intern Med. 2008 Apr;23(4):429-41.
  6. Weber V, White A, McIlvried R. An electronic medical record (EMR)-based intervention to reduce polypharmacy and falls in an ambulatory rural elderly population. J Gen Intern Med. 2008 Apr;23(4):399-404.
  7. Love TE, Cebul RD, Einstadter D, Jain AK, Miller H, Harris CM, Greco PJ, Husak SS, Dawson NV; DIG-IT Investigators. Electronic medical record-assisted design of a cluster-randomized trial to improve diabetes care and outcomes. J Gen Intern Med. 2008 Apr;23(4):383-91.
  8. Persell SD, Denecke-Dattalo TA, Dunham DP, Baker DW. Patient-directed intervention versus clinician reminders alone to improve aspirin use in diabetes: a cluster randomized trial. Jt Comm J Qual Patient Saf. 2008 Feb;34(2):98-105.
  9. van Wyk JT, van Wijk MA, Sturkenboom MC, Mosseveld M, Moorman PW, van der Lei J. Electronic alerts versus on-demand decision support to improve dyslipidemia treatment: a cluster randomized controlled trial. Circulation. 2008 Jan 22;117(3):371-8. Epub 2008 Jan 2.
  10. Thomas KG, Thomas MR, Stroebel RJ, McDonald FS, Hanson GJ, Naessens JM, Huschka TR, Kolars JC. Use of a registry-generated audit, feedback, and patient reminder intervention in an internal medicine resident clinic--a randomized trial. J Gen Intern Med. 2007 Dec;22(12):1740-4. Epub 2007 Nov 1.
  11. Mulvaney SA, Bickman L, Giuse NB, Lambert EW, Sathe NA, Jerome RN. A randomized effectiveness trial of a clinical informatics consult service: impact on evidence-based decision-making and knowledge implementation. J Am Med Inform Assoc. 2008 Mar-Apr;15(2):203-11. Epub 2007 Dec 20.

For Patients
  1. Harari D, Iliffe S, Kharicha K, Egger M, Gillmann G, von Renteln-Kruse W, Beck J, Swift C, Stuck A. Promotion of health in older people: a randomised controlled trial of health risk appraisal in British general practice. Age Ageing. 2008 Sep;37(5):565-71
  2. Ten Wolde GB, Dijkstra A, van Empelen P, van den Hout W, Neven AK, Zitman F. Long-term effectiveness of computer-generated tailored patient education on benzodiazepines: a randomized controlled trial. Addiction. 2008 Apr;103(4):662-70.
  3. Kypri K, Langley JD, Saunders JB, Cashell-Smith ML, Herbison P. Randomized controlled trial of web-based alcohol screening and brief intervention in primary care. Arch Intern Med. 2008 Mar 10;168(5):530-6.
  4. Matheny ME, Gandhi TK, Orav EJ, Ladak-Merchant Z, Bates DW, Kuperman GJ, Poon EG. Impact of an automated test results management system on patients' satisfaction about test result communication. Arch Intern Med. 2007 Nov 12;167(20):2233-9.
  5. Priebe S, McCabe R, Bullenkamp J, et al. Structured patient-clinician communication and 1-year outcome in community mental healthcare: cluster randomised controlled trial. Br J Psychiatry. 2007 Nov;191:420-6.
Studies showing no statistically significant difference with CDSS intervention vs. alternatives
  1. Hansagi H, Olsson M, Hussain A, Ohlén G. Is information sharing between the emergency department and primary care useful to the care of frequent emergency department users? Eur J Emerg Med. 2008 Feb;15(1):34-9.
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Personal Health Records

  1. Grant RW, Wald JS, Schnipper JL, Gandhi TK, Poon EG, Orav EJ, Williams DH, Volk LA, Middleton B. Practice-linked online personal health records for type 2 diabetes mellitus: a randomized controlled trial.  Arch Intern Med. 2008 Sep 8;168(16):1776-82.

Telemedicine
  1. Meyer BC, Raman R, Hemmen T, Obler R, Zivin JA, Rao R, Thomas RG, Lyden PD. Efficacy of site-independent telemedicine in the STRokE DOC trial: a randomised, blinded, prospective study.  Lancet Neurol. 2008 Sep;7(9):787-95.
  2. Dansky KH, Vasey J, Bowles K. Impact of telehealth on clinical outcomes in patients with heart failure. Clin Nurs Res. 2008 Aug;17(3):182-99.
  3. Leimig R, Gower G, Thompson DA, Winsett RP.  Infection, rejection, and hospitalizations in transplant recipients using telehealth. Prog Transplant. 2008 Jun;18(2):97-102.
  4. Green BB, Cook AJ, Ralston JD, Fishman PA, Catz SL, Carlson J, Carrell D, Tyll L, Larson EB, Thompson RS. Effectiveness of home blood pressure monitoring, Web communication, and pharmacist care on hypertension control: a randomized controlled trial. JAMA. 2008 Jun 25;299(24):2857-67.
  5. Santamore WP, Homko CJ, Kashem A, McConnell TR, Menapace FJ, Bove AA. Accuracy of blood pressure measurements transmitted through a telemedicine system in underserved populations. Telemed J E Health. 2008 May;14(4):333-8.
  6. Madsen LB, Kirkegaard P, Pedersen EB. Blood pressure control during telemonitoring of home blood pressure. A randomized controlled trial during 6 months. Blood Press. 2008;17(2):78-86.
  7. Shea S; IDEATel Consortium. The Informatics for Diabetes and Education Telemedicine (IDEATel) project. Trans Am Clin Climatol Assoc. 2007;118:289-304.
  8. Waldmann A, Katalinic A, Schwaab B, Richardt G, Sheikhzadeh A, Raspe H. The TeleGuard trial of additional telemedicine care in CAD patients. 2 Morbidity and mortality after 12 months. J Telemed Telecare. 2008;14(1):22-6.  (See also The TeleGuard trial of additional telemedicine care in CAD patients. 1 Utilization of the system. by the same authors)
  9. Ellison LM, Nguyen M, Fabrizio MD, Soh A, Permpongkosol S, Kavoussi LR. Postoperative robotic telerounding: a multicenter randomized assessment of patient outcomes and satisfaction. Arch Surg. 2007 Dec;142(12):1177-81; discussion 1181.
  10. Varma N. Rationale and design of a prospective study of the efficacy of a remote monitoring system used in implantable cardioverter defibrillator follow-up: the Lumos-T Reduces Routine Office Device Follow-Up Study (TRUST) study. Am Heart J. 2007 Dec;154(6):1029-34. Epub 2007 Sep 27.
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The Practice of Informatics
  1. Bereznicki BJ, Peterson GM, Jackson SL, Walters EH, Fitzmaurice KD, Gee PR. Data-mining of medication records to improve asthma management. Med J Aust. 2008 Jul 7;189(1):21-5.
  2. Meystre SM, Haug PJ. Randomized controlled trial of an automated problem list with improved sensitivity. Int J Med Inform. 2008 Sep;77(9):602-12. Epub 2008 Feb 15.
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Candidate new literature in Bioinformatics
Topic Areas
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Human health and disease
  1. Castellanos-Rubio A, Martin-Pagola A, Santín I, Hualde I, Aransay AM, Castaño L, Vitoria JC, Bilbao JR.  Combined functional and positional gene information for the identification of susceptibility variants in celiac disease. Gastroenterology. 2008 Mar;134(3):738-46. Epub 2007 Nov 28.
  2. Cooper GM, Johnson JA, Langaee TY, et al.  A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. Blood. 2008 Aug 15;112(4):1022-7. Epub 2008 Jun 5.
  3. Uhl GR, Liu QR, Drgon T, Johnson C, Walther D, Rose JE, David SP, Niaura R, Lerman C. Molecular genetics of successful smoking cessation: convergent genome-wide association study results. Arch Gen Psychiatry. 2008 Jun;65(6):683-93.

Model systems for understanding biology
  1. Tagkopoulos I, Liu YC, Tavazoie S. Predictive behavior within microbial genetic networks. Science. 2008 Jun 6;320(5881):1313-7. Epub 2008 May 8.
  2. Isalan M, Lemerle C, Michalodimitrakis K, Horn C, Beltrao P, Raineri E, Garriga-Canut M, Serrano L. Evolvability and hierarchy in rewired bacterial gene networks. Nature. 2008 Apr 17;452(7189):840-5.

The practice of bioinformatics
  1. Chaussabel D, Quinn C, Shen J, Patel P et al.  A modular analysis framework for blood genomics studies: application to systemic lupus erythematosus. Immunity. 2008 Jul;29(1):150-64.

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Notable Events

#10 – Personal Genome Project data available, October 2008
 #9 – ONC Strategic Plan published
 #8 – Massachusetts joins Nevada in requiring encryption of  person identifiable data
 #7 – Exchange of clinical data using HITSP standards orchestrated by ONC, Sept 23.2008
 #6 – AMIA organizes Rockefeller Global eHealth conference
 #5 - CMS Medicare Improvements Act of 2008 pays more for e-prescribing
 #4 – Explosion of molecular data
 #3 -  FDA Sentinel Initiative launched
 #2 – NIH Public Access policy becomes mandatory
 #1 – Obama wins Presidency on platform including $50B for EMR infrastructure
 

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Search methodology used to identify potentially high impact literature


Many thanks to Rebecca Jerome, MLS for developing and iteratively refining search profiles for both clinical and bioinformatics for publications with Entrez date Nov 2007 – Oct 2008.

Clinical informatics searching methods: 

  • Clinical trials that included > 100 patients or providers, and those which appear to have the potential for significant clinical impact, e.g. the carvedilol study)
  • Primary PubMed search string:  randomized controlled trial[ptyp] AND (telemedicine[mh] OR informatics[tiab] OR medical informatics[mh])
  • Secondary PubMed search string: randomized[ti] AND (telemedicine[mh] OR informatics[tiab] OR medical informatics[mh])
  • Follow-up with examination of editorials from JAMIA and news sites (e.g. Reuters) to identify 2-3 additional studies

 Computational biology searching methods:

  • Primary PubMed search string: computational biology[mh] NOT (review[pt] OR letter[pt] OR case reports[pt] OR editorial[pt])
  • Also (genomic[ti] OR genome[ti] OR bioinformatic*[ti]), limited to the core clinical journals.
  • Secondary PubMed search string: computational biology[mh] AND (letter[pt] OR editorial[pt])
  • To see which articles were generating more discussion, follow-up with consideration of key science blogs and news sites
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