Recent Publications from Champoux Lab |
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Stewart, L., Redinbo, M. R., Qiu, X., Hol, W. G. J. and Champoux, J. J. (1998). A Model For the Mechanism of Human Topoisomerase I. Science 279:1534-1541. Kelleher, C. D. and Champoux, J. J. (1998). Characterization of RNA Strand Displacement Synthesis by Moloney Murine Leukemia Virus Reverse Transcriptase. J. Biol. Chem. 273:9976-9986. Kelleher, C. D. and Champoux, J. J. (2000). RNA Degradation and Primer Selection by Moloney Murine Leukemia Virus Reverse Transcriptase Contribute to the Accuracy of Plus-Strand Initiation. J. Biol. Chem. 275:13061-13070. Redinbo, M. R., Champoux, J. J. and Hol, W. G. J. (2000). Novel Insights into Catalytic Mechanism from a Crystal Structure of Human Topoisomerase I in Complex with DNA. Biochemistry 39:6832-6840. Ireton, G. C., Stewart, L., Parker, L. H. and Champoux, J. J. (2000). Expression of Human Topoisomerase I With a Partial Deletion of the Linker Region Yields Monomeric and Dimeric Enzymes That Respond Differently to Camptothecin. J. Biol. Chem. 275:25820-25830. Schultz, S. J., Zhang, M., Kelleher, C. D. and Champoux, J. J. (2000). Analysis of Plus-Strand Primer Selection, Removal, and Re-Utilization by Retroviral Reverse Transcriptases. J. Biol. Chem. 275:32299-32309. Yang, Z. and Champoux, J. J. (2001). The Role of Histidine 632 in Catalysis by Human Topoisomerase I. J. Biol. Chem. 276:677-685. Winshell, J. and
Champoux, J. J. (2001). Structural
Alterations in the DNA Ahead of the Primer Terminus During Displacement
Synthesis by Reverse Transcriptases. J. Mol. Biol. 306:931-943. Champoux, J. J. (2001). DNA Topoisomerases: Structure,
Function and Mechanism. Annu. Rev.
Biochem. 70:369-413. Interthal, H., Pouliot, J. J. and Champoux, J. J. (2001). The Tyrosyl-DNA Phosphodiesterase Tdp1 is a Member of the Phospholipase D Superfamily. Proc. Natl. Acad. Sci. USA 98:12009-12014. Davies, D. R., Interthal, H., Champoux, J. J., and Hol, W. G. J. (2002). The Crystal Structure of Human Tyrosyl-DNA Phosphodiesterase, Tdp1. Structure 10:237-248. Champoux, J. J. (2002). A First View of the Structure of a Type IA Topoisomerase with Bound DNA. Trends in Pharmacol. Sci. 23:199-201. Yang, Z. and Champoux, J. J. (2002). Reconstitution of Enzymatic Activity by the Association of the Cap and Catalytic Domains of Human Topoisomerase I. J. Biol. Chem. 277:30815-30823. Champoux, J. J. (2002). Commentary—Type IA DNA Topoisomerases: Strictly One Step at a Time. Proc. Natl. Acad. Sci. USA 99:11998-2000. Davies, D. R., Interthal, H., Champoux, J. J. and Hol, W. G. J. (2002). Insights into Substrate Binding and Catalytic Mechanism of Human Tyrosyl DNA Phosphodiesterase (Tdp1) from Vanadate- and Tungstate-Inhibited Structures. J. Mol. Biol. 324:917-932. Davies, D. R., Interthal, H., Champoux J. J. and Hol, W. G. J. (2003). Crystal Structure of a Transition State Mimic for Tyrosyl-DNA Phosphodiesterase (Tdp1) Assembled From Vanadate, DNA and a Topoisomerase I-Derived Peptide. Chemistry and Biology 10:139-147. Schultz, S. J., Zhang, M. and Champoux, J. J. (2003). Specific Cleavages by RNase H Facilitate Initiation of Plus-Strand RNA Synthesis by Moloney Murine Leukemia Virus. J. Virol. 77:5275-5285. Carey, J. F., Schultz, S. J., Sisson, L., Fazzio, T. G. and Champoux, J. J. (2003). DNA Relaxation by Human Topoisomerase I Occurs in the Closed Clamp Conformation of the Protein. Proc. Natl. Acad. Sci. USA. 100:5640-5645. Interthal, H., Quigley, P. M., Hol, W.G. J., and Champoux, J. J. (2004). The Role of Lysine 532 in the Catalytic Mechanism of Human Topoisomerase I. J. Biol. Chem. 279:2984-2992. Davies, D. R., Interthal, H., Champoux, J. J., and Hol, W. G. J. (2004). Explorations of Peptide and Oligonucleotide Binding Sites of Tyrosyl-DNA Phosphodiesterase (Tdp1) Using Vanadate Complexes. J. Med. Chem. 47:829-837. |
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