• Selected high impact publications in Clinical Informatics, November 2006 - October 2007
  
• Selected high impact publications in Bioinformatics, November 2006 - October 2007
• Notable Events since the last AMIA Symposium
• Search methodology used to identify literature
• PowerPoint slides used at the session
• Links to other Year in Review sessions
  

• Unintended Consequences of Technology
  
• Computerized Clinical Decision Support
• Telemedicine
• The Practice of Informatics
  

1. Linder JA, Ma J, Bates DW, Middleton B, Stafford RS. Electronic health record use and the quality of ambulatory care in the United States.
   Arch Intern Med. 2007 Jul 9;167(13):1400-5.

1. Raebel MA, Charles J, Dugan J, Carroll NM, Korner EJ, Brand DW, Magid DJ. Randomized trial to improve prescribing safety in ambulatory elderly patients.
   J Am Geriatr Soc. 2007 Jul;55(7):977-85.
2. Raebel MA, Carroll NM, Kelleher JA, Chester EA, Berga S, Magid DJ. Randomized trial to improve prescribing safety during pregnancy.
   J Am Med Inform Assoc. 2007 Jul-Aug;14(4):440-50. Epub 2007 Apr 25.
3. Unrod M, Smith M, Spring B, DePue J, Redd W, Winkel G. Randomized controlled trial of a computer-based, tailored intervention to increase smoking cessation counseling by primary care physicians. J Gen Intern Med. 2007 Apr;22(4):478-84.
4. Wadland WC, Holtrop JS, Weismantel D, Pathak PK, Fadel H, Powell J. Practice-based referrals to a tobacco cessation quit line: assessing the impact of comparative feedback vs general reminders. Ann Fam Med. 2007 Mar-Apr;5(2):135-42.
5. Bentz CJ, Bayley KB, Bonin KE, Fleming L, Hollis JF, Hunt JS, LeBlanc B, McAfee T, Payne N, Siemienczuk J. Provider feedback to improve 5A's tobacco cessation in primary care: a cluster randomized clinical trial.
   Nicotine Tob Res. 2007 Mar;9(3):341-9.
6. Chaudhry R, Scheitel SM, McMurtry EK, Leutink DJ, Cabanela RL, Naessens JM, Rahman AS, Davis LA, Stroebel RJ. Web-based proactive system to improve breast cancer screening: a randomized controlled trial. Arch Intern Med. 2007 Mar 26;167(6):606-11.
7. Bailey TC, Noirot LA, Blickensderfer A, Rachmiel E, Schaiff R, Kessels A, Braverman A, Goldberg A, Waterman B, Dunagan WC. An intervention to improve secondary prevention of coronary heart disease. Arch Intern Med. 2007 Mar 26;167(6):586-90.
8. Rothschild JM, McGurk S, Honour M, Lu L, McClendon AA, Srivastava P, Churchill WH, Kaufman RM, Avorn J, Cook EF, Bates DW. Assessment of education and computerized decision support interventions for improving transfusion practice.
   Transfusion. 2007 Feb;47(2):228-39.
9. Kheterpal S, Gupta R, Blum JM, Tremper KK, O'Reilly M, Kazanjian PE. Electronic reminders improve procedure documentation compliance and professional fee reimbursement.
   Anesth Analg. 2007 Mar;104(3):592-7.

1. Thomson RG, Eccles MP, Steen IN, Greenaway J, Stobbart L, Murtagh MJ, May CR. A patient decision aid to support shared decision-making on anti-thrombotic treatment of patients with atrial fibrillation: randomised controlled trial. Qual Saf Health Care. 2007 Jun;16(3):216-23.
2. Saitz R, Palfai TP, Freedner N, Winter MR, Macdonald A, Lu J, Ozonoff A, Rosenbloom DL, Dejong W. Screening and brief intervention online for college students: the ihealth study.
   Alcohol Alcohol. 2007 Jan-Feb;42(1):28-36. Epub 2006 Nov 26.
3. Cintron A, Phillips R, Hamel MB. The effect of a web-based, patient-directed intervention on knowledge, discussion, and completion of a health care proxy.
   J Palliat Med. 2006 Dec;9(6):1320-8.
4. Strecher VJ, Shiffman S, West R. Moderators and mediators of a web-based computer-tailored smoking cessation program among nicotine patch users.
   Nicotine Tob Res. 2006 Dec;8 Suppl 1:S95-101.
5. Japuntich SJ, Zehner ME, Smith SS, Jorenby DE, Valdez JA, Fiore MC, Baker TB, Gustafson DH. Smoking cessation via the internet: a randomized clinical trial of an internet intervention as adjuvant treatment in a smoking cessation intervention.
   Nicotine Tob Res. 2006 Dec;8 Suppl 1:S59-67.

1. Curtis JR, Westfall AO, Allison J, Becker A, Melton ME, Freeman A, Kiefe CI, MacArthur M, Ockershausen T, Stewart E, Weissman N, Saag KG. Challenges in improving the quality of osteoporosis care for long-term glucocorticoid users: a prospective randomized trial. Arch Intern Med. 2007 Mar 26;167(6):591-6.
2. Glassman PA, Belperio P, Lanto A, Simon B, Valuck R, Sayers J, Lee M. The utility of adding retrospective medication profiling to computerized provider order entry in an ambulatory care population. J Am Med Inform Assoc. 2007 Jul-Aug;14(4):424-31. Epub 2007 Apr 25.
3. Schapira MM, Gilligan MA, McAuliffe T, Garmon G, Carnes M, Nattinger AB. Decision-making at menopause: a randomized controlled trial of a computer-based hormone therapy decision-aid. Patient Educ Couns. 2007 Jul;67(1-2):100-7. Epub 2007 Apr 2.
4. Tuil WS, Verhaak CM, Braat DD, de Vries Robbe PF, Kremer JA. Empowering patients undergoing in vitro fertilization by providing Internet access to medical data.
   Fertil Steril. 2007 Aug;88(2):361-8. Epub 2007 Apr 9.

1. Artinian NT, Flack JM, Nordstrom CK, Hockman EM, Washington OG, Jen KL, Fathy M. Effects of nurse-managed telemonitoring on blood pressure at 12-month follow-up among urban African Americans. Nurs Res. 2007 Sep-Oct;56(5):312-22.
2. Fortney JC, Pyne JM, Edlund MJ, Williams DK, Robinson DE, Mittal D, Henderson KL. A randomized trial of telemedicine-based collaborative care for depression.
   J Gen Intern Med. 2007 Aug;22(8):1086-93. Epub 2007 May 10.
3. O'Reilly R, Bishop J, Maddox K, Hutchinson L, Fisman M, Takhar J. Is telepsychiatry equivalent to face-to-face psychiatry? Results from a randomized controlled equivalence trial. Psychiatr Serv. 2007 Jun;58(6):836-43.
4. Jan RL, Wang JY, Huang MC, Tseng SM, Su HJ, Liu LF. An internet-based interactive telemonitoring system for improving childhood asthma outcomes in Taiwan.
   Telemed J E Health. 2007 Jun;13(3):257-68.
5. Chan DS, Callahan CW, Hatch-Pigott VB, Lawless A, Proffitt HL, Manning NE, Schweikert M, Malone FJ. Internet-based home monitoring and education of children with asthma is comparable to ideal office-based care: results of a 1-year asthma in-home monitoring trial.
6. Whitten P, Mickus M. Home telecare for COPD/CHF patients: outcomes and perceptions.
   J Telemed Telecare. 2007;13(2):69-73.
   Pediatrics. 2007 Mar;119(3):569-78. 
7. Trief PM, Teresi JA, Izquierdo R, Morin PC, Goland R, Field L, Eimicke JP, Brittain R, Starren J, Shea S, Weinstock RS. Psychosocial outcomes of telemedicine case management for elderly patients with diabetes: the randomized IDEATel trial.
   Diabetes Care. 2007 May;30(5):1266-8. Epub 2007 Feb 26. No abstract available.
8. Tudiver F, Wolff LT, Morin PC, Teresi J, Palmas W, Starren J, Shea S, Weinstock RS. Primary care providers' perceptions of home diabetes telemedicine care in the IDEATel project.
   J Rural Health. 2007 Winter;23(1):55-61.
9. Pak H, Triplett CA, Lindquist JH, Grambow SC, Whited JD. Store-and-forward teledermatology results in similar clinical outcomes to conventional clinic-based care.
   J Telemed Telecare. 2007;13(1):26-30.
10. Livingston P, White V, Hayman J, Hill D. How acceptable is a referral and telephone-based outcall programme for men diagnosed with cancer? A feasibility study.
    Eur J Cancer Care (Engl). 2006 Dec;15(5):467-75.
11. Mittag O, China C, Hoberg E, Juers E, Kolenda KD, Richardt G, Maurischat C, Raspe H. Outcomes of cardiac rehabilitation with versus without a follow-up intervention rendered by telephone (Luebeck follow-up trial): overall and gender-specific effects.
    Int J Rehabil Res. 2006 Dec;29(4):295-302.
12. Conlin PR, Fisch BM, Cavallerano AA, Cavallerano JD, Bursell SE, Aiello LM. Nonmydriatic teleretinal imaging improves adherence to annual eye examinations in patients with diabetes.
    J Rehabil Res Dev. 2006 Sep-Oct;43(6):733-40.

1. Beebe TJ, Locke GR 3rd, Barnes SA, Davern ME, Anderson KJ. Mixing web and mail methods in a survey of physicians. Health Serv Res. 2007 Jun;42(3 Pt 1):1219-34.
2. Bates BR, Romina SM, Ahmed R. The effect of improved readability scores on consumers' perceptions of the quality of health information on the internet.
   J Cancer Educ. 2007 Spring;22(1):15-20.
3. Tideman RL, Chen MY, Pitts MK, Ginige S, Slaney M, Fairley CK. A randomised controlled trial comparing computer-assisted with face-to-face sexual history taking in a clinical setting.
   Sex Transm Infect. 2007 Feb;83(1):52-6. Epub 2006 Nov 10.
4. Schneider SM, Hood LE. Virtual reality: a distraction intervention for chemotherapy.
   Oncol Nurs Forum. 2007 Jan;34(1):39-46.
5. Roumie CL, Elasy TA, Wallston KA, Pratt S, Greevy RA, Liu X, Alvarez V, Dittus RS, Speroff T. Clinical inertia: a common barrier to changing provider prescribing behavior.
   Jt Comm J Qual Patient Saf. 2007 May;33(5):277-85.

• Human health and disease
• Model systems for understanding biology
  
• The practice of bioinformatics
  

1. The Wellcome Trust Case Control Consortium.  Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.
   Nature 447, 661-678 (7 June 2007) | doi:10.1038/nature05911; Received 26 March 2007; Accepted 11 May 2007
2. Estivill X, Armengol L. Copy number variants and common disorders: filling the gaps and exploring complexity in genome-wide association studies.
   PLoS Genet. 2007 Oct 19;3(10):e190.
3. Levy S, Sutton G, Ng PC, Feuk L, Halpern AL, et al. (2007) The Diploid Genome Sequence of an Individual Human. PLoS Biol 5(10): e254 doi:10.1371/journal.pbio.0050254
4. Cordon-Cardo C, Kotsianti A, Verbel DA, Teverovskiy M, Capodieci P, Hamann S, Jeffers Y, Clayton M, Elkhettabi F, Khan FM, Sapir M, Bayer-Zubek V, Vengrenyuk Y, Fogarsi S, Saidi O, Reuter VE, Scher HI, Kattan MW, Bianco FJ, Wheeler TM, Ayala GE, Scardino PT, Donovan MJ Improved prediction of prostate cancer recurrence through systems pathology.
   J Clin Invest. 2007 Jul;117(7):1876-83.

1.  Moore DF, Gelderman MP, Ferreira PA, Fuhrmann SR, Yi H, Elkahloun A, Lix LM, Brady RO, Schiffmann R, Goldin E. Genomic abnormalities of the murine model of Fabry disease after disease-related perturbation, a systems biology approach.
   Proc Natl Acad Sci U S A. 2007 May 8;104(19):8065-70. Epub 2007 Apr 30.

1. Duarte NC, Becker SA, Jamshidi N, Thiele I, Mo ML, Vo TD, Srivas R, Palsson BO. Global reconstruction of the human metabolic network based on genomic and bibliomic data.
   Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):1777-82. Epub 2007 Jan 31.
2. Edwards RJ, Moran N, Devocelle M, Kiernan A, Meade G, Signac W, Foy M, Park SD, Dunne E, Kenny D, Shields DC. Bioinformatic discovery of novel bioactive peptides.
   Nat Chem Biol. 2007 Feb;3(2):108-12. Epub 2007 Jan 14.
3. Shen J, Zhang J, Luo X, Zhu W, Yu K, Chen K, Li Y, Jiang H. Predicting protein-protein interactions based only on sequences information.
   Proc Natl Acad Sci U S A. 2007 Mar 13;104(11):4337-41. Epub 2007 Mar 5.
4. Bandeira N, Tsur D, Frank A, Pevzner PA. Protein identification by spectral networks analysis.
   Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6140-5. Epub 2007 Apr 2.
5. Lim WK, Wang K, Lefebvre C, Califano A. Comparative analysis of microarray normalization procedures: effects on reverse engineering gene networks.
   Bioinformatics. 2007 Jul 1;23(13):i282-8.
   

1. October 30, 2007.  CMS provides financial incentives to small practices to adopt electronic medical records.
2. September 4, 2007.  Publication of J. Craig Venter's complete DNA sequence.
   
3. September 5, 2007.  Office of National Coordinator begins plan to transition American Health Information Community to the private sector.
   
4. October 5, 2007.  Microsoft launches HealthVault PHR, Google follows on October 17. `
   
5. December, 2006 Legislation
   
6. January - October 2007.  AMIA wins visibility, credibility, funding on national landscape.
7. September 30, 2007.  NIH redefines scope of CTSA program with increasing numbers of awards but decreased budgets.
8. December 2006.  Legislation mandates reporting of clinical trial results in Clinicaltrials.gov
   

Many thanks to Rebecca Jerome, MLS for developing and iteratively refining search profiles for both clinical and bioinformatics, and to Yin Aphinyanaphongs and his faculty mentors, whose Evidence Based Medicine search engine* for identifying high quality literature was applied to articles indexed by the MeSH heading 'Medical Informatics' and its child terms, for publications with Entrez date Nov 2006 – Oct 2007,

Clinical informatics searching methods: 

• Clinical trials that included > 100 patients or providers, and those which appear to have the potential for significant clinical impact, e.g. the carvedilol study)
• Primary PubMed search string:  randomized controlled trial[ptyp] AND (telemedicine[mh] OR informatics[tiab] OR medical informatics[mh])
• Secondary PubMed search string: randomized[ti] AND (telemedicine[mh] OR informatics[tiab] OR medical informatics[mh])
• Follow-up with examination of editorials from JAMIA and news sites (e.g. Reuters) to identify 2-3 additional studies

 Computational biology searching methods:

• Primary PubMed search string: computational biology[mh] NOT (review[pt] OR letter[pt] OR case reports[pt] OR editorial[pt])
• Secondary PubMed search string: computational biology[mh] AND (letter[pt] OR editorial[pt])
• To see which articles were generating more discussion, follow-up with consideration of key science blogs and news sites