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University of
Washington


UW
Dermatologic Surgery
Botox®
Dr Berg provides Botox® injections at the UW
Dermatologic Surgery Center and the UW Cosmetic Surgery
Center. Botulinum toxin in dermatologic surgery is useful
for treatment of dynamic wrinkles (e.g. frown lines or
"crow's feet"). Botox®
has been used for treatment of a variety of medical
conditions for many years, and it recently received specific
FDA approval for cosmetic use in frown lines. Botulinum
Toxin is also very successful at reducing sweat particularly
under the arms in people with excess sweating
(hyperhidrosis).
WHAT
IS BOTULINUM TOXIN OR
BOTOX®?
Botox®
is the trade name of Botulinum toxin Type A which is a
purified protein produced by a bacterium called Clostridium
botulinum. Like many things, excess is a bad thing ... in
large doses taken internally, usually from eating
contaminated canned foods, it causes a disease called
botulism. Used in purified form, in tiny amounts and in
specific muscles, injections of Botox®
will relax the action of that specific muscle, achieving
desired effects. It is used widely in medicine in several
conditions for treatment of excess muscle spasm and to relax
muscles around the eyes. In dermatology and cosmetic surgery
it is primarily used for treatment of unwanted lines and
localized excess sweating (hyperhidrosis).
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BOTOX FOR WRINKLES AND FROWN
LINES
WHAT CAUSES WRINKLES AND
FROWN
LINES?
Frown lines and some wrinkles are caused by the constant
action of muscles underneath the skin. In particular a
furrow in the area between our eyebrows may appear and
persist because of the repeated, often unconscious action of
a muscle called "corrugator". These furrows can produce an
angry or frustrated look on our face. Muscles around the eye
are responsible for the "crow's feet" wrinkles that appear
on the outside aspect of the eyes.
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WHAT BENEFITS CAN I
EXPECT?
Botox®
can relax the underlying muscle in which it is injected. By
relaxing these muscles, frown lines and certain other lines
become less noticeable or deep, especially during day to day
activities. Most patients do not find that Botox®
makes them "expressionless", but in fact find that used
properly certain targeted areas respond very well.
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HOW IS THE BOTOX GIVEN?
This depends on the muscle being treated. To improve
frown lines, the BOTOX®
is injected directly into the corrugator muscle. This
reduces your ability to contract the muscle and the frown
line gradually fades away. While the BOTOX®
is working you will be unable to vigorously draw your
eyebrows together when you frown.
DOES THE INJECTION
HURT?
The treatment itself takes only a few minutes and just
feels like the minor sting of the needle. Very rarely
bruising (visible but usually painless) may occur from the
needle.
IS THERE A DANGER OF BOTULISM
FROM BOTOX®?
No. Given by trained physicians in the correct amount
there is no danger of botulism from Botox®.
Botulism is caused by very large amounts of the toxin in the
system usually from eating contaminated food. Only a tiny
fraction of the toxic dose is used in medical indications.
Botox®
has been used since the 1980s (in larger doses than you will
receive) for the treatment of muscle diseases (like muscle
spasm) and has been shown to be extremely safe in many
published medical studies and articles.
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WILL THE TREATMENT BE
PERMANENT?
No. The Botox®
will begin to work in 2-4 days. Gradually over three to four
months the BOTOX®
effect will fade. When the frown line begins to reappear, a
simple repeat injection is all that is necessary to maintain
the effect.
WHAT ARE THE SIDE
EFFECTS?
There is a small sting as the injection occurs. Rarely
there can be a bruise at the site. Less than 1% of patients
may develop a slight lowering (ptosis) of the eyelid. This
may or may not be noticed and is always temporary. Other
side effects are rare and can be discussed with your doctor.
This may or may not be noticed and is always temporary.
Botox®
should not be used if you may be pregnant or if you are
taking aminoglycoside antibiotics (you can ask your doctor).
It should not be used if you have a history of myasthenia
gravis.
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Photos of Patient Before and After Botox for
Frown Lines
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Frowning - Before Botox
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Frowning - After Botox
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At Rest - Before Botox
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At Rest - After Botox
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BOTOX FOR LOCALIZED
HYPERHIDROSIS
WHAT IS LOCALIZED
HYPERHIDROSIS?
Hyperhidrosis refers
to a condition of abnormally excessive sweating. This can be
generalized (all over) or localized to specific areas, most
commonly the axilla (armpits) or palms. When severe,
localized hyperhidrosis can lead to significant effects on
quality of life, necessitating frequent clothing changes and
causing significant stress and/or impairment in social or
work situations. In most cases localized hyperhidrosis is a
condition that occurs without a known cause. In rare cases,
it may be related to internal problems. Consultation with a
physician is recommended before considering medical
treatments for hyperhidrosis for this reason.
WHAT ARE TREATMENTS FOR
HYPERHIDROSIS?
Options for
treatment of localized hyperhidrosis vary depending on the
area to be treated. Consultation with a physician (e.g.
dermatologist) who is knowledgeable about this condition is
recommended. Use of Aluminum Chloride (Drysol®)
liquid is effective in some people. This is a medication
available through the pharmacy. Devices are available
(iontophoresis) which may help block the excess
sweating for some people. For the axillae (armpits), surgery
under local anesthesia (suction curettage) can be done to
try and give long-lasting sweat reduction. Surgery to
destroy the nerves that supply the sweat glands may also be
a very useful permanent solution in some patients. This is
called thoracic sympathectomy. Finally Botox®
has been shown in several medical studies to be a very
effective treatment for patients with localized
hyperhidrosis, especially in the axilla.
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HOW DOES BOTOX WORK FOR
HYPERHIDROSIS?
Botox®
blocks the nervous system stimulation of the sweat glands in
the armpits or palms or other localized areas. It is
directly injected into the skin in the area that is sweating
excessively. After a few days, significant and often
dramatic reduction in sweating is seen in many patients. The
duration of effect lasts on average 4-6 months, but some
patients get up to a year of reduced sweating from an
injection. Side effects are minimal in the axilla though
transient muscle weakness can occur in the palms.
Further information on Botulinum Toxin Type A
(Botox®) is well presented by the American Society
for Dermatologic Surgery (ASDS) at their website.
Click
here for the ASDS page on Botulinum Toxin
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