AMIA Informatics 2006 Year in Review
A compendium of notable publications and events in the field of biomedical informatics, November 2005 - October 2006
Daniel Masys, M.D.
Professor and Chair
Dept. of Biomedical Informatics
Vanderbilt University School of Medicine

Presented here are the citations discussed at the Year in Review session at the AMIA Symposium, Tuesday morning November 14, 2006 at 8:30

Candidate new literature in Clinical Informatics
Topic Areas
Unintended Consequences of Technology

  1. Han YY, Carcillo JA, Venkataraman ST, Clark RS, Watson RS, Nguyen TC, Bayir H, Orr RA. Unexpected increased mortality after implementation of a commercially sold computerized physician order entry system.  Pediatrics. 2005 Dec;116(6):1506-12.

Computerized Clinical Decision Support

  1. Feldstein AC, Smith DH, Perrin N, Yang X, Simon SR, Krall M, Sittig DF, Ditmer D, Platt R, Soumerai SB.  Reducing warfarin medication interactions: an interrupted time series evaluation. Arch Intern Med. 2006 May 8;166(9):1009-15.  PMID: 16682575
  2. Feldstein A, Elmer PJ, Smith DH, Herson M, Orwoll E, Chen C, Aickin M, Swain MC. Electronic medical record reminder improves osteoporosis management after a fracture: a randomized, controlled trial. J Am Geriatr Soc. 2006 Mar;54(3):450-7. PMID: 16551312
  3. Lester WT, Grant RW, Barnett GO, Chueh HC. Randomized controlled trial of an informatics-based intervention to increase statin prescription for secondary prevention of coronary disease. J Gen Intern Med. 2006 Jan;21(1):22-9. PMID: 16423119
  4. Roumie CL, Elasy TA, Greevy R, Griffin MR, Liu X, Stone WJ, Wallston KA, Dittus RS, Alvarez V, Cobb J, Speroff T.  Improving blood pressure control through provider education, provider alerts, and patient education: a cluster randomized trial. Ann Intern Med. 2006 Aug 1;145(3):165-75. PMID: 16880458
  5. Thomas RE, Croal BL, Ramsay C, Eccles M, Grimshaw J. Effect of enhanced feedback and brief educational reminder messages on laboratory test requesting in primary care: a cluster randomised trial. Lancet. 2006 Jun 17;367(9527):1990-6. PMID: 16782489
  6. Simon SR, Smith DH, Feldstein AC, Perrin N, Yang X, Zhou Y, Platt R, Soumerai SB. Computerized prescribing alerts and group academic detailing to reduce the use of potentially inappropriate medications in older people. J Am Geriatr Soc. 2006 Jun;54(6):963-8. PMID: 16776793
  7. Berner ES, Houston TK, Ray MN, Allison JJ, Heudebert GR, Chatham WW, Kennedy JI Jr, Glandon GL, Norton PA, Crawford MA, Maisiak RS. Improving ambulatory prescribing safety with a handheld decision support system: a randomized controlled trial. J Am Med Inform Assoc. 2006 Mar-Apr;13(2):171-9. Epub 2005 Dec 15. PMID: 16357350
  8. Finckh A, de Pablo P, Katz JN, Neumann G, Lu Y, Wolfe F, Duryea J. Performance of an automated computer-based scoring method to assess joint space narrowing in rheumatoid arthritis: a longitudinal study. Arthritis Rheum. 2006 May;54(5):1444-50. PMID: 16645974
  9. McGregor JC, Weekes E, Forrest GN, Standiford HC, Perencevich EN, Furuno JP, Harris AD. Impact of a computerized clinical decision support system on reducing inappropriate antimicrobial use: a randomized controlled trial. J Am Med Inform Assoc. 2006 Jul-Aug;13(4):378-84. Epub 2006 Apr 18.  PMID: 16622162
  10. Alper BS, White DS, Ge B. Physicians answer more clinical questions and change clinical decisions more often with synthesized evidence: a randomized trial in primary care. Ann Fam Med. 2005 Nov-Dec;3(6):507-13.  PMID: 16338914
Studies showing no statistically significant difference with CDSS intervention vs. alternatives

  1. Palen TE, Raebel M, Lyons E, Magid DM. Evaluation of laboratory monitoring alerts within a computerized physician order entry system for medication orders. Am J Manag Care. 2006 Jul;12(7):389-95. PMID: 16834525
  2. LaPointe NM, DeLong ER, Chen A, Hammill BG, Muhlbaier LH, Califf RM, Kramer JM. Multifaceted intervention to promote beta-blocker use in heart failure.
    Am Heart J. 2006 May;151(5):992-8. PMID: 16644320
  3. Trief PM, Morin PC, Izquierdo R, Teresi J, Eimicke JP, Goland R, Starren J, Shea S, Weinstock RS. Depression and glycemic control in elderly ethnically diverse patients with diabetes: the IDEATel project. Diabetes Care. 2006 Apr;29(4):830-5. PMID: 16567823

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  1. McConnochie KM, Conners GP, Brayer AF, Goepp J, Herendeen NE, Wood NE, Thomas A, Ahn DS, Roghmann KJ. Differences in diagnosis and treatment using telemedicine versus in-person evaluation of acute illness.  Ambul Pediatr. 2006 Jul-Aug;6(4):187-95; discussion 196-7. PMID: 16843248
  2. De Las Cuevas C, Arredondo MT, Cabrera MF, Sulzenbacher H, Meise U. Randomized clinical trial of telepsychiatry through videoconference versus face-to-face conventional psychiatric treatment. Telemed J E Health. 2006 Jun;12(3):341-50. PMID: 16796502
  3. Frangou S, Sachpazidis I, Stassinakis A, Sakas G. Telemonitoring of medication adherence in patients with schizophrenia.
    Telemed J E Health. 2005 Dec;11(6):675-83. PMID: 16430387
  4. Andersson G, Bergstrom J, Hollandare F, Carlbring P, Kaldo V, Ekselius L. Internet-based self-help for depression: randomised controlled trial.
    Br J Psychiatry. 2005 Nov;187:456-61. PMID: 16260822 
  5. Wong HT, Poon WS, Jacobs P, Goh KY, Leung CH, Lau FL, Kwok S, Ng S, Chow L.  The comparative impact of video consultation on emergency neurosurgical referrals. Neurosurgery. 2006 Sep;59(3):607-13; discussion 607-13. PMID: 16955042
  6. Fortney JC, Pyne JM, Edlund MJ, Robinson DE, Mittal D, Henderson KL. Design and implementation of the telemedicine-enhanced antidepressant management study.Gen Hosp Psychiatry. 2006 Jan-Feb;28(1):18-26. PMID: 16377361
  7. Spaeder J, Najjar SS, Gerstenblith G, Hefter G, Kern L, Palmer JG, Gottlieb SH, Kasper EK. Rapid titration of carvedilol in patients with congestive heart failure: a randomized trial of automated telemedicine versus frequent outpatient clinic visits. Am Heart J. 2006 Apr;151(4):844.e1-10. PMID: 16569544

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Health Professions Education
  1. Schilling K, Wiecha J, Polineni D, Khalil S. An interactive web-based curriculum on evidence-based medicine: design and effectiveness.
    Fam Med. 2006 Feb;38(2):126-32.  PMID: 16450235 [PubMed - indexed for MEDLINE]
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The Practice of Informatics

  1. Kaushal R, Jha AK, Franz C, Glaser J, Shetty KD, Jaggi T, Middleton B, Kuperman GJ, Khorasani R, Tanasijevic M, Bates DW.  Return on investment for a computerized physician order entry system.  J Am Med Inform Assoc 2006;13:261-266.
  2. Litchfield J, Freeman J, Schou H, Elsley M, Fuller R, Chubb B. Is the future for clinical trials internet-based? A cluster randomized clinical trial.
    Clin Trials. 2005;2(1):72-9. PMID: 16279581 [PubMed - indexed for MEDLINE]
  3. Kozer E, Scolnik D, MacPherson A, Rauchwerger D, Koren G. Using a preprinted order sheet to reduce prescription errors in a pediatric emergency department: a randomized, controlled trial. Pediatrics. 2005 Dec;116(6):1299-302.  PMID: 16322150 [PubMed - indexed for MEDLINE
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Candidate new literature in Bioinformatics
Topic Areas
Human health and disease
  1. Sjoblom T, Jones S, Wood LD, Parsons DW, Lin J, Barber TD, Mandelker D, Leary RJ, Ptak J, Silliman N, Szabo S, Buckhaults P, Farrell C, Meeh P, Markowitz SD, Willis J, Dawson D, Willson JK, Gazdar AF, Hartigan J, Wu L, Liu C, Parmigiani G, Park BH, Bachman KE, Papadopoulos N, Vogelstein B, Kinzler KW, Velculescu VE.  The consensus coding sequences of human breast and colorectal cancers. Science. 2006 Oct 13;314(5797):268-74. Epub 2006 Sep 7.
  2. Tiffin N, Adie E, Turner F, Brunner HG, van Driel MA, Oti M, Lopez-Bigas N, Ouzounis C, Perez-Iratxeta C, Andrade-Navarro MA, Adeyemo A, Patti ME, Semple CA, Hide W. Computational disease gene identification: a concert of methods prioritizes type 2 diabetes and obesity candidate genes.
    Nucleic Acids Res. 2006 Jun 6;34(10):3067-81. Print 2006. PMID: 16757574
  3. Fabian MA, Biggs WH 3rd, Treiber DK, Atteridge CE, Azimioara MD, Benedetti MG, Carter TA, Ciceri P, Edeen PT, Floyd M, Ford JM, Galvin M, Gerlach JL, Grotzfeld RM, Herrgard S, Insko DE, Insko MA, Lai AG, Lelias JM, Mehta SA, Milanov ZV, Velasco AM, Wodicka LM, Patel HK, Zarrinkar PP, Lockhart DJ.  A small molecule-kinase interaction map for clinical kinase inhibitors. Nat Biotechnol. 2005 Mar;23(3):329-36. Epub 2005 Feb 13.  PMID: 15711537
  4. Bentley SD, Aanensen DM, Mavroidi A, Saunders D, Rabbinowitsch E, Collins M, Donohoe K, Harris D, Murphy L, Quail MA, Samuel G, Skovsted IC, Kaltoft MS, Barrell B, Reeves PR, Parkhill J, Spratt BG. Genetic analysis of the capsular biosynthetic locus from all 90 pneumococcal serotypes.
    PLoS Genet. 2006 Mar;2(3):e31. Epub 2006 Mar 10. PMID: 16532061
Model systems for understanding biology

  1. Yandell M, Mungall CJ, Smith C, Prochnik S, Kaminker J, Hartzell G, Lewis S, Rubin GM. Large-scale trends in the evolution of gene structures within 11 animal genomes. PLoS Comput Biol. 2006 Mar;2(3):e15. Epub 2006 Mar 3. PMID: 16518452
  2. Beye M, Gattermeier I, Hasselmann M, Gempe T, Schioett M, Baines JF, Schlipalius D, Mougel F, Emore C, Rueppell O, Sirvio A, Guzman-Novoa E, Hunt G, Solignac M, Page RE Jr. Exceptionally high levels of recombination across the honey bee genome.  Genome Res. 2006 Oct 25; [Epub ahead of print] PMID: 17065604 [PubMed - as supplied by publisher]
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The practice of bioinformatics

  1. Butte AJ and Kohane IS. Creation and implications of a phenome-genome network.  Nat Biotechnol. 2006 Jan;24(1):55-62.

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Top Five Notable Events
  1. May 3, 2006.  VA laptop computer with personal information on 26 million veterans stolen
  2. July 20, 2006. IOM Report released on Medication Errors, estimating 1.5 million persons harmed and $3.5 B cost, advocating all prescriptions by electronic methods by 2010
  3. July 27, 2006.  House passes Health Information Technology Promotion Act of 2005, 270-148.
  4. September 19, 2006.  National Library of Medicine 2006 Long Range Plan released
  5. September 20, 2006.  Robert Kolodner named acting HHS' acting national coordinator for health information technology, replacing David Brailer
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Search methodology used to identify potentially high impact literature

Many thanks to Rebecca Jerome, MLS for developing and iteratively refining search profiles for both clinical and bioinformatics, and to Yin Aphinyanaphongs and his faculty mentors, whose Evidence Based Medicine search engine* for identifying high quality literature was applied to articles indexed by the MeSH heading 'Medical Informatics' and its child terms, for publications with Entrez date Nov 2005 – Oct 2006,

Clinical informatics searching methods: 

  • Clinical trials that included > 100 patients or providers, and those which appear to have the potential for significant clinical impact, e.g. the carvedilol study)
  • Primary PubMed search string:  randomized controlled trial[ptyp] AND (telemedicine[mh] OR informatics[tiab] OR medical informatics[mh])
  • Secondary PubMed search string: randomized[ti] AND (telemedicine[mh] OR informatics[tiab] OR medical informatics[mh])
  • Follow-up with examination of editorials from JAMIA and news sites (e.g. Reuters) to identify 2-3 additional studies

 Computational biology searching methods:

  • Primary PubMed search string: computational biology[mh] NOT (review[pt] OR letter[pt] OR case reports[pt] OR editorial[pt])
  • Secondary PubMed search string: computational biology[mh] AND (letter[pt] OR editorial[pt])
  • To see which articles were generating more discussion, follow-up with consideration of key science blogs and news sites
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*Aphinyanaphongs Y, Tsamardinos I, Statnikov A, Hardin D, Aliferis CF.  Text categorization models for high-quality article retrieval in internal medicine. J Am Med Inform Assoc. 2005 Mar-Apr;12(2):207-16. Epub 2004 Nov 23.  PMID: 15561789