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Dr. Daniel R. Masys is an Affiliate (volunteer) Professor of
Biomedical and Health Informatics, joining the Department of Biomedical
Informatics and Medical Education after retiring as Professor and Chair of
the Department of Biomedical Informatics and Professor of Medicine at the
Vanderbilt University School of Medicine in 2011. An honors graduate of
Princeton University and the Ohio State University College of Medicine, he
completed postgraduate training in Internal Medicine, Hematology and Medical
Oncology at the University of California, San Diego, and the Naval Regional
Medical Center, San Diego. He served as Chief of the International
Cancer Research Data Bank of the National Cancer Institute, National
Institutes of Health, and was also Director of the Lister Hill National Center
for Biomedical Communications, which is a computer research and development
division of the National Library of Medicine. He also served as
Director of Biomedical Informatics at the University of California, San Diego
School of Medicine, Director of the UCSD Human Research Protections Program,
and Professor of Medicine.
Dr. Masys is an
elected member of the National Academy of Medicine (formerly the Institute of
Medicine) of the National Academy of Sciences. He is a Diplomate of the
American Board of Internal Medicine in Medicine, Hematology, and Medical
Oncology. He is a Fellow of the American College of Physicians, and
Fellow and Past President of the American College of Medical
Informatics.
Dr. Masys' professional interests include development of informatics
infrastructure for conducting clinical and translational research,
genome-phenome correlation using phenotype data derived from electronic
medical records data, and approaches to incorporating genomic data
effectively into clinical systems.
Recent professional service
Selected Presentations
(GenomeTV) Keynote
talk at the NIH Genomic Medicine 7
conference on genomic clinical decision support, Bethesda, MD, October 2014.
Selected Recent Publications. (A complete MEDLINE
bibliography is available here):
Masys DR, Benson
DA. Don Lindberg and the
Creation of the National Center for Biotechnology Information. Stud
Health Technol Inform. 2022 Feb 1;288:113-121. doi: 10.3233/SHTI210986. PMID: 35102833.
Ackerman
MJ, Howe SE, Masys DR. Don Lindberg, High Performance Computing and Communications, and
Telemedicine. Stud Health Technol Inform. 2022 Feb 1;288:122-133.
doi: 10.3233/SHTI210987. PMID: 35102834.
Monroe-Wise
A, Kinuthia J, Fuller S, Dunbar M, Masuda D, Opiyo E, Muchai B, Chepken C, Omwenga E, Oboko R, Osoti A,
Masys D Chung MH. Improving Information and
Communications Technology (ICT) Knowledge and Skills to Develop Health
Research Capacity in Kenya. Online Journal of Public Health Informatics.
2019 Dec 31;11(3):e22. doi: 10.5210/ojphi.v11i3.10323. eCollection 2019.
Masys DR. Electronic Health Records
and Genomic Medicine. Chapter 9 in Ginsburg GS, Willard HF (eds.) Genomic
and Precision Medicine, Third Edition: Foundations, Translation, and
Implementation. Elsevier Academic Press. 2017.
ISBN-13: 978-0128006818.
Riley WT, Nilsen
WJ, Manolio TA, Masys DR, Lauer M. News from the NIH:
potential contributions of the behavioral and social sciences to the
precision medicine initiative. Transl Behav Med. 2015 Sep;5(3):243-6.
Malinowski
JR, Denny JC, Bielinski SJ, Basford MA, Bradford Y, Peissig PL, Carrell D,
Crosslin DR, Pathak J, Rasmussen L, Pacheco J, Kho A, Newton KM, Li R, Kullo
IJ, Chute CG, Chisholm RL, Jarvik GP, Larson EB, McCarty CA, Masys DR,
Roden DM, de Andrade M, Ritchie MD, Crawford DC. Genetic Variants
Associated with Serum Thyroid Stimulating Hormone (TSH) Levels in European
Americans and African Americans from the eMERGE
Network. PLoS One. 2014 Dec 1;9(12):e111301.
Denny JC,
Bastarache L, Ritchie MD, Carroll RJ, Zink R, Mosley JD, Field JR, Pulley JM,
Ramirez AH, Bowton E, Basford MA, Carrell DS, Peissig PL, Kho AN, Pacheco JA,
Rasmussen LV, Crosslin DR, Crane PK, Pathak J, Bielinski SJ, Pendergrass SA,
Xu H, Hindorff LA, Li R, Manolio TA, Chute CG, Chisholm RL, Larson EB, Jarvik
GP, Brilliant MH, McCarty CA, Kullo IJ, Haines JL, Crawford DC, Masys DR,
Roden DM. Systematic comparison of
phenome-wide association study of electronic medical record data and
genome-wide association study data. Nat Biotechnol. 2013 Nov
24;31(12):1102-1111.
Cortes CP, Wehbe
FH, McGowan CC, Shepherd BE, Duda SN, Jenkins CA, Gonzalez E, Carriquiry G,
Schechter M, Padgett D, Cesar C, Madero JS, Pape JW, Masys DR,
Sterling TR; Caribbean, Central American, South American Network for HIV
Research of the International Epidemiologic Databases to Evaluate AIDS.
Duration of
anti-tuberculosis therapy and timing of antiretroviral therapy initiation:
association with mortality in HIV-related tuberculosis. PLoS One. 2013 Sep 16;8(9):e74057.
Shameer K,
Denny JC, Ding K, Jouni H, Crosslin DR, de Andrade M, Chute CG, Peissig P,
Pacheco JA, Li R, Bastarache L, Kho AN, Ritchie MD, Masys DR, Chisholm
RL, Larson EB, McCarty CA, Roden DM, Jarvik GP, Kullo IJ. A genome- and
phenome-wide association study to identify genetic variants influencing
platelet count and volume and their pleiotropic effects. Hum Genet.
2013 Sep 12.
Ding K, de Andrade M, Manolio TA,
Crawford DC, Rasmussen-Torvik LJ, Ritchie MD, Denny JC, Masys DR,
Jouni H, Pachecho JA, Kho AN, Roden DM, Chisholm R,
Kullo IJ. Genetic
Variants That Confer Resistance to Malaria Are Associated with Red Blood Cell
Traits in African-Americans: An Electronic Medical
Record-based Genome-Wide Association Study. G3 (Bethesda). 2013 Jul
8;3(7):1061-8.
Oetjens MT, Denny JC, Ritchie MD, Gillani NB, Richardson DM, Restrepo NA,
Pulley JM, Dilks HH, Basford MA, Bowton E, Masys DR, Wilke RA, Roden
DM, Crawford DC. Assessment
of a pharmacogenomic marker panel in a polypharmacy population identified
from electronic medical records. Pharmacogenomics. 2013
May;14(7):735-44.
Ritchie MD, Denny JC, Zuvich RL, Crawford DC, Schildcrout
JS, Bastarache L, Ramirez AH, Mosely JD, Pulley JM, Basford MA, Bradford Y,
Rasmussen LV, Pathak J, Chute CG, Kullo IJ, McCarty CA, Chisholm RL, Kho AN,
Carlson CS, Larson EB, Jarvik GP, Sotoodehnia N,
Manolio TA, Li R, Masys DR, Haines JL, Roden DM. Genome- and Phenome-Wide
Analysis of Cardiac Conduction Identifies Markers of Arrhythmia Risk.
Circulation. 2013 Mar 5.
Masys DR, Harris PA, Fearn PA, Kohane IS, Designing a public square
for research computing. Sci. Transl. Med. 4, 149fs32 (August 2012).
Schildcrout JS, Denny JC, Bowton E, Gregg W, Pulley
JM, Basford MA, Cowan JD, Xu H, Ramirez AH, Crawford DC, Ritchie MD, Peterson
JF, Masys DR, Wilke RA, Roden DM. Optimizing drug outcomes
through pharmacogenetics: a case for preemptive genotyping. Clin Pharmacol Ther. 2012 Aug; 92(2):235-42.
Pulley JM, Denny JC, Peterson JF, Bernard GR, Vnencak-Jones CL, Ramirez AH,
Delaney JT, Bowton E, Brothers K, Johnson K, Crawford DC, Schildcrout
J, Masys DR, Dilks HH, Wilke RA, Clayton EW, Shultz E, Laposata M,
McPherson J, Jirjis JN, Roden DM. Operational Implementation of
Prospective Genotyping for Personalized Medicine: The Design of the
Vanderbilt PREDICT Project. Clin Pharmacol
Ther. 2012 May 16
Ding K, Shameer K, Jouni H, Masys DR, Jarvik GP,
Kho AN, Ritchie MD, McCarty CA, Chute CG, Manolio TA, Kullo IJ. Genetic Loci implicated in
erythroid differentiation and cell cycle regulation are associated with red
blood cell traits. Mayo Clin Proc. 2012
May;87(5):461-74.
Ramirez AH, Shi Y, Schildcrout
JS, Delaney JT, Xu H, Oetjens MT, Zuvich RL, Basford MA, Bowton E, Jiang M,
Speltz P, Zink R, Cowan J, Pulley JM, Ritchie MD, Masys DR, Roden DM,
Crawford DC, Denny JC. Predicting
warfarin dosage in European-Americans and African-Americans using DNA samples linked to an
electronic health record. Pharmacogenomics. 2012 Feb 13.
Masys DR, Jarvik GP, Abernethy NF,
Anderson NR, Papanicolaou GJ, Paltoo DN, Hoffman MA, Kohane IS, Levy
HP. Technical
desiderata for the integration of genomic data into Electronic Health
Records. J Biomed Inform. 2011 Dec 27.
Delaney JT, Ramirez AH, Bowton E, Pulley JM, Basford MA, Schildcrout
JS, Shi Y, Zink R, Oetjens M, Xu H, Cleator JH, Jahangir E, Ritchie MD, Masys
DR, Roden DM, Crawford DC, Denny JC. Predicting Clopidogrel
Response Using DNA Samples Linked to an Electronic Health Record. Clin Pharmacol Ther. 2011 Dec 21. doi:
10.1038/clpt.2011.221.
Denny JC, Crawford DC, Ritchie MD, Bielinski SJ, Basford MA, Bradford Y, Chai
HS, Bastarache L, Zuvich R, Peissig P, Carrell D, Ramirez AH, Pathak J, Wilke
RA, Rasmussen L, Wang X, Pacheco JA, Kho AN, Hayes MG, Weston N, Matsumoto M,
Kopp PA, Newton KM, Jarvik GP, Li R, Manolio TA, Kullo IJ, Chute CG, Chisholm
RL, Larson EB, McCarty CA, Masys DR, Roden DM, de Andrade M. Variants near FOXE1 are
associated with hypothyroidism and other thyroid conditions: using electronic
medical records for genome- and phenome-wide studies. Am J Hum Genet.
2011 Oct 7;89(4):529-42
Xu H, Jiang M, Oetjens M, Bowton EA, Ramirez AH, Jeff JM, Basford MA, Pulley
JM, Cowan JD, Wang X, Ritchie MD, Masys DR, Roden DM, Crawford DC,
Denny JC. Facilitating pharmacogenetic
studies using electronic health records and natural-language processing: a
case study of warfarin. J Am
Med Inform Assoc. 2011 Jul-Aug;18(4):387-91.
McCarty CA,
Chisholm RL, Chute CG, Kullo IJ, Jarvik GP, Larson EB, Li R, Masys DR,
Ritchie MD, Roden DM, Struewing JP, Wolf WA; eMERGE
Team. The eMERGE Network: a consortium of biorepositories linked to
electronic medical records data for conducting genomic studies. BMC Med Genomics. 2011 Jan 26;4:13.
Malin B, Benitez K, Masys D. Never too old
for anonymity: a statistical standard for demographic data sharing via the
HIPAA Privacy Rule. J Am
Med Inform Assoc. 2011 Jan-Feb;18(1):3-10.
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