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Necessary But Not Sufficient

by Greg Crowther and Do Peterson


Lyrics

The muscle starts to pull its load, but glucose use is slow
Because [Pi] and [ADP] and [AMP] are low.

CHORUS:
Necessary but not sufficient:
Something's there and yet something's missin',
And the textbook authors sure will be surprised.
High metabolites? Not sufficient.
Muscles pulling tight? Not sufficient.
The two must coexist for flux to rise.

Contraction ends, and once again, the glucose use subsides.
This sudden drop cannot be stopped by high metabolites.

CHORUS

'Cause you need two things to turn glycolysis on,
And you need two things to keep the flux going strong.
Yes, you need two things; you need two things,
Just two things.

'Cause you need two things to turn glycolysis on,
And you need two things to keep the flux going strong.
Yes, you need two things; you need two things,
Just two things.


Comments

This song is based on two research papers: The control of glycolysis in contracting skeletal muscle. I. Turning it on and II. Turning it off.